TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 487.635 | Formula: C26H41N5O4
H donors: 2 H acceptors: 4 LogP: 0.73 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CCC(CC1)NC(=O)NC12CC3CC(C2)CC(C1)C3)CCC(=O)N1CCN(CC1)C(=O)C
InChi: 1S/C26H41N5O4/c1-18(32)29-8-10-31(11-9-29)24(34)3-2-23(33)30-6-4-22(5-7-30)27-25(35)28-26-15-19-12-20(16-26)14-21(13-19)17-26/h19-22H,2-17H2,1H3,(H2,27,28,35)
InChiKey: GEUHGQUBATVBTI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epoxide hydrolase 2, cytoplasmic	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	epoxide hydrolase EphA	Get druggable targets OG5_129061	All targets in OG5_129061
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	Get druggable targets OG5_129061	All targets in OG5_129061

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	serine/threonine kinase, putative	0.0288	0.8859	0.8859
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0288	0.8859	1
Echinococcus multilocularis	protein kinase	0.0288	0.8859	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0288	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0288	0.8859	1
Giardia lamblia	Kinase, NEK	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0288	0.8859	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0288	0.8859	1
Schistosoma mansoni	serine/threonine protein kinase	0.0288	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0288	0.8859	0.8859
Trichomonas vaginalis	TK family protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0288	0.8859	0.8859
Echinococcus granulosus	tyrosine protein kinase Blk	0.0288	0.8859	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0288	0.8859	1
Trypanosoma cruzi	3-methylcrotonyl-CoA carboxylase, putative	0.0069	0.1259	0.1422
Entamoeba histolytica	tyrosine kinase, putative	0.0288	0.8859	0.8859
Loa Loa (eye worm)	TK protein kinase	0.0288	0.8859	1
Onchocerca volvulus		0.0288	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0288	0.8859	0.8859
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Brugia malayi	SRC-1	0.0288	0.8859	1
Loa Loa (eye worm)	TK protein kinase	0.0288	0.8859	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0095	0.2151	0.2151
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Trypanosoma brucei	Pseudokinase, putative	0.0288	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0288	0.8859	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	conserved hypothetical protein	0.0288	0.8859	1
Brugia malayi	hypothetical protein	0.0288	0.8859	1
Onchocerca volvulus		0.0288	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Entamoeba histolytica	hypothetical protein	0.0321	1	1
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0128	0.331	0.3736
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Schistosoma mansoni	thyroid hormone receptor	0.0139	0.3668	0.414
Trichomonas vaginalis	conserved hypothetical protein	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0288	0.8859	0.8859
Echinococcus granulosus	propionyl coenzyme A carboxylase alpha chain	0.0069	0.1259	0.1422
Loa Loa (eye worm)	TK/FER protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0288	0.8859	1
Giardia lamblia	Kinase, NEK	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0288	0.8859	1
Plasmodium falciparum	protein kinase, putative	0.0288	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0288	0.8859	1
Plasmodium falciparum	protein kinase, putative	0.0288	0.8859	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0288	0.8859	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0095	0.2151	0.2428
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Entamoeba histolytica	protein kinase, putative	0.0288	0.8859	0.8859
Onchocerca volvulus		0.0288	0.8859	1
Entamoeba histolytica	hypothetical protein	0.0288	0.8859	0.8859
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	TK protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	carboxyl transferase domain-containing protein	0.0175	0.494	0.5575
Loa Loa (eye worm)	TK/FER protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Echinococcus granulosus	protein kinase	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0136	0.3563	0.4022
Echinococcus granulosus	ephrin type A receptor 4 A	0.0288	0.8859	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0139	0.3668	0.414
Brugia malayi	Muscleblind-like protein	0.0144	0.3853	0.4349
Schistosoma mansoni	hypothetical protein	0.0288	0.8859	1
Echinococcus multilocularis	propionyl coenzyme A carboxylase alpha chain	0.0069	0.1259	0.1422
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0288	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Schistosoma mansoni	protein kinase	0.0288	0.8859	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0288	0.8859	1
Leishmania major	protein kinase, putative	0.0288	0.8859	1
Wolbachia endosymbiont of Brugia malayi	Acetyl/propionyl-CoA carboxylase, alpha subunit	0.0069	0.1259	0.5
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0288	0.8859	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0288	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0288	0.8859	0.8859
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Entamoeba histolytica	tyrosin kinase, putative	0.0288	0.8859	0.8859
Entamoeba histolytica	tyrosine kinase, putative	0.0288	0.8859	0.8859
Entamoeba histolytica	hypothetical protein	0.0288	0.8859	0.8859
Entamoeba histolytica	ankyrin repeat protein	0.0288	0.8859	0.8859
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0128	0.331	0.3736
Schistosoma mansoni	protein kinase	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Leishmania major	hypothetical protein, conserved	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0288	0.8859	1
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0272	0.0307
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0272	0.0307
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Trichomonas vaginalis	conserved hypothetical protein	0.0288	0.8859	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0288	0.8859	0.8859
