Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0138 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.5318 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.2087 | 0.8696 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.5318 | 0.5318 |
Onchocerca volvulus | 0.0037 | 0.1197 | 0.4987 | |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0884 | 0.1663 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0138 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0138 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.2087 | 0.3925 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.5318 | 0.5318 |
Echinococcus multilocularis | acetylcholinesterase | 0.0138 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0138 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0138 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0138 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0138 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0138 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1197 | 0.1197 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.2087 | 0.3925 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0884 | 0.1663 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.24 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.5318 | 0.5318 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.24 | 0.4514 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.24 | 0.4514 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.5318 | 0.5318 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2087 | 0.2087 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.5318 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.5318 | 0.5318 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.5318 | 0.5318 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.5318 | 0.5318 |
Brugia malayi | chromobox protein homolog 3 | 0.0047 | 0.2087 | 0.2087 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.5318 | 0.5318 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.4125 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 9.4662 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.