Detailed information for compound 1855020

Basic information

Technical information
  • TDR Targets ID: 1855020
  • Name: 5-methyl-2-(3-nitrophenyl)-4-phenyl-1H-pyrazo l-3-one
  • MW: 295.293 | Formula: C16H13N3O3
  • H donors: 1 H acceptors: 3 LogP: 3.31 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=N(=O)c1cccc(c1)n1[nH]c(c(c1=O)c1ccccc1)C
  • InChi: 1S/C16H13N3O3/c1-11-15(12-6-3-2-4-7-12)16(20)18(17-11)13-8-5-9-14(10-13)19(21)22/h2-10,17H,1H3
  • InChiKey: AZYSDRGARDURMY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 11E-411S
  • SMR000337745
  • 5-methyl-2-(3-nitrophenyl)-4-phenyl-1,2-dihydro-3H-pyrazol-3-one
  • MLS000756080
  • Oprea1_185497
  • ZINC03052162

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus granulosus integrin linked protein kinase 0.0313 0.341 0.341
Echinococcus granulosus natriuretic peptide receptor 1 0.0313 0.341 0.341
Loa Loa (eye worm) TK/FER protein kinase 0.0313 0.341 1
Echinococcus granulosus protein kinase 0.0313 0.341 0.341
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0313 0.341 0.341
Schistosoma mansoni serine/threonine protein kinase 0.0313 0.341 0.341
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0313 0.341 1
Entamoeba histolytica hypothetical protein, conserved 0.0313 0.341 0.5
Echinococcus granulosus fibroblast growth factor receptor 4 0.0313 0.341 0.341
Brugia malayi Receptor family ligand binding region containing protein 0.0313 0.341 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0313 0.341 0.341
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0313 0.341 0.341
Leishmania major hypothetical protein, conserved 0.0313 0.341 1
Loa Loa (eye worm) hypothetical protein 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0313 0.341 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0313 0.341 0.341
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Echinococcus multilocularis kinase suppressor of Ras 1 0.0313 0.341 0.341
Loa Loa (eye worm) TK/FAK protein kinase 0.0313 0.341 1
Schistosoma mansoni protein kinase 0.0313 0.341 0.341
Echinococcus granulosus tyrosine protein kinase csk 0.0313 0.341 0.341
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0313 0.341 0.341
Trypanosoma cruzi protein kinase, putative 0.0313 0.341 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0313 0.341 0.341
Loa Loa (eye worm) TK/FER protein kinase 0.0313 0.341 1
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Giardia lamblia Kinase 0.0313 0.341 0.5
Entamoeba histolytica tyrosin kinase, putative 0.0313 0.341 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0313 0.341 0.5
Trichomonas vaginalis TK family protein kinase 0.0313 0.341 1
Loa Loa (eye worm) hypothetical protein 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0313 0.341 0.341
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Brugia malayi hypothetical protein 0.0313 0.341 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Entamoeba histolytica tyrosine kinase, putative 0.0313 0.341 0.5
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0313 0.341 0.341
Brugia malayi hypothetical protein 0.0313 0.341 1
Trichomonas vaginalis protein tyrosine kinase, putative 0.0313 0.341 1
Onchocerca volvulus 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Trichomonas vaginalis conserved hypothetical protein 0.0313 0.341 1
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0313 0.341 1
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0313 0.341 0.341
Schistosoma mansoni hypothetical protein 0.0313 0.341 0.341
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Loa Loa (eye worm) TK/CSK protein kinase 0.0313 0.341 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0313 0.341 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0313 0.341 1
Loa Loa (eye worm) serine/threonine protein kinase 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0313 0.341 0.341
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0313 0.341 0.5
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0313 0.341 0.341
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Echinococcus granulosus activated cdc42 kinase 1 0.0313 0.341 0.341
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0212 0.0621
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus multilocularis tyrosine protein kinase pr2 0.0313 0.341 0.341
Echinococcus multilocularis activated cdc42 kinase 1 0.0313 0.341 0.341
Echinococcus granulosus tyrosine protein kinase Blk 0.0313 0.341 0.341
Entamoeba histolytica serine/threonine kinase, putative 0.0313 0.341 0.5
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus multilocularis protein kinase 0.0313 0.341 0.341
