Detailed information for compound 1860349

Basic information

Technical information
  • TDR Targets ID: 1860349
  • Name: 2-[4-[(carbamothioylhydrazinylidene)methyl]-2 -methoxyphenoxy]-N-(4-methylphenyl)acetamide
  • MW: 372.441 | Formula: C18H20N4O3S
  • H donors: 3 H acceptors: 1 LogP: 2.41 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=N/NC(=S)N)ccc1OCC(=O)Nc1ccc(cc1)C
  • InChi: 1S/C18H20N4O3S/c1-12-3-6-14(7-4-12)21-17(23)11-25-15-8-5-13(9-16(15)24-2)10-20-22-18(19)26/h3-10H,11H2,1-2H3,(H,21,23)(H3,19,22,26)/b20-10+
  • InChiKey: HJPALVQNWFRKHH-KEBDBYFISA-N  


Substructure search Similarity search

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Synonyms

  • 2-[4-[(E)-(carbamothioylhydrazinylidene)methyl]-2-methoxyphenoxy]-N-(4-methylphenyl)acetamide
  • 2-[4-[(carbamothioylhydrazono)methyl]-2-methoxy-phenoxy]-N-(4-methylphenyl)acetamide
  • 2-[4-[(E)-(carbamothioylhydrazono)methyl]-2-methoxy-phenoxy]-N-(4-methylphenyl)acetamide
  • 2-[4-[(carbamothioylhydrazono)methyl]-2-methoxyphenoxy]-N-(4-methylphenyl)acetamide
  • 2-[4-[(E)-(carbamothioylhydrazono)methyl]-2-methoxyphenoxy]-N-(4-methylphenyl)acetamide
  • 2-[2-methoxy-4-[(E)-(thiocarbamoylhydrazono)methyl]phenoxy]-N-(4-methylphenyl)acetamide
  • 2-[2-methoxy-4-[(thiocarbamoylhydrazono)methyl]phenoxy]-N-(4-methylphenyl)acetamide
  • 2-[4-[(E)-(carbamothioylhydrazinylidene)methyl]-2-methoxy-phenoxy]-N-(4-methylphenyl)ethanamide
  • 2-[4-[(carbamothioylhydrazinylidene)methyl]-2-methoxy-phenoxy]-N-(4-methylphenyl)ethanamide
  • AK-968/40641626
  • 2-{4-[2-(aminocarbothioyl)carbohydrazonoyl]-2-methoxyphenoxy}-N-(4-methylphenyl)acetamide
  • MLS000325415
  • SMR000159680

