Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1577 | 0.572 |
Loa Loa (eye worm) | carboxylesterase | 0.0141 | 0.2757 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0141 | 0.2757 | 0.998 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0267 | 0.0968 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0142 | 0.2763 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0049 | 0.0168 | 0.0606 |
Echinococcus granulosus | acetylcholinesterase | 0.0141 | 0.2757 | 0.998 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0101 | 0.162 | 0.162 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0476 | 0.1727 |
Echinococcus multilocularis | expressed conserved protein | 0.0093 | 0.141 | 0.5102 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.006 | 0.0476 | 0.0476 |
Echinococcus multilocularis | serotonin transporter | 0.006 | 0.0476 | 0.1723 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0099 | 0.1577 | 0.5709 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.006 | 0.0476 | 0.1727 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 0.2757 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0476 | 0.1727 |
Echinococcus granulosus | acetylcholinesterase | 0.0141 | 0.2757 | 0.998 |
Onchocerca volvulus | 0.006 | 0.0476 | 0.5 | |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0099 | 0.1577 | 0.572 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.006 | 0.0476 | 0.1723 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.006 | 0.0476 | 0.5 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0099 | 0.1577 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0141 | 0.2757 | 0.2757 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.2757 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.006 | 0.0476 | 0.0476 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0141 | 0.2757 | 0.998 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 0.2757 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0141 | 0.2757 | 0.998 |
Loa Loa (eye worm) | norepinephrine transporter | 0.006 | 0.0476 | 0.1727 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0142 | 0.2763 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0141 | 0.2757 | 0.998 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.2757 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0099 | 0.1577 | 0.5709 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0476 | 0.1727 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0141 | 0.2757 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.006 | 0.0476 | 0.1727 |
Echinococcus granulosus | expressed conserved protein | 0.0093 | 0.141 | 0.5102 |
Loa Loa (eye worm) | serotonin transporter b | 0.006 | 0.0476 | 0.1727 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 18.3 % | Estrogenic activity in human MCF7 cells assessed as cell proliferation at 1 uM by MTS assay relative to basal level | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.