Detailed information for compound 1854814

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 342.394 | Formula: C21H18N4O
  • H donors: 1 H acceptors: 2 LogP: 4.03 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(n1)c(ccc2)N=Cc1c(C)[nH]n(c1=O)c1ccccc1
  • InChi: 1S/C21H18N4O/c1-14-11-12-16-7-6-10-19(20(16)23-14)22-13-18-15(2)24-25(21(18)26)17-8-4-3-5-9-17/h3-13,24H,1-2H3
  • InChiKey: OKVVSJSJFPXEJA-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) aspartyl protease 6 0.0047 0.032 0.0332
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0114 0.1683
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0019 0.0003
Loa Loa (eye worm) HMP-2 protein 0.0097 0.0746 0.0798
Loa Loa (eye worm) acetylcholinesterase 1 0.1084 0.9163 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0089
Chlamydia trachomatis protoporphyrinogen oxidase 0.0064 0.0465 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0064 0.0465 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0114 0.1683
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0064 0.0465 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0159 0.1317
Toxoplasma gondii aspartyl protease ASP1 0.0047 0.032 0.6454
Schistosoma mansoni DNA polymerase eta 0.0054 0.0376 0.0376
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0114 0.0037
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0019 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0019 0.0003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0159 0.3184
Leishmania major DNA polymerase eta, putative 0.0038 0.0239 0.2604
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0047 0.032 0.032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0019 0.0021
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0595 0.5336
Onchocerca volvulus Huntingtin homolog 0.0148 0.1177 0.4949
Plasmodium falciparum plasmepsin VI 0.0047 0.032 0.6768
Loa Loa (eye worm) carboxylesterase 0.0183 0.1478 0.1597
Schistosoma mansoni BC026374 protein (S09 family) 0.0183 0.1478 0.1478
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0078 0.0067
Schistosoma mansoni hypothetical protein 0.0019 0.0078 0.0078
Echinococcus multilocularis acetylcholinesterase 0.1084 0.9163 1
Brugia malayi hypothetical protein 0.0183 0.1478 0.1597
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0019 0.0003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0159 0.0156
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0159 0.0944
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0067 0.0483 0.9918
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0019 0.0003
Loa Loa (eye worm) hypothetical protein 0.0148 0.1177 0.1269
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0159 0.1317
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0019 0.0019
Onchocerca volvulus 0.0183 0.1478 0.623
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0183 0.1478 0.1478
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0429 0.0451
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0003
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0064 0.0465 0.0508
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0114 0.1683
Onchocerca volvulus 0.0047 0.032 0.1294
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0595 1
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0519 0.2144
Brugia malayi Eukaryotic aspartyl protease family protein 0.0047 0.032 0.0332
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0595 1
Schistosoma mansoni topbp1 0.0012 0.0017 0.0017
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0018 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0159 0.0185
Entamoeba histolytica protein kinase, putative 0.0139 0.1101 1
Schistosoma mansoni hypothetical protein 0.0019 0.0078 0.0078
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0568 0.0603
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0229 0.4519
Brugia malayi nuclear receptor NHR-88 0.0012 0.0019 0.0003
Loa Loa (eye worm) hypothetical protein 0.0183 0.1478 0.1597
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0018 0.002
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0019 0.0011
Onchocerca volvulus 0.0183 0.1478 0.623
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0376 0.6218
Brugia malayi aspartic protease BmAsp-2, identical 0.0047 0.032 0.0332
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.0465 0.0533
Entamoeba histolytica hypothetical protein, conserved 0.0028 0.0158 0.1305
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0098 0.0105
Onchocerca volvulus Huntingtin homolog 0.0148 0.1177 0.4949
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0309 0.0337
Trypanosoma brucei unspecified product 0.0016 0.0052 0.0617
Echinococcus granulosus microtubule associated protein 2 0.0833 0.7024 0.7666
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0019 0.0003
Brugia malayi nuclear hormone receptor 0.0012 0.0019 0.0003
