Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Serotonin receptor | 0.0024 | 0.0479 | 1 |
Onchocerca volvulus | 0.0024 | 0.0479 | 0.5 | |
Onchocerca volvulus | 0.0024 | 0.0479 | 0.5 | |
Leishmania major | DNA polymerase eta, putative | 0.0022 | 0.04 | 0.5 |
Onchocerca volvulus | 0.0024 | 0.0479 | 0.5 | |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.04 | 1 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0024 | 0.0479 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.04 | 1 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0024 | 0.0479 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.04 | 1 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0024 | 0.0479 | 1 |
Trypanosoma brucei | unspecified product | 0.0022 | 0.04 | 1 |
Echinococcus multilocularis | g protein coupled receptor | 0.0024 | 0.0479 | 1 |
Onchocerca volvulus | 0.0024 | 0.0479 | 0.5 | |
Schistosoma mansoni | amine GPCR | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | sex peptide receptor | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | g protein coupled receptor | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0024 | 0.0479 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.04 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0024 | 0.0479 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0022 | 0.04 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.04 | 1 |
Echinococcus granulosus | g protein coupled receptor | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0024 | 0.0479 | 1 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | neuropeptide receptor | 0.0024 | 0.0479 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0189 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0022 | 0.04 | 0.5 |
Echinococcus granulosus | neuropeptide receptor | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0479 | 1 |
Brugia malayi | Dopamine receptor protein 1 | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | biogenic amine receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0024 | 0.0479 | 1 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | neuropeptide receptor | 0.0024 | 0.0479 | 1 |
Brugia malayi | AKH receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Onchocerca volvulus | 0.0024 | 0.0479 | 0.5 | |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0024 | 0.0479 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.04 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.04 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0024 | 0.0479 | 1 |
Onchocerca volvulus | 0.0024 | 0.0479 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.0024 | 0.0479 | 1 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0024 | 0.0479 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0189 | 1 | 1 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | allatostatin A receptor | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.0024 | 0.0479 | 1 |
Brugia malayi | sulfakinin receptor protein | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | amine GPCR | 0.0024 | 0.0479 | 1 |
Onchocerca volvulus | 0.0024 | 0.0479 | 0.5 | |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.0024 | 0.0479 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.04 | 1 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | histamine h1 receptor | 0.0024 | 0.0479 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0024 | 0.0479 | 0.5 |
Onchocerca volvulus | 0.0024 | 0.0479 | 0.5 | |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0024 | 0.0479 | 1 |
Brugia malayi | neuropeptide F receptor | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0024 | 0.0479 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0189 | 1 | 1 |
Brugia malayi | neuropeptide F receptor | 0.0024 | 0.0479 | 1 |
Brugia malayi | GnHR receptor homolog | 0.0024 | 0.0479 | 1 |
Brugia malayi | Melatonin receptor type 1A | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | biogenic amine receptor | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | biogenic amine receptor | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | fmrfamide receptor | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | orexin receptor type 2 | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0024 | 0.0479 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0022 | 0.04 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | opsin-like receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | fmrfamide receptor | 0.0024 | 0.0479 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.04 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0189 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.0024 | 0.0479 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0189 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | g protein coupled receptor | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0024 | 0.0479 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0024 | 0.0479 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0024 | 0.0479 | 1 |
Brugia malayi | G protein-coupled receptor | 0.0024 | 0.0479 | 1 |
Onchocerca volvulus | 0.0024 | 0.0479 | 0.5 | |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0189 | 1 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | amine GPCR | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | g-protein coupled receptor | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | somatostatin receptor | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | neuropeptide receptor | 0.0024 | 0.0479 | 1 |
Onchocerca volvulus | 0.0024 | 0.0479 | 0.5 | |
Schistosoma mansoni | neuropeptide receptor | 0.0024 | 0.0479 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0024 | 0.0479 | 1 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0024 | 0.0479 | 1 |
Brugia malayi | ORL1-like opioid receptor | 0.0024 | 0.0479 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | opsin-like receptor | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | sex peptide receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Brugia malayi | larval opioid receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Onchocerca volvulus | 0.0024 | 0.0479 | 0.5 | |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | somatostatin receptor | 0.0024 | 0.0479 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.04 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0024 | 0.0479 | 1 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.0024 | 0.0479 | 1 |
Brugia malayi | Dopamine receptor | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | amine GPCR | 0.0024 | 0.0479 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0022 | 0.04 | 0.5 |
Onchocerca volvulus | 0.0024 | 0.0479 | 0.5 | |
Echinococcus granulosus | G protein coupled receptor 139 | 0.0024 | 0.0479 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0479 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.04 | 1 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.0024 | 0.0479 | 1 |
Brugia malayi | RE15519p | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Onchocerca volvulus | 0.0024 | 0.0479 | 0.5 | |
Onchocerca volvulus | 0.0024 | 0.0479 | 0.5 | |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | myosin xvIII | 0.0024 | 0.0479 | 1 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | neuropeptide s receptor | 0.0024 | 0.0479 | 1 |
Brugia malayi | G-protein coupled receptor | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0024 | 0.0479 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.04 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | g-protein coupled receptor | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0024 | 0.0479 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | allatostatin A receptor | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0024 | 0.0479 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.04 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.0024 | 0.0479 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0479 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.04 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | amine GPCR | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0024 | 0.0479 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.04 | 1 |
Onchocerca volvulus | 0.0024 | 0.0479 | 0.5 | |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0022 | 0.04 | 1 |
Brugia malayi | Dopamine receptor protein 2 | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Onchocerca volvulus | 0.0024 | 0.0479 | 0.5 | |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0189 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0189 | 1 | 0.5 |
Echinococcus granulosus | dro:myosuppressin receptor | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | g protein coupled receptor | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | orexin receptor type 2 | 0.0024 | 0.0479 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | adenoreceptor | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0024 | 0.0479 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Brugia malayi | putative neuropeptide receptor | 0.0024 | 0.0479 | 1 |
Onchocerca volvulus | 0.0024 | 0.0479 | 0.5 | |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0024 | 0.0479 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | serotonin receptor | 0.0024 | 0.0479 | 1 |
Brugia malayi | Serotonin receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | fmrfamide receptor | 0.0024 | 0.0479 | 1 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | opsin-like receptor | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.04 | 1 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0024 | 0.0479 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.04 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0022 | 0.04 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0479 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0024 | 0.0479 | 1 |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.0024 | 0.0479 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | <= 40 % | Induction of granulocytic differentiation in human U937 cells assessed as CD11c positive/propidium iodide negative cells at 50 uM after 30 hrs by FACS analysis | ChEMBL. | No reference |
Inhibition (binding) | Inhibition of HDAC in human U937 cells assessed as slight increase in histone H3 acetylation at 50 uM after 24 hrs by western blot analysis | ChEMBL. | No reference | |
Inhibition (binding) | Inhibition of HDAC in human U937 cells assessed as slight increase in alpha tubulin acetylation at 50 uM after 24 hrs by western blot analysis | ChEMBL. | No reference | |
Inhibition (binding) | = 37 % | Inhibition of human recombinant full length C-terminal His tagged HDAC4 expressed in baculovirus system using non-histone trifluoroacetyl-lysine derivative as substrate at 5 uM incubated for 15 mins prior to substrate addition by fluorimetric analysis | ChEMBL. | No reference |
Inhibition (binding) | = 46 % | Inhibition of human recombinant full length C-terminal His tagged HDAC1 expressed in baculovirus system using histone H3 as substrate at 5 uM incubated for 15 mins prior to substrate addition by fluorimetric analysis | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.