Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | No references |
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 19 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | cytochrome p450-like protein | cytochrome P450, family 2, subfamily C, polypeptide 19 | 490 aa | 411 aa | 23.1 % |
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.4661 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4661 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 0.4661 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.4661 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.4661 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.4661 | 0.3352 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.4661 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.4661 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.4661 | 0.5 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0.4661 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4661 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.4661 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.4661 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.4661 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.4661 | 0.3352 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.4661 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.4661 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.4661 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.4661 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.4661 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 1 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.4661 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.4661 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.4661 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.4661 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.4661 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.4661 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4661 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4661 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.4661 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4661 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0.4661 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.4661 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0.4661 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4661 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.4661 | 0.3352 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.4661 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4661 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4661 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4661 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0019 | 0.1969 | 0.4224 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.4661 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.4661 | 0.5 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0.4661 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.4661 | 0.3352 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.4661 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | = 4.466835922 uM | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
AC50 (functional) | = 5.011872336 uM | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
AC50 (functional) | = 28.18382931 uM | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
AC50 (functional) | = 28.18382931 uM | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
AC50 (functional) | = 35.48133892 uM | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
AC50 (functional) | 100 uM | PubChem BioAssay. Fluorescence polarization aasay to screen for inhibitors that compete for the binding of FadD28 to a bisubstrate Measured in Biochemical System Using Plate Reader - 2147-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.1472 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.