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0078 0.0067
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0019 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0052 0.0617
Loa Loa (eye worm) hypothetical protein 0.0047 0.032 0.0332
Echinococcus granulosus beta catenin 0.0097 0.0746 0.0815
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0183 0.1478 0.1961
Plasmodium falciparum plasmepsin VII 0.0047 0.032 0.6768
Brugia malayi Carboxylesterase family protein 0.1084 0.9163 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1084 0.9163 0.9163
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0047 0.032 0.032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0003
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0064 0.0465 0.0582
Echinococcus granulosus dnaJ subfamily B 0.0494 0.4129 0.4506
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0019 0.0003
Brugia malayi Probable ATP-dependent helicase DHX35 0.0073 0.0536 0.0568
Loa Loa (eye worm) hypothetical protein 0.0029 0.0159 0.0156
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0568 0.0603
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0028 0.0158 0.2445
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0019 0.0003
Schistosoma mansoni hypothetical protein 0.0028 0.0158 0.0158
Loa Loa (eye worm) carboxylesterase 0.0183 0.1478 0.1597
Echinococcus granulosus neuroligin 0.0183 0.1478 0.1613
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0114 0.0126
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0089
Schistosoma mansoni cathepsin D (A01 family) 0.0047 0.032 0.032
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0019 0.0019
Echinococcus multilocularis tumor protein p63 0.0391 0.3252 0.3549
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0114 0.0114
Schistosoma mansoni topbp1 0.0012 0.0017 0.0017
Brugia malayi Pepsin A precursor 0.0047 0.032 0.0332
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0028 0.0158 0.0916
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0017 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0159 0.0185
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0229 0.0229
Echinococcus granulosus lysine specific histone demethylase 1A 0.0064 0.0465 0.0508
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0114 0.1683
Plasmodium falciparum plasmepsin IX 0.0047 0.032 0.6768
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0019 0.0011
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0047 0.032 0.0349
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0568 0.0568
Plasmodium falciparum protoporphyrinogen oxidase 0.0064 0.0465 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0114 0.1683
Loa Loa (eye worm) hypothetical protein 0.0019 0.0078 0.0067
Plasmodium falciparum plasmepsin I 0.0047 0.032 0.6768
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0047 0.032 0.0332
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0183 0.1478 0.1478
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0064 0.0465 0.0465
Loa Loa (eye worm) HMG box family protein 0.0065 0.0471 0.0497
Schistosoma mansoni hypothetical protein 0.0041 0.0266 0.0266
Treponema pallidum DNA ligase (lig) 0.0012 0.0017 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0019 0.0021
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0595 0.065
Plasmodium falciparum plasmepsin IV 0.0047 0.032 0.6768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0159 0.0101
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0114 0.0898
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0114 0.0126
Echinococcus multilocularis para nitrobenzyl esterase 0.0183 0.1478 0.1613
Brugia malayi Ribonuclease 2-5A family protein 0.0139 0.1101 0.1186
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0028 0.0158 0.2445
Giardia lamblia DINP protein human, muc B family 0.0023 0.0114 0.6884
Schistosoma mansoni hypothetical protein 0.0019 0.0078 0.0078
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0114 0.0415
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0019 0.0003
Echinococcus granulosus tar DNA binding protein 0.0076 0.0568 0.062
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0019 0.0021
Trichomonas vaginalis spcc417.12 protein, putative 0.0183 0.1478 0.623
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0047 0.032 0.032
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0554 0.0554
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0047 0.032 0.032
Schistosoma mansoni hypothetical protein 0.0019 0.0078 0.0078
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0098 0.1808
Loa Loa (eye worm) hypothetical protein 0.0183 0.1478 0.1597
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0523 0.0523
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0114 0.1683
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0047 0.032 0.032
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0114 0.0124
