Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1704 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1243 | 0.6735 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0473 | 0.1278 | 0.1278 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0473 | 0.1278 | 0.1278 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1243 | 0.6735 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.1704 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1704 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1243 | 0.6735 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0473 | 0.1278 | 0.1278 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1243 | 0.6735 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.1704 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1704 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 0 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1704 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1704 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1243 | 0.6735 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.1704 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0473 | 0.1278 | 0.1278 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1243 | 0.6735 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0473 | 0.1278 | 0.1278 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1704 | 1 | 1 |
Onchocerca volvulus | 0.0473 | 0.1278 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.