Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | heat shock protein 85, putative | 0.0075 | 0.0116 | 0.0615 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0424 | 0.0925 | 0.4126 |
Onchocerca volvulus | 0.0029 | 0.001 | 0.0095 | |
Mycobacterium leprae | TWO COMPONENT SENSOR HISTIDINE KINASE PRRB | 0.0047 | 0.0051 | 0.0044 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0503 | 0.1108 | 1 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0074 | 0.0113 | 0.1008 |
Mycobacterium leprae | Probable lipase LipE | 0.0034 | 0.0021 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0021 | 0.0188 |
Trichomonas vaginalis | sensory transduction histidine kinase bacterial, putative | 0.0047 | 0.0051 | 0.0399 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.0082 | 0.0346 |
Onchocerca volvulus | 0.0231 | 0.0479 | 0.5253 | |
Leishmania major | heat shock protein 83-1 | 0.0075 | 0.0116 | 0.0615 |
Trichomonas vaginalis | heat shock protein, putative | 0.0075 | 0.0116 | 0.0988 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.006 | 0.0082 | 0.0422 |
Mycobacterium tuberculosis | Conserved protein | 0.0034 | 0.0021 | 0.0014 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DevS | 0.0047 | 0.0051 | 0.0044 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0047 | 0.0051 | 0.0306 |
Echinococcus multilocularis | heat shock protein 90 | 0.0028 | 0.0007 | 0.0034 |
Brugia malayi | Probable DNA topoisomerase II | 0.0503 | 0.1108 | 1 |
Leishmania major | DNA topoisomerase III, putative | 0.0074 | 0.0113 | 0.0598 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.001 | 0.0078 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0417 | 0.091 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0034 | 0.0021 | 0.0014 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.0082 | 0.0346 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0503 | 0.1108 | 0.8152 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0074 | 0.0113 | 0.0292 |
Trichomonas vaginalis | receptor histidine kinase, putative | 0.0047 | 0.0051 | 0.0399 |
Giardia lamblia | Pms1-like protein | 0.0047 | 0.0051 | 0.0443 |
Mycobacterium tuberculosis | Possible two component system response sensor kinase membrane associated PhoR | 0.0047 | 0.0051 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0021 | 0.0188 |
Trichomonas vaginalis | mismatch repair protein Mlh1C (mutL homolog) | 0.0047 | 0.0051 | 0.0399 |
Mycobacterium ulcerans | putative regultory protein | 0.0047 | 0.0051 | 0.0044 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0961 | 0.217 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.052 | 0.4688 |
Echinococcus multilocularis | DNA topoisomerase 3 beta 1 | 0.0074 | 0.0113 | 0.0651 |
Leishmania major | heat shock protein 83-1 | 0.0075 | 0.0116 | 0.0615 |
Trichomonas vaginalis | sensory transduction histidine kinase, putative | 0.0047 | 0.0051 | 0.0399 |
Schistosoma mansoni | heat shock protein | 0.0075 | 0.0116 | 0.1036 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0074 | 0.0113 | 0.096 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0417 | 0.091 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0258 | 0.054 | 0.4871 |
Plasmodium vivax | endoplasmin, putative | 0.0075 | 0.0116 | 0.0491 |
Schistosoma mansoni | DNA topoisomerase II | 0.0503 | 0.1108 | 1 |
Mycobacterium ulcerans | sensor kinase from two component regulatory system | 0.0047 | 0.0051 | 0.0044 |
Trichomonas vaginalis | sensor histidine kinase, putative | 0.0047 | 0.0051 | 0.0399 |
Schistosoma mansoni | endoplasmin | 0.0075 | 0.0116 | 0.1036 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0007 | 0.0056 |
Mycobacterium tuberculosis | Two component sensor kinase MprB | 0.0047 | 0.0051 | 0.0044 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0034 | 0.0021 | 0.0014 |
