Detailed information for compound 1854203

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 321.285 | Formula: C14H15N3O6
  • H donors: 4 H acceptors: 7 LogP: -1.85 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1C[C@@](O)(C=C([C@H]1O)c1nnn(c1)Cc1ccco1)C(=O)O
  • InChi: 1S/C14H15N3O6/c18-11-5-14(22,13(20)21)4-9(12(11)19)10-7-17(16-15-10)6-8-2-1-3-23-8/h1-4,7,11-12,18-19,22H,5-6H2,(H,20,21)/t11-,12-,14+/m1/s1
  • InChiKey: NYWTZVOKGDKDQA-BZPMIXESSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) Starlite/ChEMBL No references
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 3-dehydroquinate dehydratase Starlite/ChEMBL No references
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) 3-dehydroquinate dehydratase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium leprae 3-dehydroquinate dehydratase AroD (AroQ) (3-dehydroquinase) (Type II DHQase) Get druggable targets OG5_132746 All targets in OG5_132746
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) Get druggable targets OG5_132746 All targets in OG5_132746
Mycobacterium ulcerans 3-dehydroquinate dehydratase Get druggable targets OG5_132746 All targets in OG5_132746
Candida albicans 3-dehydroquinase Get druggable targets OG5_132746 All targets in OG5_132746
Candida albicans 3-dehydroquinate dehydratase Get druggable targets OG5_132746 All targets in OG5_132746
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma congolense Methyltransferase domain/Methyltransferase involved in Williams-Beuren syndrome, putative 3-dehydroquinate dehydratase   157 aa 127 aa 24.4 %
Plasmodium yoelii glucosamine-fructose-6-phosphate aminotransferase 3-dehydroquinate dehydratase   157 aa 178 aa 20.8 %
Mycobacterium tuberculosis Possible alanine rich transferase 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 147 aa 148 aa 26.4 %
Plasmodium berghei glutamine--fructose-6-phosphate aminotransferase [isomerizing], putative 3-dehydroquinate dehydratase   157 aa 178 aa 20.2 %
Trypanosoma congolense hypothetical protein, conserved 3-dehydroquinate dehydratase   157 aa 127 aa 24.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0112 0.096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0181 0.0479
Brugia malayi cytochrome P450 0.0028 0.0035 0.0414
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0023 0.0023 0.0196
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0028 0.0235
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.008
Mycobacterium leprae Probable lipase LipE 0.0036 0.0054 0.0019
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0014 0.0083
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.008
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0259 0.2246
Schistosoma mansoni zinc finger protein 0.0016 0.0007 0.0035
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0013 0.0102
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0109
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0054 0.004
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0054 0.004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.011 0.0228 0.0603
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0181 0.2282
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0023 0.0023 0.0196
Onchocerca volvulus 0.0036 0.0054 0.1756
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0329 0.0316
Mycobacterium ulcerans hypothetical protein 0.0154 0.0329 0.0316
Mycobacterium ulcerans hypothetical protein 0.0036 0.0054 0.004
Echinococcus multilocularis cpg binding protein 0.0032 0.0045 0.0118
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0074
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0012 0.0098
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0028 0.0035 0.0022
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0005 0.0059
Echinococcus granulosus neuropeptide receptor A26 0.0478 0.1088 0.9515
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0035 0.0411
Entamoeba histolytica hypothetical protein 0.0106 0.0217 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0028 0.0035 0.0022
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0105 0.1169
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.0103 0.088
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0108 0.0094
Leishmania major DNA polymerase kappa, putative 0.0019 0.0013 0.008
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0028 0.0035 0.0339
Leishmania major cytochrome p450-like protein 0.0045 0.0076 0.0821
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0054 0.0778
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0013 0.0163
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.0653 0.7681
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0023 0.0023 0.0196
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0028 0.0035 0.0022
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0056 0.0674
Schistosoma mansoni lamin 0.0028 0.0035 0.0282
Schistosoma mansoni cpg binding protein 0.0032 0.0045 0.0374
Brugia malayi beta-lactamase 0.0036 0.0054 0.0651
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0103 0.9536
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0118 0.1321
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.008
Schistosoma mansoni hypothetical protein 0.0409 0.0927 0.8103
Onchocerca volvulus 0.0028 0.0035 0.1023
