TDR Targets

Basic information

Technical information

TDR Targets ID: 185760
Name: N-[2-(diaminomethylideneamino)-4H-thiochromen o[4,3-d][1,3]thiazol-8-yl]acetamide
MW: 319.405 | Formula: C13H13N5OS2
H donors: 3 H acceptors: 2 LogP: 0.73 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)Nc1ccc2c(c1)c1nc(sc1CS2)N=C(N)N
InChi: 1S/C13H13N5OS2/c1-6(19)16-7-2-3-9-8(4-7)11-10(5-20-9)21-13(17-11)18-12(14)15/h2-4H,5H2,1H3,(H,16,19)(H4,14,15,17,18)
InChiKey: BSAPZXXDUCVUEL-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-(2-guanidino-4H-thiochromeno[4,3-d]thiazol-8-yl)acetamide
N-[2-[bis(azanyl)methylideneamino]-4H-thiochromeno[4,3-d][1,3]thiazol-8-yl]ethanamide
N-[2-(diaminomethylideneamino)-4H-thiochromeno[4,3-d][1,3]thiazol-8-yl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	DINP protein human, muc B family	0.0021	0.0651	0.5148
Trypanosoma brucei	unspecified product	0.0021	0.0651	0.291
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.001	0.0035	0.0251
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0651	0.291
Schistosoma mansoni	hypothetical protein	0.0031	0.1265	0.1265
Entamoeba histolytica	recQ family helicase, putative	0.0014	0.0248	0.0381
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0011	0.0066	0.0066
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0651	0.291
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.001	0.0035	0.0158
Echinococcus granulosus	lysine specific demethylase 6a	0.001	0.0035	0.0035
Trichomonas vaginalis	DNA helicase recq, putative	0.0026	0.0944	0.1453
Echinococcus multilocularis	lysine specific demethylase 5A	0.0038	0.1647	0.1647
Brugia malayi	Bromodomain containing protein	0.0031	0.1265	0.1837
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0651	0.291
Loa Loa (eye worm)	hypothetical protein	0.0112	0.5948	0.853
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0011	0.0066	0.0525
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0122	0.6499	1
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0651	0.291
Brugia malayi	Bloom's syndrome protein homolog	0.0026	0.0944	0.1372
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0651	0.0946
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0011	0.0066	0.0066
Echinococcus granulosus	JmjC domain containing protein 4	0.001	0.0035	0.0035
Echinococcus granulosus	jumonji domain containing protein	0.0044	0.1976	0.1976
Trypanosoma cruzi	DNA polymerase eta, putative	0.0048	0.2237	1
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0043	0.0062
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0103	0.5395	0.5395
Trypanosoma cruzi	DNA polymerase eta, putative	0.0034	0.1408	0.6296
Giardia lamblia	PHD finger protein 15	0.0031	0.1265	1
Echinococcus multilocularis	bloom syndrome protein	0.0026	0.0944	0.0944
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0021	0.0651	0.1002
Leishmania major	DNA polymerase eta, putative	0.0034	0.1408	0.6296
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0103	0.5395	0.5395
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0021	0.0651	0.1002
Loa Loa (eye worm)	RecQ helicase	0.0026	0.0944	0.1354
Echinococcus multilocularis	alkaline phosphatase	0.0175	0.9575	0.9575
Schistosoma mansoni	hypothetical protein	0.0091	0.4711	0.4711
Echinococcus multilocularis	alkaline phosphatase, intestinal, gene 2	0.0175	0.9575	0.9575
Trichomonas vaginalis	m-phase inducer phosphatase, putative	0.0122	0.6499	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0651	0.291
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0066	0.0096
Loa Loa (eye worm)	hypothetical protein	0.001	0.0035	0.0051
Echinococcus granulosus	alkaline phosphatase intestinal gene 2	0.0175	0.9575	0.9575
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0651	1
Schistosoma mansoni	DNA polymerase eta	0.0048	0.2237	0.2237
Mycobacterium leprae	Probable thiosulfate sulfurtransferase SseA (RHODANESE) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE)	0.001	0	0.5
Schistosoma mansoni	phosphatidylserine receptor	0.001	0.0035	0.0035
Loa Loa (eye worm)	jmjC domain-containing protein	0.001	0.0035	0.0051
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0066	0.0471
Loa Loa (eye worm)	jmjC domain-containing protein	0.001	0.0035	0.0051
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0122	0.6499	1
Brugia malayi	Rhodanese-like domain containing protein	0.0122	0.6499	0.9442
Trypanosoma brucei	DNA polymerase eta, putative	0.0048	0.2237	1
Giardia lamblia	Sgs1 DNA helicase, putative	0.0011	0.0066	0.0525
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.0651	0.0651
Schistosoma mansoni	jumonji domain containing protein	0.0082	0.4173	0.4173
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0651	0.291
Plasmodium falciparum	phd finger protein, putative	0.0031	0.1265	1
Echinococcus granulosus	dna polymerase kappa	0.0021	0.0651	0.0651
Trichomonas vaginalis	cdc25b, putative	0.0122	0.6499	1
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.001	0.0043	0.0338
