Detailed information for compound 1858650

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 417.671 | Formula: C26H47N3O
  • H donors: 0 H acceptors: 0 LogP: 5.91 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCCCN1CCN(CC1)CCCCCCCCCOc1ccccc1)C
  • InChi: 1S/C26H47N3O/c1-3-27(2)18-13-14-20-29-23-21-28(22-24-29)19-12-7-5-4-6-8-15-25-30-26-16-10-9-11-17-26/h9-11,16-17H,3-8,12-15,18-25H2,1-2H3
  • InChiKey: XJZONJKJCXUGHY-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ap endonuclease 0.0018 0.0006 0.0053
Schistosoma mansoni endoplasmin 0.0072 0.0137 0.1214
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.0042 0.0373
Loa Loa (eye worm) hypothetical protein 0.0035 0.0047 0.042
Plasmodium falciparum heat shock protein 90 0.0072 0.0137 0.0626
Leishmania major heat shock protein 83-1 0.0072 0.0137 0.0763
Trypanosoma brucei developmentally regulated phosphoprotein 0.0045 0.0072 0.037
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0028 0.0157
Echinococcus multilocularis rho GTPase activating protein 20 0.0071 0.0134 0.0772
Leishmania major heat shock protein 83-1 0.0072 0.0137 0.0763
Leishmania major developmentally regulated phosphoprotein-like protein 0.0045 0.0072 0.0402
Entamoeba histolytica heat shock protein 90, putative 0.0072 0.0137 0.1214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0103 0.0541
Brugia malayi glutaminase DH11.1 0.0249 0.056 0.4967
Trichomonas vaginalis glutaminase, putative 0.0249 0.056 0.4967
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0042 0.0234
Toxoplasma gondii heat shock protein 90, putative 0.0072 0.0137 0.0994
Trypanosoma cruzi Heat shock protein 83, putative 0.0072 0.0137 0.0763
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.041 0.0944 0.6866
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.093 0.2186 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0033 0.0042 0.0036
Mycobacterium ulcerans beta-lactamase 0.0033 0.0042 0.0036
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0045 0.0072 0.0066
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0045 0.0072 0.0303
Toxoplasma gondii exonuclease III APE 0.0018 0.0006 0.0043
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0006 0.0053
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0197 0.0434 0.3849
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.041 0.0944 0.0939
Mycobacterium ulcerans two component regulator - sensor kinase 0.0045 0.0072 0.0066
Chlamydia trachomatis DNA gyrase subunit A 0.0092 0.0183 0.0524
Schistosoma mansoni heat shock protein 0.0072 0.0137 0.1214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0103 0.0541
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.0042 0.0373
Trypanosoma brucei DNA topoisomerase IA, putative 0.0071 0.0134 0.0715
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.0042 0.0373
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0031 0.0274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0103 0.0541
Echinococcus multilocularis heat shock protein 90 0.0027 0.0028 0.0163
Trichomonas vaginalis receptor histidine kinase, putative 0.0045 0.0072 0.0639
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0028 0.0252
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0071 0.0134 0.0586
Leishmania major DNA topoisomerase III, putative 0.0071 0.0134 0.0746
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 0.4198 1 1
Brugia malayi intermediate filament protein 0.0025 0.0022 0.0198
Trypanosoma brucei heat shock protein, putative 0.0072 0.0137 0.0732
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0031 0.0179
Plasmodium vivax hypothetical protein, conserved 0.0045 0.0072 0.033
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0045 0.0072 0.0066
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0028 0.025
Mycobacterium tuberculosis Conserved protein 0.0033 0.0042 0.0036
Mycobacterium ulcerans esterase/lipase LipP 0.0033 0.0042 0.0036
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0071 0.0134 0.0106
Trichomonas vaginalis DNA topoisomerase II, putative 0.0487 0.1127 1