Trichomonas vaginalis | glutaminase, putative | 0.0258 | 0.054 | 0.4838 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.001 | 0.005 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.001 | 0.0078 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0503 | 0.1108 | 0.5086 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0075 | 0.0116 | 0.0541 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0075 | 0.0116 | 0.0615 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DosT | 0.0047 | 0.0051 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.001 | 0.0088 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0047 | 0.0051 | 0.0306 |
Leishmania major | heat shock protein 83-1 | 0.0075 | 0.0116 | 0.0615 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0061 | 0.0082 | 0.0427 |
Mycobacterium ulcerans | two component sensory transduction histidine kinase MtrB | 0.0047 | 0.0051 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0021 | 0.0188 |
Leishmania major | cathepsin L-like protease | 0.006 | 0.0082 | 0.0422 |
Mycobacterium tuberculosis | Two component sensor histidine kinase PrrB | 0.0047 | 0.0051 | 0.0044 |
Mycobacterium tuberculosis | Probable two component sensor kinase | 0.0047 | 0.0051 | 0.0044 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.0082 | 0.0346 |
Plasmodium vivax | heat shock protein 86, putative | 0.0075 | 0.0116 | 0.0491 |
Mycobacterium leprae | PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 | 0.0047 | 0.0051 | 0.0044 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0075 | 0.0116 | 0.0541 |
Treponema pallidum | chemotaxis histidine kinase (cheA) | 0.0047 | 0.0051 | 0.0203 |
Leishmania major | heat shock protein 83-1 | 0.0075 | 0.0116 | 0.0615 |
Loa Loa (eye worm) | DNA topoisomerase III | 0.0074 | 0.0113 | 0.1017 |
Mycobacterium tuberculosis | Probable sensor protein KdpD | 0.0047 | 0.0051 | 0.0044 |
Mycobacterium ulcerans | integral membrane indolylacetylinositol arabinosyltransferase EmbC | 0.4338 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0051 | 0.046 |
Trypanosoma brucei | heat shock protein, putative | 0.0075 | 0.0116 | 0.0541 |
Echinococcus multilocularis | rho GTPase activating protein 20 | 0.0074 | 0.0113 | 0.0651 |
Leishmania major | DNA topoisomerase ii | 0.0429 | 0.0938 | 0.5263 |
Treponema pallidum | DNA topoisomerase I (topA) | 0.0074 | 0.0113 | 0.0489 |
Trypanosoma brucei | DNA topoisomerase III, putative | 0.0074 | 0.0113 | 0.0524 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0424 | 0.0925 | 0.0919 |
Leishmania major | hypothetical protein, conserved | 0.0047 | 0.0051 | 0.0249 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.0444 | 0.4008 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.0082 | 0.0346 |
Echinococcus multilocularis | geminin | 0.016 | 0.0313 | 0.1818 |
Toxoplasma gondii | DNA topoisomerase family protein | 0.0074 | 0.0113 | 0.0764 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0503 | 0.1108 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.052 | 0.4688 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0074 | 0.0113 | 0.1008 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0026 | 0.0236 |
Brugia malayi | kinase, mitochondrial precursor | 0.0047 | 0.0051 | 0.045 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0075 | 0.0116 | 0.0615 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0075 | 0.0116 | 0.0541 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0034 | 0.0021 | 0.0014 |
Brugia malayi | glutaminase DH11.1 | 0.0258 | 0.054 | 0.4866 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0034 | 0.0021 | 0.0126 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0429 | 0.0938 | 0.5225 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0034 | 0.0021 | 0.0078 |
Onchocerca volvulus | 0.0074 | 0.0113 | 0.1228 | |
Schistosoma mansoni | glutaminase | 0.0258 | 0.054 | 0.4866 |
Mycobacterium tuberculosis | Conserved protein | 0.0034 | 0.0021 | 0.0014 |
Trichomonas vaginalis | receptor histidine kinase, putative | 0.0047 | 0.0051 | 0.0399 |
Mycobacterium ulcerans | beta-lactamase | 0.0034 | 0.0021 | 0.0014 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0417 | 0.091 | 1 |
