Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.4866 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0867 | 0.1781 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0636 | 0.1306 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.0796 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0796 | 0.1636 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.4538 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.4538 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2978 | 0.2978 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.5547 | 0.5547 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0796 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0018 | 0.0475 | 0.0976 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2803 | 0.2803 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0636 | 0.0636 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0021 | 0.0636 | 0.1401 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0796 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.1138 | 0.2339 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2363 | 0.5207 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.1355 | 0.1355 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0796 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.258 | 0.258 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0796 | 0.0796 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.5938 | 0.5938 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2586 | 0.2586 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0021 | 0.0636 | 0.1401 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0796 | 0.0796 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0021 | 0.0636 | 0.1401 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.0796 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0475 | 0.0976 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0796 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0692 | 0.0692 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0963 | 0.0963 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0796 | 0.1636 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0963 | 0.198 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0867 | 0.1909 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0636 | 0.1306 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.1138 | 0.2508 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0796 | 0.1754 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.1138 | 0.2508 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0021 | 0.0636 | 0.1401 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0867 | 0.1909 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0796 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0796 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0796 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0796 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0636 | 0.1306 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0796 | 0.1754 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.0796 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0796 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2363 | 0.5207 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0796 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0796 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0636 | 0.1306 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0796 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.2589 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.