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0045 0.0072 0.0416
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0006 0.0027
Onchocerca volvulus 0.0025 0.0022 0.024
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0042 0.0192
Trichomonas vaginalis esterase, putative 0.0033 0.0042 0.0373
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0028 0.025
Echinococcus granulosus geminin 0.0155 0.0333 0.2956
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0415 0.0957 0.5322
Plasmodium vivax DNA topoisomerase 3, putative 0.0071 0.0134 0.0612
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0045 0.0072 0.0066
Chlamydia trachomatis DNA gyrase subunit B 0.093 0.2186 1
Leishmania major heat shock protein 83-1 0.0072 0.0137 0.0763
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.0042 0.0373
Leishmania major heat shock protein 83-1 0.0072 0.0137 0.0763
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0591 0.1376 1
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0045 0.0072 0.0416
Trypanosoma brucei heat shock protein 90, putative 0.0072 0.0137 0.0732
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) 0.4198 1 1
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0045 0.0072 0.0639
Loa Loa (eye worm) glutaminase 0.0249 0.056 0.4967
Trypanosoma cruzi heat shock protein 85, putative 0.0072 0.0137 0.0763
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0006 0.0053
Brugia malayi Pre-SET motif family protein 0.0028 0.0031 0.0274
Leishmania major mitochondrial DNA topoisomerase II 0.0765 0.1793 1
Mycobacterium tuberculosis Probable two component sensor kinase 0.0045 0.0072 0.0066
Mycobacterium tuberculosis Conserved protein 0.0045 0.0072 0.0066
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0071 0.0134 0.1186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0103 0.0541
Brugia malayi Pre-SET motif family protein 0.0197 0.0434 0.3849
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.041 0.0944 0.4304
Echinococcus multilocularis endoplasmin 0.0027 0.0028 0.0163
Mycobacterium tuberculosis Probable hydrolase 0.0033 0.0042 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0103 0.0541
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0415 0.0957 0.5322
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0071 0.0134 0.0746
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0027 0.0028 0.0102
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0045 0.0072 0.0066
Trypanosoma cruzi DNA topoisomerase II, putative 0.0415 0.0957 0.5337
Echinococcus multilocularis musashi 0.0025 0.0022 0.0129
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0006 0.0034
Mycobacterium ulcerans two component sensor kinase MprB 0.0045 0.0072 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0031 0.0274
Trypanosoma cruzi heat shock protein 85, putative 0.0072 0.0137 0.0763
Leishmania major heat shock protein 83-1 0.0072 0.0137 0.0763
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0025 0.0022 0.0198
Leishmania major heat shock protein 83-1 0.0072 0.0137 0.0763
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0045 0.0072 0.0066
Mycobacterium ulcerans DNA gyrase subunit A 0.041 0.0944 0.0939
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0006 0.0053
Loa Loa (eye worm) intermediate filament protein 0.0025 0.0022 0.0198
Toxoplasma gondii ABC1 family protein 0.0033 0.0042 0.0305
Brugia malayi beta-lactamase 0.0033 0.0042 0.0373
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0045 0.0072 0.0524
Echinococcus multilocularis heat shock protein 0.0072 0.0137 0.079
Trypanosoma brucei heat shock protein, putative 0.0072 0.0137 0.0732
Schistosoma mansoni hypothetical protein 0.0155 0.0333 0.2956
Onchocerca volvulus 0.0028 0.0031 0.0333
Schistosoma mansoni lamin 0.0025 0.0022 0.0198
Onchocerca volvulus 0.0224 0.0499 0.5367
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0045 0.0072 0.0639
Mycobacterium ulcerans DNA topoisomerase I 0.0071 0.0134 0.0128
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0045 0.0072 0.0066
Entamoeba histolytica DNA topoisomerase III, putative 0.0071 0.0134 0.1186
