Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.359 | 0.359 |
Loa Loa (eye worm) | Smad1 | 0.001 | 0.0316 | 0.0316 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.5122 | 0.5122 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0316 | 0.0316 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.359 | 0.6812 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.001 | 0.0316 | 0.0316 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.359 | 0.6812 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.359 | 0.6812 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.359 | 0.6812 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.359 | 0.6812 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0316 | 0.0316 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0316 | 0.0316 |
Brugia malayi | RNA binding protein | 0.0076 | 0.5122 | 0.5122 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.359 | 0.6812 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.5122 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5122 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.5122 | 0.5122 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5122 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.5122 | 0.5122 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.359 | 0.6812 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5122 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5122 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.5122 | 0.5122 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0316 | 0.0316 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.5122 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.5122 | 0.5122 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.001 | 0.0316 | 0.0316 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5122 | 1 |
Brugia malayi | Smad1 | 0.001 | 0.0316 | 0.0316 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.359 | 0.359 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 260 uM | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493224] | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.6535 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.