Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | monoamine oxidase A | Starlite/ChEMBL | No references |
Homo sapiens | monoamine oxidase B | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase A | 527 aa | 474 aa | 22.4 % |
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase B | 520 aa | 462 aa | 19.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.1574 | 0.7966 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0667 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0717 | 0.0443 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1574 | 0.7966 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1574 | 0.7966 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1574 | 0.7966 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1574 | 0.7966 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1574 | 0.7966 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1574 | 0.7966 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1574 | 0.7966 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1574 | 0.7966 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1574 | 0.7966 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0717 | 0.0443 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1574 | 0.7966 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1574 | 0.7966 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.31 uM | Inhibition of human MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate assessed as hydrogen peroxide production by fluorimetric method | ChEMBL. | No reference |
IC50 (binding) | = 7.07 uM | Inhibition of human MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate assessed as hydrogen peroxide production by fluorimetric method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.