Mycobacterium tuberculosis | Two component sensory transduction histidine kinase MtrB | 0.0047 | 0.0051 | 0.0044 |
Trichomonas vaginalis | endoplasmin, putative | 0.0061 | 0.0084 | 0.0702 |
Wolbachia endosymbiont of Brugia malayi | topoisomerase IA, TopA | 0.0074 | 0.0113 | 0.0489 |
Echinococcus multilocularis | heat shock protein 90 | 0.0075 | 0.0116 | 0.0669 |
Echinococcus granulosus | DNA topoisomerase 3 alpha | 0.0074 | 0.0113 | 0.1008 |
Trypanosoma cruzi | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative | 0.0047 | 0.0051 | 0.0249 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0074 | 0.0113 | 0.0598 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.0082 | 0.0346 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0047 | 0.0051 | 0.045 |
Brugia malayi | GRF zinc finger family protein | 0.0074 | 0.0113 | 0.1008 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0503 | 0.1108 | 1 |
Schistosoma mansoni | endoplasmin | 0.0075 | 0.0116 | 0.1036 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0791 | 0.1775 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.0082 | 0.0346 |
Mycobacterium ulcerans | glutaminase | 0.0258 | 0.054 | 0.0533 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.0082 | 0.0346 |
Schistosoma mansoni | hypothetical protein | 0.016 | 0.0313 | 0.2814 |
Leishmania major | hypothetical protein, conserved | 0.0034 | 0.0021 | 0.0078 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0047 | 0.0051 | 0.0291 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0034 | 0.0021 | 0.0126 |
Schistosoma mansoni | hypothetical protein | 0.016 | 0.0313 | 0.2814 |
Trichomonas vaginalis | set domain proteins, putative | 0.0231 | 0.0479 | 0.4283 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0034 | 0.0021 | 0.0115 |
Mycobacterium tuberculosis | Two component sensor kinase [second part] | 0.0047 | 0.0051 | 0.0044 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0074 | 0.0113 | 0.0764 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.0082 | 0.0346 |
Mycobacterium leprae | Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) | 0.4338 | 1 | 1 |
Mycobacterium tuberculosis | Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) | 0.4338 | 1 | 1 |
Mycobacterium tuberculosis | Possible two component sensor kinase TcrY | 0.0047 | 0.0051 | 0.0044 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0034 | 0.0021 | 0.0014 |
Trypanosoma brucei | heat shock protein, putative | 0.0075 | 0.0116 | 0.0541 |
Plasmodium vivax | hypothetical protein, conserved | 0.0034 | 0.0021 | 0.0051 |
Mycobacterium ulcerans | two component sensor histidine kinase SenX3 | 0.0047 | 0.0051 | 0.0044 |
Plasmodium falciparum | heat shock protein 90 | 0.0075 | 0.0116 | 0.0306 |
Leishmania major | heat shock protein 83-1 | 0.0075 | 0.0116 | 0.0615 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0055 | 0.0069 | 0.0353 |
Trypanosoma brucei | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative | 0.0047 | 0.0051 | 0.0172 |
Mycobacterium ulcerans | two component sensor histidine kinase TrcS | 0.0047 | 0.0051 | 0.0044 |
Trichomonas vaginalis | heat shock protein, putative | 0.0061 | 0.0084 | 0.0702 |
Mycobacterium ulcerans | two component system membrane associated sensor kinase | 0.0047 | 0.0051 | 0.0044 |
Plasmodium vivax | hypothetical protein, conserved | 0.0047 | 0.0051 | 0.0191 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.001 | 0.0078 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0034 | 0.0021 | 0.0014 |
Mycobacterium ulcerans | two component sensor histidine kinase DevS | 0.0047 | 0.0051 | 0.0044 |
Trypanosoma brucei | heat shock protein, putative | 0.0075 | 0.0116 | 0.0541 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0034 | 0.0021 | 0.0078 |
Leishmania major | heat shock protein 83-1 | 0.0075 | 0.0116 | 0.0615 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.061 | 0.1357 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0034 | 0.0021 | 0.0178 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0217 | 0.0445 | 0.0438 |
