Detailed information for compound 1859029

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 332.298 | Formula: C13H11F3N2O3S
  • H donors: 1 H acceptors: 3 LogP: 2.51 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C1CC(=O)N(/C(=N\c2cccc(c2)C(F)(F)F)/S1)C
  • InChi: 1S/C13H11F3N2O3S/c1-18-10(19)6-9(11(20)21)22-12(18)17-8-4-2-3-7(5-8)13(14,15)16/h2-5,9H,6H2,1H3,(H,20,21)/b17-12+
  • InChiKey: YFUCTAGBQAOWKN-SFQUDFHCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.1028 0.0941
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.1946 0.1946
Echinococcus granulosus zinc finger protein 0.0026 0.1328 0.1269
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.1946 0.5
Entamoeba histolytica protein kinase rad3, putative 0.0012 0.0169 0.0182
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0021 0.09 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0021 0.09 0.0801
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.1946 0.1899
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.4114 0.4319
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0021 0.09 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Echinococcus multilocularis 6 phosphofructokinase 0.0127 0.9303 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0127 0.9303 1
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0862 0.0758
Loa Loa (eye worm) hypothetical protein 0.0048 0.3001 0.31
Schistosoma mansoni hypothetical protein 0.0018 0.0642 0.0642
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0375 0.0225
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0375 0.0225
Leishmania major ATP-dependent phosphofructokinase 0.0127 0.9303 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.1028 0.0941
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.09 0.0801
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.3196 0.3314
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.4114 0.4319
Echinococcus granulosus fetal alzheimer antigen falz 0.003 0.1604 0.157
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.3196 0.3314
Schistosoma mansoni hypothetical protein 0.0024 0.1137 0.1137
Schistosoma mansoni cpg binding protein 0.007 0.4771 0.4771
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.4114 0.4364
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.1028 0.0941
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0375 0.0225
Toxoplasma gondii exonuclease III APE 0.0023 0.1028 0.0854
Brugia malayi 6-phosphofructokinase 0.0127 0.9303 1
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.1946 0.1946
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0375 0.0225
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.4114 0.4319
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0375 0.0225
Trypanosoma brucei ISWI complex protein 0.0018 0.0642 0.0404
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.1028 0.0941
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0277 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.9303 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.09 0.0801
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0277 0.0118
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0805 0.0805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Echinococcus multilocularis fetal alzheimer antigen, falz 0.003 0.1604 0.157
Schistosoma mansoni cpg binding protein 0.007 0.4771 0.4771
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0021 0.09 0.069
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0021 0.09 0.069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.1946 0.1946
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.4304 0.4527
Loa Loa (eye worm) hypothetical protein 0.0053 0.3468 0.3611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0021 0.09 0.0298
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.1028 0.0941
Schistosoma mansoni 6-phosphofructokinase 0.0127 0.9303 0.9303
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.4114 0.4009
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0805 0.0805
Brugia malayi PHD-finger family protein 0.0033 0.1823 0.1811
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.1028 0.0941
Trichomonas vaginalis helicase, putative 0.0014 0.0375 0.0225
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0021 0.09 0.069
Mycobacterium ulcerans 6-phosphofructokinase 0.0127 0.9303 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.003 0.1604 0.1604
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.1028 0.0446
Loa Loa (eye worm) hypothetical protein 0.0013 0.0277 0.0118
Echinococcus multilocularis zinc finger protein 0.0026 0.1328 0.1269
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0127 0.9303 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.1028 0.1106
Trypanosoma cruzi ISWI complex protein 0.0018 0.0642 0.0518
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.4114 0.4319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.1028 0.5284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0375 0.0225
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.3196 0.3314
Trypanosoma cruzi target of rapamycin kinase 3 0.0021 0.09 0.0801
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.1946 0.2092
Onchocerca volvulus 0.0064 0.4304 0.5
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.1946 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0127 0.9303 1
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.9303 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0124 0.9068 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.5049 0.5343
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.4114 0.4319
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.09 0.0801
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0021 0.09 0.09
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0795 0.0685
Loa Loa (eye worm) histone methyltransferase 0.002 0.0795 0.0685
Brugia malayi phosphofructokinase 0.0127 0.9303 1
Schistosoma mansoni zinc finger protein 0.0026 0.1328 0.1328
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0486 0.0486
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0795 0.0685
Schistosoma mansoni zinc finger protein 0.0018 0.0642 0.0642
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0375 0.0225
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.09 0.0801
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.09 0.0801
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0375 0.0225
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.4114 0.4319
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0029 0.1527 0.1486
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0021 0.09 0.0801
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0904 0.0804
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0012 0.0169 0.0182
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0127 0.9303 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0486 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0375 0.0225
Echinococcus multilocularis serine protein kinase ATM 0.0029 0.1527 0.1486
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0486 0.0346
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.1946 0.3255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Schistosoma mansoni 6-phosphofructokinase 0.0127 0.9303 0.9303