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0013 0.0234
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0163
Brugia malayi Cytochrome P450 family protein 0.0085 0.0167 0.2103
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0028 0.0035 0.0022
Loa Loa (eye worm) hypothetical protein 0.0238 0.0528 0.6714
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0011 0.0072
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0028 0.0035 0.0022
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0013 0.0031
Loa Loa (eye worm) FAD binding domain-containing protein 0.0023 0.0023 0.0296
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0056 0.0581
Loa Loa (eye worm) TAR-binding protein 0.0124 0.0259 0.3295
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0014 0.0083
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0108 0.0094
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.0158
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0056 0.0145
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0071 0.0767
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0035 0.0444
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0054 0.0778
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0028 0.0035 0.0022
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.0103 0.0271
Echinococcus multilocularis methionine synthase reductase 0.0014 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0684
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0013 0.0033
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.014 0.1777
Loa Loa (eye worm) beta-lactamase 0.0036 0.0054 0.0684
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0293 0.3404
Mycobacterium tuberculosis Conserved protein 0.0036 0.0054 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0118 0.1321
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0054 0.056
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0181 0.2309
Onchocerca volvulus 0.0028 0.0035 0.1023
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0028 0.0035 0.0022
Schistosoma mansoni cytochrome P450 0.0028 0.0035 0.0284
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0028 0.0035 0.0022
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0054 0.004
Trichomonas vaginalis sulfite reductase, putative 0.0023 0.0023 0.0252
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.003 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0118 0.1321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0118 0.1321
Echinococcus multilocularis lamin dm0 0.0028 0.0035 0.009
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0056 0.0809
Brugia malayi PHD-finger family protein 0.0022 0.0022 0.0243
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.0103 0.1313
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0187 0.0407 0.1079
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0066 0.0702
Echinococcus multilocularis geminin 0.0501 0.1143 0.3037
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0074
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0013 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0118 0.1321
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0259 0.2246
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0684
Chlamydia trachomatis sulfite reductase 0.0014 0.0003 0.5
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0037 0.047
Onchocerca volvulus 0.0029 0.0037 0.1101
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0028 0.0035 0.0022
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0028 0.0222
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.0259 0.3271
Loa Loa (eye worm) cytochrome P450 family protein 0.0085 0.0167 0.2131
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0035 0.0339
Toxoplasma gondii exonuclease III APE 0.0019 0.0014 0.0518
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.0653 0.7681
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0066 0.0702
Brugia malayi PHD-finger family protein 0.0027 0.0034 0.0396
Onchocerca volvulus Huntingtin homolog 0.0127 0.0266 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0056 0.0145
Echinococcus granulosus methionine synthase reductase 0.0014 0.0003 0.0014
Brugia malayi Bromodomain containing protein 0.0059 0.0109 0.1355
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0086 0.1067
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0011 0.0026
Toxoplasma gondii ABC1 family protein 0.0036 0.0054 0.4557
Echinococcus granulosus cytochrome P450 2K1 0.0028 0.0035 0.0298
Mycobacterium ulcerans glutaminase 0.0265 0.0589 0.0577
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0071 0.0767
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0071 0.0874
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0108 0.0094
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0074
Loa Loa (eye worm) CYP4Cod1 0.0045 0.0076 0.0964
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0086 0.0944
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0011 0.0086
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0013 0.0478
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0013 0.0072
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0023 0.0023 0.0059
Onchocerca volvulus Alhambra homolog 0.0057 0.0103 0.3674
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0054 0.004