Leishmania major | heat shock protein 83-1 | 0.0075 | 0.0116 | 0.0615 |
Toxoplasma gondii | ABC1 family protein | 0.0034 | 0.0021 | 0.0082 |
Loa Loa (eye worm) | DNA topoisomerase III beta-1 | 0.0074 | 0.0113 | 0.1017 |
Mycobacterium leprae | Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( | 0.0074 | 0.0113 | 0.0106 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0075 | 0.0116 | 0.0787 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0424 | 0.0925 | 0.4246 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0034 | 0.0021 | 0.0178 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0075 | 0.0116 | 0.0031 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.006 | 0.0082 | 0.0422 |
Echinococcus granulosus | endoplasmin | 0.0028 | 0.0007 | 0.0053 |
Trypanosoma brucei | heat shock protein, putative | 0.0075 | 0.0116 | 0.0541 |
Leishmania major | cathepsin L-like protease | 0.006 | 0.0082 | 0.0422 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.0082 | 0.0346 |
Mycobacterium tuberculosis | Conserved protein | 0.0047 | 0.0051 | 0.0044 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0424 | 0.0925 | 0.4126 |
Leishmania major | heat shock protein 83-1 | 0.0075 | 0.0116 | 0.0615 |
Mycobacterium ulcerans | integral membrane indolylacetylinositol arabinosyltransferase EmbA | 0.4338 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.006 | 0.0082 | 0.0422 |
Trichomonas vaginalis | esterase, putative | 0.0034 | 0.0021 | 0.0126 |
Brugia malayi | Pre-SET motif family protein | 0.0203 | 0.0413 | 0.3725 |
Brugia malayi | heat shock protein 90 | 0.0075 | 0.0116 | 0.1036 |
Leishmania major | heat shock protein 83-1 | 0.0075 | 0.0116 | 0.0615 |
Plasmodium vivax | DNA topoisomerase 3, putative | 0.0074 | 0.0113 | 0.0477 |
Leishmania major | heat shock protein 83-1 | 0.0075 | 0.0116 | 0.0615 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0001 | 0.001 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0034 | 0.0021 | 0.0014 |
Mycobacterium ulcerans | two component sensor histidine kinase PrrB | 0.0047 | 0.0051 | 0.0044 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0028 | 0.0007 | 0.0053 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0503 | 0.1108 | 1 |
Trypanosoma brucei | DNA topoisomerase IA, putative | 0.0074 | 0.0113 | 0.0524 |
Mycobacterium ulcerans | lipase LipD | 0.0034 | 0.0021 | 0.0014 |
Loa Loa (eye worm) | intermediate filament protein | 0.0025 | 0.0001 | 0.001 |
Giardia lamblia | DNA topoisomerase III | 0.0074 | 0.0113 | 0.1065 |
Brugia malayi | DNA topoisomerase III | 0.0074 | 0.0113 | 0.1008 |
Giardia lamblia | DNA topoisomerase II | 0.0456 | 0.0999 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0075 | 0.0116 | 0.0615 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0075 | 0.0116 | 0.1097 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0026 | 0.0236 |
Giardia lamblia | DNA topoisomerase III | 0.0074 | 0.0113 | 0.1065 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0424 | 0.0925 | 0.4238 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0034 | 0.0021 | 0.0126 |
Mycobacterium leprae | Probable two-component sensor kinase | 0.0047 | 0.0051 | 0.0044 |
Leishmania major | DNA topoisomerase 1A | 0.0074 | 0.0113 | 0.0598 |
Trypanosoma brucei | DNA topoisomerase III, putative | 0.0074 | 0.0113 | 0.0524 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0034 | 0.0021 | 0.0126 |
Leishmania major | heat shock protein 83-1 | 0.0075 | 0.0116 | 0.0615 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.0082 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0026 | 0.0236 |
Echinococcus granulosus | DNA topoisomerase 3 beta 1 | 0.0074 | 0.0113 | 0.1008 |
Mycobacterium tuberculosis | Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) | 0.4338 | 1 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0034 | 0.0021 | 0.0178 |
Loa Loa (eye worm) | glutaminase | 0.0258 | 0.054 | 0.4871 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.006 | 0.0082 | 0.0346 |