Echinococcus multilocularis heat shock protein 70 0.0313 0.341 0.341
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0313 0.341 0.341
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0313 0.341 0.341
Brugia malayi ephrin receptor 1 precursor 0.0313 0.341 1
Plasmodium falciparum protein kinase, putative 0.0313 0.341 0.5
Echinococcus multilocularis receptor type guanylyl cyclase 0.0313 0.341 0.341
Schistosoma mansoni protein kinase 0.0313 0.341 0.341
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0313 0.341 1
Schistosoma mansoni protein kinase 0.0313 0.341 0.341
Loa Loa (eye worm) TK/FER protein kinase 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0313 0.341 1
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Entamoeba histolytica serine/threonine kinase, putative 0.0313 0.341 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Schistosoma mansoni protein kinase 0.0313 0.341 0.341
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0313 0.341 0.341
Trypanosoma brucei Flagellum attachment zone protein 20 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0313 0.341 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Onchocerca volvulus 0.0313 0.341 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0313 0.341 0.341
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0313 0.341 0.341
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0313 0.341 0.5
Onchocerca volvulus 0.0313 0.341 1
Toxoplasma gondii STE kinase 0.0313 0.341 1
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0313 0.341 0.341
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0149 0.0149
Onchocerca volvulus 0.0313 0.341 1
Loa Loa (eye worm) TK/FER protein kinase 0.0313 0.341 1
Loa Loa (eye worm) TK protein kinase 0.0313 0.341 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0313 0.341 0.341
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Giardia lamblia Protein 21.1 0.0313 0.341 0.5
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0313 0.341 0.341
Entamoeba histolytica tyrosin kinase, putative 0.0313 0.341 0.5
Loa Loa (eye worm) hypothetical protein 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Entamoeba histolytica serine/threonine kinase, putative 0.0313 0.341 0.5
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0313 0.341 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0313 0.341 0.341
Onchocerca volvulus 0.0313 0.341 1
Schistosoma mansoni protein kinase 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0313 0.341 1
Loa Loa (eye worm) TK/FER protein kinase 0.0313 0.341 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0313 0.341 0.341
Plasmodium vivax protein kinase, putative 0.0313 0.341 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0313 0.341 0.5
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Entamoeba histolytica hypothetical protein 0.0313 0.341 0.5
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0313 0.341 0.341
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Onchocerca volvulus 0.0313 0.341 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0313 0.341 0.341
Schistosoma mansoni serine/threonine protein kinase 0.0313 0.341 0.341
Loa Loa (eye worm) hypothetical protein 0.0313 0.341 1
Loa Loa (eye worm) TK/RYK protein kinase 0.0313 0.341 1
Trichomonas vaginalis conserved hypothetical protein 0.0313 0.341 1
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Entamoeba histolytica tyrosine kinase, putative 0.0313 0.341 0.5
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Brugia malayi Guanylyl cyclase protein 23 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Onchocerca volvulus 0.0313 0.341 1
Entamoeba histolytica cysteine surface protein, putative 0.0313 0.341 0.5
Entamoeba histolytica receptor protein kinase, putative 0.0313 0.341 0.5
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Mycobacterium leprae conserved hypothetical protein 0.0043 0 0.5
Brugia malayi hypothetical protein 0.0313 0.341 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0149 0.0149
Loa Loa (eye worm) TK/FER protein kinase 0.0313 0.341 1
Plasmodium falciparum protein kinase, putative 0.0313 0.341 0.5
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus granulosus insulin receptor 0.0313 0.341 0.341
Echinococcus multilocularis c src tyrosine kinase 0.0313 0.341 0.341
Trichomonas vaginalis conserved hypothetical protein 0.0313 0.341 1
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Loa Loa (eye worm) hypothetical protein 0.0313 0.341 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0313 0.341 1
Echinococcus multilocularis integrin linked protein kinase 0.0313 0.341 0.341
Brugia malayi integrin-linked kinase 0.0313 0.341 1
