Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0055 | 0 | 0.5 | |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0206 | 0.4664 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0206 | 0.4664 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0206 | 0.4664 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0206 | 0.4664 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0206 | 0.4664 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0206 | 0.4664 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0206 | 0.4664 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0206 | 0.4664 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0257 | 0.626 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0206 | 0.4664 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0206 | 0.4664 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0206 | 0.4664 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0206 | 0.4664 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0206 | 0.4664 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0206 | 0.4664 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0206 | 0.4664 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0206 | 0.4664 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0206 | 0.4664 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0378 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.