Brugia malayi hypothetical protein 0.0244 0.0542 0.6879
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0108 0.0094
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.0507 0.0494
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0684
Leishmania major p450 reductase, putative 0.0023 0.0023 0.0196
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0054 0.0684
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0014 0.0033
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0013 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0181 0.1567
Loa Loa (eye worm) ctsf protein 0.0017 0.0009 0.0109
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0028 0.0035 0.0339
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0074
Echinococcus granulosus geminin 0.0501 0.1143 1
Plasmodium falciparum nitric oxide synthase, putative 0.0023 0.0023 0.1547
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0009 0.0051
Echinococcus granulosus intermediate filament protein 0.0028 0.0035 0.0295
Loa Loa (eye worm) hypothetical protein 0.0127 0.0266 0.3384
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0013 0.0088
Brugia malayi glutaminase DH11.1 0.0265 0.0589 0.7492
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0277
Leishmania major cathepsin L-like protease 0.0017 0.0009 0.0022
Schistosoma mansoni hypothetical protein 0.0028 0.0035 0.0284
Schistosoma mansoni cpg binding protein 0.0032 0.0045 0.0374
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.0103 0.0893
Echinococcus multilocularis cysteine protease 0.0017 0.0009 0.002
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0009 0.0022
Brugia malayi intermediate filament protein 0.0028 0.0035 0.0411
Brugia malayi hypothetical protein 0.0127 0.0266 0.3361
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0028 0.0071
Giardia lamblia Hypothetical protein 0.002 0.0017 0.0409
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0011 0.0072
Brugia malayi beta-lactamase family protein 0.0036 0.0054 0.0651
Echinococcus multilocularis neuropeptide s receptor 0.0478 0.1088 0.289
Loa Loa (eye worm) RNA binding protein 0.0124 0.0259 0.3295
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.008
Brugia malayi jmjC domain containing protein 0.0018 0.0013 0.0128
Loa Loa (eye worm) hypothetical protein 0.0349 0.0786 1
Echinococcus granulosus zinc finger protein 0.0022 0.0021 0.0172
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0005 0.0024
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0012 0.003
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0074
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.0259 0.3295
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0013 0.0031
Schistosoma mansoni intermediate filament proteins 0.0028 0.0035 0.0282
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0076 0.0964
Echinococcus multilocularis peregrin 0.0059 0.0109 0.0286
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0023 0.0023 0.0196
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0054 0.046
Loa Loa (eye worm) fibroinase 0.0017 0.0009 0.0109
Loa Loa (eye worm) FAD binding domain-containing protein 0.0014 0.0003 0.0035
Schistosoma mansoni hypothetical protein 0.0057 0.0103 0.088
Schistosoma mansoni hypothetical protein 0.0021 0.002 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.008
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.002 0.025
Plasmodium vivax JmjC domain containing protein 0.0018 0.0013 0.0444
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0013 0.0084
Brugia malayi Calcitonin receptor-like protein seb-1 0.0349 0.0786 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0068 0.0868
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0013 0.0423
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0118 0.1321
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0028 0.0035 0.0022
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0056 0.4694
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0013 0.0444
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0014 0.0028
Echinococcus multilocularis jumonji domain containing protein 0.0079 0.0155 0.041
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0014 0.0088
Leishmania major cathepsin L-like protease 0.0063 0.0118 0.1321
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0349 0.0786 1
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0054 0.0019
Trypanosoma cruzi p450 reductase, putative 0.0023 0.0023 0.0196
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0014 0.5
Trypanosoma cruzi cytochrome P450, putative 0.0045 0.0076 0.0821
Loa Loa (eye worm) hypothetical protein 0.0028 0.0035 0.0444
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0009 0.0022
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0014 0.0088
Echinococcus multilocularis 0.0028 0.0035 0.009
Leishmania major cathepsin L-like protease 0.0017 0.0009 0.0022
Schistosoma mansoni survival motor neuron protein 0.005 0.0086 0.0733
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0014 0.0175
Brugia malayi beta-lactamase family protein 0.0036 0.0054 0.0651
Brugia malayi RNA binding protein 0.0124 0.0259 0.3271
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0028 0.0035 0.0022
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0035
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0009 0.0065