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.3196 0.3314
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.9303 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0021 0.09 0.09
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0029 0.1527 0.1527
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.1946 1
Brugia malayi 6-phosphofructokinase 0.0127 0.9303 1
Schistosoma mansoni ap endonuclease 0.0023 0.1028 0.1028
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.2555 0.2612
Echinococcus granulosus cpg binding protein 0.007 0.4771 0.5038
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0916 0.0817
Brugia malayi Bromodomain containing protein 0.0045 0.2775 0.2853
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0916 0.0916
Brugia malayi CXXC zinc finger family protein 0.0064 0.4304 0.4527
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0021 0.09 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0375 0.0225
Leishmania major phosphatidylinositol kinase related protein, putative 0.0021 0.0904 0.0302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0021 0.09 0.0968
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.9303 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.1946 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.2555 0.2612
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0021 0.09 0.0298
Loa Loa (eye worm) 6-phosphofructokinase 0.0127 0.9303 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.4114 0.4251
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0805 0.0696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.3196 0.3196
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.4114 0.4009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0375 0.0225
Brugia malayi MAP kinase sur-1 0.0062 0.4114 0.4319
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.3196 0.3314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Schistosoma mansoni cpg binding protein 0.0064 0.4304 0.4304
Echinococcus granulosus 6 phosphofructokinase 0.0127 0.9303 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0916 0.0916
Loa Loa (eye worm) hypothetical protein 0.0021 0.0916 0.0817
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0952 0.0857
Entamoeba histolytica hypothetical protein 0.0029 0.1527 0.1641
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.09 0.0801
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.3196 0.3196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.4114 0.4114
Echinococcus granulosus serine protein kinase ATM 0.0029 0.1527 0.1486
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.9303 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Toxoplasma gondii FATC domain-containing protein 0.0029 0.1527 0.1421
Schistosoma mansoni bromodomain containing protein 0.0077 0.5381 0.5381
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0029 0.1527 0.1384
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.1028 0.0398
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.3196 0.3314
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0021 0.09 0.0298
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.1946 0.1946
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.1946 0.1899
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0021 0.09 0.069
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.4114 0.4319
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0375 0.0225
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.4114 0.4319
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.1946 0.1946
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.1028 0.0941
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0127 0.9303 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0805 0.0696
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0375 0.0225
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0021 0.09 0.0801
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.1137 0.1059
Trypanosoma brucei protein kinase, putative 0.0062 0.4114 0.4251
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.1946 0.1109
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0021 0.09 0.069
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0375 0.0225
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0486 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Loa Loa (eye worm) phosphofructokinase 0.0127 0.9303 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0375 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0375 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0375 0.0225
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.1946 1
Trypanosoma cruzi ISWI complex protein 0.0018 0.0642 0.0518
Leishmania major phosphatidylinositol 3-kinase, putative 0.0021 0.09 0.0298
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.4114 0.4319
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.1028 0.0832
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.4114 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0021 0.09 0.0968
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.1204 0.1133
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0021 0.09 0.0801
Loa Loa (eye worm) hypothetical protein 0.0025 0.1204 0.1133
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.4114 0.4319
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.1946 0.1899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Echinococcus multilocularis cpg binding protein 0.007 0.4771 0.5038
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0916 0.0817
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.9303 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.1028 0.0941
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.4114 0.4319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.1946 0.1946
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.09 0.0801
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.1946 0.1946
Schistosoma mansoni fkbp-rapamycin associated protein 0.0012 0.0169 0.0169
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0029 0.1527 0.1486
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.9303 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.3196 0.3196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.1527 0.1486
Brugia malayi Bromodomain containing protein 0.0091 0.6468 0.6896
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.4114 0.4319
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.4114 0.4319
Schistosoma mansoni ap endonuclease 0.0023 0.1028 0.1028
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.1946 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0127 0.9303 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0021 0.09 0.0709
Loa Loa (eye worm) hypothetical protein 0.0045 0.2781 0.286
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.1028 0.5
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0486 0.0346
Loa Loa (eye worm) hypothetical protein 0.0083 0.5781 0.6145
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.5049 0.5343

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0032 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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