Brugia malayi hypothetical protein 0.0064 0.0465 0.049
Echinococcus granulosus dna polymerase eta 0.0054 0.0376 0.0411
Brugia malayi Carboxylesterase family protein 0.0183 0.1478 0.1597
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0159 0.0156
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0114 0.0037
Trypanosoma cruzi UDP-galactopyranose mutase 0.0064 0.0465 0.7752
Schistosoma mansoni cpg binding protein 0.0035 0.0211 0.0211
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0211 0.0213
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0098 0.0014
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0229 0.025
Echinococcus multilocularis geminin 0.0205 0.1661 0.1813
Plasmodium vivax plasmepsin V, putative 0.0047 0.032 0.6768
Echinococcus multilocularis GPCR, family 2 0.0019 0.0078 0.0085
Plasmodium vivax plasmepsin IV, putative 0.0047 0.032 0.6768
Plasmodium falciparum plasmepsin II 0.0047 0.032 0.6768
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0568 0.062
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0114 0.1683
Echinococcus granulosus GPCR family 2 0.0019 0.0078 0.0085
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0047 0.032 0.032
Echinococcus granulosus hypothetical protein 0.0302 0.2489 0.2717
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0019 0.0003
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0019 0.0019
Echinococcus multilocularis serine:threonine protein kinase:endoribonuclease 0.0139 0.1101 0.1202
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0229 0.0229
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0078 0.0085
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0047 0.032 0.6454
Echinococcus multilocularis BC026374 protein (S09 family) 0.0183 0.1478 0.1613
Mycobacterium ulcerans dehydrogenase 0.0064 0.0465 0.0582
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0098 0.1808
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0158 0.0603
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0159 0.0185
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0851 0.7175 1
Plasmodium vivax hypothetical protein, conserved 0.0064 0.0465 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0159 0.0185
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0019 0.0019
Echinococcus granulosus BC026374 protein S09 family 0.0183 0.1478 0.1613
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0064 0.0465 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0239 0.4734
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0028 0.0158 0.2445
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0183 0.1478 0.1478
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0595 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0078 0.0067
Schistosoma mansoni gliotactin 0.0183 0.1478 0.1478
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0019 0.0003
Entamoeba histolytica DNA repair and recombination protein, putative 0.0028 0.0158 0.1305
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0089
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0019 0.0021
Schistosoma mansoni cathepsin D (A01 family) 0.0047 0.032 0.032
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0017 0.0018
Echinococcus multilocularis acetylcholinesterase 0.1084 0.9163 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.7024 0.7024
Loa Loa (eye worm) hypothetical protein 0.0183 0.1478 0.1597
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0047 0.032 0.0349
Loa Loa (eye worm) hypothetical protein 0.0064 0.0465 0.049
Echinococcus granulosus carboxylesterase 5A 0.1084 0.9163 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.032 0.0332
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0019 0.0003
Onchocerca volvulus 0.0064 0.0465 0.1913
Schistosoma mansoni pangolin 0.0065 0.0471 0.0471
Onchocerca volvulus 0.0035 0.0211 0.0829
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0183 0.1478 0.1961
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0019 0.0019
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0159 0.0185
Echinococcus granulosus para nitrobenzyl esterase 0.0183 0.1478 0.1613
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0114 0.1683
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0078 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0114 0.1683
Trichomonas vaginalis serine threonine-protein kinase, putative 0.0071 0.0519 0.2144
Onchocerca volvulus 0.0012 0.0019 0.0011
Schistosoma mansoni hypothetical protein 0.0237 0.1939 0.1939
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0019 0.0021
Plasmodium vivax SET domain protein, putative 0.0037 0.0229 0.4739
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0595 0.0595
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0211 0.0231
Loa Loa (eye worm) hypothetical protein 0.0183 0.1478 0.1597
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0019 0.0021