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0071 0.0134 0.1186
Trypanosoma brucei Heat shock protein 83, putative 0.0072 0.0137 0.0732
Trichomonas vaginalis receptor histidine kinase, putative 0.0045 0.0072 0.0639
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0045 0.0072 0.0066
Schistosoma mansoni ap endonuclease 0.0018 0.0006 0.0053
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0027 0.0028 0.0022
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0071 0.0134 0.1186
Trypanosoma cruzi heat shock protein 90, putative 0.0072 0.0137 0.0763
Loa Loa (eye worm) hypothetical protein 0.0241 0.054 0.4788
Echinococcus multilocularis beta LACTamase domain containing family member 0.0033 0.0042 0.0243
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0045 0.0072 0.0066
Echinococcus multilocularis lamin 0.0025 0.0022 0.0129
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0031 0.0225
Schistosoma mansoni pyruvate dehydrogenase 0.0045 0.0072 0.0639
Trichomonas vaginalis sensor histidine kinase, putative 0.0045 0.0072 0.0639
Plasmodium vivax DNA gyrase subunit A, putative 0.041 0.0944 0.432
Mycobacterium ulcerans DNA gyrase subunit B 0.093 0.2186 0.2181
Brugia malayi GRF zinc finger family protein 0.0071 0.0134 0.1186
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbB 0.4198 1 1
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0765 0.1793 1
Echinococcus multilocularis geminin 0.0155 0.0333 0.1923
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0045 0.0072 0.033
Leishmania major hypothetical protein, conserved 0.0033 0.0042 0.0234
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0071 0.0134 0.0746
Mycobacterium ulcerans glutaminase 0.0249 0.056 0.0554
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0006 0.0053
Leishmania major heat shock protein 83-1 0.0072 0.0137 0.0763
Echinococcus granulosus beta LACTamase domain containing family member 0.0033 0.0042 0.0373
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0071 0.0134 0.0972
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0765 0.1793 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0033 0.0042 0.0373
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.041 0.0944 0.4304
Loa Loa (eye worm) glutaminase 2 0.0249 0.056 0.4967
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0045 0.0072 0.0044
Schistosoma mansoni endoplasmin 0.0072 0.0137 0.1214
Leishmania major hypothetical protein, conserved 0.0045 0.0072 0.0402
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0006 0.0053
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.0031 0.0274
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0188
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0071 0.0134 0.1186
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0006 0.0033
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.0028 0.0157
Leishmania major heat shock protein 83-1 0.0072 0.0137 0.0763
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0045 0.0072 0.0066
Loa Loa (eye worm) TOPoisomerase family member 0.0487 0.1127 1
Mycobacterium ulcerans putative regultory protein 0.0045 0.0072 0.0066
Plasmodium vivax DNA topoisomerase II, putative 0.0487 0.1127 0.5155
Trypanosoma cruzi cruzipain precursor, putative 0.0058 0.0103 0.0573
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0006 0.0033
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0053 0.0091 0.0505
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0033 0.0042 0.0036
Mycobacterium tuberculosis Probable lipase LipD 0.0033 0.0042 0.0036
Trypanosoma brucei DNA topoisomerase III, putative 0.0071 0.0134 0.0715
Onchocerca volvulus 0.0033 0.0042 0.0452
Echinococcus multilocularis lamin dm0 0.0025 0.0022 0.0129
Trypanosoma cruzi heat shock protein 90, putative 0.0059 0.0103 0.0577
Loa Loa (eye worm) hypothetical protein 0.021 0.0464 0.4121
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0028 0.025
Onchocerca volvulus 0.0033 0.0042 0.0452
Mycobacterium leprae Probable lipase LipE 0.0033 0.0042 0.0014
Toxoplasma gondii DNA topoisomerase family protein 0.0071 0.0134 0.0972
