Detailed information for compound 1857650

Basic information

Technical information
  • TDR Targets ID: 1857650
  • Name: N-[[4-(2,3-dihydro-1,4-benzodioxin-7-ylamino) -4-oxobutan-2-ylidene]amino]-3-hydroxybenzami de
  • MW: 369.371 | Formula: C19H19N3O5
  • H donors: 3 H acceptors: 3 LogP: 1.76 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C/C(=N/NC(=O)c1cccc(c1)O)/C)Nc1ccc2c(c1)OCCO2
  • InChi: 1S/C19H19N3O5/c1-12(21-22-19(25)13-3-2-4-15(23)10-13)9-18(24)20-14-5-6-16-17(11-14)27-8-7-26-16/h2-6,10-11,23H,7-9H2,1H3,(H,20,24)(H,22,25)/b21-12+
  • InChiKey: MUOHVNRVRRNRGZ-CIAFOILYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[[3-(2,3-dihydro-1,4-benzodioxin-7-ylamino)-1-methyl-3-oxo-propylidene]amino]-3-hydroxy-benzamide
  • N-[[3-(2,3-dihydro-1,4-benzodioxin-7-ylamino)-1-methyl-3-oxopropylidene]amino]-3-hydroxybenzamide
  • N-[[3-(2,3-dihydro-1,4-benzodioxin-7-ylamino)-3-keto-1-methyl-propylidene]amino]-3-hydroxy-benzamide
  • N-[[4-(2,3-dihydro-1,4-benzodioxin-7-ylamino)-4-oxo-butan-2-ylidene]amino]-3-hydroxy-benzamide
  • BAS 00409007
  • STK117665

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0043 0.1492 0.2206
Loa Loa (eye worm) carboxylesterase 0.0203 0.774 1
Schistosoma mansoni gliotactin 0.0034 0.1141 0.1127
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0034 0.1141 0.1141
Trypanosoma brucei glucosidase, putative 0.0014 0.0338 0.0455
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0338 0.0149
Trichomonas vaginalis ran, putative 0.0014 0.0328 0.0127
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0012 0.0268 0.0268
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0571 0.0565
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0338 0.4105
Toxoplasma gondii hypothetical protein 0.0041 0.1415 0.9477
Loa Loa (eye worm) glutaminase 0.0134 0.502 0.6486
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0039 0.1327 0.1327
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0024 0.0755 0.1087
Echinococcus multilocularis neuroligin 0.0034 0.1141 0.1141
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.1313 0.1933
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.001 0.0176 0.0209
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1313 0.1933
Echinococcus granulosus disco interacting protein 2 0.0019 0.0535 0.0535
Echinococcus multilocularis snurportin 1 0.0196 0.7469 0.7469
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.1313 0.1933
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0034 0.1141 0.1127
Echinococcus multilocularis importin subunit beta 1 0.0018 0.0517 0.0517
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.001 0.0176 0.0161
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0012 0.0268 0.0347
Loa Loa (eye worm) glutaminase 2 0.0134 0.502 0.6486
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0039 0.1327 0.1314
Loa Loa (eye worm) carboxylesterase 0.0034 0.1141 0.1474
Schistosoma mansoni alpha-glucosidase 0.0054 0.1891 0.1879
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0039 0.1327 0.1314
Onchocerca volvulus 0.0034 0.1141 0.9043
Trypanosoma cruzi importin beta-1 subunit, putative 0.0015 0.0382 0.052
Loa Loa (eye worm) hypothetical protein 0.0019 0.0535 0.0691
Brugia malayi Glycosyl hydrolases family 31 protein 0.0062 0.223 0.2748
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.1058 0.1546
Echinococcus multilocularis muscleblind protein 0.0164 0.6194 0.6194
Giardia lamblia DINP protein human, muc B family 0.0024 0.0755 1
Schistosoma mansoni ran 0.0014 0.0328 0.0313
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.1492 0.2918
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0014 0.0328 0.0439
Echinococcus granulosus cpg binding protein 0.0034 0.1126 0.1126
Leishmania major mitochondrial DNA polymerase beta 0.0175 0.663 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0338 0.0149
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0025 0.076 0.1094
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0571 0.0571
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0012 0.0268 0.1663
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0516 0.0723
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.1415 1
Loa Loa (eye worm) CYP4Cod1 0.0009 0.0142 0.0184
Loa Loa (eye worm) hypothetical protein 0.0032 0.1058 0.1367
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1313 0.1933
Brugia malayi Carboxylesterase family protein 0.0034 0.1141 0.1314
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0014 0.0328 0.0439
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.1492 0.2918
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0338 0.0149
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0034 0.1141 0.279
Schistosoma mansoni ap endonuclease 0.0012 0.0268 0.0253
Echinococcus multilocularis geminin 0.0261 1 1
Echinococcus granulosus DNA methyltransferase 2, putative 0.001 0.0176 0.0176
Trypanosoma brucei DNA polymerase eta, putative 0.0032 0.1058 0.1546