Onchocerca volvulus 0.0183 0.1478 0.623
Brugia malayi Pre-SET motif family protein 0.0037 0.0229 0.0232
Echinococcus granulosus serine:threonine protein kinase:endoribonuclease 0.0139 0.1101 0.1202
Toxoplasma gondii aspartyl protease 0.0047 0.032 0.6454
Echinococcus granulosus acetylcholinesterase 0.1084 0.9163 1
Onchocerca volvulus 0.0047 0.032 0.1294
Onchocerca volvulus Cirhin homolog 0.0097 0.0741 0.3088
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0019 0.0021
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0114 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0019 0.0003
Brugia malayi ecdysteroid receptor 0.0012 0.0019 0.0003
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0595 0.065
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0028 0.0158 0.0173
Loa Loa (eye worm) hypothetical protein 0.0183 0.1478 0.1597
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0019 0.0003
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0047 0.032 0.032
Schistosoma mansoni cpg binding protein 0.0037 0.0228 0.0228
Mycobacterium tuberculosis Possible oxidoreductase 0.0064 0.0465 0.0533
Brugia malayi Carboxylesterase family protein 0.0183 0.1478 0.1597
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0052 0.0617
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0047 0.032 0.032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0019 0.0003
Schistosoma mansoni cpg binding protein 0.0037 0.0228 0.0228
Brugia malayi SWIRM domain containing protein 0.0064 0.0465 0.049
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0019 0.0003
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0114 0.0106
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0595 1
Entamoeba histolytica protein kinase, putative 0.0139 0.1101 1
Echinococcus multilocularis protoporphyrinogen oxidase 0.0064 0.0465 0.0508
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0019 0.0019
Brugia malayi hypothetical protein 0.0148 0.1177 0.1269
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0429 0.0451
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0114 0.1683
Onchocerca volvulus 0.0183 0.1478 0.623
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0019 0.0003
Leishmania major UDP-galactopyranose mutase 0.0064 0.0465 0.7297
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0159 0.0156
Echinococcus multilocularis nibrin 0.0012 0.0017 0.0018
Echinococcus granulosus lysine specific histone demethylase 1A 0.0064 0.0465 0.0508
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0229 0.0229
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0915 0.7725 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0595 0.0633
Loa Loa (eye worm) hypothetical protein 0.0054 0.0376 0.0393
Toxoplasma gondii histone lysine-specific demethylase 0.0064 0.0465 0.9535
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0064 0.0465 0.0465
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0019 0.0019
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0266 0.0273
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0003
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0097 0.0746 0.0798
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0159 0.0185
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0018 0.002
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0017 0.0018
Mycobacterium ulcerans oxidoreductase 0.0064 0.0465 0.0582
Brugia malayi hypothetical protein 0.0047 0.032 0.0332
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.4129 0.4506
Echinococcus multilocularis carboxylesterase 5A 0.1084 0.9163 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0019 0.0019
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0029 0.0159 0.0156
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0183 0.1478 0.1613
Brugia malayi Carboxylesterase family protein 0.0183 0.1478 0.1597
Schistosoma mansoni amine oxidase 0.0064 0.0465 0.0465
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0064 0.0465 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0159 0.0944
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0114 0.0114
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0047 0.032 0.0332
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0019 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0064 0.0465 1
Loa Loa (eye worm) IRE protein kinase 0.0139 0.1101 0.1186
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0114 0.0415
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0229 0.025
Leishmania major DNA polymerase eta, putative 0.0054 0.0376 0.5453
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0183 0.1478 0.1613
Loa Loa (eye worm) hypothetical protein 0.1084 0.9163 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0019 0.0019
Mycobacterium tuberculosis Carboxylesterase LipT 0.0183 0.1478 0.1961
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0019 0.0003
