Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Trypanosoma brucei | hypothetical protein, conserved | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1047 | 0.4014 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2034 | 0.5094 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0796 | 0.1835 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1528 | 0.5859 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.222 | 0.7722 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0799 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0257 | 1 | 1 |
Plasmodium falciparum | phd finger protein, putative | 0.0035 | 0.0444 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0035 | 0.0444 | 0.0601 |
Mycobacterium ulcerans | citrate lyase beta subunit, CitE_2 | 0.003 | 0.0201 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0799 | 0.2778 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.3896 | 1 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0035 | 0.0444 | 0.1543 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0.0444 | 0.5 |
Echinococcus granulosus | peregrin | 0.0038 | 0.0567 | 0.1231 |
Echinococcus multilocularis | citrate lyase subunit beta protein | 0.003 | 0.0201 | 0.0268 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0257 | 1 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0035 | 0.0444 | 0.1701 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0035 | 0.0444 | 0.0906 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.003 | 0.0201 | 0.5 |
Giardia lamblia | PHD finger protein 15 | 0.0035 | 0.0444 | 0.5 |
Onchocerca volvulus | Alhambra homolog | 0.0035 | 0.0444 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.0763 | 0.1747 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2034 | 0.5094 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0799 | 0.2778 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0444 | 0.1701 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0045 | 0.0862 | 0.2999 |
Echinococcus granulosus | citrate lyase subunit beta protein | 0.003 | 0.0201 | 0.0268 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0799 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0799 | 0.1842 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.092 | 0.1897 |
Trichomonas vaginalis | Citrate lyase beta chain, putative | 0.003 | 0.0201 | 0.5 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0035 | 0.0444 | 0.0906 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0444 | 0.1543 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0045 | 0.0862 | 0.3307 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1146 | 0.4395 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0099 | 0.0346 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.003 | 0.0201 | 0.5 |
Echinococcus multilocularis | peregrin | 0.0038 | 0.0567 | 0.1231 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0799 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0799 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.206 | 0.7899 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0444 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.003 | 0.0201 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.003 | 0.0201 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0923 | 0.3541 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0799 | 0.1568 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.2875 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.283 | 0.7097 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.3896 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.3896 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2607 | 1 |
Mycobacterium tuberculosis | Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) | 0.003 | 0.0201 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0799 | 0.1842 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0045 | 0.0862 | 0.2999 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.1038 | 0.2472 |
Brugia malayi | jmjC domain containing protein | 0.0045 | 0.0862 | 0.1741 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.1038 | 0.2472 |
Mycobacterium ulcerans | hypothetical protein | 0.003 | 0.0201 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0257 | 1 | 0.5 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0.0444 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0045 | 0.0862 | 0.2009 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0567 | 0.0937 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0796 | 0.1835 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.4125 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (binding) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.