TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 356.462 | Formula: C20H28N4O2
H donors: 3 H acceptors: 3 LogP: 4.85 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1n[nH]c(c1)C(=O)N/N=C\c1cc(c(c(c1)C(C)(C)C)O)C(C)(C)C
InChi: 1S/C20H28N4O2/c1-12-8-16(23-22-12)18(26)24-21-11-13-9-14(19(2,3)4)17(25)15(10-13)20(5,6)7/h8-11,25H,1-7H3,(H,22,23)(H,24,26)/b21-11-
InChiKey: CEAWQWWVOBUDFC-NHDPSOOVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	Werner syndrome, RecQ helicase-like	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	DNA helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Entamoeba histolytica	recQ family DNA helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania mexicana	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Giardia lamblia	Sgs1 DNA helicase, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Leishmania donovani	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Theileria parva	DNA helicase, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	DNA helicase recq5	Get druggable targets OG5_126644	All targets in OG5_126644
Schistosoma mansoni	DNA helicase recq1	Get druggable targets OG5_126644	All targets in OG5_126644
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Babesia bovis	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus granulosus	ATP dependent DNA helicase Q1	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus granulosus	ATP dependent DNA helicase Q5	Get druggable targets OG5_126644	All targets in OG5_126644
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania infantum	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Leishmania braziliensis	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus granulosus	bloom syndrome protein	Get druggable targets OG5_126644	All targets in OG5_126644
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium knowlesi	ADP-dependent DNA helicase RecQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Neospora caninum	hypothetical protein	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus multilocularis	bloom syndrome protein	Get druggable targets OG5_126644	All targets in OG5_126644
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126644	All targets in OG5_126644
Schistosoma japonicum	ko:K03654 ATP-dependent DNA helicase RecQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Schistosoma mansoni	blooms syndrome DNA helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Trichomonas vaginalis	DNA helicase recq1, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	ATP dependent DNA helicase Q5	Get druggable targets OG5_126644	All targets in OG5_126644
Entamoeba histolytica	recQ family helicase, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium knowlesi	ATP-dependent DNA helicase Q1, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Brugia malayi	Bloom's syndrome protein homolog	Get druggable targets OG5_126644	All targets in OG5_126644
Cryptosporidium hominis	DEAD/DEAH box helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Treponema pallidum	ATP-dependent DNA helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium berghei	ADP-dependent DNA helicase RecQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Theileria parva	hypothetical protein	Get druggable targets OG5_126644	All targets in OG5_126644
Trypanosoma brucei gambiense	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium yoelii	ATP-dependent DNA helicase-related	Get druggable targets OG5_126644	All targets in OG5_126644
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium yoelii	ATP-dependent DNA helicase recQ-related	Get druggable targets OG5_126644	All targets in OG5_126644
Cryptosporidium parvum	RecQ bloom helicase (RNA helicase+hrdc)	Get druggable targets OG5_126644	All targets in OG5_126644
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126644	All targets in OG5_126644
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	DNA helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Loa Loa (eye worm)	ATP-dependent DNA helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Trichomonas vaginalis	DNA helicase recq, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	Get druggable targets OG5_126644	All targets in OG5_126644
Loa Loa (eye worm)	RecQ helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Trichomonas vaginalis	DNA helicase recq, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Neospora caninum	hypothetical protein	Get druggable targets OG5_126644	All targets in OG5_126644
Schistosoma japonicum	Bloom syndrome protein homolog, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium falciparum	ATP-dependent DNA helicase Q1	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus multilocularis	ATP dependent DNA helicase Q1	Get druggable targets OG5_126644	All targets in OG5_126644
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium berghei	ATP-dependent DNA helicase Q1, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Babesia bovis	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.2475	0.2462
Schistosoma mansoni	blooms syndrome DNA helicase	0.0023	0.0846	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0296	0.0396
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0308	0.1071
Trichomonas vaginalis	DNA helicase recq1, putative	0.0029	0.1153	1
Brugia malayi	Bloom's syndrome protein homolog	0.0029	0.1153	0.4194
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0308	0.0413
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0308	0.0413
Brugia malayi	steroid hormone receptor	0.0012	0.0308	0.1071
Loa Loa (eye worm)	hypothetical protein	0.006	0.2725	0.3854
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0012	0.0296	0.0278
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.2475	0.3498
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0308	0.029
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0308	0.1071
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0308	0.1071
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0652	0.2344
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0308	0.0413
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0308	0.0308
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0308	0.0308
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.2475	0.2462
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0652	0.0636
Schistosoma mansoni	hypothetical protein	0.0019	0.0652	0.0652
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1766	0.2488
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0652	0.0636
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.2725	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0308	0.029
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0308	0.0308
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0308	0.0308
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.002	0.068	0.5
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0308	0.029
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0308	0.029
