TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 472.857 | Formula: C21H18ClFN6O4
H donors: 2 H acceptors: 6 LogP: 2.25 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: OCCOC[C@@H](C(=O)Nc1ccc(cn1)F)Oc1ncnc2c1cnn2c1ccccc1Cl
InChi: 1S/C21H18ClFN6O4/c22-15-3-1-2-4-16(15)29-19-14(10-27-29)21(26-12-25-19)33-17(11-32-8-7-30)20(31)28-18-6-5-13(23)9-24-18/h1-6,9-10,12,17,30H,7-8,11H2,(H,24,28,31)/t17-/m0/s1
InChiKey: VPDZTPHDUAHHPV-KRWDZBQOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucokinase (hexokinase 4)	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania braziliensis	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei gambiense	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium vivax	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Entamoeba histolytica	hexokinase 2	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania infantum	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium knowlesi	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania infantum	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase type 2	Get druggable targets OG5_126743	All targets in OG5_126743
Brugia malayi	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma cruzi	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Cryptosporidium parvum	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126743	All targets in OG5_126743
Treponema pallidum	hexokinase (hxk)	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium yoelii	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Theileria parva	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania major	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Schistosoma mansoni	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Toxoplasma gondii	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania mexicana	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Onchocerca volvulus		Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania mexicana	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium falciparum	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hexokinase type II	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase type 2	Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W)	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Entamoeba histolytica	hexokinase 1	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania donovani	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma cruzi	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Leishmania major	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Schistosoma japonicum	ko:K00844 hexokinase [EC2.7.1.1], putative	Get druggable targets OG5_126743	All targets in OG5_126743
Plasmodium berghei	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Theileria parva	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Onchocerca volvulus		Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus granulosus	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Loa Loa (eye worm)	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Cryptosporidium hominis	hexokinase i	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei gambiense	hexokinase, putative	Get druggable targets OG5_126743	All targets in OG5_126743
Babesia bovis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Onchocerca volvulus		Get druggable targets OG5_126743	All targets in OG5_126743
Candida albicans	similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose	Get druggable targets OG5_126743	All targets in OG5_126743
Brugia malayi	Hexokinase family protein	Get druggable targets OG5_126743	All targets in OG5_126743
Neospora caninum	cDNA FLJ57348, highly similar to Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA, related	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma congolense	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Trypanosoma brucei	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743
Echinococcus multilocularis	hexokinase	Get druggable targets OG5_126743	All targets in OG5_126743