Mycobacterium leprae | conserved hypothetical protein | 0.0034 | 0.0021 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0021 | 0.0188 |
Wolbachia endosymbiont of Brugia malayi | signal transduction histidine kinase and receiver | 0.0047 | 0.0051 | 0.0203 |
Echinococcus multilocularis | endoplasmin | 0.0028 | 0.0007 | 0.0034 |
Brugia malayi | DNA topoisomerase III beta-1 | 0.0074 | 0.0113 | 0.1008 |
Mycobacterium ulcerans | two component regulator - sensor kinase | 0.0047 | 0.0051 | 0.0044 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0429 | 0.0938 | 0.5263 |
Leishmania major | heat shock protein 83-1 | 0.0075 | 0.0116 | 0.0615 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0075 | 0.0116 | 0.1045 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.001 | 0.0078 |
Brugia malayi | beta-lactamase | 0.0034 | 0.0021 | 0.0178 |
Trypanosoma brucei | heat shock protein, putative | 0.0075 | 0.0116 | 0.0541 |
Leishmania major | heat shock protein 83-1 | 0.0075 | 0.0116 | 0.0615 |
Schistosoma mansoni | heat shock protein | 0.0075 | 0.0116 | 0.1036 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0034 | 0.0021 | 0.0126 |
Plasmodium falciparum | DNA topoisomerase 3, putative | 0.0074 | 0.0113 | 0.0292 |
Trypanosoma brucei | heat shock protein, putative | 0.0075 | 0.0116 | 0.0541 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0034 | 0.0021 | 0.0178 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0791 | 0.1775 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0034 | 0.0021 | 0.0014 |
Mycobacterium tuberculosis | Conserved protein | 0.0034 | 0.0021 | 0.0014 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0791 | 0.1775 | 1 |
Trypanosoma cruzi | DNA topoisomerase IA, putative | 0.0074 | 0.0113 | 0.0598 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0034 | 0.0021 | 0.0178 |
Mycobacterium leprae | Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) | 0.4338 | 1 | 1 |
Loa Loa (eye worm) | endoplasmin | 0.0075 | 0.0116 | 0.1045 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0503 | 0.1108 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0961 | 0.217 | 0.2164 |
Wolbachia endosymbiont of Brugia malayi | membrane associated signal transduction histidine kinase | 0.0047 | 0.0051 | 0.0203 |
Trypanosoma brucei | heat shock protein, putative | 0.0075 | 0.0116 | 0.0541 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0791 | 0.1775 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0075 | 0.0116 | 0.0615 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0203 | 0.0413 | 0.3731 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0961 | 0.217 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0034 | 0.0021 | 0.0188 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.001 | 0.0078 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0961 | 0.217 | 0.2164 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0047 | 0.0051 | 0.045 |
Mycobacterium tuberculosis | Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) | 0.4338 | 1 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0424 | 0.0925 | 0.4246 |
Leishmania major | heat shock protein 83-1 | 0.0075 | 0.0116 | 0.0615 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0324 | 0.0693 | 0.0687 |
Echinococcus granulosus | heat shock protein 90 | 0.0028 | 0.0007 | 0.0053 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0047 | 0.0052 | 0.0253 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0034 | 0.0021 | 0.0188 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0424 | 0.0925 | 0.6794 |
Trypanosoma cruzi | DNA topoisomerase IA, putative | 0.0074 | 0.0113 | 0.0598 |
Plasmodium falciparum | endoplasmin, putative | 0.0061 | 0.0084 | 0.0158 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0075 | 0.0116 | 0.0787 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0961 | 0.217 | 1 |
Onchocerca volvulus | 0.0034 | 0.0021 | 0.0217 | |
Trichomonas vaginalis | sensory transduction histidine kinase bacterial, putative | 0.0047 | 0.0051 | 0.0399 |