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0288	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0321	1	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Brugia malayi	Tyrosine-protein kinase PR2	0.0288	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0288	0.8859	1
Schistosoma mansoni	serine/threonine protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0288	0.8859	0.8859
Loa Loa (eye worm)	hypothetical protein	0.0288	0.8859	1
Echinococcus granulosus	integrin linked protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	conserved hypothetical protein	0.0288	0.8859	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0288	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0288	0.8859	0.8859
Echinococcus granulosus	Niemann Pick C1 protein	0.0136	0.3563	0.4022
Entamoeba histolytica	hypothetical protein	0.0037	0.0131	0.0131
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0288	0.8859	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Schistosoma mansoni	ephrin receptor	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Echinococcus multilocularis	acetyl coenzyme A carboxylase 1	0.0182	0.516	0.5825
Echinococcus granulosus	protein tyrosine kinase	0.0288	0.8859	1
Echinococcus multilocularis	insulin receptor	0.0288	0.8859	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0288	0.8859	1
Loa Loa (eye worm)	TK protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	AGC family protein kinase	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Schistosoma mansoni	ephrin receptor	0.0288	0.8859	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0288	0.8859	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0288	0.8859	1
Brugia malayi	protein-tyrosine kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Schistosoma mansoni	pyruvate carboxylase	0.0069	0.1259	0.1422
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0288	0.8859	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0288	0.8859	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0095	0.2151	0.2428
Entamoeba histolytica	serine/threonine kinase, putative	0.0288	0.8859	0.8859
Schistosoma mansoni	hypothetical protein	0.0039	0.0221	0.0249
Loa Loa (eye worm)	TK/FER protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0288	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0288	0.8859	0.8859
Onchocerca volvulus		0.0288	0.8859	1
Trypanosoma cruzi	protein kinase, putative	0.0288	0.8859	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0288	0.8859	1
Echinococcus multilocularis	activin receptor type	0.0288	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0288	0.8859	0.8859
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Entamoeba histolytica	ankyrin repeat protein	0.0288	0.8859	0.8859
Entamoeba histolytica	hypothetical protein, conserved	0.0288	0.8859	0.8859
Entamoeba histolytica	tyrosine kinase, putative	0.0288	0.8859	0.8859
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0288	0.8859	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0288	0.8859	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0321	1	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0288	0.8859	1
Echinococcus granulosus	expressed conserved protein	0.0089	0.1951	0.2202
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0288	0.8859	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0288	0.8859	1
Echinococcus multilocularis	protein patched	0.0041	0.0272	0.0307
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0288	0.8859	1
Plasmodium falciparum	protein kinase, putative	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0288	0.8859	0.8859
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0288	0.8859	1
Schistosoma mansoni	methylcrotonyl-CoA carboxylase	0.0069	0.1263	0.1425
Loa Loa (eye worm)	hypothetical protein	0.0288	0.8859	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0288	0.8859	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Echinococcus granulosus	epidermal growth factor receptor	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0131	0.0131
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Mycobacterium leprae	Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP)	0.0069	0.1259	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0288	0.8859	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0288	0.8859	0.8859
Echinococcus granulosus	tyrosine kinase	0.0288	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0288	0.8859	0.8859
Loa Loa (eye worm)	hypothetical protein	0.005	0.059	0.0666
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0288	0.8859	1
Loa Loa (eye worm)	SRC-1	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0288	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0288	0.8859	0.8859
Echinococcus granulosus	insulin receptor	0.0288	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Echinococcus granulosus	kinase suppressor of Ras 1	0.0288	0.8859	1
Brugia malayi	Carboxyl transferase domain containing protein	0.0175	0.494	0.5575
Schistosoma mansoni	protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Echinococcus granulosus	Niemann Pick C1 protein	0.0095	0.2151	0.2428
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Echinococcus granulosus	tyrosine protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Echinococcus multilocularis	protein kinase	0.0288	0.8859	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0288	0.8859	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0288	0.8859	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0288	0.8859	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0288	0.8859	1
Echinococcus multilocularis	protein tyrosine kinase	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Schistosoma mansoni	protein kinase	0.0288	0.8859	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0288	0.8859	0.8859
Toxoplasma gondii	protein kinase	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Onchocerca volvulus		0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Schistosoma mansoni	protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0288	0.8859	1
