Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.0076 | 0.6004 | 0.6004 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6004 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6004 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.6004 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1767 | 0.1767 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1767 | 0.2943 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6004 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6004 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1767 | 0.1767 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.6004 | 0.6004 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.6004 | 0.6004 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.6004 | 0.6004 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.3289 | 0.3289 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6004 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.6004 | 0.6004 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.6004 | 0.6004 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.6004 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.3289 | 0.3289 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.