Detailed information for compound 1858362

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 300.395 | Formula: C18H24N2O2
  • H donors: 1 H acceptors: 2 LogP: 2.43 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCC/N=C(/C1=C(O)c2c(C1=O)cccc2)\C)CC
  • InChi: 1S/C18H24N2O2/c1-4-20(5-2)12-8-11-19-13(3)16-17(21)14-9-6-7-10-15(14)18(16)22/h6-7,9-10,21H,4-5,8,11-12H2,1-3H3/b19-13+
  • InChiKey: LJAWEWFYEUZYSN-CPNJWEJPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0016 0.0036 0.0294
Mycobacterium leprae conserved hypothetical protein 0.004 0.0676 0.0766
Schistosoma mansoni hypothetical protein 0.0017 0.0079 0.0112
Loa Loa (eye worm) ctsf protein 0.0016 0.0036 0.0031
Loa Loa (eye worm) glutaminase 2 0.0277 0.699 0.6989
Schistosoma mansoni hypothetical protein 0.0017 0.0079 0.0112
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0036 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0036 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.1224 1
Mycobacterium ulcerans lipase LipD 0.004 0.0676 0.0967
Loa Loa (eye worm) hypothetical protein 0.004 0.0676 0.0671
Schistosoma mansoni tar DNA-binding protein 0.0137 0.3255 0.4657
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0036 0.0052
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0676 0.0967
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.1224 1
Plasmodium vivax vivapain-2 0.0016 0.0036 0.0494
Schistosoma mansoni hypothetical protein 0.0038 0.0619 0.0885
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0676 0.0967
Brugia malayi Smad1 0.0027 0.0321 0.0321
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0096 0.2159 0.3374
Brugia malayi Cathepsin L-like precursor 0.0016 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0055 0.1084 0.108
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0079 0.0242
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0321 0.0316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0036 0.0052
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0 0.5
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0036 0.0494
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0079 0.0079
Mycobacterium tuberculosis Probable oxidoreductase 0.0106 0.2444 0.3818
Schistosoma mansoni smad1 5 8 and 0.0027 0.0321 0.0459
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0676 0.5519
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0036 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0036 0.0052
Loa Loa (eye worm) Smad1 0.0027 0.0321 0.0316
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0619 0.0619
Plasmodium vivax glutathione reductase, putative 0.0042 0.0729 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0055 0.1084 0.8858
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0321 0.0986
Schistosoma mansoni tar DNA-binding protein 0.0137 0.3255 0.4657
Echinococcus granulosus GPCR family 2 0.0017 0.0079 0.0242
Plasmodium vivax hypothetical protein, conserved 0.004 0.0676 0.9262
Brugia malayi beta-lactamase family protein 0.004 0.0676 0.0676
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0676 0.1056
Plasmodium falciparum glutathione reductase 0.0042 0.0729 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0636 0.091
Echinococcus multilocularis cysteine protease 0.0016 0.0036 0.0111
Echinococcus granulosus smad 0.0027 0.0321 0.0986
Brugia malayi Thioredoxin reductase 0.0042 0.0729 0.0729
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.1224 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0676 0.0671
Onchocerca volvulus 0.004 0.0676 0.2153
Brugia malayi glutathione reductase 0.0042 0.0729 0.0729
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0096 0.2159 0.3374
Brugia malayi RNA recognition motif domain containing protein 0.0137 0.3255 0.3255
Plasmodium falciparum thioredoxin reductase 0.0042 0.0729 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0036 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0036 0.0052
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0036 0.0052
Brugia malayi MH1 domain containing protein 0.0015 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0036 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0137 0.3255 0.4657
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0036 0.0052
Leishmania major cathepsin L-like protease 0.0016 0.0036 0.0294
Leishmania major cathepsin L-like protease 0.0016 0.0036 0.0294
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0036 0.0052
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0321 0.0459
Leishmania major cathepsin L-like protease 0.0061 0.1224 1
Schistosoma mansoni hypothetical protein 0.0017 0.0079 0.0112
Plasmodium vivax vivapain-2 0.0016 0.0036 0.0494
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0106 0.2444 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.3007 0.3003
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0321 0.0316
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.1224 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0036 0.0052
Leishmania major cathepsin L-like protease 0.0016 0.0036 0.0294
Schistosoma mansoni tar DNA-binding protein 0.0137 0.3255 0.4657
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0676 0.1056
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0036 0.0111
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0676 0.0967