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Echinococcus multilocularis insulin receptor 0.0313 0.341 0.341
Echinococcus granulosus tyrosine kinase 0.0313 0.341 0.341
Loa Loa (eye worm) TK/FER protein kinase 0.0313 0.341 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0313 0.341 0.341
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0212 0.0621
Loa Loa (eye worm) TK protein kinase 0.0313 0.341 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus granulosus kinase suppressor of Ras 1 0.0313 0.341 0.341
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0149 0.0149
Echinococcus granulosus retinal guanylyl cyclase 2 0.0313 0.341 0.341
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0149 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0149 0.0149
Echinococcus granulosus raf serine:threonine protein kinase 0.0313 0.341 0.341
Echinococcus multilocularis tyrosine protein kinase shark 0.0313 0.341 0.341
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Loa Loa (eye worm) TK/FER protein kinase 0.0313 0.341 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0313 0.341 0.341
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0313 0.341 0.341
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Schistosoma mansoni protein kinase 0.0313 0.341 0.341
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Schistosoma mansoni protein kinase 0.0313 0.341 0.341
Entamoeba histolytica tyrosine kinase, putative 0.0313 0.341 0.5
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0313 0.341 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0313 0.341 0.341
Echinococcus granulosus epidermal growth factor receptor 0.0313 0.341 0.341
Loa Loa (eye worm) TK/FER protein kinase 0.0313 0.341 1
Mycobacterium ulcerans lipase LipD 0.0043 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0313 0.341 1
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0313 0.341 0.5
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Leishmania major protein kinase, putative 0.0313 0.341 1
Echinococcus granulosus tyrosine kinase 0.0313 0.341 0.341
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus multilocularis protein kinase 0.0313 0.341 0.341
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0313 0.341 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Loa Loa (eye worm) TK/DDR protein kinase 0.0313 0.341 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0313 0.341 1
Entamoeba histolytica tyrosine kinase, putative 0.0313 0.341 0.5
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Schistosoma mansoni ephrin receptor 0.0313 0.341 0.341
Entamoeba histolytica ankyrin repeat protein 0.0313 0.341 0.5
Loa Loa (eye worm) hypothetical protein 0.0313 0.341 1
Trichomonas vaginalis conserved hypothetical protein 0.0313 0.341 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0313 0.341 1
Onchocerca volvulus 0.0313 0.341 1
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Trichomonas vaginalis conserved hypothetical protein 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0313 0.341 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0313 0.341 1
Entamoeba histolytica hypothetical protein 0.0313 0.341 0.5
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0313 0.341 0.341
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0313 0.341 0.341
Loa Loa (eye worm) RGC/RGC protein kinase 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Entamoeba histolytica serine/threonine kinase, putative 0.0313 0.341 0.5
Mycobacterium ulcerans hypothetical protein 0.0043 0 0.5
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0313 0.341 0.341
Trypanosoma brucei Pseudokinase, putative 0.0313 0.341 1
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Entamoeba histolytica tyrosine kinase, putative 0.0313 0.341 0.5
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0313 0.341 0.341
Echinococcus multilocularis tyrosine protein kinase csk 0.0313 0.341 0.341
Echinococcus multilocularis protein tyrosine kinase 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Loa Loa (eye worm) SRC-1 0.0313 0.341 1
Loa Loa (eye worm) hypothetical protein 0.0313 0.341 1
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Echinococcus multilocularis raf serine:threonine protein kinase 0.0313 0.341 0.341
Trichomonas vaginalis protein kinase atn1, putative 0.0313 0.341 1
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Trichomonas vaginalis AGC family protein kinase 0.0313 0.341 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0313 0.341 0.341
Loa Loa (eye worm) TK/ROR protein kinase 0.0313 0.341 1
Echinococcus granulosus tyrosine protein kinase 0.0313 0.341 0.341
