Detailed information for compound 1859296

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 467.518 | Formula: C24H29N5O5
  • H donors: 1 H acceptors: 3 LogP: 3.56 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(o1)C(=O)N1CCN([C@@H]2[C@@H]1CCCC2)c1nc(N)c2c(n1)cc(c(c2)OC)OC
  • InChi: 1S/C24H29N5O5/c1-31-19-12-14-15(13-20(19)32-2)26-24(27-22(14)25)29-11-10-28(16-6-4-5-7-17(16)29)23(30)18-8-9-21(33-3)34-18/h8-9,12-13,16-17H,4-7,10-11H2,1-3H3,(H2,25,26,27)/t16-,17-/m0/s1
  • InChiKey: YPZGDVOCTNSNRN-IRXDYDNUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0574 0.9287 1
Brugia malayi Nuclear hormone receptor-like 1 0.0303 0.4666 0.5024
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0574 0.9287 0.9284
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0574 0.9287 1
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1274 0.2522
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0271 0.4112 0.4398
Loa Loa (eye worm) hypothetical protein 0.0175 0.2476 0.2666
Echinococcus granulosus Nuclear hormone receptor HR96 0.0271 0.4112 0.441
Brugia malayi nuclear hormone receptor family member nhr-6 0.0271 0.4112 0.4427
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0382 0.0361
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0462 0.0497
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0175 0.2476 1
Loa Loa (eye worm) hypothetical protein 0.0271 0.4112 0.4427
Brugia malayi RNA binding protein 0.0069 0.0675 0.0726
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0115 0.1447 0.7321
Plasmodium vivax glycogen synthase kinase 3, putative 0.011 0.1369 0.5438
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0412 0.1496
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1274 0.2522
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0123 0.1592 0.8342
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0675 0.0726
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0574 0.9287 1
Brugia malayi Nuclear hormone receptor-like 1 0.0303 0.4666 0.5024
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.011 0.1369 0.1429
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0533 0.0574
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1274 0.2522
Onchocerca volvulus 0.0271 0.4112 0.4398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0574 0.9287 1
Echinococcus granulosus FTZ F1 alpha 0.0574 0.9287 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.0608 0.1388
Loa Loa (eye worm) hypothetical protein 0.0033 0.0048 0.0052
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0412 0.0414
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.006 0.0519 0.1938
Loa Loa (eye worm) CMGC/GSK protein kinase 0.011 0.1369 0.1474
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.011 0.1369 0.5438
Schistosoma mansoni hypothetical protein 0.0194 0.2792 0.2757
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0574 0.9287 0.9284
Entamoeba histolytica protein kinase domain containing protein 0.011 0.1369 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0574 0.9287 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0574 0.9287 1
Brugia malayi follicle stimulating hormone receptor 0.0268 0.4065 0.4377
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0574 0.9287 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0271 0.4112 0.4398
Schistosoma mansoni nuclear receptor nhr-48 0.0271 0.4112 0.4083
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.1274 0.1372
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0271 0.4112 0.441
Brugia malayi nuclear hormone receptor 0.0574 0.9287 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0271 0.4112 0.4083
Loa Loa (eye worm) hypothetical protein 0.0271 0.4112 0.4427
Loa Loa (eye worm) DR-78 0.0271 0.4112 0.4427
Brugia malayi nuclear receptor RXR 0.0303 0.4666 0.5024
Loa Loa (eye worm) hypothetical protein 0.0303 0.4666 0.5024
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0574 0.9287 1
Plasmodium falciparum glycogen synthase kinase 3 0.011 0.1369 0.4636
Onchocerca volvulus 0.0574 0.9287 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0303 0.4666 0.464
Mycobacterium tuberculosis Probable oxidoreductase 0.0137 0.1826 1
Brugia malayi Thioredoxin reductase 0.0054 0.0412 0.0443
Loa Loa (eye worm) hypothetical protein 0.0271 0.4112 0.4427
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.1274 0.1372
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0675 0.0629
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0154 0.0166
Brugia malayi Pre-SET motif family protein 0.0228 0.3381 0.3641
Echinococcus multilocularis nuclear receptor nhr 48 0.0271 0.4112 0.4398