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0035 0.0339
Schistosoma mansoni hypothetical protein 0.011 0.0228 0.1975
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0028 0.0035 0.0022
Toxoplasma gondii ImpB/MucB/SamB family protein 0.003 0.0041 0.3274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0118 0.1321
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.0542 0.1437
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.0542 0.4731
Trichomonas vaginalis esterase, putative 0.0036 0.0054 0.0778
Brugia malayi Bromodomain containing protein 0.0079 0.0155 0.1943
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0028 0.0035 0.0022
Trichomonas vaginalis glutaminase, putative 0.0265 0.0589 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0028 0.0035 0.0339
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0118 0.1321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0118 0.1321
Leishmania major DNA polymerase eta, putative 0.003 0.0041 0.0408
Loa Loa (eye worm) hypothetical protein 0.0057 0.0103 0.1313
Trypanosoma cruzi cytochrome P450, putative 0.0045 0.0076 0.0821
Echinococcus multilocularis dna polymerase eta 0.0043 0.0071 0.0186
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0296
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0258 0.3288
Brugia malayi Cytochrome P450 family protein 0.0045 0.0076 0.0932
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0118 0.1321
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0014 0.0246
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0013 0.0094
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0066 0.0702
Loa Loa (eye worm) glutaminase 0.0265 0.0589 0.7501
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0013 0.0079
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0054 0.004
Giardia lamblia Nitric oxide synthase, inducible 0.002 0.0017 0.0409
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0108 0.0283
Onchocerca volvulus 0.0036 0.0054 0.1756
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0056 0.0463
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0028 0.0035 0.0022
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.002 0.0017 0.0147
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0028 0.0035 0.0022
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0013 0.0108
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0013 0.0084
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0028 0.0035 0.0022
Brugia malayi hypothetical protein 0.0106 0.0217 0.2737
Brugia malayi jmjC domain containing protein 0.0073 0.014 0.1748
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0028 0.0035 0.0022
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0054 0.4779
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0108 0.0933
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0057 0.0147
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0118 0.1321
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0181 0.0479
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0056 0.0581
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0013 0.0033
Schistosoma mansoni cpg binding protein 0.0029 0.0037 0.03
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0106 0.0217 0.0574
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.014 0.1201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0118 0.1321
Leishmania major cathepsin L-like protease 0.0017 0.0009 0.0022
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0013 0.0079
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0028 0.0035 0.0022
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0074
Echinococcus multilocularis GPCR, family 2 0.011 0.0228 0.0603
Onchocerca volvulus Huntingtin homolog 0.0127 0.0266 1
Toxoplasma gondii hypothetical protein 0.0047 0.008 0.7187
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0023 0.0023 0.0193
Brugia malayi flavodoxin family protein 0.0023 0.0023 0.0261
Brugia malayi TAR-binding protein 0.0124 0.0259 0.3271
Echinococcus multilocularis neuropeptide receptor A26 0.0478 0.1088 0.289
Brugia malayi AF-10 protein 0.0019 0.0013 0.0135
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0056 0.0463
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0013 0.0478
Brugia malayi CXXC zinc finger family protein 0.0029 0.0037 0.0436
Leishmania major DNA polymerase eta, putative 0.0043 0.0071 0.0767
Schistosoma mansoni ap endonuclease 0.0019 0.0014 0.0096
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0028 0.0035 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0028 0.0035 0.0022
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0009 0.002
Plasmodium vivax hypothetical protein, conserved 0.002 0.0017 0.0935
Echinococcus multilocularis lamin 0.0028 0.0035 0.009
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0054 0.014
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0014 0.0543
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.008
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0131
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0795
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0118 0.031
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0349 0.0786 1
Echinococcus multilocularis cysteine protease 0.0017 0.0009 0.002