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0313 0.341 0.341
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0313 0.341 1
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0313 0.341 0.5
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0313 0.341 1
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Loa Loa (eye worm) TK/EPH protein kinase 0.0313 0.341 1
Loa Loa (eye worm) TK protein kinase 0.0313 0.341 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Loa Loa (eye worm) TK protein kinase 0.0313 0.341 1
Entamoeba histolytica tyrosine kinase, putative 0.0313 0.341 0.5
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0313 0.341 1
Entamoeba histolytica serine/threonine kinase, putative 0.0313 0.341 0.5
Echinococcus granulosus geminin 0.0205 0.204 0.204
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Echinococcus granulosus tyrosine protein kinase shark 0.0313 0.341 0.341
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0313 0.341 0.341
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0313 0.341 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0313 0.341 1
Loa Loa (eye worm) TK/FER protein kinase 0.0313 0.341 1
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0 0.5
Schistosoma mansoni protein tyrosine kinase 0.0313 0.341 0.341
Echinococcus multilocularis tyrosine kinase 0.0313 0.341 0.341
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0313 0.341 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0313 0.341 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0313 0.341 0.341
Echinococcus multilocularis ephrin type A receptor 4 A 0.0313 0.341 0.341
Loa Loa (eye worm) TK protein kinase 0.0313 0.341 1
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Echinococcus multilocularis natriuretic peptide receptor 1 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0313 0.341 0.341
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Brugia malayi Furin-like cysteine rich region family protein 0.0313 0.341 1
Plasmodium falciparum tyrosine kinase-like protein 0.0313 0.341 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0313 0.341 1
Onchocerca volvulus 0.0313 0.341 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0313 0.341 0.341
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0149 0.0149
Plasmodium vivax tyrosine kinase-like protein, putative 0.0313 0.341 1
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus multilocularis transfer RNA-Thr 0.0313 0.341 0.341
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0313 0.341 0.341
Entamoeba histolytica tyrosin kinase, putative 0.0313 0.341 0.5
Entamoeba histolytica hypothetical protein 0.0313 0.341 0.5
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Onchocerca volvulus 0.0313 0.341 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Echinococcus multilocularis tyrosine kinase 0.0313 0.341 0.341
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0313 0.341 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0313 0.341 0.5
Loa Loa (eye worm) TK/Met protein kinase 0.0313 0.341 1
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Plasmodium vivax tyrosine kinase-like protein, putative 0.0313 0.341 1
Brugia malayi Raf kinase 0.0313 0.341 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0313 0.341 1
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0313 0.341 0.341
Brugia malayi SRC-1 0.0313 0.341 1
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0313 0.341 0.5
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Echinococcus granulosus c src tyrosine kinase 0.0313 0.341 0.341
Giardia lamblia Kinase, NEK 0.0313 0.341 0.5
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Echinococcus multilocularis tyrosine protein kinase Blk 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0313 0.341 0.341
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0313 0.341 0.341
Schistosoma mansoni protein kinase 0.0313 0.341 0.341
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0313 0.341 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0149 0.0437
Entamoeba histolytica hypothetical protein 0.0313 0.341 0.5
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Entamoeba histolytica serine/threonine kinase, putative 0.0313 0.341 0.5
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0313 0.341 1
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0313 0.341 1
Entamoeba histolytica tyrosin kinase, putative 0.0313 0.341 0.5
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Giardia lamblia Kinase, NEK 0.0313 0.341 0.5
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0313 0.341 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0313 0.341 0.341
