Detailed information for compound 185313

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 193.593 | Formula: C7H4ClN5
  • H donors: 2 H acceptors: 3 LogP: 0.91 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1c[nH]c(n1)c1nc(c[nH]1)C#N
  • InChi: 1S/C7H4ClN5/c8-5-3-11-7(13-5)6-10-2-4(1-9)12-6/h2-3H,(H,10,12)(H,11,13)
  • InChiKey: JDFWENXPPXBAGB-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cytochrome P450 family protein 0.0047 0.0564 0.0565
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.013
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0702 0.9778 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0097 0.1261 0.1278
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0124 0.008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0523 0.0523
Echinococcus multilocularis Tetratricopeptide repeat protein 1 0.0016 0.0124 0.0124
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0097 0.1261 0.1278
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0172 0.0163
Echinococcus multilocularis lamin 0.0026 0.0268 0.0268
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0702 0.9778 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0702 0.9778 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.1571 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.013 0.0086
Toxoplasma gondii O-linked N-acetylglucosamine transferase 0.0016 0.0124 0.0642
Schistosoma mansoni lamin 0.0026 0.0268 0.0268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0523 0.0523
Echinococcus granulosus tar DNA binding protein 0.0126 0.167 0.167
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0172 0.013
Loa Loa (eye worm) hypothetical protein 0.0013 0.0078 0.0067
Brugia malayi CXXC zinc finger family protein 0.0028 0.0298 0.0292
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0124 0.0081
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0078 0.0078
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0097 0.1261 1
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0702 0.9778 1
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0097 0.1261 1
Echinococcus granulosus dna polymerase eta 0.0019 0.0172 0.0172
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0172 0.013
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0112 0.1483 0.1483
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0024 0.0024
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0702 0.9778 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.013 0.0086
Onchocerca volvulus 0.0026 0.0268 0.1267
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0069 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.013
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0097 0.1261 0.1248
Loa Loa (eye worm) TAR-binding protein 0.0126 0.167 0.1697
Echinococcus granulosus cytochrome P450 2K1 0.001 0.0046 0.0046
Trypanosoma brucei stress-inducible protein STI1-like, putative 0.0016 0.0124 0.0081
Schistosoma mansoni Smad4 0.0008 0.0013 0.0013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0172 0.013
Schistosoma mansoni tar DNA-binding protein 0.0126 0.167 0.167
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.013 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0126 0.167 0.167
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.013 0.0006
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0702 0.9778 0.9778
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.056 0.056
Echinococcus multilocularis Smad4 0.0008 0.0013 0.0013
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.013 0.0006
Trypanosoma brucei small glutamine-rich tetratricopeptide repeat protein, putative 0.0016 0.0124 0.0081
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.1404 0.8901
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.167 0.1697
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.013 0.0006
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0097 0.1261 0.1151
Schistosoma mansoni fk506 binding protein 0.0097 0.1261 0.1261
Trypanosoma brucei stress-inducible protein STI1-like, putative 0.0016 0.0124 0.0081
Schistosoma mansoni o-linked n-acetylglucosamine transferase ogt 0.0016 0.0124 0.0124
Trichomonas vaginalis fk506 binding protein, putative 0.0097 0.1261 0.1178
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.013 0.0086
Schistosoma mansoni immunophilin 0.0718 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0165 0.0122
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0172 0.013
Schistosoma mansoni immunophilin 0.0621 0.8641 0.8641
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0124 0.0124
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0097 0.1261 0.7964
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0523 0.0523
Loa Loa (eye worm) RNA binding protein 0.0126 0.167 0.1697
Trypanosoma cruzi N-acetyltransferase subunit Nat1, putative 0.0016 0.0124 0.008
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.013 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.013
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0097 0.1261 0.1248
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0097 0.1261 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0088 0.0043
Echinococcus granulosus cpg binding protein 0.003 0.0321 0.0321
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD) 0.0097 0.1261 0.1178
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0523 0.0523
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0165 0.0156
Schistosoma mansoni lamin 0.0026 0.0268 0.0268
Mycobacterium tuberculosis Probable reductase 0.0107 0.1404 0.8901
Trypanosoma cruzi serine/threonine protein phosphatase type 5, putative 0.0016 0.0124 0.008
Echinococcus multilocularis small glutamine rich tetratricopeptide 0.0016 0.0124 0.0124
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0268 0.0261
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.013 0.013
Treponema pallidum NADH oxidase 0.0016 0.013 0.0006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.013 0.0086
Mycobacterium ulcerans hypothetical protein 0.0097 0.1261 0.1248
Giardia lamblia Hypothetical protein 0.0097 0.1261 0.1178