Toxoplasma gondii heat shock protein HSP90 0.0072 0.0137 0.0994
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0071 0.0134 0.1186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0103 0.0541
Loa Loa (eye worm) hypothetical protein 0.0035 0.0047 0.042
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0045 0.0072 0.0066
Trypanosoma brucei heat shock protein, putative 0.0072 0.0137 0.0732
Leishmania major heat shock protein 83-1 0.0072 0.0137 0.0763
Echinococcus granulosus endoplasmin 0.0027 0.0028 0.025
Brugia malayi DNA topoisomerase III beta-1 0.0071 0.0134 0.1186
Mycobacterium leprae Probable two-component sensor kinase 0.0045 0.0072 0.0044
Giardia lamblia DNA topoisomerase II 0.0441 0.1018 1
Brugia malayi Endoplasmin precursor 0.0072 0.0137 0.1214
Loa Loa (eye worm) beta-lactamase 0.0033 0.0042 0.0373
Leishmania major DNA topoisomerase ii 0.0415 0.0957 0.5337
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0045 0.0072 0.0066
Chlamydia trachomatis DNA topoisomerase I 0.0071 0.0134 0.0292
Giardia lamblia Heat shock protein HSP 90-alpha 0.0072 0.0137 0.1292
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0031 0.0274
Mycobacterium leprae Probable two component sensor kinase MprB 0.0045 0.0072 0.0044
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbA 0.4198 1 1
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0045 0.0072 0.0066
Mycobacterium tuberculosis Possible penicillin-binding protein 0.021 0.0465 0.046
Chlamydia trachomatis DNA gyrase subunit A 0.041 0.0944 0.4126
Mycobacterium tuberculosis Conserved protein 0.0033 0.0042 0.0036
Trypanosoma brucei heat shock protein, putative 0.0072 0.0137 0.0732
Plasmodium vivax endoplasmin, putative 0.0072 0.0137 0.0626
Mycobacterium tuberculosis Conserved protein 0.0033 0.0042 0.0036
Loa Loa (eye worm) hypothetical protein 0.0033 0.0042 0.0373
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0404 0.0929 1
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0028 0.0157
Mycobacterium leprae conserved hypothetical protein 0.0033 0.0042 0.0014
Schistosoma mansoni DNA topoisomerase II 0.0487 0.1127 1
Entamoeba histolytica heat shock protein 90, putative 0.0072 0.0137 0.1214
Treponema pallidum heat shock protein 90 0.0027 0.0028 0.0102
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0006 0.0053
Mycobacterium tuberculosis Possible two component sensor kinase 0.0045 0.0072 0.0066
Echinococcus multilocularis heat shock protein 90 0.0072 0.0137 0.079
Plasmodium falciparum DNA gyrase subunit A 0.041 0.0944 0.432
Loa Loa (eye worm) hypothetical protein 0.0033 0.0042 0.0373
Echinococcus granulosus lamin 0.0025 0.0022 0.0198
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0006 0.0033
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0313 0.0713 0.0687
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0045 0.0072 0.0066
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0006 0.0027
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0487 0.1127 1
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0042 0.0202
Plasmodium falciparum DNA topoisomerase 3, putative 0.0071 0.0134 0.0612
Onchocerca volvulus 0.0025 0.0022 0.024
Plasmodium vivax DNA gyrase subunit B, putative 0.093 0.2186 1
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.0284 0.2518
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0103 0.0541
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0045 0.0072 0.0524
Loa Loa (eye worm) hypothetical protein 0.0241 0.054 0.4788
Leishmania major DNA topoisomerase III, putative 0.0071 0.0134 0.0746
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0045 0.0072 0.037
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0198
Trypanosoma brucei heat shock protein, putative 0.0072 0.0137 0.0732
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0033 0.0042 0.0373
Leishmania major DNA topoisomerase 1A 0.0071 0.0134 0.0746
Giardia lamblia DNA topoisomerase III 0.0071 0.0134 0.1262
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0404 0.0929 1
Giardia lamblia Pms1-like protein 0.0045 0.0072 0.0653
