Detailed information for compound 1860152

Basic information

Technical information
  • TDR Targets ID: 1860152
  • Name: 1-[5-chloro-3-methyl-1-[3-(trifluoromethyl)ph enyl]pyrazol-4-yl]-N-(1,2,4-triazol-4-yl)meth animine
  • MW: 354.718 | Formula: C14H10ClF3N6
  • H donors: 0 H acceptors: 3 LogP: 3.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nn(c(c1/C=N/n1cnnc1)Cl)c1cccc(c1)C(F)(F)F
  • InChi: 1S/C14H10ClF3N6/c1-9-12(6-21-23-7-19-20-8-23)13(15)24(22-9)11-4-2-3-10(5-11)14(16,17)18/h2-8H,1H3/b21-6+
  • InChiKey: FWQIZZQZBKRFBY-AERZKKPOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[5-chloro-3-methyl-1-[3-(trifluoromethyl)phenyl]-4-pyrazolyl]-N-(1,2,4-triazol-4-yl)methanimine
  • (Z)-[5-chloro-3-methyl-1-[3-(trifluoromethyl)phenyl]pyrazol-4-yl]methylene-(1,2,4-triazol-4-yl)amine
  • [5-chloro-3-methyl-1-[3-(trifluoromethyl)phenyl]pyrazol-4-yl]methylene-(1,2,4-triazol-4-yl)amine
  • (E)-[5-chloro-3-methyl-1-[3-(trifluoromethyl)phenyl]pyrazol-4-yl]methylene-(1,2,4-triazol-4-yl)amine
  • ZINC03255240
  • MLS000055536
  • SMR000066045
  • T0506-8304
  • Enamine_002432
  • ZINC03255237

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0474 0.1806
Echinococcus multilocularis musashi 0.0033 0.4057 0.72
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0056 0.0056
Brugia malayi intermediate filament protein 0.0033 0.4057 0.5031
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.2628 1
Trichomonas vaginalis helicase, putative 0.0008 0.0474 0.1806
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.1864 0.2312
Schistosoma mansoni cpg binding protein 0.0037 0.465 0.465
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.2628 0.4664
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.2628 0.4664
Onchocerca volvulus 0.0033 0.4057 0.9297
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.8861 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0474 0.1806
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0891 0.1581
Echinococcus multilocularis cpg binding protein 0.0037 0.465 0.8253
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0474 0.1806
Echinococcus granulosus GPCR family 2 0.0019 0.2097 0.3722
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0474 0.1806
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0474 0.1806
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.4057 0.5031
Echinococcus multilocularis lamin dm0 0.0033 0.4057 0.72
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.2628 0.3259
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0891 0.1581
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.2628 0.3259
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.5634 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0474 0.1806
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0584 0.1037
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.4057 0.5031
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.2097 0.3722
Schistosoma mansoni hypothetical protein 0.0019 0.2097 0.2097
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.2628 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0474 0.1806
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0474 0.1806
Loa Loa (eye worm) hypothetical protein 0.0019 0.2097 0.2601
Echinococcus granulosus lamin 0.0033 0.4057 0.72
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.2628 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.2097 0.2601
Loa Loa (eye worm) hypothetical protein 0.0015 0.1527 0.1894
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0474 0.1806
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0871 0.108
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.2628 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.2097 0.3722
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.2097 0.3722
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.2628 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.8063 1
Entamoeba histolytica hypothetical protein 0.0043 0.5634 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0584 0.1037
Schistosoma mansoni lamin 0.0033 0.4057 0.4057
Schistosoma mansoni hypothetical protein 0.0043 0.5634 0.5634
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.5301 0.6575
Loa Loa (eye worm) hypothetical protein 0.0015 0.1527 0.1894
Schistosoma mansoni cpg binding protein 0.0035 0.4363 0.4363
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0474 0.1806
Onchocerca volvulus 0.0033 0.4057 0.9297
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.2097 0.2601
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.8063 1
Entamoeba histolytica hypothetical protein 0.0043 0.5634 1
Schistosoma mansoni hypothetical protein 0.0019 0.2097 0.2097
Brugia malayi Latrophilin receptor protein 2 0.0019 0.2097 0.2601
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.2628 0.5
Echinococcus multilocularis lamin 0.0033 0.4057 0.72
Schistosoma mansoni ap endonuclease 0.0023 0.2628 0.2628
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.2097 0.3722
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0474 0.1806
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0474 0.1806
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.1614 0.2864
Schistosoma mansoni lamin 0.0033 0.4057 0.4057
Brugia malayi CXXC zinc finger family protein 0.0035 0.4363 0.5411
Entamoeba histolytica hypothetical protein 0.0043 0.5634 1
Echinococcus granulosus intermediate filament protein 0.0033 0.4057 0.72
Loa Loa (eye worm) hypothetical protein 0.0032 0.397 0.4924
Schistosoma mansoni intermediate filament proteins 0.0033 0.4057 0.4057
Loa Loa (eye worm) hypothetical protein 0.006 0.8063 1
Echinococcus granulosus cpg binding protein 0.0037 0.465 0.8253
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0474 0.1806
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.2628 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.4057 0.5031
Schistosoma mansoni ap endonuclease 0.0023 0.2628 0.2628
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.2628 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.1614 0.2864
Loa Loa (eye worm) hypothetical protein 0.0016 0.1614 0.2001
Toxoplasma gondii exonuclease III APE 0.0023 0.2628 0.2966
Schistosoma mansoni hypothetical protein 0.0041 0.5301 0.5301
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0474 0.1806
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0474 0.1806
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0584 0.1037
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.2097 0.3722
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0474 0.1806
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.2628 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0584 0.1037
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.1864 0.2312
Echinococcus granulosus lamin dm0 0.0033 0.4057 0.72
Loa Loa (eye worm) hypothetical protein 0.0041 0.5301 0.6575
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.5634 1
Schistosoma mansoni hypothetical protein 0.0019 0.2097 0.2097
Schistosoma mansoni cpg binding protein 0.0037 0.465 0.465
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0474 0.1806
Entamoeba histolytica hypothetical protein 0.0043 0.5634 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.4057 0.5031
Onchocerca volvulus 0.0035 0.4363 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.4363 0.5411
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.2628 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.2628 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.5634 0.5634
Schistosoma mansoni hypothetical protein 0.0019 0.2097 0.2097
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0584 0.0584
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0891 0.1105
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.2628 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.2628 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.8063 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.2628 0.4664
Brugia malayi hypothetical protein 0.0043 0.5634 0.6987

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7943 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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