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0338 0.4105
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0015 0.0382 0.024
Plasmodium vivax importin-beta 2, putative 0.0018 0.0517 1
Trypanosoma brucei unspecified product 0.0034 0.1129 0.1654
Echinococcus granulosus snurportin 1 0.0196 0.7469 0.7469
Trypanosoma cruzi cytochrome P450, putative 0.0009 0.0142 0.0157
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0039 0.0158
Mycobacterium tuberculosis Conserved hypothetical protein 0.0092 0.3397 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1313 0.1933
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0025 0.076 0.1094
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0338 0.0455
Loa Loa (eye worm) hypothetical protein 0.0018 0.0517 0.0669
Onchocerca volvulus 0.0034 0.1141 0.9043
Toxoplasma gondii exonuclease III APE 0.0012 0.0268 0.1708
Leishmania major cytochrome p450-like protein 0.0009 0.0142 0.0157
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0525 0.0738
Schistosoma mansoni cpg binding protein 0.0034 0.1126 0.1112
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0571 0.0557
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0039 0.1327 0.1314
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0014 0.0328 0.2115
Brugia malayi hypothetical protein 0.0034 0.1141 0.1314
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1313 0.1933
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0039 0.0023
Toxoplasma gondii hypothetical protein 0.0028 0.0901 0.5994
Echinococcus granulosus dna polymerase kappa 0.0039 0.1313 0.1313
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.1313 0.1933
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0012 0.0268 0.4781
Loa Loa (eye worm) hypothetical protein 0.0164 0.6194 0.8002
Brugia malayi Carboxylesterase family protein 0.0203 0.774 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0043 0.1492 0.1492
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0012 0.0268 0.046
Loa Loa (eye worm) hypothetical protein 0.0034 0.1141 0.1474
Echinococcus granulosus dna polymerase eta 0.0032 0.1058 0.1058
Schistosoma mansoni alpha glucosidase 0.0014 0.0338 0.0324
Leishmania major modification methylase-like protein 0.001 0.0176 0.0209
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0525 0.3452
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0039 0.1327 0.1314
Trichomonas vaginalis glutaminase, putative 0.0134 0.502 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0571 0.0738
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.1313 0.2558
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0175 0.663 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1313 0.1933
Echinococcus granulosus carboxylesterase 5A 0.0203 0.774 0.774
Trypanosoma brucei importin beta-1 subunit, putative 0.0018 0.0517 0.0726
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.003 0.097 0.1412
Trypanosoma brucei unspecified product 0.0014 0.0332 0.0444
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0009 0.0142 0.0208
Echinococcus multilocularis lysosomal alpha glucosidase 0.0062 0.223 0.223
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0025 0.076 0.1094
Schistosoma mansoni BC026374 protein (S09 family) 0.0034 0.1141 0.1127
Loa Loa (eye worm) hypothetical protein 0.0006 0.0043 0.0056
Leishmania major GTP-binding protein, putative 0.0014 0.0328 0.0439
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0043 0.1492 0.3914
Loa Loa (eye worm) hypothetical protein 0.0203 0.774 1
Mycobacterium ulcerans glutaminase 0.0134 0.502 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0338 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1313 0.1933
Leishmania major DNA polymerase kappa, putative 0.0024 0.0755 0.1087
Loa Loa (eye worm) cytochrome P450 family protein 0.0009 0.0142 0.0184
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0012 0.0268 0.0347
Schistosoma mansoni aldehyde dehydrogenase 0.0043 0.1492 0.1479
Echinococcus multilocularis DNA methyltransferase 2, putative 0.001 0.0176 0.0176
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0571 0.097
Onchocerca volvulus 0.0034 0.1141 0.9043
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.1313 0.2199
Brugia malayi Muscleblind-like protein 0.0164 0.6194 0.7965
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0014 0.0328 0.0439
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.1313 0.1933
Loa Loa (eye worm) hypothetical protein 0.0203 0.774 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0338 0.0149
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.001 0.0176 0.0999
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0012 0.0268 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0338 0.0149
Loa Loa (eye worm) hypothetical protein 0.0026 0.0818 0.1057
Echinococcus multilocularis carboxylesterase 5A 0.0203 0.774 0.774
Treponema pallidum exodeoxyribonuclease (exoA) 0.0012 0.0268 0.5