Brugia malayi Intermediate filament tail domain containing protein 0.0025 0.0022 0.0198
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 0.4198 1 1
Chlamydia trachomatis DNA gyrase subunit B 0.0651 0.1521 0.6851
Schistosoma mansoni glutaminase 0.0249 0.056 0.4967
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0033 0.0042 0.0373
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0033 0.0042 0.0036
Plasmodium vivax heat shock protein 86, putative 0.0072 0.0137 0.0626
Trypanosoma brucei DNA topoisomerase III, putative 0.0071 0.0134 0.0715
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0045 0.0072 0.0066
Treponema pallidum DNA topoisomerase I (topA) 0.0071 0.0134 0.0586
Echinococcus granulosus heat shock protein 0.0072 0.0137 0.1214
Plasmodium falciparum DNA gyrase subunit B 0.093 0.2186 1
Leishmania major cathepsin L-like protease 0.0058 0.0103 0.0573
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0045 0.0072 0.0639
Giardia lamblia DNA topoisomerase III 0.0071 0.0134 0.1262
Schistosoma mansoni intermediate filament proteins 0.0025 0.0022 0.0198
Trichomonas vaginalis penicillin-binding protein, putative 0.0033 0.0042 0.0373
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0045 0.0072 0.0044
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0045 0.0072 0.0303
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.074 0.1733 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0072 0.0639
Loa Loa (eye worm) hypothetical protein 0.0033 0.0042 0.0373
Onchocerca volvulus 0.0071 0.0134 0.1439
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0487 0.1127 1
Leishmania major heat shock protein 83-1 0.0072 0.0137 0.0763
Leishmania major heat shock protein 83-1 0.0072 0.0137 0.0763
Brugia malayi kinase, mitochondrial precursor 0.0045 0.0072 0.0639
Echinococcus granulosus heat shock protein 90 0.0027 0.0028 0.025
Trypanosoma brucei DNA topoisomerase ii 0.0765 0.1793 1
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0045 0.0072 0.0402
Loa Loa (eye worm) hypothetical protein 0.0035 0.0047 0.042
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 0.4198 1 1
Loa Loa (eye worm) heat shock protein 90 0.0072 0.0137 0.1214
Mycobacterium ulcerans heat shock protein 90 0.0027 0.0028 0.0022
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0045 0.0072 0.0402
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0045 0.0072 0.0066
Loa Loa (eye worm) hypothetical protein 0.0033 0.0042 0.0373
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0071 0.0134 0.1186
Entamoeba histolytica DNA topoisomerase III, putative 0.0071 0.0134 0.1186
Brugia malayi beta-lactamase family protein 0.0033 0.0042 0.0373
Leishmania major cathepsin L-like protease 0.0058 0.0103 0.0573
Leishmania major heat shock protein 83-1 0.0072 0.0137 0.0763
Loa Loa (eye worm) hypothetical protein 0.0028 0.0031 0.0274
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0103 0.0573
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0487 0.1127 1
Loa Loa (eye worm) endoplasmin 0.0072 0.0137 0.1214
Brugia malayi Probable DNA topoisomerase II 0.0487 0.1127 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0042 0.0373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0103 0.0541
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0103 0.0541
Mycobacterium tuberculosis Probable lipase LipE 0.0033 0.0042 0.0036
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0045 0.0072 0.0639
Plasmodium vivax SET domain protein, putative 0.0028 0.0031 0.0141
Schistosoma mansoni hypothetical protein 0.0155 0.0333 0.2956
Loa Loa (eye worm) hypothetical protein 0.021 0.0464 0.4121
Loa Loa (eye worm) hypothetical protein 0.0033 0.0042 0.0373
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0071 0.0134 0.0772
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.0031 0.0179
Trichomonas vaginalis heat shock protein, putative 0.0059 0.0105 0.0935
Mycobacterium ulcerans hypothetical protein 0.0033 0.0042 0.0036
Leishmania major heat shock protein 83-1 0.0072 0.0137 0.0763
Trypanosoma brucei heat shock protein 90, putative 0.0072 0.0137 0.0732