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0047 0.032 0.0332
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0159 0.0156
Onchocerca volvulus 0.0287 0.2362 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0078 0.0085
Echinococcus granulosus dna polymerase kappa 0.0023 0.0114 0.0124
Mycobacterium ulcerans monoamine oxidase 0.0064 0.0465 0.0582
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0089
Onchocerca volvulus 0.0037 0.0229 0.0906
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0568 0.0603
Brugia malayi Carboxylesterase family protein 0.0183 0.1478 0.1597
Brugia malayi hypothetical protein 0.0047 0.032 0.0332
Plasmodium falciparum plasmepsin V 0.0047 0.032 0.6768
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0183 0.1478 0.623
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0078 0.0085
Brugia malayi steroid hormone receptor 0.0012 0.0019 0.0003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0064 0.0465 0.049
Giardia lamblia Rrm3p helicase 0.0028 0.0158 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0568 0.0568
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0229 0.0229
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0019 0.0003
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0028 0.0158 0.0173
Onchocerca volvulus 0.0183 0.1478 0.623
Trypanosoma brucei unspecified product 0.0016 0.0052 0.0617
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0019 0.0021
Schistosoma mansoni neuroligin 3 (S09 family) 0.0183 0.1478 0.1478
Schistosoma mansoni amine oxidase 0.0064 0.0465 0.0465
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0019 0.0003
Echinococcus multilocularis dna polymerase eta 0.0054 0.0376 0.0411
Schistosoma mansoni DNA ligase IV 0.0012 0.0017 0.0017
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0376 0.6218
Trichomonas vaginalis set domain proteins, putative 0.0287 0.2362 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0229 0.0232
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0114 0.1683
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0047 0.032 0.032
Brugia malayi CXXC zinc finger family protein 0.0035 0.0211 0.0213
Schistosoma mansoni hypothetical protein 0.0205 0.1661 0.1661
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0429 0.0451
Loa Loa (eye worm) RNA binding protein 0.0076 0.0568 0.0603
Echinococcus multilocularis 0.0064 0.0465 0.0508
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0028 0.0158 0.2445
Echinococcus multilocularis cpg binding protein 0.0037 0.0228 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0019 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0568 0.0568
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0114 0.1683
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0376 0.0393
Echinococcus granulosus pangolin 0.0065 0.0471 0.0514
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0159 0.3184
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.7024 0.7666
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0114 0.1683
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0239 0.3849
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0114 0.1683
Loa Loa (eye worm) hypothetical protein 0.0041 0.0266 0.0273
Echinococcus granulosus cpg binding protein 0.0037 0.0228 0.0249
Loa Loa (eye worm) carboxylesterase 0.1084 0.9163 1
Toxoplasma gondii aspartyl protease ASP3 0.0047 0.032 0.6454
Brugia malayi RNA binding protein 0.0076 0.0568 0.0603
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0019 0.0021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0019 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0019 0.0003
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0028 0.0158 0.2445
Brugia malayi aspartic protease BmAsp-1, identical 0.0047 0.032 0.0332
Schistosoma mansoni hypothetical protein 0.0494 0.4129 0.4129
Loa Loa (eye worm) hypothetical protein 0.0073 0.0536 0.0568
Brugia malayi TAR-binding protein 0.0076 0.0568 0.0603
Schistosoma mansoni hypothetical protein 0.0205 0.1661 0.1661
Echinococcus multilocularis protein pangolin J 0.0065 0.0471 0.0514
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0019 0.0003
Onchocerca volvulus 0.0029 0.0159 0.0609
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0114 0.0124
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0309 0.0337
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0047 0.032 0.1294
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0019 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0159 0.1317
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0003
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0595 0.0633
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0568 0.0568
Echinococcus multilocularis beta catenin 0.0097 0.0746 0.0815
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0114 0.1683
Loa Loa (eye worm) hypothetical protein 0.0064 0.0465 0.049
