Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Squalene synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0632 | 0 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0632 | 0 | 0.5 |
Onchocerca volvulus | 0.0632 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.3738 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.3738 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.3738 | 1 | 1 |
Onchocerca volvulus | 0.0632 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.3738 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0632 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0632 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0632 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.3738 | 1 | 1 |
Onchocerca volvulus | 0.0632 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0632 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.3738 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3738 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3738 | 1 | 1 |
Onchocerca volvulus | 0.0632 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.3738 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3738 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3738 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0632 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3738 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | nM | Compound was tested for in vitro inhibitory activity against Candida albicans 2005E microsomal SQS; Not tested | ChEMBL. | 7932554 |
IC50 (binding) | 0 nM | Compound was tested for in vitro inhibitory activity against Candida albicans 2005E microsomal SQS; Not tested | ChEMBL. | 7932554 |
IC50 (binding) | = 32 nM | Inhibition of juvenile male rat liver microsomal squalene synthase | ChEMBL. | 7932554 |
IC50 (binding) | = 32 nM | Inhibition of juvenile male rat liver microsomal squalene synthase | ChEMBL. | 7932554 |
MIC (functional) | = 4 ug ml-1 | Compound was tested for an antifungal whole cell assay to obtain minimum inhibitory concentration against Cryptococcus neoformans 2867E | ChEMBL. | 7932554 |
MIC (functional) | = 4 ug ml-1 | Compound was tested for an antifungal whole cell assay to obtain minimum inhibitory concentration against Cryptococcus neoformans 2867E | ChEMBL. | 7932554 |
MIC (functional) | = 16 ug ml-1 | Compound was tested for an antifungal whole cell assay to obtain minimum inhibitory concentration against Aspergillus niger 48238 | ChEMBL. | 7932554 |
MIC (functional) | = 31 ug ml-1 | Compound was tested for an antifungal whole cell assay to obtain minimum inhibitory concentration against Candida albicans C316 | ChEMBL. | 7932554 |
MIC (functional) | = 31 ug ml-1 | Compound was tested for an antifungal whole cell assay to obtain minimum inhibitory concentration against Candida albicans C316 | ChEMBL. | 7932554 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.