Mycobacterium tuberculosis | Possible two component sensor kinase | 0.0047 | 0.0051 | 0.0044 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.001 | 0.0078 |
Trichomonas vaginalis | two component sensor and regulator histidine kinase bacteria, putative | 0.0047 | 0.0051 | 0.0399 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0021 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.0444 | 0.4008 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0025 | 0.0001 | 0.001 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0429 | 0.0938 | 0.5263 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.0047 | 0.0051 | 0.0249 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0075 | 0.0116 | 0.0615 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0503 | 0.1108 | 0.499 |
Brugia malayi | Endoplasmin precursor | 0.0075 | 0.0116 | 0.1036 |
Echinococcus granulosus | geminin | 0.016 | 0.0313 | 0.2814 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0424 | 0.0925 | 0.0919 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.0047 | 0.0051 | 0.0172 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0075 | 0.0116 | 0.0031 |
Onchocerca volvulus | 0.0034 | 0.0021 | 0.0217 | |
Echinococcus granulosus | heat shock protein 90 | 0.0075 | 0.0116 | 0.1036 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.006 | 0.0082 | 0.0422 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.001 | 0.005 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0074 | 0.0113 | 0.0598 |
Brugia malayi | beta-lactamase family protein | 0.0034 | 0.0021 | 0.0178 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0961 | 0.217 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0075 | 0.0116 | 0.0541 |
Onchocerca volvulus | 0.0034 | 0.0021 | 0.0217 | |
Echinococcus multilocularis | heat shock protein | 0.0075 | 0.0116 | 0.0669 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0961 | 0.217 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0034 | 0.0021 | 0.0014 |
Mycobacterium ulcerans | integral membrane indolylacetylinositol arabinosyltransferase EmbB | 0.4338 | 1 | 1 |
Mycobacterium ulcerans | two component system response phosphate sensor kinase, PhoR | 0.0047 | 0.0051 | 0.0044 |
Mycobacterium tuberculosis | Two component sensor histidine kinase TrcS | 0.0047 | 0.0051 | 0.0044 |
Leishmania major | heat shock protein 83-1 | 0.0075 | 0.0116 | 0.0615 |
Mycobacterium leprae | Probable two component sensor kinase MprB | 0.0047 | 0.0051 | 0.0044 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0095 | 0.0162 | 0.0524 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.006 | 0.0082 | 0.0422 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0074 | 0.0113 | 0.096 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0765 | 0.1715 | 1 |
Mycobacterium ulcerans | two component sensor kinase MprB | 0.0047 | 0.0051 | 0.0044 |
Echinococcus granulosus | heat shock protein | 0.0075 | 0.0116 | 0.1036 |
Mycobacterium ulcerans | DNA topoisomerase I | 0.0074 | 0.0113 | 0.0106 |
Leishmania major | heat shock protein 83-1 | 0.0075 | 0.0116 | 0.0615 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0034 | 0.0021 | 0.0014 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0175 | 0.0348 | 0.0341 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.0047 | 0.0051 | 0.0249 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0503 | 0.1108 | 0.6459 |
Leishmania major | DNA topoisomerase III, putative | 0.0074 | 0.0113 | 0.0598 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0074 | 0.0113 | 0.0598 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0503 | 0.1108 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0021 | 0.0188 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0034 | 0.0021 | 0.0014 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0673 | 0.1503 | 0.6851 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0429 | 0.0938 | 0.5225 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0047 | 0.0051 | 0.0291 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.