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.1089 0.1406
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0014 0.0338 0.0437
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0012 0.0268 0.0268
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0083 0.3032 0.4541
Echinococcus multilocularis BC026374 protein (S09 family) 0.0034 0.1141 0.1141
Entamoeba histolytica hypothetical protein 0.0015 0.0382 0.5198
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0035 0.1177 0.1163
Schistosoma mansoni cpg binding protein 0.0033 0.1089 0.1075
Echinococcus granulosus lysosomal alpha glucosidase 0.0062 0.223 0.223
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0014 0.0328 0.0244
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.1313 0.1933
Entamoeba histolytica Ran family GTPase 0.0014 0.0328 0.3836
Echinococcus multilocularis lysosomal alpha glucosidase 0.0062 0.223 0.223
Toxoplasma gondii DNA methyltransferase 2, putative 0.001 0.0176 0.1089
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0571 1
Echinococcus granulosus acetylcholinesterase 0.0203 0.774 0.774
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0755 0.1087
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0034 0.1141 0.1127
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0015 0.0382 0.024
Brugia malayi glutaminase DH11.1 0.0134 0.502 0.642
Mycobacterium tuberculosis Carboxylesterase LipT 0.0034 0.1141 0.279
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0026 0.0818 0.1158
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0516 0.0723
Brugia malayi exodeoxyribonuclease III family protein 0.0012 0.0268 0.0165
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0026 0.0818 0.0804
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0011 0.0223 0.1404
Echinococcus multilocularis disco interacting protein 2 0.0019 0.0535 0.0535
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0338 0.0149
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0034 0.1141 0.1141
Mycobacterium ulcerans carboxylesterase, LipT 0.0034 0.1141 0.2212
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.078 0.1125
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.1492 0.2918
Loa Loa (eye worm) cytochrome P450 family protein 0.0009 0.0142 0.0184
Toxoplasma gondii histone lysine methyltransferase SET1 0.0031 0.103 0.6867
Trichomonas vaginalis sucrase-isomaltase, putative 0.0014 0.0338 0.0149
Echinococcus multilocularis acetylcholinesterase 0.0203 0.774 0.774
Echinococcus granulosus neutral alpha glucosidase AB 0.0014 0.0338 0.0338
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0014 0.0328 0.21
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0012 0.0268 0.0347
Toxoplasma gondii melibiase subfamily protein 0.0039 0.1327 0.8881
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0014 0.0328 0.0424
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0019 0.0535 0.052
Schistosoma mansoni hypothetical protein 0.0196 0.7469 0.7465
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0034 0.1141 0.1127
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.078 0.1125
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.1129 0.1654
Plasmodium falciparum importin beta, putative 0.0018 0.0517 0.3478
Leishmania major importin beta-1 subunit, putative 0.0015 0.0382 0.052
Echinococcus granulosus acetylcholinesterase 0.0203 0.774 0.774
Echinococcus granulosus muscleblind protein 0.0164 0.6194 0.6194
Schistosoma mansoni DNA polymerase eta 0.0032 0.1058 0.1044
Echinococcus multilocularis neutral alpha glucosidase AB 0.0014 0.0338 0.0338
Trichomonas vaginalis importin beta-1, putative 0.0015 0.0382 0.024
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0014 0.0328 0.6038
Leishmania major alpha glucosidase II subunit, putative 0.0014 0.0338 0.0455
Onchocerca volvulus 0.0033 0.1089 0.8264
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0014 0.0328 0.0328
Brugia malayi Carboxylesterase family protein 0.0034 0.1141 0.1314
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0338 0.0258
Schistosoma mansoni acetylcholinesterase 0.0034 0.1141 0.1127
Onchocerca volvulus 0.0036 0.1205 1
Echinococcus granulosus para nitrobenzyl esterase 0.0034 0.1141 0.1141
Schistosoma mansoni hypothetical protein 0.0261 1 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0571 0.0571
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.001 0.0176 0.2873
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0175 0.663 1
Brugia malayi Carboxylesterase family protein 0.0034 0.1141 0.1314
Echinococcus multilocularis cpg binding protein 0.0034 0.1126 0.1126
Schistosoma mansoni importin beta-1 0.0018 0.0517 0.0503
Brugia malayi Carboxylesterase family protein 0.0034 0.1141 0.1314
Schistosoma mansoni hypothetical protein 0.0261 1 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0034 0.1141 0.1837
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0571 0.0557
Schistosoma mansoni aldehyde dehydrogenase 0.0043 0.1492 0.1479