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0097 0.1261 0.1178
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.013 0.0086
Schistosoma mansoni cpg binding protein 0.003 0.0321 0.0321
Brugia malayi intermediate filament protein 0.0026 0.0268 0.0261
Echinococcus multilocularis fk506 binding protein 0.0702 0.9778 0.9778
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0702 0.9778 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0165 0.0156
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0097 0.1261 0.1278
Onchocerca volvulus 0.0026 0.0268 0.1267
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.013
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0702 0.9778 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 0.0261
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.013
Schistosoma mansoni tar DNA-binding protein 0.0126 0.167 0.167
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0165 0.0156
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0523 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.1261 0.1178
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0172 0.013
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0702 0.9778 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.013 0.0086
Echinococcus multilocularis dna polymerase eta 0.0019 0.0172 0.0172
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0702 0.9778 1
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0124 0.008
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0172 0.005
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0172 0.0163
Loa Loa (eye worm) hypothetical protein 0.0026 0.0261 0.0254
Toxoplasma gondii tetratricopeptide repeat domain containing protein 0.0016 0.0124 0.0642
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0172 0.0172
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0564 0.0565
Schistosoma mansoni intermediate filament proteins 0.0026 0.0268 0.0268
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0718 1 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0098 0.0087
Echinococcus granulosus lamin 0.0026 0.0268 0.0268
Echinococcus granulosus dna polymerase kappa 0.0019 0.0172 0.0172
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0097 0.1261 0.1248
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0097 0.1261 0.1151
Brugia malayi Cytochrome P450 family protein 0.001 0.0046 0.0034
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.013 0.013
Echinococcus granulosus FK506 binding protein 2 0.0097 0.1261 0.1261
Trypanosoma brucei unspecified product 0.0013 0.0088 0.0043
Loa Loa (eye worm) TPR Domain containing protein 0.0016 0.0124 0.0113
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0172 0.0163
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0097 0.1261 0.1248
Toxoplasma gondii thioredoxin reductase 0.0047 0.056 0.4232
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0621 0.8641 0.8641
Loa Loa (eye worm) hypothetical protein 0.0605 0.8419 0.8609
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0743 0.0743
Brugia malayi Thioredoxin reductase 0.0047 0.056 0.056
Schistosoma mansoni protein phosphatase-5 0.0016 0.0124 0.0124
Loa Loa (eye worm) FKBP5 protein 0.0702 0.9778 1
Schistosoma mansoni cytochrome P450 0.001 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0097 0.1261 0.1261
Leishmania major stress-induced protein sti1 0.0016 0.0124 0.008
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.1404 0.8901
Schistosoma mansoni cellular tumor antigen P53 0.0097 0.1262 0.1262
Leishmania major trypanothione reductase 0.0047 0.056 0.0528
Leishmania major hypothetical protein, conserved 0.0016 0.0124 0.0081
Echinococcus granulosus stress induced phosphoprotein 1 0.0016 0.0124 0.0124
Echinococcus granulosus intermediate filament protein 0.0026 0.0268 0.0268
Trypanosoma brucei TPR-repeat-containing chaperone protein DNAJ, putative 0.0016 0.0124 0.008
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0097 0.1261 0.1278
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0097 0.1261 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.1404 0.8901
Plasmodium falciparum thioredoxin reductase 0.0016 0.013 0.0006
Trypanosoma brucei trypanothione reductase 0.0047 0.056 0.0528
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0172 0.013
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.013 0.0086
Trichomonas vaginalis immunophilin, putative 0.0702 0.9778 1
Trypanosoma brucei unspecified product 0.0019 0.0172 0.013
Trypanosoma brucei serine/threonine protein phosphatase 5 0.0016 0.0124 0.008
Brugia malayi Cytochrome P450 family protein 0.0019 0.0165 0.0156
Brugia malayi TPR Domain containing protein 0.0016 0.0124 0.0113
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0172 0.0172
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0621 0.8641 0.8641
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0097 0.1261 0.1248
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.013 0.0086
Plasmodium falciparum glutathione reductase 0.0016 0.013 0.0006
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.056 0.0528
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.013 0.069
Plasmodium falciparum thioredoxin reductase 0.0047 0.056 0.0452
Loa Loa (eye worm) hypothetical protein 0.0019 0.0172 0.0163
Onchocerca volvulus 0.0097 0.1261 0.9984
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.013 0.0086
Trypanosoma cruzi N-acetyltransferase subunit Nat1, putative 0.0016 0.0124 0.008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.013 0.0086
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0702 0.9778 1
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0165 0.0122
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0097 0.1261 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0718 1 1
Leishmania major hypothetical protein, conserved 0.0016 0.0124 0.008
Loa Loa (eye worm) UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 0.0016 0.0124 0.0114
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0098 0.0087
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0172 0.0172
