Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | muscleblind protein | 0.018 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.1007 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3769 | 0.3561 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0324 | 0.0324 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.1007 | 0.0706 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.7828 | 0.7755 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.7828 | 0.7755 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.7828 | 0.7755 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3769 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0324 | 0.0324 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.1007 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3769 | 0.3769 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3769 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3769 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1649 | 0.4376 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3769 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1649 | 0.137 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3769 | 0.3561 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0324 | 0.0324 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0324 | 0.0859 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1007 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0324 | 0.0324 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1007 | 0.0706 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1007 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2792 | 0.2551 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3769 | 0.3561 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3769 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0324 | 0.0859 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3769 | 0.3561 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2792 | 0.2551 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3769 | 0.3769 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0324 | 0.0859 |
Brugia malayi | hypothetical protein | 0.002 | 0.036 | 0.0037 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3769 | 0.3561 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1649 | 0.137 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.1007 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0324 | 0.0859 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0324 | 0.0324 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.1007 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.1007 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2792 | 0.2551 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.1007 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3769 | 0.3561 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2792 | 0.2551 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0324 | 0.0324 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1413 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 10.3225 uM | PubChem BioAssay. qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | 12.5893 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.