Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 50 uM | Cytotoxicity against human THP1 cells | ChEMBL. | No reference |
EC50 (functional) | Antileishmanial activity against promastigote stage of Leishmania donovani MHOM/ET/67/HU3 assessed as parasite viability after 48 hrs by resazurin dye-based assay | ChEMBL. | No reference | |
EC50 (functional) | > 50 uM | Antileishmanial activity against amastigote stage of Leishmania donovani MHOM/ET/67/HU3 infected in human THP1 cells assessed as parasite clearance after 3 days by Draq5 staining-based confocal microscopic analysis | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.