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0014	0.0248	0.1108
Brugia malayi	AF-10 protein	0.001	0.0043	0.0062
Schistosoma mansoni	alkaline phosphatase	0.0175	0.9575	0.9575
Echinococcus multilocularis	peregrin	0.0031	0.1265	0.1265
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.1647	0.1647
Onchocerca volvulus		0.0122	0.6499	1
Echinococcus granulosus	intestinal type alkaline phosphatase	0.0175	0.9575	0.9575
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0031	0.1265	0.1265
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.001	0.0035	0.0035
Brugia malayi	ImpB/MucB/SamB family protein	0.0048	0.2237	0.325
Echinococcus granulosus	intestinal type alkaline phosphatase 1	0.0175	0.9575	0.9575
Schistosoma mansoni	m-phase inducer phosphatase(cdc25)	0.0122	0.6499	0.6499
Echinococcus multilocularis	jumonji domain containing protein	0.0044	0.1976	0.1976
Schistosoma mansoni	hypothetical protein	0.0182	1	1
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.001	0.0043	0.0191
Schistosoma mansoni	DNA helicase recq1	0.0011	0.0066	0.0066
Echinococcus granulosus	dna polymerase eta	0.0048	0.2237	0.2237
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0023	0.0763	0.603
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.001	0.0043	0.0043
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0066	0.0096
Loa Loa (eye worm)	jmjC domain-containing protein	0.001	0.0035	0.0051
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0066	0.0471
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0034	0.1408	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0065	0.3197	0.4585
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0014	0.0248	0.1108
Schistosoma mansoni	protein phosphatase 2C	0.001	0.0035	0.0035
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.0651	0.0651
Brugia malayi	MH2 domain containing protein	0.0128	0.6883	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0128	0.6883	0.987
Leishmania major	hypothetical protein, conserved	0.001	0.0035	0.0158
Brugia malayi	PHD-finger family protein	0.0031	0.1265	0.1837
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0651	0.291
Plasmodium vivax	hypothetical protein, conserved	0.001	0.0043	0.0338
Echinococcus multilocularis	m phase inducer phosphatase(cdc25)	0.0122	0.6499	0.6499
Echinococcus multilocularis	jumonji domain containing 1A	0.001	0.0035	0.0035
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0014	0.0248	0.1108
Trichomonas vaginalis	cdc25c, putative	0.0122	0.6499	1
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0651	0.291
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0651	0.291
Trichomonas vaginalis	cdc25b, putative	0.0122	0.6499	1
Schistosoma mansoni	jumonji domain containing protein	0.001	0.0035	0.0035
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0278	0.1243
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0651	1
Mycobacterium leprae	PROBABLE THIOSULFATE SULFURTRANSFERASE CYSA2 (RHODANESE-LIKE PROTEIN) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRAN	0.001	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2561	0.3673
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0651	0.291
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0651	0.291
Trypanosoma brucei	unspecified product	0.0014	0.0278	0.1243
Brugia malayi	jmjC domain containing protein	0.001	0.0035	0.0051
Schistosoma mansoni	hypothetical protein	0.0182	1	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0651	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.0651	0.0651
Onchocerca volvulus		0.0122	0.6499	1
Loa Loa (eye worm)	hypothetical protein	0.0122	0.6499	0.932
Trichomonas vaginalis	DNA helicase recq1, putative	0.0026	0.0944	0.1453
Loa Loa (eye worm)	PHD-finger family protein	0.0031	0.1265	0.1814
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.001	0.0035	0.0035
Echinococcus granulosus	m phase inducer phosphatasecdc25	0.0122	0.6499	0.6499
Schistosoma mansoni	phd/f-box containing protein	0.001	0.0035	0.0035
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0651	0.291
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.0651	0.0934
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.001	0.0043	0.0303
Onchocerca volvulus		0.0122	0.6499	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0651	0.291
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0011	0.0066	0.0095
Mycobacterium leprae	Conserved hypothetical protein	0.001	0	0.5
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0651	0.291
Brugia malayi	jmjC domain containing protein	0.001	0.0035	0.0051
Trypanosoma brucei	unspecified product	0.0014	0.0278	0.1243
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0278	0.1243
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0278	0.1243
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0031	0.1265	0.1265
Loa Loa (eye worm)	jmjC domain-containing protein	0.0038	0.1647	0.2361
Brugia malayi	jmjC domain containing protein	0.0038	0.1647	0.2392
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0651	0.291