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens nuclear receptor subfamily 5, group A, member 1 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus FTZ F1 alpha Get druggable targets OG5_149993 All targets in OG5_149993
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus FTZ F1 nuclear receptor protein nuclear receptor subfamily 5, group A, member 1 461 aa 460 aa 32.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0014 0.0032 0.0058
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0018 0.0018
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0101 0.0101
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0533 0.3156
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0101 0.19
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0018 0.0109
Mycobacterium tuberculosis Probable oxidoreductase 0.0138 0.132 0.9853
Toxoplasma gondii cathepsin CPL 0.002 0.0101 0.0109
Toxoplasma gondii thioredoxin reductase 0.0055 0.0455 0.2941
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0018 0.0033
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0486 0.0874
Leishmania major cathepsin L-like protease 0.0077 0.0688 0.4797
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.041 0.0852
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0101 0.0101
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0032 0.0058
Trypanosoma brucei protein kinase, putative 0.0062 0.0533 0.7746
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0101 0.021
Treponema pallidum NADH oxidase 0.0019 0.0088 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0018 0.0109
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0088 0.1923
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0018 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.19
Brugia malayi Cathepsin L-like precursor 0.0014 0.0032 0.0058
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0533 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0101 0.0149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0101 0.19
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0018 0.0038
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0533 0.7746
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0018 0.0109
Leishmania major cathepsin L-like protease 0.002 0.0101 0.0109
Schistosoma mansoni aldehyde dehydrogenase 0.014 0.1338 0.7929
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0088 0.1274
Brugia malayi glutathione reductase 0.0055 0.0455 0.0819
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0124 0.1177 0.8707
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0688 1
Plasmodium falciparum thioredoxin reductase 0.0019 0.0088 0.1923
Leishmania major trypanothione reductase 0.0055 0.0455 0.2941
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0088 0.0158
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0455 0.0455
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0018 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.041 0.2429
Mycobacterium ulcerans aldehyde dehydrogenase 0.014 0.1338 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.008 0.0167
Leishmania major cathepsin L-like protease 0.0077 0.0688 0.4797
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0101 0.2222
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0517 0.7525
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0018 0.0038
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0018 0.0033
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0533 0.3558
Plasmodium falciparum glutathione reductase 0.0019 0.0088 0.1923
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0455 0.0947
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0088 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0018 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0688 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0138 0.132 0.9853
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0533 0.1107
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.041 0.041
Brugia malayi Cathepsin L-like precursor 0.002 0.0101 0.0182
Brugia malayi Latrophilin receptor protein 2 0.0018 0.008 0.0144
Echinococcus granulosus cathepsin l1 0.002 0.0101 0.021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0688 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0018 0.0033
Onchocerca volvulus 0.002 0.0101 1
Schistosoma mansoni hypothetical protein 0.0018 0.008 0.0476
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0018 0.0033
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.014 0.1338 0.1338
Plasmodium vivax vivapain-2 0.002 0.0101 0.2222
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0018 0.0038
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0018 0.0109
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0018 0.0018
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0455 0.6624
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0101 0.0182
Leishmania major cysteine peptidase A (CPA) 0.002 0.0101 0.0109
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0533 0.7746
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0688 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0018 0.0033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0088 0.1274
Brugia malayi steroid hormone receptor 0.0012 0.0018 0.0033
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0018 0.0109
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0018 0.0018
Onchocerca volvulus 0.002 0.0101 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0032 0.0604
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0101 0.06
Brugia malayi MAP kinase sur-1 0.0062 0.0533 0.0958
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.014 0.1338 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0533 0.1107
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0486 0.0874
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0455 0.2941
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0298 0.0536
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0688 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0018 0.0033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0088 0.1274
Leishmania major cathepsin L-like protease 0.002 0.0101 0.0109
Mycobacterium tuberculosis Probable reductase 0.0124 0.1177 0.8707
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0088 0.5
Trypanosoma brucei trypanothione reductase 0.0055 0.0455 0.6624
Plasmodium vivax glutathione reductase, putative 0.0055 0.0455 1
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0455 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0018 0.0033
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0018 0.0109
Onchocerca volvulus Cathepsin L homolog 0.002 0.0101 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.041 0.2429
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0088 0.1274
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0533 0.3558
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0018 0.0038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0088 0.1274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.19
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0018 0.0033
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0124 0.1177 0.8707
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0101 0.021
Onchocerca volvulus 0.0014 0.0032 0.166
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0533 0.3558
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0101 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0032 0.0604
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0688 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0088 0.1923
Loa Loa (eye worm) fibroinase 0.002 0.0101 0.0149
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0619 0.8997
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0101 0.19
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.008 0.0112
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0088 0.1274
Echinococcus granulosus cathepsin l1 0.0014 0.0032 0.0067
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.041 0.0707
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0101 0.19
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0688 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0124 0.1177 0.8707
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.008 0.008
Onchocerca volvulus Cathepsin F homolog 0.002 0.0101 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0088 0.1274
Onchocerca volvulus 0.002 0.0101 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0018 0.0038
Brugia malayi follicle stimulating hormone receptor 0.0549 0.556 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0018 0.0033
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0018 0.0109
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0018 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.19
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0533 0.0928
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0032 0.0191
Loa Loa (eye worm) ctsf protein 0.002 0.0101 0.0149