Brugia malayi SH2 domain containing protein 0.0313 0.341 1
Toxoplasma gondii protein kinase 0.0313 0.341 1
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0313 0.341 0.5
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0313 0.341 0.5
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Plasmodium falciparum protein kinase, putative 0.0313 0.341 0.5
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Mycobacterium leprae Probable lipase LipE 0.0043 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0313 0.341 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0313 0.341 0.341
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0313 0.341 1
Entamoeba histolytica hypothetical protein 0.0313 0.341 0.5
Loa Loa (eye worm) hypothetical protein 0.0313 0.341 1
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0313 0.341 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Loa Loa (eye worm) protein kinase domain-containing protein 0.0313 0.341 1
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0313 0.341 1
Schistosoma mansoni serine/threonine protein kinase 0.0313 0.341 0.341
Echinococcus multilocularis tyrosine protein kinase HCK 0.0313 0.341 0.341
Entamoeba histolytica tyrosine kinase, putative 0.0313 0.341 0.5
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0313 0.341 0.341
Loa Loa (eye worm) TK protein kinase 0.0313 0.341 1
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0313 0.341 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0212 0.0621
Echinococcus granulosus activated cdc42 kinase 1 0.0313 0.341 0.341
Entamoeba histolytica tyrosine kinase, putative 0.0313 0.341 0.5
Loa Loa (eye worm) hypothetical protein 0.0313 0.341 1
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Entamoeba histolytica hypothetical protein 0.0313 0.341 0.5
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0313 0.341 1
Loa Loa (eye worm) hypothetical protein 0.0313 0.341 1
Echinococcus multilocularis epidermal growth factor receptor 0.0313 0.341 0.341
Loa Loa (eye worm) TK protein kinase 0.0313 0.341 1
Entamoeba histolytica tyrosine kinase, putative 0.0313 0.341 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0313 0.341 0.341
Onchocerca volvulus 0.0313 0.341 1
Entamoeba histolytica hypothetical protein 0.0313 0.341 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0313 0.341 0.5
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus multilocularis epidermal growth factor receptor 0.0313 0.341 0.341
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Loa Loa (eye worm) TK/INSR protein kinase 0.0313 0.341 1
Loa Loa (eye worm) TK/FER protein kinase 0.0313 0.341 1
Schistosoma mansoni serine/threonine protein kinase 0.0313 0.341 0.341
Loa Loa (eye worm) hypothetical protein 0.0313 0.341 1
Schistosoma mansoni hypothetical protein 0.0205 0.204 0.204
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Onchocerca volvulus Tyrosine kinase homolog 0.0313 0.341 1
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0313 0.341 0.341
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0313 0.341 0.341
Brugia malayi Tyrosine-protein kinase abl-1 0.0313 0.341 1
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0313 0.341 0.341
Onchocerca volvulus 0.0313 0.341 1
Onchocerca volvulus 0.0313 0.341 1
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Leishmania major protein kinase, putative 0.0313 0.341 1
Trypanosoma cruzi protein kinase, putative 0.0313 0.341 1
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0313 0.341 0.341
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2966 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus multilocularis FL cytokine receptor 0.0313 0.341 0.341
Brugia malayi C-terminal src kinase protein 1 0.0313 0.341 1
Entamoeba histolytica hypothetical protein 0.0313 0.341 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0313 0.341 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0313 0.341 0.341
Loa Loa (eye worm) hypothetical protein 0.0313 0.341 1
Mycobacterium ulcerans beta-lactamase 0.0043 0 0.5
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0313 0.341 1
Brugia malayi Tyrosine-protein kinase PR2 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Loa Loa (eye worm) TK protein kinase 0.0313 0.341 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0313 0.341 0.341
Entamoeba histolytica tyrosine kinase, putative 0.0313 0.341 0.5
Echinococcus multilocularis tyrosine protein kinase Abl 0.0313 0.341 0.341
Echinococcus multilocularis tyrosine protein kinase csk 0.0313 0.341 0.341
