Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0152 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0152 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0152 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0026 | 0.023 | 0.023 |
Loa Loa (eye worm) | carboxylesterase | 0.0152 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.023 | 0.023 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0152 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.023 | 0.023 |
Brugia malayi | Carboxylesterase family protein | 0.0026 | 0.023 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.023 | 0.023 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0026 | 0.023 | 0.023 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0026 | 0.023 | 0.023 |
Echinococcus multilocularis | acetylcholinesterase | 0.0152 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0152 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0026 | 0.023 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0026 | 0.023 | 0.023 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0026 | 0.023 | 0.023 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0026 | 0.023 | 0.023 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0152 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0026 | 0.023 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.023 | 0.023 |
Onchocerca volvulus | 0.0026 | 0.023 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.0026 | 0.023 | 0.023 |
Brugia malayi | Carboxylesterase family protein | 0.0152 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0152 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.023 | 0.023 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0026 | 0.023 | 0.023 |
Brugia malayi | Carboxylesterase family protein | 0.0026 | 0.023 | 0.023 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0026 | 0.023 | 0.023 |
Onchocerca volvulus | 0.0026 | 0.023 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0026 | 0.023 | 0.023 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0026 | 0.023 | 0.023 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0026 | 0.023 | 1 |
Onchocerca volvulus | 0.0026 | 0.023 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0026 | 0.023 | 0.023 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0026 | 0.023 | 0.023 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0026 | 0.023 | 0.023 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0026 | 0.023 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0026 | 0.023 | 0.023 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0026 | 0.023 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0026 | 0.023 | 0.023 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0026 | 0.023 | 1 |
Onchocerca volvulus | 0.0026 | 0.023 | 0.5 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0026 | 0.023 | 0.023 |
Schistosoma mansoni | acetylcholinesterase | 0.0026 | 0.023 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.023 | 0.023 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0026 | 0.023 | 0.023 |
Onchocerca volvulus | 0.0026 | 0.023 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.023 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.023 | 0.023 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.