Loa Loa (eye worm) steroid hormone receptor 0.0574 0.9287 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0137 0.1826 1
Echinococcus granulosus peptidase Clp S14 family 0.0115 0.1447 0.1533
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0123 0.1592 0.8342
Loa Loa (eye worm) hypothetical protein 0.0574 0.9287 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0574 0.9287 1
Schistosoma mansoni nuclear hormone receptor 0.0574 0.9287 0.9284
Loa Loa (eye worm) hypothetical protein 0.0271 0.4112 0.4427
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0462 0.0497
Brugia malayi hypothetical protein 0.0303 0.4666 0.5024
Echinococcus granulosus ecdysone induced protein 78C 0.0574 0.9287 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0115 0.1447 0.1514
Brugia malayi intracellular kinase 0.011 0.1369 0.1474
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0137 0.1826 1
Schistosoma mansoni hypothetical protein 0.0039 0.0154 0.0106
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0175 0.2476 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0574 0.9287 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0271 0.4112 0.441
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0574 0.9287 1
Toxoplasma gondii thioredoxin reductase 0.0054 0.0412 0.1496
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.011 0.1369 0.1327
Brugia malayi glutathione reductase 0.0054 0.0412 0.0443
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0382 0.0382
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.1274 0.9014
Brugia malayi nuclear hormone receptor family member odr-7 0.0271 0.4112 0.4427
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0175 0.2476 0.2644
Plasmodium vivax glutathione reductase, putative 0.0054 0.0412 0.1496
Entamoeba histolytica protein kinase, putative 0.011 0.1369 1
Onchocerca volvulus Bile acid receptor homolog 0.0574 0.9287 1
Entamoeba histolytica protein kinase domain containing protein 0.011 0.1369 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0271 0.4112 0.441
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0574 0.9287 1
Loa Loa (eye worm) hypothetical protein 0.0574 0.9287 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0574 0.9287 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0175 0.2476 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0116 0.0095
Onchocerca volvulus Protein ultraspiracle homolog 0.0574 0.9287 1
Brugia malayi nuclear receptor RXR 0.0271 0.4112 0.4427
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0574 0.9287 1
Loa Loa (eye worm) hypothetical protein 0.0574 0.9287 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0574 0.9287 1
Brugia malayi steroid hormone receptor 0.0574 0.9287 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0574 0.9287 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0175 0.2476 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0271 0.4112 0.4427
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0382 0.0335
Brugia malayi Nuclear hormone receptor-like 1 0.0574 0.9287 1
Loa Loa (eye worm) hypothetical protein 0.0271 0.4112 0.4427
Loa Loa (eye worm) hypothetical protein 0.0271 0.4112 0.4427
Brugia malayi Nuclear hormone receptor E75 0.0271 0.4112 0.4427
Schistosoma mansoni hypothetical protein 0.0037 0.0116 0.0068
Schistosoma mansoni zinc finger protein 0.0271 0.4112 0.4083
Loa Loa (eye worm) hypothetical protein 0.0303 0.4666 0.5024
Brugia malayi hypothetical protein 0.0037 0.0116 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0574 0.9287 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0574 0.9287 0.9284
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0574 0.9287 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.1274 0.1327
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0123 0.1592 0.8342
Schistosoma mansoni nuclear hormone receptor 0.0271 0.4112 0.4083
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0175 0.2476 1
Schistosoma mansoni kinase 0.0054 0.0406 0.0359
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0123 0.1592 0.8342
Brugia malayi Pre-SET motif family protein 0.0033 0.0048 0.0052
Brugia malayi photoreceptor-specific nuclear receptor 0.0574 0.9287 1
Brugia malayi conserved hypotetical protein 0.0271 0.4112 0.4427
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0123 0.1592 0.5482
Brugia malayi Steroid receptor seven-up type 2 0.0574 0.9287 1
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.011 0.1369 1
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0412 0.0443
Trichomonas vaginalis CMGC family protein kinase 0.011 0.1369 0.2789
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0574 0.9287 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.0608 0.0562