Trichomonas vaginalis	conserved hypothetical protein	0.0288	0.8859	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0288	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0288	0.8859	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0288	0.8859	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0288	0.8859	0.8859
Echinococcus multilocularis	tyrosine protein kinase csk	0.0288	0.8859	1
Schistosoma mansoni	protein tyrosine kinase	0.0288	0.8859	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0288	0.8859	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0288	0.8859	1
Schistosoma mansoni	thyroid hormone receptor	0.0139	0.3668	0.414
Loa Loa (eye worm)	hypothetical protein	0.0288	0.8859	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0288	0.8859	1
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.0197	0.571	1
Brugia malayi	ephrin receptor 1 precursor	0.0288	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0288	0.8859	0.8859
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0288	0.8859	1
Giardia lamblia	Protein 21.1	0.0288	0.8859	1
Entamoeba histolytica	receptor protein kinase, putative	0.0288	0.8859	0.8859
Onchocerca volvulus		0.0288	0.8859	1
Loa Loa (eye worm)	TK protein kinase	0.0288	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0288	0.8859	0.8859
Chlamydia trachomatis	biotin carboxylase	0.0063	0.1039	0.5
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0288	0.8859	1
Toxoplasma gondii	acetyl-coA carboxylase ACC2	0.0182	0.516	0.5825
Echinococcus granulosus	tyrosine protein kinase HCK	0.0288	0.8859	1
Entamoeba histolytica	tyrosin kinase, putative	0.0288	0.8859	0.8859
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0288	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Entamoeba histolytica	protein kinase, putative	0.0288	0.8859	0.8859
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Schistosoma mansoni	patched 1	0.0041	0.0272	0.0307
Loa Loa (eye worm)	TK/DDR protein kinase	0.0288	0.8859	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0288	0.8859	0.8859
Entamoeba histolytica	hypothetical protein	0.0288	0.8859	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Onchocerca volvulus		0.0288	0.8859	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0288	0.8859	0.8859
Echinococcus multilocularis	tyrosine protein kinase csk	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Entamoeba histolytica	hypothetical protein	0.0288	0.8859	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0288	0.8859	1
Loa Loa (eye worm)	TK protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0288	0.8859	1
Brugia malayi	hypothetical protein	0.0037	0.0131	0.0148
Echinococcus granulosus	acetyl coenzyme A carboxylase 1	0.0182	0.516	0.5825
Entamoeba histolytica	hypothetical protein	0.0288	0.8859	0.8859
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0288	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase	0.0288	0.8859	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0288	0.8859	1
Schistosoma mansoni	serine/threonine RGC	0.0288	0.8859	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0526	0.0594
Onchocerca volvulus		0.0288	0.8859	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0288	0.8859	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0288	0.8859	1
Trypanosoma cruzi	protein kinase, putative	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0288	0.8859	1
Leishmania major	acetyl-CoA carboxylase, putative	0.0182	0.516	0.5825
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Onchocerca volvulus		0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Brugia malayi	integrin-linked kinase	0.0288	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0526	0.0594
Onchocerca volvulus		0.0288	0.8859	1
Echinococcus multilocularis	integrin linked protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Trypanosoma brucei	unspecified product	0.0045	0.0437	0.0494
Plasmodium falciparum	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.0131	0.3419	0.3859
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0288	0.8859	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0288	0.8859	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0288	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0288	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0288	0.8859	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0272	0.0307
Loa Loa (eye worm)	TK/CSK protein kinase	0.0288	0.8859	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0288	0.8859	0.8859
Entamoeba histolytica	tyrosine kinase, putative	0.0288	0.8859	0.8859
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0288	0.8859	0.8859
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0288	0.8859	1
Brugia malayi	CHE-14 protein	0.0041	0.0272	0.0307
Entamoeba histolytica	protein kinase, putative	0.0288	0.8859	0.8859
Loa Loa (eye worm)	TK/EPH protein kinase	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Onchocerca volvulus		0.0288	0.8859	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0288	0.8859	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0288	0.8859	1
Toxoplasma gondii	acetyl-CoA carboxylase ACC1	0.0182	0.516	0.5825
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Schistosoma mansoni	protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0197	0.571	1
Echinococcus granulosus	c src tyrosine kinase	0.0288	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0288	0.8859	0.8859
Plasmodium vivax	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.0131	0.3419	0.3859
Entamoeba histolytica	tyrosin kinase, putative	0.0288	0.8859	0.8859
Schistosoma mansoni	protein kinase	0.0288	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0288	0.8859	0.8859
Loa Loa (eye worm)	hypothetical protein	0.0144	0.3853	0.4349
Toxoplasma gondii	STE kinase	0.0288	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0288	0.8859	0.8859
Schistosoma mansoni	hypothetical protein	0.0039	0.0221	0.0249
