Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0448 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0318 | 0 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0318 | 0 | 0.5 |
Onchocerca volvulus | 0.0318 | 0 | 0.5 | |
Echinococcus multilocularis | thymidylate synthase | 0.0318 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0318 | 0 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0318 | 0 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0318 | 0 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0448 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0318 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0448 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0448 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0448 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0318 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 69.1 % | Inhibition of STS (unknown origin) expressed in HEK-293 cells assessed as transformation of [3H]-E1S into E1 at 0.1 uM by scintillation containing | ChEMBL. | No reference |
Inhibition (binding) | = 91.2 % | Inhibition of STS (unknown origin) expressed in HEK-293 cells assessed as transformation of [3H]-E1S into E1 at 1 uM by scintillation containing | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.