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0636 0.5197
Brugia malayi TAR-binding protein 0.0137 0.3255 0.3255
Loa Loa (eye worm) hypothetical protein 0.0017 0.0079 0.0074
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.1084 0.108
Loa Loa (eye worm) transcription factor SMAD2 0.039 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0036 0.0494
Mycobacterium tuberculosis Conserved protein 0.004 0.0676 0.1056
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0676 0.2075
Treponema pallidum NADH oxidase 0.0015 0 0.5
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0676 0.1056
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0079 0.0242
Loa Loa (eye worm) fibroinase 0.0016 0.0036 0.0031
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0321 0.0986
Schistosoma mansoni inositol monophosphatase 0.0038 0.0636 0.091
Leishmania major cathepsin L-like protease 0.0016 0.0036 0.0294
Echinococcus granulosus tar DNA binding protein 0.0137 0.3255 1
Schistosoma mansoni inositol monophosphatase 0.0038 0.0636 0.091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0036 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0036 0.0052
Brugia malayi beta-lactamase 0.004 0.0676 0.0676
Loa Loa (eye worm) MH2 domain-containing protein 0.039 1 1
Schistosoma mansoni hypothetical protein 0.0017 0.0079 0.0112
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0676 0.1056
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0676 0.0671
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0036 0.0052
Loa Loa (eye worm) glutaminase 0.0277 0.699 0.6989
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0676 0.0967
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.1224 1
Toxoplasma gondii ABC1 family protein 0.004 0.0676 0.9262
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0036 0.0494
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0636 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0036 0.0052
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0636 0.8723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0036 0.0052
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0636 0.091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0036 0.0052
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0321 0.0986
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0879 0.7183
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0676 0.0967
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0676 0.0967
Mycobacterium tuberculosis Probable reductase 0.0096 0.2159 0.3374
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.6401 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0137 0.3255 0.3252
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0676 0.1056
Loa Loa (eye worm) RNA binding protein 0.0137 0.3255 0.3252
Loa Loa (eye worm) inositol-1 0.0038 0.0636 0.0632
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0036 0.0052
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0036 0.0294
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.1084 0.1084
Brugia malayi Cathepsin L-like precursor 0.0016 0.0036 0.0036
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0636 0.5197
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0106 0.2444 0.3818
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0676 0.5519
Brugia malayi beta-lactamase family protein 0.004 0.0676 0.0676
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0042 0.0729 0.114
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0676 0.0967
Schistosoma mansoni smad1 5 8 and 0.0027 0.0321 0.0459
Loa Loa (eye worm) beta-lactamase 0.004 0.0676 0.0671
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0636 0.1955
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0676 0.5519
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.1224 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0036 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.1224 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0676 0.0671
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0744 0.2287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.1224 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0079 0.0242
Mycobacterium tuberculosis Conserved protein 0.004 0.0676 0.1056
Echinococcus multilocularis cysteine protease 0.0016 0.0036 0.0111
Onchocerca volvulus Huntingtin homolog 0.0128 0.3007 1
Leishmania major hypothetical protein, conserved 0.004 0.0676 0.5519
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0036 0.0052
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0636 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0036 0.0036
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0529 0.0827
Mycobacterium leprae Probable lipase LipE 0.004 0.0676 0.0766
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.1224 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0 0.5
Brugia malayi RNA binding protein 0.0137 0.3255 0.3255
Schistosoma mansoni smad1 5 8 and 0.0027 0.0321 0.0459
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0031
Schistosoma mansoni smad 0.0027 0.0321 0.0459
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0036 0.0111
Brugia malayi Cathepsin L-like precursor 0.0016 0.0036 0.0036
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0079 0.0242
Trichomonas vaginalis glutaminase, putative 0.0277 0.699 1
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0729 1