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0028 0.0035 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.008
Brugia malayi MH2 domain containing protein 0.0123 0.0258 0.3264
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.008
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0013 0.008
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0009 0.002
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0023 0.0023 0.1547
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0013 0.0088
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.002 0.0017 0.0935
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0009 0.0109
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0013 0.0088
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0056 0.0581
Entamoeba histolytica hypothetical protein 0.0106 0.0217 1
Mycobacterium ulcerans 3-dehydroquinate dehydratase 0.4286 1 1
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0023 0.0023 0.0196
Echinococcus granulosus tar DNA binding protein 0.0124 0.0259 0.2257
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0293 0.3404
Schistosoma mansoni hypothetical protein 0.011 0.0228 0.1975
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0028 0.0035 0.0022
Trypanosoma brucei hypothetical protein, conserved 0.0375 0.0848 1
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0023 0.0023 0.0196
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0054 0.0447
Brugia malayi latrophilin 2 splice variant baaae 0.0238 0.0528 0.6702
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0045 0.0076 0.0062
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0013 0.0423
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0012 0.0158
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0028 0.0035 0.0022
Leishmania major cytochrome p450-like protein 0.0028 0.0035 0.0339
Echinococcus multilocularis zinc finger protein 0.0022 0.0021 0.0052
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0118 0.1022
Brugia malayi jmjC domain containing protein 0.0018 0.0013 0.0128
Brugia malayi FAD binding domain containing protein 0.0023 0.0023 0.0261
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0028 0.0035 0.0022
Schistosoma mansoni hypothetical protein 0.0238 0.0528 0.4603
Echinococcus multilocularis musashi 0.0028 0.0035 0.009
Echinococcus granulosus cathepsin l1 0.0017 0.0009 0.0065
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0028 0.0035 0.0022
Entamoeba histolytica hypothetical protein 0.0106 0.0217 1
Leishmania major cathepsin L-like protease 0.0017 0.0009 0.0022
Loa Loa (eye worm) jmjC domain-containing protein 0.0118 0.0245 0.312
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0035 0.0444
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0028 0.0035 0.0022
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0013 0.0031
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0066 0.0702
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0108 0.1202
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.014 0.1213
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0009 0.002
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0056 0.0476
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0259 0.2246
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0054 0.0778
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0023 0.0023 0.0059
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0163
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0028 0.0035 0.0022
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0014 0.0543
Echinococcus granulosus dnaJ subfamily B 0.0409 0.0927 0.8105
Trypanosoma cruzi hypothetical protein, conserved 0.0375 0.0848 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0707
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0013 0.0094
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0108 0.0921
Schistosoma mansoni hypothetical protein 0.005 0.0086 0.0733
Leishmania major hypothetical protein, conserved 0.0375 0.0848 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0014 0.5
Brugia malayi jmjC domain containing protein 0.0187 0.0407 0.5158
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0054 0.004
Brugia malayi PHD-finger family protein 0.0057 0.0103 0.1282
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0258 0.3288
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0009 0.0065
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0181 0.1579
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0028 0.0035 0.0022
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0054 0.004
Schistosoma mansoni transcription factor LCR-F1 0.0106 0.0217 0.1879
Mycobacterium ulcerans beta-lactamase 0.0036 0.0054 0.004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0014 0.0083
Echinococcus granulosus lamin 0.0028 0.0035 0.0295
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0028 0.0035 0.0022
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0684
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0054 0.0651
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0429
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0009 0.0109
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0023 0.0023 0.0193
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.011 0.0228 0.1986
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0259 0.2246