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0308	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0308	0.0413
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0308	0.0308
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.2475	0.2475
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0652	0.0636
Schistosoma mansoni	DNA helicase recq1	0.0012	0.0296	0.0296
Schistosoma mansoni	hypothetical protein	0.0205	1	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0308	0.5
Onchocerca volvulus		0.0012	0.0308	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0308	0.0413
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0308	0.1071
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.0296	0.4422
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0025	0.0976	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0308	0.1071
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0308	0.1071
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0308	0.029
Echinococcus granulosus	GPCR family 2	0.0019	0.0652	0.0636
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0308	0.029
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0308	0.029
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0308	0.0308
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0308	0.029
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0308	0.0413
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0308	0.029
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0018	0.0018
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0018	0.0018
Schistosoma mansoni	hypothetical protein	0.0041	0.1766	0.1766
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0668	1
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0308	0.0308
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0652	0.0903
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0308	0.0308
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0012	0.0296	0.0278
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0308	0.029
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0012	0.0296	0.0278
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0308	0.0308
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0308	0.1071
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0473	0.5
Schistosoma mansoni	hypothetical protein	0.0019	0.0652	0.0652
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.1766	0.6456
Schistosoma mansoni	hypothetical protein	0.0205	1	1
Schistosoma mansoni	DNA helicase recq5	0.0012	0.0296	0.0296
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0308	0.029
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.2725	0.3854
Echinococcus granulosus	bloom syndrome protein	0.0029	0.1153	0.1137
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0308	0.0413
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0308	0.0413
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0308	0.1071
Echinococcus multilocularis	geminin	0.0205	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0308	0.0413
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.2475	0.2475
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0308	0.1071
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0308	0.029
Entamoeba histolytica	recQ family helicase, putative	0.0015	0.0473	1
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0308	0.029
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0308	0.1071
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.2475	0.2475
Echinococcus multilocularis	bloom syndrome protein	0.0029	0.1153	0.1137
Trichomonas vaginalis	DNA helicase recq, putative	0.0029	0.1153	1
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0473	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0308	0.029
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0308	0.0413
Treponema pallidum	ATP-dependent DNA helicase	0.0006	0	0.5
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.2475	0.9077
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0308	0.1071
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0308	0.029
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0308	0.5
Loa Loa (eye worm)	RecQ helicase	0.0029	0.1153	0.1616
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.2475	0.2462
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0308	0.0413
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0308	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0308	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0652	0.0903
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0012	0.0296	0.0278
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0652	0.2344
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0308	0.1071
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0652	0.0636
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0308	0.029
Brugia malayi	ecdysteroid receptor	0.0012	0.0308	0.1071
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0308	0.0413
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0308	0.1071
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0308	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0146	0.7043	1
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0473	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.2475	0.2462
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0308	0.0413
Schistosoma mansoni	hypothetical protein	0.0019	0.0652	0.0652
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0308	0.0308
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.2725	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.0296	0.4422
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0308	0.1071
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0012	0.0296	0.0396
Brugia malayi	nuclear hormone receptor	0.0012	0.0308	0.1071
Schistosoma mansoni	coup transcription factor	0.0012	0.0308	0.0308
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.0296	0.1027
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0308	0.029
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0308	0.029
Schistosoma mansoni	hypothetical protein	0.0019	0.0652	0.0652
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0308	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0308	0.0413
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0652	0.0636
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0308	0.0308
Giardia lamblia	Sgs1 DNA helicase, putative	0.0012	0.0296	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0308	0.0308
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.0296	0.1027
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0308	0.1071

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.7943 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 3.5481 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.081 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	63.0957 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3194076

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1859438