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0702 0.9778 0.9778
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.013 0.0006
Plasmodium falciparum glutathione reductase 0.0047 0.056 0.0452
Echinococcus granulosus tumor protein p63 0.0661 0.92 0.92
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0097 0.1261 0.1248
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0097 0.1261 0.1248
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0069 0.0058
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.013 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.013
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.013 0.0086
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0172 0.0172
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0523 0.0523
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0172 0.013
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.1404 0.8901
Schistosoma mansoni tar DNA-binding protein 0.0126 0.167 0.167
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0097 0.1261 0.1178
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0024 0.0012
Echinococcus multilocularis O glycosyltransferase 0.0016 0.0124 0.0124
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0013 0.0013
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0702 0.9778 1
Loa Loa (eye worm) TPR Domain containing protein 0.0016 0.0124 0.0114
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0013 0.0013
Schistosoma mansoni smad1 5 8 and 0.0008 0.0013 0.0013
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0165 0.0122
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0097 0.1261 0.1178
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0718 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0172 0.0172
Brugia malayi MH2 domain containing protein 0.0116 0.1537 0.1561
Loa Loa (eye worm) glutathione reductase 0.0047 0.056 0.056
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0172 0.013
Leishmania major fk506-binding protein 1-like protein 0.0702 0.9778 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0097 0.1261 0.1278
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.013 0.012
Onchocerca volvulus 0.0097 0.1261 0.9984
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0702 0.9778 1
Schistosoma mansoni heat shock protein 70 0.0016 0.0124 0.0124
Schistosoma mansoni DNAj homolog subfamily C member 0.0016 0.0124 0.0124
Brugia malayi TPR Domain containing protein 0.0016 0.0124 0.0113
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0097 0.1261 0.1278
Echinococcus granulosus dnaJ subfamily B 0.0402 0.5551 0.5551
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0702 0.9778 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.013 0.0086
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.006
Echinococcus granulosus STIP1 y and U box containing protein 1 0.0016 0.0124 0.0124
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0172 0.013
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0078 0.0078
Schistosoma mansoni DNA polymerase eta 0.0019 0.0172 0.0172
Echinococcus multilocularis mitochondrial import receptor subunit tom34 0.0016 0.0124 0.0124
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0298 0.0292
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.013 0.0086
Trypanosoma cruzi stress-inducible protein STI1-like, putative 0.0016 0.0124 0.0081
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0172 0.013
Trypanosoma brucei unspecified product 0.0013 0.0088 0.0043
Schistosoma mansoni cpg binding protein 0.0028 0.0298 0.0298
Echinococcus multilocularis cpg binding protein 0.003 0.0321 0.0321
Leishmania major peptidylprolyl isomerase-like protein 0.0702 0.9778 1
Brugia malayi cytochrome P450 0.001 0.0046 0.0034
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0097 0.1261 0.1178
Giardia lamblia DINP protein human, muc B family 0.0019 0.0172 0.005
Echinococcus granulosus small glutamine rich tetratricopeptide 0.0016 0.0124 0.0124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0523 0.0523
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.013 0.0006
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0165 0.0122
Echinococcus granulosus Tetratricopeptide repeat protein 1 0.0016 0.0124 0.0124
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.013 0.0086
Trypanosoma cruzi serine/threonine protein phosphatase type 5, putative 0.0016 0.0124 0.008
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0013 0.0013
Schistosoma mansoni smad1 5 8 and 0.0008 0.0013 0.0013
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.1404 0.8901
Brugia malayi TAR-binding protein 0.0126 0.167 0.1697
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0172 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.1261 0.1178
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0097 0.1261 0.1248
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.167 0.1697
Trichomonas vaginalis fk506-binding protein, putative 0.0702 0.9778 1
Loa Loa (eye worm) TPR domain-containing protein 0.0016 0.0124 0.0114
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.013 0.0086
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.013 0.069
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0097 0.1261 0.1261
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.056 0.056
Echinococcus multilocularis lamin dm0 0.0026 0.0268 0.0268
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1537 0.1561
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.1571 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.1261 0.1278
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.013
Brugia malayi TPR Domain containing protein 0.0016 0.0124 0.0114
Brugia malayi glutathione reductase 0.0047 0.056 0.056
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0097 0.1261 0.1178
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.013
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0653 0.4999
Schistosoma mansoni smad 0.0008 0.0013 0.0013
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0097 0.1261 1
Echinococcus multilocularis stress induced phosphoprotein 1 0.0016 0.0124 0.0124