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0028 0.0035 0.0022
Leishmania major cathepsin L-like protease 0.0017 0.0009 0.0022
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0038 0.0456
Loa Loa (eye worm) hypothetical protein 0.0098 0.0198 0.2525
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0028 0.0035 0.0022
Brugia malayi jmjC domain containing protein 0.0018 0.0013 0.0128
Mycobacterium tuberculosis Conserved protein 0.0036 0.0054 0.004
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0013 0.008
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0009 0.0074
Brugia malayi Bromodomain containing protein 0.004 0.0062 0.0761
Echinococcus granulosus peregrin 0.0059 0.0109 0.0943
Loa Loa (eye worm) latrophilin receptor protein 2 0.011 0.0228 0.2901
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0054 0.0447
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0181 0.1579
Echinococcus multilocularis tar DNA binding protein 0.0124 0.0259 0.0685
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0187 0.0407 0.3551
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0023 0.0023 0.0196
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.011 0.0228 0.1986
Mycobacterium ulcerans lipase LipD 0.0036 0.0054 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0056 0.0809
Entamoeba histolytica hypothetical protein 0.0106 0.0217 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0028 0.0035 0.0022
Mycobacterium tuberculosis Conserved protein 0.0036 0.0054 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.008
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0014 0.0083
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0013 0.0137
Loa Loa (eye worm) cytochrome P450 0.0028 0.0035 0.0448
Toxoplasma gondii cytochrome p450 superfamily protein 0.0028 0.0035 0.2681
Schistosoma mansoni cytochrome P450 reductase 0.0023 0.0023 0.0179
Leishmania major cathepsin L-like protease 0.0063 0.0118 0.1321
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0009 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0054 0.056
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0013 0.008
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.0653 0.7681
Schistosoma mansoni lamin 0.0028 0.0035 0.0282
Schistosoma mansoni bromodomain containing protein 0.0067 0.0127 0.1086
Schistosoma mansoni jumonji domain containing protein 0.0148 0.0317 0.2755
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0054 0.056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0012 0.0085
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0056 0.0581
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0056 0.2253
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0103 0.9497
Schistosoma mansoni hypothetical protein 0.011 0.0228 0.1975
Brugia malayi Cytochrome P450 family protein 0.0028 0.0035 0.0414
Brugia malayi Cytochrome P450 family protein 0.0045 0.0076 0.0932
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.011 0.0228 0.2876
Loa Loa (eye worm) cysteine protease 0.0017 0.0009 0.0109
Schistosoma mansoni zinc finger protein 0.0022 0.0021 0.0159
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0056 0.0476
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0014 0.011
Schistosoma mansoni hypothetical protein 0.0501 0.1143 1
Leishmania major hypothetical protein, conserved 0.0036 0.0054 0.056
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0108 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.0293 0.3404
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0028 0.0035 0.0022
Giardia lamblia PHD finger protein 15 0.0057 0.0103 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0056 0.0809
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0013 0.0163
Trypanosoma cruzi hypothetical protein, conserved 0.0375 0.0848 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0181 0.1567
Leishmania major cathepsin L-like protease 0.0063 0.0118 0.1321
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0023 0.0023 0.0196
Leishmania major hypothetical protein, conserved 0.0018 0.0013 0.0072
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.0041 0.0408
Trypanosoma brucei unspecified product 0.0019 0.0013 0.008
Schistosoma mansoni hypothetical protein 0.0106 0.0217 0.1879
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0013 0.008
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0057 0.0485
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0028 0.0035 0.0022
Echinococcus granulosus jumonji domain containing protein 0.0079 0.0155 0.135
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0118 0.1321
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0013 0.0102
Schistosoma mansoni ap endonuclease 0.0019 0.0014 0.0096
Schistosoma mansoni glutaminase 0.0265 0.0589 0.5145
Echinococcus granulosus lamin dm0 0.0028 0.0035 0.0295
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0684
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0108 0.0921
Onchocerca volvulus 0.0036 0.0054 0.1756
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0028 0.0035 0.0022
Schistosoma mansoni DNA polymerase eta 0.0043 0.0071 0.06
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0028 0.0035 0.0022
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0028 0.0035 0.0022