Onchocerca volvulus 0.0034 0.1141 0.9043
Schistosoma mansoni ap endonuclease 0.0012 0.0268 0.0253
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0203 0.774 0.7736
Brugia malayi Carboxylesterase family protein 0.0203 0.774 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1313 0.1933
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0039 0.1327 0.1327
Loa Loa (eye worm) hypothetical protein 0.0034 0.1141 0.1474
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0175 0.663 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0043 0.1492 0.1492
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.1313 0.1933
Loa Loa (eye worm) hypothetical protein 0.0034 0.1141 0.1474
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0083 0.3032 0.4541
Schistosoma mansoni alpha-glucosidase 0.0054 0.1891 0.1879
Loa Loa (eye worm) carboxylesterase 0.0034 0.1141 0.1474
Echinococcus granulosus neuroligin 0.0034 0.1141 0.1141
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0012 0.0268 0.3195
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0014 0.0328 0.4034
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.001 0.0176 0.1089
Trypanosoma cruzi cytochrome P450, putative 0.0009 0.0142 0.0157
Brugia malayi CXXC zinc finger family protein 0.0033 0.1089 0.1246
Trypanosoma brucei importin beta-1 subunit, putative 0.0018 0.0517 0.0726
Mycobacterium ulcerans hypothetical protein 0.0092 0.3397 0.6742
Loa Loa (eye worm) hypothetical protein 0.0034 0.1141 0.1474
Loa Loa (eye worm) acetylcholinesterase 1 0.0203 0.774 1
Brugia malayi Melibiase family protein 0.0026 0.0818 0.089
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.1313 0.2558
Leishmania major DNA polymerase eta, putative 0.0019 0.0525 0.0738
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0026 0.0818 0.0804
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0338 0.0455
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0516 0.0723
Brugia malayi RNA, U transporter 1 0.0052 0.1842 0.2238
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0025 0.076 0.1094
Trypanosoma brucei cytochrome P450, putative 0.0009 0.0142 0.0157
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0039 0.1327 0.1327
Brugia malayi Importin beta-1 subunit 0.0018 0.0517 0.0494
Schistosoma mansoni neuroligin 3 (S09 family) 0.0034 0.1141 0.1127
Echinococcus multilocularis acetylcholinesterase 0.0203 0.774 0.774
Leishmania major DNA polymerase eta, putative 0.0032 0.1058 0.1546
Toxoplasma gondii HEAT repeat-containing protein 0.0018 0.0517 0.3399
Schistosoma mansoni glutaminase 0.0134 0.502 0.5012
Echinococcus multilocularis dna polymerase eta 0.0032 0.1058 0.1058
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.1313 0.2199
Echinococcus granulosus importin subunit beta 1 0.0018 0.0517 0.0517
Trichomonas vaginalis spcc417.12 protein, putative 0.0034 0.1141 0.1837
Brugia malayi ImpB/MucB/SamB family protein 0.0032 0.1058 0.1205
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0012 0.0268 0.2313
Brugia malayi polk-prov protein 0.0025 0.078 0.084
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0196 0.7469 0.965
Echinococcus granulosus BC026374 protein S09 family 0.0034 0.1141 0.1141
Loa Loa (eye worm) hypothetical protein 0.0034 0.1141 0.1474
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1313 0.1933
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0012 0.0268 0.0346
Echinococcus multilocularis muscleblind protein 1 0.0164 0.6194 0.6194
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0268 0.0347
Loa Loa (eye worm) hypothetical protein 0.0164 0.6194 0.8002
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0024 0.0755 0.1558
Echinococcus multilocularis para nitrobenzyl esterase 0.0034 0.1141 0.1141
Echinococcus multilocularis dna polymerase kappa 0.0039 0.1313 0.1313
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0083 0.3032 0.4541
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0034 0.1141 0.279
Toxoplasma gondii aldehyde dehydrogenase 0.0043 0.1492 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1313 0.1933
Echinococcus granulosus GTP binding nuclear protein Ran 0.0014 0.0328 0.0328
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0014 0.0338 0.2187
Brugia malayi Disco-interacting protein 2 homolog 0.0019 0.0535 0.0517
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0062 0.223 0.2881
Loa Loa (eye worm) hypothetical protein 0.0025 0.078 0.1008
Trypanosoma brucei unspecified product 0.0014 0.0332 0.0444
Schistosoma mansoni cpg binding protein 0.0034 0.1126 0.1112
Schistosoma mansoni ran 0.0014 0.0328 0.0313
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0338 0.0149
Loa Loa (eye worm) hypothetical protein 0.0034 0.1141 0.1474
Onchocerca volvulus 0.0034 0.1141 0.9043
Loa Loa (eye worm) hypothetical protein 0.0034 0.1141 0.1474

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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