Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0666 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0666 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0666 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0666 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0666 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0666 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0666 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0666 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0666 | 1 | 1 |
Brugia malayi | hexokinase | 0.0096 | 0.0592 | 0.0592 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0592 | 0.0592 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0666 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0666 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 0.0592 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0666 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0666 | 1 | 0.5 |
Onchocerca volvulus | 0.0096 | 0.0592 | 1 | |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0666 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0666 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0666 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 0.0592 | 0.0592 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 0.0592 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0096 | 0.0592 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0666 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0666 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0666 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 0.0592 | 0.5 |
Onchocerca volvulus | 0.0096 | 0.0592 | 1 | |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0666 | 1 | 1 |
Onchocerca volvulus | 0.0096 | 0.0592 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0087 | 0.0087 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 0.0592 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0096 | 0.0592 | 0.0592 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 0.0592 | 0.0592 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 6.9 | Activity at glucokinase (unknown origin) | ChEMBL. | No reference |
IC50 (binding) | = 4.5 | Inhibition of human ERG | LITERATURE. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.