Detailed information for compound 1859310

Basic information

Technical information
  • TDR Targets ID: 1859310
  • Name: [4-[[4-(trifluoromethoxy)phenyl]methoxy]pheny l]methanamine
  • MW: 297.272 | Formula: C15H14F3NO2
  • H donors: 1 H acceptors: 0 LogP: 3.43 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCc1ccc(cc1)OCc1ccc(cc1)OC(F)(F)F
  • InChi: 1S/C15H14F3NO2/c16-15(17,18)21-14-7-3-12(4-8-14)10-20-13-5-1-11(9-19)2-6-13/h1-8H,9-10,19H2
  • InChiKey: HCLPVIXYECSYGX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [4-[4-(trifluoromethoxy)benzyl]oxybenzyl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.5825 0.7032
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.941 0.941
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.5825 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.5825 0.619
Onchocerca volvulus 0.0004 0 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.8282 1
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.8282 0.8282
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 1 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0067 0.941 0.941
Plasmodium vivax hypothetical protein, conserved 0.0004 0 0.5
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.8282 0.9486
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.8282 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 1 1
Onchocerca volvulus 0.0004 0 0.5
Brugia malayi MAP kinase sur-1 0.0059 0.8282 0.8802
Onchocerca volvulus Sepiapterin reductase homolog 0.0004 0 0.5
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.5825 0.7032
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.8282 0.8282
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.5825 0.7032
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0004 0 0.5
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0004 0 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.8282 0.8282
Toxoplasma gondii aldehyde dehydrogenase 0.0071 1 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0004 0 0.5
Onchocerca volvulus 0.0004 0 0.5
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0004 0 0.5
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.8282 0.8282
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.8731 1
Mycobacterium leprae Probable oxidoreductase 0.0004 0 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0067 0.941 0.941
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0004 0 0.5
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.8282 1
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.5825 0.5825
Plasmodium falciparum steroid dehydrogenase, putative 0.0004 0 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.8282 1
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.8282 1
Plasmodium vivax steroid dehydrogenase, putative 0.0004 0 0.5
Trypanosoma brucei protein kinase, putative 0.0059 0.8282 1
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0004 0 0.5
Onchocerca volvulus 0.0004 0 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.8282 1
Onchocerca volvulus 0.0004 0 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0071 1 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.5825 0.5825
Onchocerca volvulus 0.0004 0 0.5
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.5825 0.5825
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0067 0.941 0.941
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0067 0.941 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.8282 0.8282
Schistosoma mansoni aldehyde dehydrogenase 0.0071 1 1
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.8282 0.8282
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.8282 0.8282
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.5825 0.7032
Onchocerca volvulus 0.0004 0 0.5
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.5825 0.5825
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.5825 0.6671
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.5825 0.7032
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0067 0.941 0.941
Onchocerca volvulus 0.0004 0 0.5
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.5825 0.5825
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.8282 0.8282
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0067 0.941 0.941
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.5825 0.5825
Onchocerca volvulus 0.0004 0 0.5
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.5825 0.7032
Onchocerca volvulus 0.0004 0 0.5
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.8282 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.8282 1
Onchocerca volvulus 0.0004 0 0.5
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.5825 0.5825
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 1 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 1 1
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.8282 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.5825 0.5825
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0004 0 0.5
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0004 0 0.5
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.8282 1
Onchocerca volvulus 0.0004 0 0.5
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.941 0.941
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.5825 0.7032
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0004 0 0.5
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.5825 0.5825
Onchocerca volvulus 0.0004 0 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0004 0 0.5
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0004 0 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.