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0028 0.0035 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0054 0.0778
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0131 0.0346
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0056 0.0145
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 0.4286 1 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0028 0.0035 0.0022
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0054 0.0778
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.008
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0076 0.0964
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0021 0.0053
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0054 0.004
Loa Loa (eye worm) glutaminase 2 0.0265 0.0589 0.7501
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0013 0.0102
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0013 0.0031
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0684
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0054 0.004
Loa Loa (eye worm) hypothetical protein 0.0046 0.0077 0.0976
Echinococcus granulosus phd:f box containing protein 0.0018 0.0013 0.0102
Loa Loa (eye worm) hypothetical protein 0.0244 0.0542 0.689
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.014 0.1201
Schistosoma mansoni hypothetical protein 0.0019 0.0013 0.0093
Loa Loa (eye worm) hypothetical protein 0.0073 0.0141 0.1791
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0023 0.0023 0.001
Brugia malayi Latrophilin receptor protein 2 0.011 0.0228 0.2876
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0021 0.0176
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0118 0.1321
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.008
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0056 0.0476
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0118 0.1321
Echinococcus granulosus GPCR family 2 0.011 0.0228 0.1986
Schistosoma mansoni hypothetical protein 0.011 0.0228 0.1975
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0259 0.2246
Echinococcus granulosus cpg binding protein 0.0032 0.0045 0.0387
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0009 0.002
Trypanosoma brucei cytochrome P450, putative 0.0045 0.0076 0.0821
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0028 0.0035 0.0022
Leishmania major cytochrome P450 reductase, putative 0.002 0.0017 0.0124
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0013 0.0072
Onchocerca volvulus 0.005 0.0086 0.3021
Brugia malayi jmjC domain containing protein 0.0018 0.0013 0.0128
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.162 0.3761 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0087 0.0952
Leishmania major cytochrome p450-like protein 0.0028 0.0035 0.0339
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0013 0.0072
Plasmodium vivax flavodoxin domain containing protein 0.002 0.0017 0.0904
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0106 0.0217 0.189
Loa Loa (eye worm) hypothetical protein 0.011 0.0228 0.2901
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0103 1
Echinococcus granulosus neuropeptide s receptor 0.0478 0.1088 0.9515
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0014 0.014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0012 0.0085
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.0653 0.7681
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0103 0.9536
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0013 0.0088
Echinococcus granulosus dna polymerase eta 0.0043 0.0071 0.0613
Schistosoma mansoni hypothetical protein 0.0501 0.1143 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.011 0.0228 0.0603
Loa Loa (eye worm) hypothetical protein 0.0127 0.0266 0.3384
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.0927 0.2462
Loa Loa (eye worm) hypothetical protein 0.0043 0.0071 0.0906
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0013 0.0171
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0181 0.1567
Plasmodium falciparum phd finger protein, putative 0.0057 0.0103 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0013 0.0108

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 217 nM Competitive reversible inhibition of Strepotomyces coelicolor type 2 dehydroquinase expressed in Escherichia coli BL21 (DE3) cells assessed as enone-carboxylate chromophore of 3-dehydroshikimate formation using 3-dehydroquinate as substrate preincubated with enzyme for 3 mins prior to substrate addition by UV spectrophotometric assay ChEMBL. No reference
Ki (binding) = 2122 nM Competitive reversible inhibition of Mycobacterium tuberculosis type 2 dehydroquinase expressed in Escherichia coli BL21 (DE3) cells assessed as enone-carboxylate chromophore of 3-dehydroshikimate formation using 3-dehydroquinate as substrate preincubated with enzyme for 3 mins prior to substrate addition by UV spectrophotometric assay ChEMBL. No reference
Ki (binding) = 2200 nM Competitive reversible inhibition of Helicobacter pylori type 2 dehydroquinase expressed in Escherichia coli BL21 (DE3) cells assessed as enone-carboxylate chromophore of 3-dehydroshikimate formation using 3-dehydroquinate as substrate preincubated with enzyme for 3 mins prior to substrate addition by UV spectrophotometric assay ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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