Echinococcus granulosus tyrosine protein kinase HCK 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Loa Loa (eye worm) TK/ACK protein kinase 0.0313 0.341 1
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0313 0.341 0.341
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Schistosoma mansoni protein kinase 0.0313 0.341 0.341
Schistosoma mansoni protein kinase 0.0313 0.341 0.341
Echinococcus multilocularis activin receptor type 0.0313 0.341 0.341
Loa Loa (eye worm) RGC/RGC protein kinase 0.0313 0.341 1
Entamoeba histolytica ankyrin repeat protein 0.0313 0.341 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Echinococcus multilocularis geminin 0.0205 0.204 0.204
Schistosoma mansoni ephrin receptor 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0313 0.341 0.341
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0313 0.341 0.5
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0313 0.341 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0149 0.0149
Entamoeba histolytica hypothetical protein 0.0313 0.341 0.5
Echinococcus granulosus activin receptor type 0.0313 0.341 0.341
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Loa Loa (eye worm) TK protein kinase 0.0313 0.341 1
Brugia malayi protein-tyrosine kinase 0.0313 0.341 1
Entamoeba histolytica tyrosine kinase, putative 0.0313 0.341 0.5
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Loa Loa (eye worm) TK/FER protein kinase 0.0313 0.341 1
Loa Loa (eye worm) hypothetical protein 0.0313 0.341 1
Toxoplasma gondii protein kinase domain-containing protein 0.0313 0.341 1
Loa Loa (eye worm) TK protein kinase 0.0313 0.341 1
Onchocerca volvulus 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus granulosus tyrosine protein kinase csk 0.0313 0.341 0.341
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0313 0.341 0.341
Echinococcus granulosus protein tyrosine kinase 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Entamoeba histolytica tyrosine kinase, putative 0.0313 0.341 0.5
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0313 0.341 1
Brugia malayi bone morphogenetic protein type 1 receptor 0.0313 0.341 1
Entamoeba histolytica tyrosine kinase, putative 0.0313 0.341 0.5
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0313 0.341 0.5
Echinococcus multilocularis tyrosine protein kinase 0.0313 0.341 0.341
Brugia malayi SH2 domain containing protein 0.0313 0.341 1
Entamoeba histolytica protein kinase, putative 0.0313 0.341 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Entamoeba histolytica hypothetical protein 0.0313 0.341 0.5
Echinococcus granulosus ephrin type A receptor 4 A 0.0313 0.341 0.341
Schistosoma mansoni tyrosine kinase 0.0313 0.341 0.341
Entamoeba histolytica protein kinase domain containing protein 0.0313 0.341 0.5
Onchocerca volvulus 0.0313 0.341 1
Echinococcus multilocularis protein KINase family member (kin 25) 0.0313 0.341 0.341
Schistosoma mansoni tyrosine protein kinase 0.0313 0.341 0.341
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0212 0.0621
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Brugia malayi Protein kinase domain containing protein 0.0313 0.341 1
Entamoeba histolytica hypothetical protein 0.0313 0.341 0.5
Entamoeba histolytica receptor protein kinase, putative 0.0313 0.341 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0313 0.341 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0149 0.0437
Schistosoma mansoni hypothetical protein 0.0205 0.204 0.204
Echinococcus granulosus epidermal growth factor receptor 0.0313 0.341 0.341
Schistosoma mansoni serine/threonine RGC 0.0313 0.341 0.341
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Trichomonas vaginalis STE family protein kinase 0.0313 0.341 1
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0313 0.341 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0313 0.341 0.341
Trypanosoma brucei protein kinase, putative 0.0313 0.341 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0313 0.341 0.341
Schistosoma mansoni protein kinase 0.0313 0.341 0.341
Echinococcus granulosus retinal guanylyl cyclase 2 0.0313 0.341 0.341
Entamoeba histolytica tyrosine kinase, putative 0.0313 0.341 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0313 0.341 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0313 0.341 0.341
Echinococcus granulosus tyrosine kinase 0.0313 0.341 0.341
Trichomonas vaginalis TKL family protein kinase 0.0313 0.341 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0313 0.341 0.341
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0313 0.341 0.341

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3696 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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