Loa Loa (eye worm) glutathione reductase 0.0042 0.0729 0.0725
Echinococcus granulosus Smad4 0.0027 0.0321 0.0986
Mycobacterium ulcerans glutaminase 0.0277 0.699 1
Brugia malayi hypothetical protein 0.0128 0.3007 0.3007
Mycobacterium ulcerans hypothetical protein 0.004 0.0676 0.0967
Leishmania major trypanothione reductase 0.0042 0.0729 0.5958
Echinococcus multilocularis GPCR, family 2 0.0017 0.0079 0.0242
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0096 0.2159 0.8516
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0729 0.0725
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0036 0.0052
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0096 0.2159 0.3374
Toxoplasma gondii thioredoxin reductase 0.0042 0.0729 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.1084 0.1084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0036 0.0052
Brugia malayi MH1 domain containing protein 0.0027 0.0321 0.0321
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0096 0.2159 0.3374
Schistosoma mansoni Smad4 0.0027 0.0321 0.0459
Echinococcus granulosus cathepsin l1 0.0016 0.0036 0.0111
Schistosoma mansoni tar DNA-binding protein 0.0137 0.3255 0.4657
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0676 0.1056
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0636 0.091
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0321 0.0986
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.1224 1
Toxoplasma gondii cathepsin CPL 0.0016 0.0036 0.0494
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0036 0.0111
Echinococcus multilocularis smad 0.0027 0.0321 0.0986
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0729 0.5958
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.1224 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0079 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.1224 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0676 0.1056
Brugia malayi MH1 domain containing protein 0.0015 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.004 0.0676 0.0671
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0079 0.0079
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0636 0.1955
Brugia malayi Cathepsin L-like precursor 0.0016 0.0036 0.0036
Loa Loa (eye worm) TAR-binding protein 0.0137 0.3255 0.3252
Onchocerca volvulus 0.004 0.0676 0.2153
Mycobacterium tuberculosis Probable dehydrogenase 0.0096 0.2159 0.3374
Echinococcus multilocularis Smad4 0.0027 0.0321 0.0986
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0636 0.5197
Echinococcus multilocularis tar DNA binding protein 0.0137 0.3255 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0676 0.0676
Brugia malayi Cathepsin L-like precursor 0.0016 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0036 0.0052
Leishmania major cathepsin L-like protease 0.0061 0.1224 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0061 0.1224 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0636 0.091
Trichomonas vaginalis esterase, putative 0.004 0.0676 0.0967
Brugia malayi glutaminase DH11.1 0.0277 0.699 0.699
Mycobacterium ulcerans beta-lactamase 0.004 0.0676 0.0967
Brugia malayi MH1 domain containing protein 0.0027 0.0321 0.0321
Trypanosoma brucei trypanothione reductase 0.0042 0.0729 0.5958
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0036 0.0111
Onchocerca volvulus Huntingtin homolog 0.0128 0.3007 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0106 0.2444 0.3818
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0744 0.2287
Mycobacterium tuberculosis Conserved protein 0.004 0.0676 0.1056
Loa Loa (eye worm) hypothetical protein 0.0128 0.3007 0.3003
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0036 0.0052
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0036 0.0294
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0636 0.5197
Schistosoma mansoni glutaminase 0.0277 0.699 1
Loa Loa (eye worm) cysteine protease 0.0016 0.0036 0.0031
Loa Loa (eye worm) hypothetical protein 0.004 0.0676 0.0671
Brugia malayi MH2 domain containing protein 0.0027 0.0321 0.0321
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0036 0.0036
Onchocerca volvulus 0.004 0.0676 0.2153
Loa Loa (eye worm) hypothetical protein 0.0038 0.0619 0.0614
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0676 0.2075
Trypanosoma cruzi cruzipain precursor, putative 0.0061 0.1224 1
Brugia malayi Inositol-1 0.0038 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.004 0.0676 0.0671
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0036 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0036 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0036 0.0052
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0676 0.0967
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.1224 1
Brugia malayi MH2 domain containing protein 0.0027 0.0321 0.0321
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0036 0.0052
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0676 0.0967
Leishmania major cathepsin L-like protease 0.0061 0.1224 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0036 0.0111

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) 20 uM PubChem BioAssay. Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0262 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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