Brugia malayi	SH2 domain containing protein	0.0288	0.8859	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0288	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0288	0.8859	1
Entamoeba histolytica	hypothetical protein	0.0321	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	TK protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0288	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0288	0.8859	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0288	0.8859	0.8859
Schistosoma mansoni	hypothetical protein	0.0039	0.0221	0.0249
Echinococcus granulosus	tyrosine protein kinase Srms	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0288	0.8859	1
Schistosoma mansoni	serine/threonine protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Trypanosoma brucei	protein kinase, putative	0.0288	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0288	0.8859	0.8859
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Echinococcus multilocularis	epidermal growth factor receptor	0.0288	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0288	0.8859	0.8859
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0288	0.8859	0.8859
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0288	0.8859	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	STE family protein kinase	0.0288	0.8859	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0288	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0288	0.8859	1
Schistosoma mansoni	hypothetical protein	0.0037	0.0131	0.0148
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Echinococcus multilocularis	muscleblind protein	0.0144	0.3853	0.4349
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0288	0.8859	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0288	0.8859	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0288	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0288	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Loa Loa (eye worm)	hypothetical protein	0.0144	0.3853	0.4349
Trypanosoma brucei	acetyl-CoA carboxylase	0.0182	0.516	0.5825
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0288	0.8859	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0131	0.0148
Entamoeba histolytica	hypothetical protein	0.0037	0.0131	0.0131
Echinococcus multilocularis	heat shock protein 70	0.0288	0.8859	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0288	0.8859	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0131	0.0148
Giardia lamblia	Kinase	0.0288	0.8859	1
Trichomonas vaginalis	conserved hypothetical protein	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Onchocerca volvulus		0.0288	0.8859	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0288	0.8859	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0288	0.8859	0.8859
Toxoplasma gondii	protein kinase domain-containing protein	0.0288	0.8859	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0288	0.8859	0.8859
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Entamoeba histolytica	protein kinase, putative	0.0288	0.8859	0.8859
Schistosoma mansoni	tyrosine protein kinase	0.0288	0.8859	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0288	0.8859	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0288	0.8859	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0288	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0288	0.8859	0.8859
Schistosoma mansoni	methylcrotonyl-CoA carboxylase	0.0069	0.1263	0.1425
Entamoeba histolytica	tyrosine kinase, putative	0.0288	0.8859	0.8859
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0288	0.8859	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0288	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0288	0.8859	1
Trichomonas vaginalis	conserved hypothetical protein	0.0288	0.8859	1
Echinococcus multilocularis	c src tyrosine kinase	0.0288	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0288	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2151	0.2428
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0288	0.8859	1
Entamoeba histolytica	tyrosin kinase, putative	0.0288	0.8859	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0288	0.8859	1
Trichomonas vaginalis	CAMK family protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0288	0.8859	1
Echinococcus multilocularis	tyrosine kinase	0.0288	0.8859	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0288	0.8859	0.8859
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0288	0.8859	1
Brugia malayi	SH2 domain containing protein	0.0288	0.8859	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Brugia malayi	Guanylyl cyclase protein 23	0.0288	0.8859	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0288	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0288	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Brugia malayi	hypothetical protein	0.0288	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0288	0.8859	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0288	0.8859	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0288	0.8859	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0272	0.0307
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0288	0.8859	1
Entamoeba histolytica	receptor protein kinase, putative	0.0288	0.8859	0.8859
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0272	0.0307
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0288	0.8859	0.8859
Schistosoma mansoni	acetyl-CoA carboxylase	0.0182	0.516	0.5825
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0288	0.8859	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0288	0.8859	1
Echinococcus granulosus	activin receptor type	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0288	0.8859	1
Leishmania major	carboxylase, putative	0.0069	0.1259	0.1422
Schistosoma mansoni	hypothetical protein	0.0128	0.331	0.3736
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0288	0.8859	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0288	0.8859	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0288	0.8859	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0526	0.0594