Leishmania major heat shock protein 83-1 0.0072 0.0137 0.0763
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.0042 0.0373
Plasmodium falciparum DNA topoisomerase 2 0.0487 0.1127 0.5155
Echinococcus granulosus lamin dm0 0.0025 0.0022 0.0198
Trypanosoma brucei heat shock protein, putative 0.0072 0.0137 0.0732
Trichomonas vaginalis set domain proteins, putative 0.0224 0.0499 0.4426
Brugia malayi heat shock protein 90 0.0072 0.0137 0.1214
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0033 0.0042 0.0036
Mycobacterium tuberculosis Probable esterase LipL 0.0033 0.0042 0.0036
Trichomonas vaginalis heat shock protein, putative 0.0072 0.0137 0.1214
Echinococcus granulosus intermediate filament protein 0.0025 0.0022 0.0198
Mycobacterium ulcerans lipase LipD 0.0033 0.0042 0.0036
Schistosoma mansoni lamin 0.0025 0.0022 0.0198
Echinococcus granulosus heat shock protein 90 0.0072 0.0137 0.1214
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0045 0.0072 0.0066
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0045 0.0072 0.0639
Leishmania major heat shock protein 83-1 0.0072 0.0137 0.0763
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0487 0.1127 0.6505
Trypanosoma cruzi heat shock protein 85, putative 0.0072 0.0137 0.0763
Trypanosoma cruzi DNA topoisomerase II, putative 0.0415 0.0957 0.5337
Plasmodium falciparum endoplasmin, putative 0.0059 0.0105 0.0482
Leishmania major heat shock protein 83-1 0.0072 0.0137 0.0763
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbC 0.4198 1 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0028 0.022
Trichomonas vaginalis endoplasmin, putative 0.0059 0.0105 0.0935
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0169 0.0369 0.0341
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0103 0.0573
Schistosoma mansoni heat shock protein 0.0072 0.0137 0.1214
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0103 0.0573
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0042 0.0234
Trypanosoma cruzi DNA topoisomerase III, putative 0.0071 0.0134 0.0746
Leishmania major cathepsin L-like protease 0.0058 0.0103 0.0573
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0103 0.0541
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0045 0.0072 0.0639
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0404 0.0929 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0046 0.0073 0.0406
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0071 0.0134 0.1186
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0045 0.0072 0.0066
Brugia malayi MH2 domain containing protein 0.0134 0.0284 0.2518
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 0.4198 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0031 0.0274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0103 0.0541
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.093 0.2186 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.0028 0.025
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.093 0.2186 0.2181
Entamoeba histolytica DNA topoisomerase II, putative 0.0487 0.1127 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.0284 0.2518
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0045 0.0072 0.0066
Brugia malayi DNA topoisomerase III 0.0071 0.0134 0.1186
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0045 0.0072 0.0303
Trypanosoma cruzi DNA topoisomerase III, putative 0.0071 0.0134 0.0746
Toxoplasma gondii DNA topoisomerase 2, putative 0.0487 0.1127 0.8193
Onchocerca volvulus 0.0033 0.0042 0.0452
Trypanosoma cruzi DNA topoisomerase III, putative 0.0071 0.0134 0.0746
Loa Loa (eye worm) DNA topoisomerase III 0.0071 0.0134 0.1186
Brugia malayi beta-lactamase family protein 0.0033 0.0042 0.0373
Giardia lamblia Grp94/Hsp90 0.0027 0.0028 0.022
Trypanosoma brucei heat shock protein, putative 0.0072 0.0137 0.0732
Leishmania major heat shock protein 83-1 0.0072 0.0137 0.0763
Trypanosoma brucei heat shock protein, putative 0.0072 0.0137 0.0732

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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