Loa Loa (eye worm) hypothetical protein 0.0271 0.4112 0.4427
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0574 0.9287 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0675 0.0629
Toxoplasma gondii hypothetical protein 0.006 0.0519 0.1938
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.1274 0.1327
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0175 0.2476 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0574 0.9287 1
Loa Loa (eye worm) hypothetical protein 0.0574 0.9287 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0382 0.0361
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1274 0.2522
Schistosoma mansoni nuclear hormone receptor 0.0271 0.4112 0.4083
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0271 0.4112 0.4398
Brugia malayi tailless protein 0.0271 0.4112 0.4427
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0271 0.4112 0.4398
Echinococcus granulosus thyroid hormone receptor alpha 0.0271 0.4112 0.441
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0675 0.0629
Echinococcus granulosus tar DNA binding protein 0.0069 0.0675 0.0698
Loa Loa (eye worm) CMGC/GSK protein kinase 0.011 0.1369 0.1474
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0608 0.0627
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0574 0.9287 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0137 0.1826 0.6681
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0675 0.0726
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.0608 0.2053
Echinococcus granulosus nuclear receptor nhr 48 0.0271 0.4112 0.441
Echinococcus multilocularis geminin 0.0194 0.2792 0.297
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0116 0.0068
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0115 0.1447 0.4744
Loa Loa (eye worm) hypothetical protein 0.0271 0.4112 0.4427
Loa Loa (eye worm) hypothetical protein 0.0303 0.4666 0.5024
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0271 0.4112 0.4398
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0268 0.4065 0.4377
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0048 0.0022
Loa Loa (eye worm) hypothetical protein 0.0303 0.4666 0.5024
Trypanosoma brucei protein kinase, putative 0.011 0.1369 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0608 0.0606
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0115 0.1447 0.7321
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0675 0.0629
Schistosoma mansoni RAR-like nuclear receptor 0.0574 0.9287 0.9284
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0675 0.0629
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0175 0.2476 0.5
Loa Loa (eye worm) hypothetical protein 0.0271 0.4112 0.4427
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0382 0.0411
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.3381 0.3641
Brugia malayi hypothetical protein 0.0303 0.4666 0.5024
Mycobacterium tuberculosis Probable dehydrogenase 0.0123 0.1592 0.8342
Loa Loa (eye worm) nuclear hormone receptor 0.0271 0.4112 0.4427
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0271 0.4112 0.4398
Schistosoma mansoni retinoic acid receptor RXR 0.0574 0.9287 0.9284
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0271 0.4112 0.4427
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1274 0.2522
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0574 0.9287 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.1274 0.1346
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0271 0.4112 0.4083
Brugia malayi nuclear receptor NHR-88 0.0574 0.9287 1
Brugia malayi ecdysteroid receptor 0.0574 0.9287 1
Echinococcus granulosus protein kinase shaggy 0.011 0.1369 0.1448
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0303 0.4666 0.464
Loa Loa (eye worm) nuclear receptor NHR-67 0.0271 0.4112 0.4427
Loa Loa (eye worm) hypothetical protein 0.0271 0.4112 0.4427
Brugia malayi TAR-binding protein 0.0069 0.0675 0.0726
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0574 0.9287 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0574 0.9287 0.9284
Schistosoma mansoni peptidase Clp (S14 family) 0.0175 0.2476 0.244
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0574 0.9287 1
Loa Loa (eye worm) hypothetical protein 0.0271 0.4112 0.4427
Schistosoma mansoni hypothetical protein 0.0194 0.2792 0.2757
Onchocerca volvulus 0.0271 0.4112 0.4398
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0574 0.9287 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0382 0.0411
Onchocerca volvulus 0.011 0.1369 0.1429
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.1274 0.9014
Echinococcus granulosus geminin 0.0194 0.2792 0.2985
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1274 0.2522