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0003
Loa Loa (eye worm) hypothetical protein 0.0064 0.0465 0.049
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0229 0.025
Loa Loa (eye worm) hypothetical protein 0.0064 0.0465 0.049
Plasmodium vivax aspartyl protease, putative 0.0047 0.032 0.6768
Loa Loa (eye worm) hypothetical protein 0.0148 0.1177 0.1269
Brugia malayi Pre-SET motif family protein 0.0252 0.2066 0.224
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0003
Brugia malayi Carboxylesterase family protein 0.1084 0.9163 1
Plasmodium falciparum plasmepsin VIII, putative 0.0047 0.032 0.6768
Brugia malayi amine oxidase, flavin-containing family protein 0.0064 0.0465 0.049
Echinococcus granulosus tumor protein p63 0.0391 0.3252 0.3549
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0019 0.0003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.1084 0.9163 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0183 0.1478 0.1896
Plasmodium falciparum plasmepsin X 0.0047 0.032 0.6768
Plasmodium vivax aspartyl protease, putative 0.0047 0.032 0.6768
Loa Loa (eye worm) hypothetical protein 0.0064 0.0465 0.049
Loa Loa (eye worm) hypothetical protein 0.0183 0.1478 0.1597
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0047 0.032 0.6454
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0114 0.1683
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0915 0.7725 1
Plasmodium vivax aspartyl proteinase, putative 0.0047 0.032 0.6768
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0114 0.1683
Schistosoma mansoni coup transcription factor 0.0012 0.0019 0.0019
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0159 0.0101
Trypanosoma cruzi UDP-galactopyranose mutase 0.0064 0.0465 0.7752
Onchocerca volvulus 0.0057 0.0404 0.165
Loa Loa (eye worm) hypothetical protein 0.0057 0.0404 0.0423
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0019 0.0021
Plasmodium vivax aspartyl proteinase, putative 0.0047 0.032 0.6768
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0404 0.0404
Echinococcus multilocularis neuroligin 0.0183 0.1478 0.1613
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0052 0.0617
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0064 0.0465 1
Trypanosoma brucei unspecified product 0.0023 0.0114 0.1683
Loa Loa (eye worm) hypothetical protein 0.006 0.0429 0.0451
Echinococcus granulosus acetylcholinesterase 0.1084 0.9163 1
Echinococcus multilocularis T cell transcription factor 4 long C terminal 0.0065 0.0471 0.0514
Echinococcus granulosus nibrin 0.0012 0.0017 0.0018
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0019 0.0021
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0019 0.0021
Schistosoma mansoni beta-catenin 0.0097 0.0746 0.0746
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1145 0.1234
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0114 0.0106
Mycobacterium ulcerans hypothetical protein 0.0029 0.0159 0.0185
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0098 0.1808
Loa Loa (eye worm) hypothetical protein 0.0183 0.1478 0.1597
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0487 1
Echinococcus granulosus geminin 0.0205 0.1661 0.1813
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0568 0.0568
Plasmodium falciparum plasmepsin III 0.0047 0.032 0.6768
Plasmodium vivax aspartyl protease, putative 0.0047 0.032 0.6768
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0012 0.0017 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0089
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.2066 0.224
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0028 0.0158 0.0916
Brugia malayi HMG box family protein 0.0065 0.0471 0.0497
Loa Loa (eye worm) DEAH box polypeptide 35 0.0073 0.0536 0.0568
Echinococcus granulosus T cell transcription factor 4 long C terminal 0.0065 0.0471 0.0514
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0159 0.0185
Schistosoma mansoni acetylcholinesterase 0.0183 0.1478 0.1478
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0159 0.0944
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1145 0.1234
Brugia malayi MH2 domain containing protein 0.0144 0.1145 0.1234

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit NOD2 revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1848, AID1849, AID1852, AID2469, AID2475, AID2799, AID2800] ChEMBL. No reference
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit NOD1 revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1575, AID1578, AID2335, AID2466, AID2469, AID2505, AID2798, AID2800] ChEMBL. No reference
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: SAR analysis of inhibitors of TNFa specific NF-kB induction revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1852, AID2469, AID2483, AID2485, AID2800, AID2801] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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