Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase | 0.0909 | 0.9291 | 0.9267 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0788 | 0.7908 | 0.8458 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0909 | 0.9291 | 0.9267 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0909 | 0.9291 | 0.5 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0714 | 0.7057 | 0.7508 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0909 | 0.9291 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.066 | 0.6439 | 0.693 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0128 | 0.0326 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.097 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0909 | 0.9291 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0909 | 0.9291 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0909 | 0.9291 | 0.9267 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0909 | 0.9291 | 0.5 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0202 | 0.1177 | 0.088 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0909 | 0.9291 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.066 | 0.6439 | 0.6319 |
Trypanosoma brucei | protein kinase, putative | 0.0909 | 0.9291 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0909 | 0.9291 | 0.5 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0384 | 0.3268 | 0.3282 |
Loa Loa (eye worm) | glutamate receptor | 0.031 | 0.2417 | 0.2162 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0909 | 0.9291 | 0.9267 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0128 | 0.0326 | 0.5 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0202 | 0.1177 | 0.088 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0909 | 0.9291 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0909 | 0.9291 | 0.9267 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.0492 | 0.0172 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0384 | 0.3268 | 0.3518 |
Loa Loa (eye worm) | glutamate receptor | 0.0788 | 0.7908 | 0.7838 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0909 | 0.9291 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0896 | 0.9149 | 0.9847 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.066 | 0.6439 | 0.6319 |
Brugia malayi | MAP kinase sur-1 | 0.0909 | 0.9291 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.0492 | 0.053 |
Schistosoma mansoni | hypothetical protein | 0.0128 | 0.0326 | 0.035 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0909 | 0.9291 | 0.5 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0202 | 0.1177 | 0.0949 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0909 | 0.9291 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.097 | 1 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.0492 | 0.0172 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0909 | 0.9291 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0909 | 0.9291 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0909 | 0.9291 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.1177 | 0.088 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 100 mg kg-1 | Ex vivo inhibition of LTB4 production was measured in dog blood | ChEMBL. | 1848292 |
IC50 (functional) | = 1.4 uM | In vitro inhibition of LTB4 production was measured in rat blood | ChEMBL. | 1848292 |
IC50 (functional) | = 400 uM | In vitro inhibition of PGE-2 production was measured in rat blood | ChEMBL. | 1848292 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.