Loa Loa (eye worm) hypothetical protein 0.0574 0.9287 1
Echinococcus multilocularis FTZ F1 alpha 0.0574 0.9287 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0462 0.0497
Loa Loa (eye worm) hypothetical protein 0.0574 0.9287 1
Brugia malayi hypothetical protein 0.0271 0.4112 0.4427
Giardia lamblia Kinase, CMGC GSK 0.011 0.1369 1
Schistosoma mansoni coup transcription factor 0.0574 0.9287 0.9284
Brugia malayi nuclear receptor NHR-88 0.0271 0.4112 0.4427
Trypanosoma brucei polo-like protein kinase 0.0105 0.1274 0.9014
Loa Loa (eye worm) hypothetical protein 0.0039 0.0154 0.0166
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0175 0.2476 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0574 0.9287 0.9284
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0271 0.4112 0.4398
Echinococcus multilocularis thyroid hormone receptor alpha 0.0574 0.9287 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.006 0.0519 0.052
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.1274 0.2522
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0574 0.9287 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0412 0.0393
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.1274 0.9014
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.0608 0.0655
Mycobacterium tuberculosis Probable reductase 0.0123 0.1592 0.8342
Brugia malayi Nuclear hormone receptor E75 0.0271 0.4112 0.4427
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0175 0.2476 0.5
Loa Loa (eye worm) hypothetical protein 0.0574 0.9287 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0574 0.9287 0.9284
Schistosoma mansoni thyroid hormone receptor 0.0574 0.9287 0.9284
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0382 0.0382
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.1274 0.1232
Brugia malayi ecdysone receptor 0.0271 0.4112 0.4427
Schistosoma mansoni thyroid hormone receptor 0.0574 0.9287 0.9284
Giardia lamblia Kinase, CMGC GSK 0.011 0.1369 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0574 0.9287 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0574 0.9287 1
Loa Loa (eye worm) RNA binding protein 0.0069 0.0675 0.0726
Brugia malayi nuclear hormone receptor 0.0271 0.4112 0.4427
Schistosoma mansoni nuclear receptor 0.0271 0.4112 0.4083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0382 0.0335
Brugia malayi nuclear receptor NHR-67 0.0271 0.4112 0.4427
Loa Loa (eye worm) hypothetical protein 0.0271 0.4112 0.4427
Loa Loa (eye worm) hypothetical protein 0.0303 0.4666 0.5024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0574 0.9287 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0303 0.4666 0.5009
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.011 0.1369 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0303 0.4666 0.4998
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0175 0.2476 0.2628
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0175 0.2476 1
Echinococcus granulosus glycogen synthase kinase 3 beta 0.011 0.1369 0.1448
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0675 0.0726
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0175 0.2476 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.1274 0.9247
Trichomonas vaginalis CMGC family protein kinase 0.011 0.1369 0.2789
Loa Loa (eye worm) hypothetical protein 0.0271 0.4112 0.4427
Schistosoma mansoni steroid hormone receptor ad4bp 0.0574 0.9287 0.9284
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0574 0.9287 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0574 0.9287 1
Echinococcus multilocularis protein kinase shaggy 0.011 0.1369 0.1429
Brugia malayi hypothetical protein 0.0271 0.4112 0.4427
Trichomonas vaginalis set domain proteins, putative 0.026 0.3919 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0574 0.9287 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0574 0.9287 1
Onchocerca volvulus 0.026 0.3919 0.4189
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0574 0.9287 1
Brugia malayi orphan nuclear receptor NR2E1 0.0271 0.4112 0.4427
Brugia malayi Probable ClpP-like protease 0.0175 0.2476 0.2666
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0303 0.4666 0.5024
Loa Loa (eye worm) hypothetical protein 0.0057 0.0462 0.0497
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0116 0.0073
Loa Loa (eye worm) glutathione reductase 0.0054 0.0412 0.0443
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0675 0.0678
Schistosoma mansoni nuclear receptor 0.0271 0.4112 0.4083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0382 0.0335
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0574 0.9287 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

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