Leishmania major small glutamine-rich tetratricopeptide repeat protein, putative 0.0016 0.0124 0.0081
Onchocerca volvulus 0.0097 0.1262 1
Echinococcus multilocularis STIP1 y and U box containing protein 1 0.0016 0.0124 0.0124
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.013 0.055
Echinococcus granulosus lamin dm0 0.0026 0.0268 0.0268
Onchocerca volvulus 0.0016 0.0124 0.0004
Schistosoma mansoni hypothetical protein 0.001 0.0046 0.0046
Echinococcus multilocularis tumor protein p63 0.0661 0.92 0.92
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0172 0.013
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0172 0.0827
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0013 0.0013
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0013 0.0013
Brugia malayi hypothetical protein 0.0016 0.0124 0.0113
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0097 0.1261 0.1248
Trypanosoma cruzi stress-inducible protein STI1-like, putative 0.0016 0.0124 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.013
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0702 0.9778 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.1571 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0172 0.0827
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0124 0.008
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0097 0.1261 1
Echinococcus granulosus smad 0.0008 0.0013 0.0013
Schistosoma mansoni DNAj homolog subfamily C member 0.0016 0.0124 0.0124
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0023 0.001
Schistosoma mansoni cpg binding protein 0.003 0.0321 0.0321
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0268 0.0261
Leishmania major stress-inducible protein STI1 homolog 0.0016 0.0124 0.008
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0702 0.9778 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.013 0.0006
Echinococcus multilocularis tar DNA binding protein 0.0126 0.167 0.167
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0097 0.1261 0.1248
Trypanosoma brucei stress-inducible protein STI1-like, putative 0.0016 0.0124 0.0081
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0124 0.008
Onchocerca volvulus 0.0028 0.0298 0.1532
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.1571 1
Echinococcus multilocularis smad 0.0008 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0097 0.1262 0.128
Leishmania major DNA polymerase eta, putative 0.0019 0.0172 0.013
Echinococcus multilocularis 0.001 0.0046 0.0046
Echinococcus granulosus O glycosyltransferase 0.0016 0.0124 0.0124
Leishmania major cytochrome p450-like protein 0.0019 0.0165 0.0122
Echinococcus multilocularis musashi 0.0026 0.0268 0.0268
Brugia malayi RNA binding protein 0.0126 0.167 0.1697
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0702 0.9778 1
Brugia malayi Cytochrome P450 family protein 0.0019 0.0165 0.0156
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0702 0.9778 1
Schistosoma mansoni immunophilin 0.0718 1 1
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.056 0.0452
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0523 0.0523
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1537 0.1561
Trypanosoma brucei stress-induced protein sti1, putative 0.0016 0.0124 0.0081
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0523 0.0523
Echinococcus multilocularis 0.0097 0.1261 0.1261
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0172 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0124 0.0081
Loa Loa (eye worm) hypothetical protein 0.0008 0.0021 0.0008
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.013 0.0086
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.1404 0.8901
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0124 0.0113
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.056 0.3371
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.056 0.056
Brugia malayi UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 0.0016 0.0124 0.0114
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.013 0.0086
Trypanosoma brucei hypothetical protein, conserved 0.0097 0.1261 0.1248
Trichomonas vaginalis fk506-binding protein, putative 0.0097 0.1261 0.1178
Trichomonas vaginalis fk506-binding protein, putative 0.0097 0.1261 0.1178
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0124 0.0081
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.006
Echinococcus granulosus Smad4 0.0008 0.0013 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0088 0.0043
Echinococcus granulosus mitochondrial import receptor subunit tom34 0.0016 0.0124 0.0124
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0097 0.1261 0.1248
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0088 0.0043
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0097 0.1261 0.7964
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.013 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0126 0.167 0.167
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.5551 0.5551
Loa Loa (eye worm) cytochrome P450 0.001 0.0046 0.0034
Schistosoma mansoni smad1 5 8 and 0.0008 0.0013 0.0013
Loa Loa (eye worm) TPR Domain containing protein 0.0016 0.0124 0.0113
Schistosoma mansoni heat shock protein 70 0.0016 0.0124 0.0124
Plasmodium vivax glutathione reductase, putative 0.0047 0.056 0.0452
Schistosoma mansoni hypothetical protein 0.0402 0.5551 0.5551
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0172 0.005
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0268 0.0261
Trypanosoma cruzi small glutamine-rich tetratricopeptide repeat protein, putative 0.0016 0.0124 0.0081
Leishmania major DNA polymerase kappa, putative 0.0019 0.0172 0.013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0124 0.0113
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.013 0.0086

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = 95 % Peak percent change in contractile force produced by 1 mg/kg administered intravenously in anesthetetized dog ChEMBL. 2153209

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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