Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0042 | 0.0495 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0014 | 0.0015 | 0.0035 |
Trypanosoma brucei | unspecified product | 0.0029 | 0.0272 | 0.0637 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0025 | 0.0196 | 0.0181 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0042 | 0.0495 | 0.0481 |
Brugia malayi | Protein kinase domain containing protein | 0.0014 | 0.0015 | 0.0035 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0014 | 0.0015 | 0.0035 |
Brugia malayi | Protein kinase domain containing protein | 0.0014 | 0.0015 | 0.0035 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0266 | 0.4268 | 0.426 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0014 | 0.001 | 0.001 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0495 | 0.1159 |
Echinococcus multilocularis | dna polymerase kappa | 0.0042 | 0.0495 | 0.0481 |
Echinococcus multilocularis | geminin | 0.0187 | 0.2927 | 0.2916 |
Schistosoma mansoni | DNA polymerase eta | 0.0071 | 0.0968 | 0.0986 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0495 | 0.1159 |
Echinococcus granulosus | NCK adaptor protein | 0.0022 | 0.0144 | 0.0129 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.4268 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0027 | 0.0236 | 0.0222 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0042 | 0.0495 | 0.0481 |
Leishmania major | DNA polymerase eta, putative | 0.0041 | 0.0473 | 0.1109 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0041 | 0.0473 | 0.1109 |
Schistosoma mansoni | tyrosine kinase | 0.0025 | 0.0196 | 0.0199 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.4268 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0025 | 0.0196 | 0.0199 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0071 | 0.0968 | 0.2268 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0266 | 0.4268 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0014 | 0.0015 | 0.0035 |
Brugia malayi | SRC-1 | 0.0025 | 0.0196 | 0.0459 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0495 | 0.1159 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0071 | 0.0968 | 0.2268 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0042 | 0.0495 | 0.5 |
Echinococcus multilocularis | arf GAP with SH3 domain, ANK repeat and PH | 0.0017 | 0.0059 | 0.0044 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0266 | 0.4268 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0014 | 0.0015 | 0.0035 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0266 | 0.4268 | 0.4347 |
Schistosoma mansoni | nck2/grb4 | 0.0022 | 0.0144 | 0.0146 |
Brugia malayi | Variant SH3 domain containing protein | 0.0017 | 0.0064 | 0.015 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0266 | 0.4268 | 0.426 |
Giardia lamblia | DINP protein human, muc B family | 0.0042 | 0.0495 | 0.1159 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0495 | 0.1159 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0495 | 0.1159 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0013 | 0 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0266 | 0.4268 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0495 | 0.1159 |
Brugia malayi | Variant SH3 domain containing protein | 0.0022 | 0.0144 | 0.0337 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0495 | 0.1159 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0025 | 0.0196 | 0.0181 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0022 | 0.0144 | 0.0129 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0014 | 0.0015 | 0.0233 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.0495 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0968 | 0.2268 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0014 | 0.0015 | 0.0035 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.2927 | 0.2981 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0266 | 0.4268 | 1 |
Schistosoma mansoni | vav2 | 0.0017 | 0.0064 | 0.0065 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0495 | 0.1159 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0064 | 0.015 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0266 | 0.4268 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0014 | 0.0015 | 0.0035 |
Onchocerca volvulus | 0.0014 | 0.0015 | 0.5 | |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0022 | 0.0144 | 0.0146 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0495 | 0.1159 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0025 | 0.0196 | 0.0181 |
Trypanosoma brucei | unspecified product | 0.0029 | 0.0272 | 0.0637 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0041 | 0.0473 | 0.1109 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0266 | 0.4268 | 0.426 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0014 | 0.0015 | 0.0035 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0495 | 0.1159 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0025 | 0.0196 | 0.0199 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0025 | 0.0196 | 0.0181 |
Onchocerca volvulus | 0.0014 | 0.0015 | 0.5 | |
Echinococcus granulosus | mitogen activated protein kinase | 0.0266 | 0.4268 | 0.426 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0266 | 0.4268 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0266 | 0.4268 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0266 | 0.4268 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0025 | 0.0196 | 0.0199 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.0272 | 0.0637 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0022 | 0.0144 | 0.0337 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0022 | 0.0144 | 0.0337 |
Trypanosoma brucei | protein kinase, putative | 0.0266 | 0.4268 | 1 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0015 | 0.0035 |
