Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.4732 | 0.4732 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.0816 | 0.0816 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.4732 | 0.4732 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0678 | 0.0678 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.4732 | 0.4732 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.4732 | 0.4732 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.1218 | 0.1218 |
Echinococcus multilocularis | musashi | 0.0033 | 0.4732 | 0.4732 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4732 | 0.4732 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.4732 | 0.4732 |
Schistosoma mansoni | lamin | 0.0033 | 0.4732 | 0.4732 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.0816 | 0.0816 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0678 | 0.0678 |
Echinococcus multilocularis | lamin | 0.0033 | 0.4732 | 0.4732 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.4732 | 0.4732 |
Onchocerca volvulus | 0.0033 | 0.4732 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.4732 | 0.4732 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.1218 | 0.1218 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0816 | 0.0816 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.4732 | 0.4732 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.4732 | 0.4732 |
Echinococcus granulosus | lamin | 0.0033 | 0.4732 | 0.4732 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.4593 | 0.4593 |
Onchocerca volvulus | 0.0033 | 0.4732 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.2387 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.8584 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 7.0795 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.