Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | RAR-related orphan receptor C | References | |
Homo sapiens | retinoic acid receptor, gamma | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | nuclear receptor nhr-7B | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Brugia malayi | nuclear hormone receptor | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0024 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0268 | 0.9497 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.9048 | 0.9527 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0268 | 0.9497 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 11 nM | Activity at human His(GST)-tagged ROR gamma LBD expressed in Escherichia coli BL21 (DE3) cells assessed as receptor-biotinylated SRC1 peptide interaction by TR-FRET assay | ChEMBL. | No reference |
IC50 (binding) | = 60 nM | Inverse agonist activity at GAL4 DBD-fused RORgammat LBD (unknown origin) expressed in HG5LN cells after 18 hrs by luciferase reporter gene assay | LITERATURE. | 27815118 |
IC50 (binding) | = 1300 nM | Inverse agonist activity at GAL4 DBD-fused RARgamma LBD (unknown origin) expressed in human HG5LN cells after 18 hrs by luciferase reporter gene assay | LITERATURE. | 27815118 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.