Brugia malayi	jmjC domain containing protein	0.0103	0.5395	0.7838
Brugia malayi	PHD-finger family protein	0.001	0.0043	0.0062
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0651	0.291
Echinococcus multilocularis	lysine specific demethylase 6a	0.001	0.0035	0.0035
Schistosoma mansoni	alkaline phosphatase	0.0175	0.9575	0.9575
Loa Loa (eye worm)	hypothetical protein	0.0122	0.6499	0.932
Entamoeba histolytica	rodhanase-like domain containing protein	0.0122	0.6499	1
Echinococcus multilocularis	intestinal type alkaline phosphatase	0.0175	0.9575	0.9575
Onchocerca volvulus		0.0122	0.6499	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.0031	0.1265	0.8979
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.1265	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0038	0.1647	0.1647
Toxoplasma gondii	PHD-finger domain-containing protein	0.0031	0.1265	0.8979
Schistosoma mansoni	blooms syndrome DNA helicase	0.002	0.063	0.063
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.1647	0.1647
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0651	0.291
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0066	0.0095
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0017	0.0448	0.3181
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0017	0.046	0.3638
Entamoeba histolytica	rodhanase-like domain containing protein	0.0122	0.6499	1
Loa Loa (eye worm)	hypothetical protein	0.0112	0.5948	0.853
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.001	0.0035	0.0158
Echinococcus granulosus	jumonji domain containing 1A	0.001	0.0035	0.0035
Toxoplasma gondii	PHD-finger domain-containing protein	0.001	0.0043	0.0303
Loa Loa (eye worm)	MH2 domain-containing protein	0.0128	0.6883	0.987
Echinococcus multilocularis	JmjC domain containing protein 4	0.001	0.0035	0.0035
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.001	0.0035	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2237	0.3208
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0651	0.291
Trichomonas vaginalis	DNA polymerase eta, putative	0.0021	0.0651	0.1002
Echinococcus multilocularis	geminin	0.0182	1	1
Trichomonas vaginalis	DNA helicase recq, putative	0.0014	0.0248	0.0381
Mycobacterium leprae	PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB1 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE)	0.001	0	0.5
Echinococcus granulosus	PHD finger protein rhinoceros	0.0031	0.1265	0.1265
Schistosoma mansoni	hypothetical protein	0.001	0.0043	0.0043
Plasmodium vivax	JmjC domain containing protein	0.001	0.0035	0.0279
Onchocerca volvulus	Alhambra homolog	0.0031	0.1265	0.1946
Loa Loa (eye worm)	hypothetical protein	0.001	0.0043	0.0061
Brugia malayi	jmjC domain containing protein	0.001	0.0035	0.0051
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0122	0.6499	1
Plasmodium falciparum	JmjC domain-containing protein, putative	0.001	0.0035	0.0279
Brugia malayi	Rhodanese-like domain containing protein	0.0122	0.6499	0.9442
Echinococcus multilocularis	intestinal type alkaline phosphatase 1	0.0175	0.9575	0.9575
Trichomonas vaginalis	m-phase inducer phosphatase, putative	0.0122	0.6499	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.1265	0.1814
Wolbachia endosymbiont of Brugia malayi	sulfurtransferase	0.001	0	0.5
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.0651	0.0651
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.001	0.0035	0.0035
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.001	0.0035	0.0158
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0011	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.013	0.6973	1
Leishmania major	DNA polymerase eta, putative	0.0048	0.2237	1
Brugia malayi	jmjC domain containing protein	0.001	0.0035	0.0051
Echinococcus multilocularis	dna polymerase eta	0.0048	0.2237	0.2237
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.001	0.0043	0.0191
Schistosoma mansoni	DNA helicase recq5	0.0011	0.0066	0.0066
Echinococcus granulosus	alkaline phosphatase	0.0175	0.9575	0.9575
Echinococcus granulosus	bloom syndrome protein	0.0026	0.0944	0.0944
Echinococcus granulosus	peregrin	0.0031	0.1265	0.1265
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0651	0.291
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.0651	0.0651
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0651	1
Echinococcus granulosus	phd:f box containing protein	0.001	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.001	0.0035	0.0051
Chlamydia trachomatis	hypothetical protein	0.001	0	0.5
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0011	0.0066	0.0066
Echinococcus multilocularis	phd:f box containing protein	0.001	0.0035	0.0035
Entamoeba histolytica	rodhanase-like domain containing protein	0.0122	0.6499	1

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	> 100 ug ml-1	The lowest drug concentration that inhibited macroscopic colonial growth against Helicobacter pylori.	ChEMBL.	10966750

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10781911

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 185760