Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1608 | 0.1608 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0153 | 0.1608 | 0.1608 |
Leishmania major | histone deacetylase, putative | 0.0029 | 0.0228 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0904 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0153 | 0.1608 | 0.1608 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0153 | 0.1608 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1608 | 0.1608 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0153 | 0.1608 | 0.1608 |
Echinococcus granulosus | acetylcholinesterase | 0.0904 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1608 | 0.1608 |
Schistosoma mansoni | acetylcholinesterase | 0.0153 | 0.1608 | 0.1608 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0504 | 0.0504 |
Echinococcus granulosus | histone deacetylase 7 | 0.0029 | 0.0228 | 0.0228 |
Leishmania major | histone deacetylase, putative | 0.0029 | 0.0228 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0054 | 0.0504 | 0.0504 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0153 | 0.1608 | 0.1608 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.2957 | 0.2957 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.0411 | 0.4496 | 0.4496 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0153 | 0.1608 | 0.1608 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0153 | 0.1608 | 1 |
Plasmodium vivax | histone deacetylase, putative | 0.0029 | 0.0228 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0029 | 0.0228 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0034 | 0.0278 | 0.0278 |
Brugia malayi | Carboxylesterase family protein | 0.0904 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0904 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0034 | 0.0278 | 0.0278 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0029 | 0.0228 | 0.0228 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0029 | 0.0228 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.1608 | 0.1608 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1608 | 0.1608 |
Brugia malayi | amidase | 0.0054 | 0.0504 | 0.0504 |
Echinococcus granulosus | neuroligin | 0.0153 | 0.1608 | 0.1608 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0904 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0153 | 0.1608 | 0.1608 |
Brugia malayi | Histone deacetylase family protein | 0.0029 | 0.0228 | 0.0228 |
Loa Loa (eye worm) | hypothetical protein | 0.0904 | 1 | 1 |
Onchocerca volvulus | 0.0153 | 0.1608 | 1 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0153 | 0.1608 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0153 | 0.1608 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.1608 | 0.1608 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1608 | 0.1608 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0153 | 0.1608 | 0.1608 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0029 | 0.0228 | 0.0228 |
Loa Loa (eye worm) | carboxylesterase | 0.0904 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0029 | 0.0228 | 0.0228 |
Echinococcus granulosus | histone deacetylase 6 | 0.0029 | 0.0228 | 0.0228 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.2957 | 0.2957 |
Loa Loa (eye worm) | hypothetical protein | 0.0904 | 1 | 1 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0075 | 0.0737 | 0.0737 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0274 | 0.2957 | 0.2957 |
Giardia lamblia | Histone deacetylase | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0153 | 0.1608 | 0.1608 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.018 | 0.018 |
Schistosoma mansoni | amidase | 0.0054 | 0.0504 | 0.0504 |
Plasmodium falciparum | histone deacetylase, putative | 0.0029 | 0.0228 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1608 | 0.1608 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0029 | 0.0228 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0029 | 0.0228 | 1 |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.0274 | 0.2957 | 0.2957 |
Trypanosoma brucei | histone deacetylase 3 | 0.0029 | 0.0228 | 1 |
Onchocerca volvulus | 0.0153 | 0.1608 | 1 | |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0153 | 0.1608 | 0.1608 |
Echinococcus multilocularis | neuroligin | 0.0153 | 0.1608 | 0.1608 |
Plasmodium falciparum | histone deacetylase 2 | 0.0029 | 0.0228 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0054 | 0.0504 | 0.0504 |
Loa Loa (eye worm) | carboxylesterase | 0.0153 | 0.1608 | 0.1608 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0029 | 0.0228 | 0.0228 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0029 | 0.0228 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0153 | 0.1608 | 0.1608 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0153 | 0.1608 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0153 | 0.1608 | 0.1608 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0153 | 0.1608 | 0.1608 |
Onchocerca volvulus | 0.0153 | 0.1608 | 1 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0153 | 0.1608 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0029 | 0.0228 | 0.0228 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0904 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.1608 | 0.1608 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0054 | 0.0504 | 0.0504 |
Onchocerca volvulus | 0.0153 | 0.1608 | 1 | |
Echinococcus multilocularis | histone deacetylase | 0.0029 | 0.0228 | 0.0228 |
Entamoeba histolytica | histone deacetylase, putative | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0029 | 0.0228 | 0.0228 |
Brugia malayi | hypothetical protein | 0.0153 | 0.1608 | 0.1608 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0034 | 0.0278 | 0.0278 |
Trypanosoma brucei | histone deacetylase, putative | 0.0029 | 0.0228 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.013 | 0.013 |
Echinococcus granulosus | histone deacetylase | 0.0029 | 0.0228 | 0.0228 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0029 | 0.0228 | 0.0228 |
Onchocerca volvulus | 0.0153 | 0.1608 | 1 | |
Plasmodium vivax | histone deacetylase 2, putative | 0.0029 | 0.0228 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0904 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.1608 | 0.1608 |
Echinococcus multilocularis | acetylcholinesterase | 0.0904 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0153 | 0.1608 | 0.1608 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1608 | 0.1608 |
Brugia malayi | Histone deacetylase family protein | 0.0029 | 0.0228 | 0.0228 |
Echinococcus multilocularis | acetylcholinesterase | 0.0904 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0054 | 0.0504 | 0.0504 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0029 | 0.0228 | 0.0228 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0054 | 0.0504 | 0.0504 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
BP decrease (functional) | = 22 mmHg | Antihypertensive activity in spontaneously hypertensive rats(SHR) at 50 mg/kg peroral dose after 4 h, expressed as decrease in systolic blood pressure | ChEMBL. | 6115059 |
BP decrease (functional) | = 24 mmHg | Antihypertensive activity in spontaneously hypertensive rats(SHR) at 50 mg/kg peroral dose after 1 h, expressed as decrease in systolic blood pressure | ChEMBL. | 6115059 |
pA2 (functional) | = 5.06 | spasmolytic activity in isolated guinea pig ileum preparation;- log KB; (Bacl2) | ChEMBL. | 6115059 |
pA2 (binding) | = 5.46 | In vitro blocking activity against alpha adrenergic receptor, isolated from rabbit aortic strip | ChEMBL. | 6115059 |
pA2 (binding) | = 7.21 | In vitro blocking activity against beta adrenergic receptor, isolated from guinea pig atria | ChEMBL. | 6115059 |
Ratio (binding) | = 56 | Ratio of pA2 for beta-adrenergic receptor to that of alpha-adrenergic receptor | ChEMBL. | 6115059 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.