Schistosoma mansoni | development and differentiation-enhancing factor ddef | 0.0017 | 0.0059 | 0.006 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0017 | 0.0064 | 0.015 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0013 | 0 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0014 | 0.0015 | 0.0035 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0266 | 0.4268 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0495 | 0.1159 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0071 | 0.0968 | 0.2268 |
Onchocerca volvulus | 0.0014 | 0.0015 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0014 | 0.0015 | 0.0035 |
Echinococcus granulosus | dna polymerase eta | 0.0071 | 0.0968 | 0.0955 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0266 | 0.4268 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0025 | 0.0196 | 0.0181 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0014 | 0.0015 | 0.0035 |
Brugia malayi | protein-tyrosine kinase | 0.0014 | 0.0015 | 0.0035 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0014 | 0.0015 | 0.0035 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0022 | 0.0144 | 0.0146 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0495 | 0.1159 |
Brugia malayi | Protein kinase domain containing protein | 0.0014 | 0.0015 | 0.0035 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0495 | 0.1159 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0495 | 0.1159 |
Echinococcus multilocularis | dna polymerase eta | 0.0071 | 0.0968 | 0.0955 |
Brugia malayi | Variant SH3 domain containing protein | 0.0022 | 0.0144 | 0.0337 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0025 | 0.0196 | 0.0181 |
Echinococcus granulosus | geminin | 0.0187 | 0.2927 | 0.2916 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0025 | 0.0196 | 0.0181 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0042 | 0.0495 | 0.0504 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.0495 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0025 | 0.0196 | 0.0181 |
Echinococcus granulosus | c src tyrosine kinase | 0.0025 | 0.0196 | 0.0181 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.0272 | 0.0637 |
Loa Loa (eye worm) | TK protein kinase | 0.0014 | 0.0015 | 0.0035 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.2927 | 0.2981 |
Schistosoma mansoni | tyrosine kinase | 0.0595 | 0.9819 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0025 | 0.0196 | 0.0181 |
Schistosoma mansoni | tyrosine kinase | 0.0025 | 0.0196 | 0.0199 |
Echinococcus granulosus | arf GAP with SH3 domain ANK repeat and PH | 0.0017 | 0.0059 | 0.0044 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0042 | 0.0495 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0495 | 0.1159 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0025 | 0.0196 | 0.0181 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0495 | 0.1159 |
Echinococcus multilocularis | NCK adaptor protein | 0.0022 | 0.0144 | 0.0129 |
Loa Loa (eye worm) | SRC-1 | 0.0025 | 0.0196 | 0.0459 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0025 | 0.0196 | 0.0181 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0022 | 0.0144 | 0.0146 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0022 | 0.0144 | 0.0129 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0025 | 0.0196 | 0.0181 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0025 | 0.0196 | 0.0181 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0025 | 0.0196 | 0.0459 |
Onchocerca volvulus | 0.0014 | 0.0015 | 0.5 | |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0025 | 0.0196 | 0.0181 |
Schistosoma mansoni | tyrosine kinase | 0.0014 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0014 | 0.0015 | 0.0035 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.0272 | 0.0637 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0025 | 0.0196 | 0.0181 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0605 | 1 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0042 | 0.0495 | 0.0481 |
Brugia malayi | Protein kinase domain containing protein | 0.0014 | 0.0015 | 0.0035 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0014 | 0.0015 | 0.0035 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0042 | 0.0495 | 0.0504 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0495 | 0.1159 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.4268 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0042 | 0.0495 | 0.1159 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0266 | 0.4268 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0025 | 0.0196 | 0.0181 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0025 | 0.0196 | 0.0181 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0042 | 0.0495 | 0.1159 |
Onchocerca volvulus | 0.0014 | 0.0015 | 0.5 | |
Leishmania major | DNA polymerase kappa, putative | 0.0042 | 0.0495 | 0.1159 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0144 | 0.0337 |
Brugia malayi | Protein kinase domain containing protein | 0.0014 | 0.0015 | 0.0035 |
Onchocerca volvulus | 0.0014 | 0.0015 | 0.5 | |
Echinococcus multilocularis | c src tyrosine kinase | 0.0025 | 0.0196 | 0.0181 |
Schistosoma mansoni | adapter molecule crk | 0.0022 | 0.0144 | 0.0146 |
Leishmania major | DNA polymerase eta, putative | 0.0071 | 0.0968 | 0.2268 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0266 | 0.4268 | 1 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0022 | 0.0144 | 0.0337 |
Entamoeba histolytica | hypothetical protein | 0.0017 | 0.0059 | 0.1137 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0042 | 0.0495 | 0.1159 |
Trypanosoma brucei | unspecified product | 0.0042 | 0.0495 | 0.1159 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0015 | 0.0035 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Concentration (functional) | = 0.38 mM | Concentration of the highest non-toxic dose tested | ChEMBL. | 1956048 |
Ratio (functional) | = 1.5 | Sensitizer enhancement ratio was determined from the ratio of the doses required to reduce cell survival to 25% of the control value obtained from hypoxic survival curves in the presence and absence of test compound | ChEMBL. | 1956048 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.