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hexokinase family protein	glucokinase (hexokinase 4)	465 aa	470 aa	30.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0073	0.3551	0.3551
Onchocerca volvulus		0.0073	0.3551	0.3551
Loa Loa (eye worm)	TK protein kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Onchocerca volvulus		0.0073	0.3551	0.3551
Onchocerca volvulus		0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	TK/CSK protein kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	TK protein kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	TK protein kinase	0.0073	0.3551	0.3551
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0073	0.3551	0.3551
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0073	0.3551	0.3551
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Loa Loa (eye worm)	TK/FER protein kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0073	0.3551	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	TK family protein kinase	0.0073	0.3551	0.5
Echinococcus multilocularis	hexokinase	0.0096	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Brugia malayi	C-terminal src kinase protein 1	0.0073	0.3551	0.3551
Giardia lamblia	Protein 21.1	0.0073	0.3551	0.5
Trypanosoma brucei	hexokinase	0.0096	1	1
Schistosoma mansoni	hexokinase	0.0096	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.3551	0.5
Onchocerca volvulus		0.0073	0.3551	0.3551
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Echinococcus granulosus	hexokinase	0.0096	1	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0073	0.3551	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0073	0.3551	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.3551	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.3551	0.5
Brugia malayi	hypothetical protein	0.0073	0.3551	0.3551
Onchocerca volvulus		0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0073	0.3551	0.3551
Loa Loa (eye worm)	hexokinase	0.0096	1	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0081	0.5876	0.3606
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Brugia malayi	Tyrosine-protein kinase PR2	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Brugia malayi	SH2 domain containing protein	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Onchocerca volvulus	Tyrosine kinase homolog	0.0073	0.3551	0.3551
Onchocerca volvulus		0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0073	0.3551	0.3551
Onchocerca volvulus		0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0073	0.3551	0.3551
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	TK/ACK protein kinase	0.0073	0.3551	0.3551
Loa Loa (eye worm)	TK protein kinase	0.0073	0.3551	0.3551
Loa Loa (eye worm)	TK/RYK protein kinase	0.0073	0.3551	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0073	0.3551	0.3551
Onchocerca volvulus		0.0096	1	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0073	0.3551	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.3551	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.3551	0.5
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0073	0.3551	0.3551
Loa Loa (eye worm)	TK/FER protein kinase	0.0073	0.3551	0.3551
Loa Loa (eye worm)	TK/FER protein kinase	0.0073	0.3551	0.3551
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Giardia lamblia	Kinase	0.0073	0.3551	0.5
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Brugia malayi	Hexokinase family protein	0.0096	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0073	0.3551	0.5
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Entamoeba histolytica	hexokinase 1	0.0096	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.0073	0.3551	0.3551
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0073	0.3551	0.3551
Echinococcus multilocularis	hexokinase	0.0096	1	1
Onchocerca volvulus		0.0073	0.3551	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0073	0.3551	0.3551
Trypanosoma cruzi	hexokinase, putative	0.0096	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0073	0.3551	0.3551
Loa Loa (eye worm)	TK/FER protein kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Echinococcus granulosus	hexokinase type 2	0.0096	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Echinococcus granulosus	hexokinase	0.0096	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	STE family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0073	0.3551	0.3551
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0073	0.3551	0.3551
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0073	0.3551	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Leishmania major	hexokinase, putative	0.0096	1	1
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Entamoeba histolytica	hypothetical protein	0.0081	0.5876	0.3606
Loa Loa (eye worm)	TK/FER protein kinase	0.0073	0.3551	0.3551
Onchocerca volvulus		0.0073	0.3551	0.3551
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trypanosoma brucei	hexokinase	0.0096	1	1
Loa Loa (eye worm)	SRC-1	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Plasmodium falciparum	hexokinase	0.0096	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.3551	0.5
Loa Loa (eye worm)	TK/EPH protein kinase	0.0073	0.3551	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0073	0.3551	0.3551
Brugia malayi	hypothetical protein	0.0073	0.3551	0.3551
Onchocerca volvulus		0.0073	0.3551	0.3551
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Entamoeba histolytica	protein kinase, putative	0.0081	0.5876	0.3606
Loa Loa (eye worm)	TK/ABL protein kinase	0.0073	0.3551	0.3551
Loa Loa (eye worm)	hexokinase type II	0.0096	1	1
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0073	0.3551	0.3551
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Onchocerca volvulus		0.0073	0.3551	0.3551
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0073	0.3551	0.3551
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0073	0.3551	0.3551
Onchocerca volvulus		0.0096	1	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0073	0.3551	0.3551
Loa Loa (eye worm)	TK/FER protein kinase	0.0073	0.3551	0.3551
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0073	0.3551	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Onchocerca volvulus		0.0073	0.3551	0.3551
Entamoeba histolytica	hypothetical protein	0.0081	0.5876	0.3606
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0073	0.3551	0.3551
Echinococcus granulosus	hexokinase	0.0096	1	1
Brugia malayi	SH2 domain containing protein	0.0073	0.3551	0.3551
Brugia malayi	ephrin receptor 1 precursor	0.0073	0.3551	0.3551
Brugia malayi	protein-tyrosine kinase	0.0073	0.3551	0.3551
Loa Loa (eye worm)	TK/FER protein kinase	0.0073	0.3551	0.3551
Loa Loa (eye worm)	TK/FER protein kinase	0.0073	0.3551	0.3551
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0073	0.3551	0.3551
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0073	0.3551	0.3551
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Toxoplasma gondii	hexokinase	0.0096	1	1
Brugia malayi	Raf kinase	0.0073	0.3551	0.3551
Echinococcus multilocularis	hexokinase type 2	0.0096	1	1
Echinococcus multilocularis	hexokinase	0.0096	1	1
Entamoeba histolytica	hexokinase 2	0.0096	1	1
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0073	0.3551	0.3551
Giardia lamblia	Kinase, NEK	0.0073	0.3551	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trypanosoma cruzi	hexokinase, putative	0.0096	1	1
Brugia malayi	SRC-1	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Giardia lamblia	Kinase, NEK	0.0073	0.3551	0.5
Brugia malayi	Guanylyl cyclase protein 23	0.0073	0.3551	0.3551
Onchocerca volvulus		0.0073	0.3551	0.3551
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0073	0.3551	0.3551
Loa Loa (eye worm)	TK protein kinase	0.0073	0.3551	0.3551
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0073	0.3551	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0073	0.3551	0.3551
Brugia malayi	Furin-like cysteine rich region family protein	0.0073	0.3551	0.3551
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.3551	0.5
Brugia malayi	hypothetical protein	0.0073	0.3551	0.3551
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0073	0.3551	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0073	0.3551	0.3551
Brugia malayi	integrin-linked kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0073	0.3551	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0073	0.3551	0.3551
Loa Loa (eye worm)	TK protein kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Onchocerca volvulus		0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Onchocerca volvulus		0.0096	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0073	0.3551	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1468	0.1468
Loa Loa (eye worm)	hypothetical protein	0.0073	0.3551	0.3551
Loa Loa (eye worm)	TK protein kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0073	0.3551	0.3551
Entamoeba histolytica	hypothetical protein	0.0081	0.5876	0.3606
Loa Loa (eye worm)	TK protein kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	TK protein kinase	0.0073	0.3551	0.3551
Loa Loa (eye worm)	TK/ALK protein kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Treponema pallidum	hexokinase (hxk)	0.0096	1	0.5
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Trypanosoma brucei	hexokinase, putative	0.0096	1	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0073	0.3551	0.3551
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0073	0.3551	0.3551
Brugia malayi	Tyrosine-protein kinase abl-1	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Loa Loa (eye worm)	TK protein kinase	0.0073	0.3551	0.3551
Brugia malayi	Receptor family ligand binding region containing protein	0.0073	0.3551	0.3551
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Loa Loa (eye worm)	TK/Met protein kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.3551	0.5
Loa Loa (eye worm)	hexokinase	0.0096	1	1
Leishmania major	hexokinase, putative	0.0096	1	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.3551	0.3551
Onchocerca volvulus		0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0073	0.3551	0.3551
Brugia malayi	Protein kinase domain containing protein	0.0073	0.3551	0.3551
Plasmodium vivax	hexokinase, putative	0.0096	1	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0073	0.3551	0.3551
Trichomonas vaginalis	TKL family protein kinase	0.0073	0.3551	0.5
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0073	0.3551	0.3551

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 6.2	Activation of glucokinase (unknown origin)	ChEMBL.	No reference
IC50 (binding)	= 4.4	Inhibition of human ERG by electrophysiological analysis	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3221521

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1854146