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	TK protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0272	0.0307
Entamoeba histolytica	serine/threonine kinase, putative	0.0288	0.8859	0.8859
Echinococcus multilocularis	FL cytokine receptor	0.0288	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0288	0.8859	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0131	0.0131
Entamoeba histolytica	protein kinase, putative	0.0288	0.8859	0.8859
Echinococcus multilocularis	expressed conserved protein	0.0089	0.1951	0.2202
Echinococcus granulosus	epidermal growth factor receptor	0.0288	0.8859	1
Leishmania major	protein kinase, putative	0.0288	0.8859	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0288	0.8859	1
Schistosoma mansoni	protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0288	0.8859	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0288	0.8859	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0288	0.8859	1
Plasmodium vivax	protein kinase, putative	0.0288	0.8859	1
Echinococcus granulosus	muscleblind protein	0.0144	0.3853	0.4349
Schistosoma mansoni	hypothetical protein	0.0039	0.0221	0.0249
Schistosoma mansoni	protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0288	0.8859	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0288	0.8859	1
Entamoeba histolytica	tyrosine kinase, putative	0.0288	0.8859	0.8859
Schistosoma mansoni	protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0096	0.2202	0.2485
Echinococcus multilocularis	transfer RNA-Thr	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0288	0.8859	1
Trypanosoma cruzi	3-methylcrotonyl-CoA carboxylase, putative	0.0069	0.1259	0.1422
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0288	0.8859	1
Leishmania major	methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein	0.0069	0.1259	0.1422
Onchocerca volvulus		0.0288	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0288	0.8859	1
Echinococcus multilocularis	tyrosine kinase	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Trypanosoma brucei	3-methylcrotonyl-CoA carboxylase alpha subunit, putative	0.0069	0.1259	0.1422
Schistosoma mansoni	protein kinase	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Brugia malayi	Raf kinase	0.0288	0.8859	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0288	0.8859	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0288	0.8859	0.8859
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0288	0.8859	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Brugia malayi	C-terminal src kinase protein 1	0.0288	0.8859	1
Entamoeba histolytica	hypothetical protein	0.0288	0.8859	0.8859
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0288	0.8859	0.8859
Onchocerca volvulus		0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0288	0.8859	1
Echinococcus multilocularis	protein dispatched 1	0.0046	0.0471	0.0532
Echinococcus multilocularis	muscleblind protein 1	0.0144	0.3853	0.4349
Loa Loa (eye worm)	TK/ROR protein kinase	0.0288	0.8859	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0288	0.8859	1
Echinococcus granulosus	tyrosine kinase	0.0288	0.8859	1
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0131	0.0148
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Brugia malayi	hypothetical protein	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Entamoeba histolytica	cysteine surface protein, putative	0.0288	0.8859	0.8859
Loa Loa (eye worm)	hypothetical protein	0.0288	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Loa Loa (eye worm)	hypothetical protein	0.0288	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Toxoplasma gondii	pyruvate carboxylase	0.0069	0.1259	0.1422
Entamoeba histolytica	hypothetical protein	0.0288	0.8859	0.8859
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0288	0.8859	1
Entamoeba histolytica	hypothetical protein	0.0288	0.8859	0.8859
Loa Loa (eye worm)	TK protein kinase	0.0288	0.8859	1
Entamoeba histolytica	protein kinase, putative	0.0288	0.8859	0.8859
Entamoeba histolytica	protein kinase, putative	0.0288	0.8859	0.8859
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0288	0.8859	1
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Trichomonas vaginalis	TKL family protein kinase	0.0288	0.8859	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0288	0.8859	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0288	0.8859	0.8859
Trypanosoma cruzi	acetyl-CoA carboxylase	0.0112	0.276	0.3116
Loa Loa (eye worm)	TK protein kinase	0.0288	0.8859	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Trypanosoma brucei	3-methylcrotonyl-CoA carboxylase alpha subunit, putative	0.0069	0.1259	0.1422
Brugia malayi	Protein kinase domain containing protein	0.0288	0.8859	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0288	0.8859	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0288	0.8859	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0288	0.8859	0.8859
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0288	0.8859	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0526	0.0594
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0288	0.8859	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0288	0.8859	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0288	0.8859	1
Schistosoma mansoni	tyrosine kinase	0.0288	0.8859	1
Entamoeba histolytica	protein kinase domain containing protein	0.0288	0.8859	0.8859
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0288	0.8859	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0288	0.8859	1
Echinococcus granulosus	tyrosine kinase	0.0288	0.8859	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0288	0.8859	1
Onchocerca volvulus		0.0288	0.8859	1
Schistosoma mansoni	serine/threonine protein kinase	0.0288	0.8859	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 44.7 nM	Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay	ChEMBL.	25225606

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3222123

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1854322