Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1504 | 0.1504 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0132 | 0.6187 | 0.6187 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0173 | 0.8328 | 0.8328 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0356 | 0.0356 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0173 | 0.8328 | 0.8328 |
Brugia malayi | 6-phosphofructokinase | 0.0132 | 0.6187 | 0.6992 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0036 | 0.1209 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0173 | 0.8328 | 0.8328 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0036 | 0.1209 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.8328 | 0.9411 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0356 | 0.0402 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0145 | 0.6858 | 0.775 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0036 | 0.1209 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0173 | 0.8328 | 0.8328 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0173 | 0.8328 | 0.8328 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0145 | 0.6858 | 0.775 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0077 | 0.3341 | 0.3776 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0132 | 0.6187 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0132 | 0.6187 | 0.6992 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0132 | 0.6187 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0077 | 0.3341 | 0.3776 |
Brugia malayi | hypothetical protein | 0.0183 | 0.8849 | 1 |
Onchocerca volvulus | 0.0183 | 0.8849 | 1 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0179 | 0.8627 | 0.8627 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0173 | 0.8328 | 0.8328 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0036 | 0.1209 | 0.1175 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0546 | 0.0617 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0173 | 0.8328 | 0.8328 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0036 | 0.1209 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3341 | 0.3341 |
Entamoeba histolytica | pyrophosphate-dependent phosphofructokinase | 0.0036 | 0.1209 | 0.1175 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0132 | 0.6187 | 1 |
Onchocerca volvulus | 0.0173 | 0.8328 | 0.9411 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0173 | 0.8328 | 0.8328 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0132 | 0.6187 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0546 | 0.0546 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0356 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.8328 | 0.9411 |
Echinococcus granulosus | tar DNA binding protein | 0.0077 | 0.3341 | 0.3341 |
Echinococcus multilocularis | Mastin | 0.0173 | 0.8328 | 0.8328 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.8328 | 0.9411 |
Brugia malayi | MH2 domain containing protein | 0.0145 | 0.6858 | 0.775 |
Loa Loa (eye worm) | phosphofructokinase | 0.0132 | 0.6187 | 0.6992 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0173 | 0.8328 | 0.8328 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0132 | 0.6187 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0132 | 0.6187 | 1 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0173 | 0.8328 | 0.8328 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0036 | 0.1209 | 0.1175 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0173 | 0.8328 | 0.8328 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0173 | 0.8328 | 0.8328 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0132 | 0.6187 | 1 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0132 | 0.6187 | 1 |
Onchocerca volvulus | 0.0173 | 0.8328 | 0.9411 | |
Brugia malayi | Trypsin family protein | 0.0173 | 0.8328 | 0.9411 |
Echinococcus granulosus | Mastin | 0.0173 | 0.8328 | 0.8328 |
Schistosoma mansoni | hypothetical protein | 0.0206 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0132 | 0.6187 | 0.6187 |
Echinococcus multilocularis | enteropeptidase | 0.0173 | 0.8328 | 0.8328 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0173 | 0.8328 | 0.8328 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.8328 | 0.8328 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0036 | 0.1209 | 0.1175 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0036 | 0.1209 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0036 | 0.1209 | 0.1175 |
Brugia malayi | phosphofructokinase | 0.0132 | 0.6187 | 0.6992 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0356 | 0.0356 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0173 | 0.8328 | 0.8328 |
Brugia malayi | Trypsin family protein | 0.0173 | 0.8328 | 0.9411 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.8328 | 0.9411 |
Brugia malayi | Trypsin family protein | 0.0173 | 0.8328 | 0.9411 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0036 | 0.1209 | 0.1175 |
Brugia malayi | Trypsin family protein | 0.0173 | 0.8328 | 0.9411 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.8328 | 0.9411 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.8849 | 1 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0036 | 0.1209 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0077 | 0.3341 | 0.3776 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3341 | 0.3341 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0132 | 0.6187 | 0.6187 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0036 | 0.1209 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0077 | 0.3341 | 0.3341 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2494 | 0.2819 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2494 | 0.2819 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0356 | 0.0356 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0546 | 0.0546 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0173 | 0.8328 | 0.8328 |
Mycobacterium ulcerans | hypothetical protein | 0.0173 | 0.8328 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0356 | 0.0402 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0132 | 0.6187 | 0.6187 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0132 | 0.6187 | 0.6992 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0546 | 0.0546 |
Echinococcus multilocularis | geminin | 0.0206 | 1 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0132 | 0.6187 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0173 | 0.8328 | 0.8328 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0132 | 0.6187 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0173 | 0.8328 | 0.8328 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0173 | 0.8328 | 0.8328 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0173 | 0.8328 | 0.9411 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0356 | 0.0402 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3341 | 0.3341 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0132 | 0.6187 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0356 | 0.0356 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1504 | 0.17 |
Onchocerca volvulus | 0.0173 | 0.8328 | 0.9411 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3341 | 0.3341 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0356 | 0.0402 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0036 | 0.1209 | 1 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0173 | 0.8328 | 0.9411 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0546 | 0.0546 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0173 | 0.8328 | 0.8328 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0036 | 0.1209 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.8328 | 0.9411 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0356 | 0.0356 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0173 | 0.8328 | 0.8328 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0036 | 0.1209 | 0.1175 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0356 | 0.0356 |
Onchocerca volvulus | 0.0173 | 0.8328 | 0.9411 | |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0173 | 0.8328 | 0.8328 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0356 | 0.0356 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0173 | 0.8328 | 0.8328 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0356 | 0.0356 |
Trichomonas vaginalis | 6-phosphofructokinase, putative | 0.0036 | 0.1209 | 0.1175 |
Brugia malayi | RNA binding protein | 0.0077 | 0.3341 | 0.3776 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0546 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0173 | 0.8328 | 0.8328 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0356 | 0.0356 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0173 | 0.8328 | 0.8328 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0036 | 0.1209 | 0.1175 |
Brugia malayi | TAR-binding protein | 0.0077 | 0.3341 | 0.3776 |
Echinococcus granulosus | enteropeptidase | 0.0173 | 0.8328 | 0.8328 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0173 | 0.8328 | 0.8328 |
Brugia malayi | hypothetical protein | 0.0173 | 0.8328 | 0.9411 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0173 | 0.8328 | 0.8328 |
Loa Loa (eye worm) | trypsin family protein | 0.0173 | 0.8328 | 0.9411 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2494 | 0.2819 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.8328 | 0.9411 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0077 | 0.3341 | 0.3776 |
Onchocerca volvulus | 0.0173 | 0.8328 | 0.9411 | |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0546 | 0.0617 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0132 | 0.6187 | 0.6992 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0132 | 0.6187 | 0.7249 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3341 | 0.3341 |
Schistosoma mansoni | hypothetical protein | 0.0206 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.8328 | 0.8328 |
Onchocerca volvulus | 0.0173 | 0.8328 | 0.9411 | |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0036 | 0.1209 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2494 | 0.2819 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1504 | 0.17 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0132 | 0.6187 | 1 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0132 | 0.6187 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 5 % | Inhibition of N-terminal truncated Plasmodium falciparum recombinant DHODH assessed as ubiquinone reduction to 2,6-dichloroindophenol at 10 uM by spectrophotometric analysis relative to control | ChEMBL. | No reference |
Inhibition (binding) | = 26 % | Inhibition of N-terminal truncated human recombinant DHODH assessed as ubiquinone reduction to 2,6-dichloroindophenol at 10 uM by spectrophotometric analysis relative to control | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.