Brugia malayi Cathepsin L-like precursor 0.002 0.0101 0.0182
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0088 0.1274
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0018 0.0033
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0018 0.0018
Brugia malayi nuclear hormone receptor 0.0012 0.0018 0.0033
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0018 0.0109
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0101 0.2222
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0101 0.19
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0533 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0688 1
Plasmodium falciparum glutathione reductase 0.0055 0.0455 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0101 0.19
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0533 0.0533
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0688 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0486 0.0844
Leishmania major cathepsin L-like protease 0.002 0.0101 0.0109
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0101 0.0101
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.014 0.1338 0.2781
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0088 0.1274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0688 1
Echinococcus multilocularis cysteine protease 0.002 0.0101 0.0101
Brugia malayi nuclear receptor NHR-88 0.0012 0.0018 0.0033
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0486 0.0844
Brugia malayi Cathepsin L-like precursor 0.002 0.0101 0.0182
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0088 0.1274
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0533 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0088 0.1274
Brugia malayi ecdysteroid receptor 0.0012 0.0018 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.19
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0088 0.1923
Onchocerca volvulus 0.002 0.0101 1
Brugia malayi Thioredoxin reductase 0.0055 0.0455 0.0819
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.014 0.1338 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.19
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0688 1
Onchocerca volvulus 0.002 0.0101 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0688 1
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0533 0.0533
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0688 1
Loa Loa (eye worm) glutathione reductase 0.0055 0.0455 0.0789
Loa Loa (eye worm) cysteine protease 0.002 0.0101 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.19
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0018 0.0109
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0688 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0018 0.0033
Plasmodium falciparum thioredoxin reductase 0.0055 0.0455 1
Leishmania major cathepsin L-like protease 0.002 0.0101 0.0109
Mycobacterium tuberculosis Probable dehydrogenase 0.0124 0.1177 0.8707
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0101 0.19
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0018 0.0033
Onchocerca volvulus 0.002 0.0101 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0101 0.0149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0101 0.19
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0088 0.0182
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0101 0.2222
Echinococcus multilocularis cysteine protease 0.002 0.0101 0.0101
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0101 0.06
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0036 0.0064
Loa Loa (eye worm) hypothetical protein 0.0014 0.0032 0.0025
Schistosoma mansoni hypothetical protein 0.0039 0.0298 0.1767
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0533 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0018 0.0038
Brugia malayi Cathepsin L-like precursor 0.002 0.0101 0.0182
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0088 0.0519
Loa Loa (eye worm) hypothetical protein 0.0014 0.0032 0.0025
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0036 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.041 0.2429
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0018 0.0038
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0088 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0018 0.0033
Plasmodium vivax vivapain-2 0.002 0.0101 0.2222
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0018 0.008 0.0476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.19
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.19
Leishmania major cathepsin L-like protease 0.0077 0.0688 0.4797
Loa Loa (eye worm) hypothetical protein 0.0018 0.008 0.0112
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0101 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.19
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0088 0.1644
Mycobacterium ulcerans aldehyde dehydrogenase 0.014 0.1338 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0018 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0533 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0018 0.0018
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.041 0.0738
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0018 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.19
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0101 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0088 0.1274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.19
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0138 0.132 0.9853
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0088 0.1923
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0455 0.0789
Schistosoma mansoni hypothetical protein 0.0018 0.008 0.0476
Brugia malayi cathepsin L-like precursor 0.0014 0.0032 0.0058
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0032 0.3182
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0018 0.0109
Mycobacterium ulcerans aldehyde dehydrogenase 0.014 0.1338 1
Schistosoma mansoni coup transcription factor 0.0012 0.0018 0.0109
Brugia malayi Cathepsin L-like precursor 0.002 0.0101 0.0182
Onchocerca volvulus Cathepsin L homolog 0.002 0.0101 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0533 0.7746
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0101 0.19
Entamoeba histolytica cysteine protease, putative 0.002 0.0101 1
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0088 0.1644
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0018 0.0033
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0124 0.1177 0.8707
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0101 0.19
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.041 0.0852
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0549 0.556 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.19
Leishmania major cathepsin L-like protease 0.002 0.0101 0.0109
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.008 0.0167
Onchocerca volvulus 0.002 0.0101 1
Schistosoma mansoni hypothetical protein 0.0018 0.008 0.0476
Loa Loa (eye worm) hypothetical protein 0.0014 0.0032 0.0025
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.008 0.0144
Echinococcus granulosus GPCR family 2 0.0018 0.008 0.0167
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.008 0.008
Brugia malayi Cathepsin L-like precursor 0.002 0.0101 0.0182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0688 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.008 0.008
Toxoplasma gondii aldehyde dehydrogenase 0.014 0.1338 1
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0101 0.1472
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0533 0.7746
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.041 0.041
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0018 0.0109
Schistosoma mansoni aldehyde dehydrogenase 0.014 0.1338 0.7929
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0138 0.132 1
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0101 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0533 0.7746
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0088 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.19
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0101 0.19
Echinococcus granulosus FTZ F1 alpha 0.0477 0.4812 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0298 0.0505
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0088 0.1274
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0101 0.19

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 8.044 uM PubChem BioAssay. Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput dose response assay to identify inverse agonists of the Steroidogenic Factor 1 Nuclear Receptor (SF1; NR5A1). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 35.882 uM PubChem BioAssay. Luminescence-based cell-based high throughput dose response assay for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 35.882 uM PubChem BioAssay. Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent))] ChEMBL. No reference
Potency (functional) 5.8048 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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