Detailed information for compound 1860855

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 659.645 | Formula: C30H48Cl2N6O6
  • H donors: 6 H acceptors: 6 LogP: 3.76 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 3
  • SMILES: COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)NC(=O)CC(CC(NC(=O)[C@H](Cc1c[nH]cn1)N)CC(C)C)O.Cl.Cl
  • InChi: 1S/C30H46N6O6.2ClH/c1-18(2)11-21(34-28(39)24(31)14-22-16-32-17-33-22)13-23(37)15-26(38)36-27(19(3)4)29(40)35-25(30(41)42-5)12-20-9-7-6-8-10-20;;/h6-10,16-19,21,23-25,27,37H,11-15,31H2,1-5H3,(H,32,33)(H,34,39)(H,35,40)(H,36,38);2*1H/t21?,23?,24-,25-,27-;;/m0../s1
  • InChiKey: WJBGTGBKWXAYRT-HHAGGXDFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis chromobox protein 1 0.0073 0.1441 0.1439
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Giardia lamblia PHD finger protein 15 0.0031 0.0419 0.2415
Echinococcus granulosus lamin 0.0028 0.0364 0.0361
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0037 0.0574 0.0561
Giardia lamblia Cathepsin B precursor 0.0063 0.1187 1
Brugia malayi Matrixin family protein 0.0037 0.0574 0.1135
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0744 0.1306
Giardia lamblia Cathepsin B precursor 0.0063 0.1187 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0873 0.1743
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0453 0.045
Echinococcus multilocularis cathepsin L cysteine protease 0.0092 0.1897 0.1895
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0969 0.1704
Echinococcus multilocularis importin subunit beta 1 0.003 0.0411 0.0408
Entamoeba histolytica cysteine proteinase 2 0.005 0.0873 0.4054
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0157 0.3447 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0382 0.0514
Echinococcus multilocularis cysteine protease 0.0092 0.1897 0.1895
Onchocerca volvulus 0.0038 0.0592 0.1039
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0873 0.2527
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0063 0.1187 0.3438
Schistosoma mansoni hypothetical protein 0.0053 0.0945 0.0933
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0092 0.1897 0.2548
Echinococcus granulosus cathepsin b 0.0157 0.3447 0.3445
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0219 0.0257
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Onchocerca volvulus Cathepsin F homolog 0.0092 0.1897 0.334
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0969 0.4611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0175 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0063 0.1199 0.2109
Echinococcus granulosus importin subunit beta 1 0.003 0.0411 0.0408
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0175 0.0162
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0615 0.0603
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.7448 1
Schistosoma mansoni cathepsin F (C01 family) 0.0092 0.1897 0.1887
Onchocerca volvulus 0.0063 0.1199 0.2109
Schistosoma mansoni cpg binding protein 0.003 0.0409 0.0396
Brugia malayi hypothetical protein 0.0027 0.032 0.0622
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0175 0.0328
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0175 0.0303
Plasmodium vivax vivapain-2 0.0092 0.1897 0.9297
Brugia malayi chromobox protein homolog 3 0.0041 0.0669 0.1329
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0453 0.1613
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.1897 0.334
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.032 0.0841
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0873 0.4054
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0969 0.2618
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0219 0.0239
Plasmodium vivax unspecified product 0.0029 0.0382 0.1119
Echinococcus granulosus cathepsin l cysteine peptidase 0.0092 0.1897 0.1895
Loa Loa (eye worm) hypothetical protein 0.0053 0.0945 0.1269
Leishmania major importin beta-1 subunit, putative 0.0025 0.0274 0.0879
Entamoeba histolytica hypothetical protein 0.0025 0.0274 0.0573
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0235
Onchocerca volvulus 0.0028 0.0364 0.0637
Loa Loa (eye worm) hypothetical protein 0.0092 0.1897 0.2548
Loa Loa (eye worm) hypothetical protein 0.0045 0.0767 0.103
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0175 0.0303
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0419 0.1419
Loa Loa (eye worm) hypothetical protein 0.0037 0.0574 0.077
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0274 0.0478
Plasmodium vivax unspecified product 0.005 0.0873 0.3769
Schistosoma mansoni lamin 0.0028 0.0364 0.0352
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0012 0.0009
Plasmodium falciparum phd finger protein, putative 0.0031 0.0419 0.1419
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0382 0.0667
Schistosoma mansoni lamin 0.0028 0.0364 0.0352
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0873 0.1743
Loa Loa (eye worm) hypoxia-induced factor 1 0.0158 0.3481 0.4675
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.032 0.0351
Echinococcus granulosus cathepsin l1 0.0092 0.1897 0.1895
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0419 0.1419
Entamoeba histolytica cysteine protease, putative 0.0092 0.1897 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0382 0.0514
Brugia malayi Papain family cysteine protease containing protein 0.0092 0.1897 0.3818
Entamoeba histolytica cysteine proteinase 1, putative 0.005 0.0873 0.4054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0453 0.044
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0409 0.0406
Plasmodium falciparum cysteine proteinase falcipain 1 0.005 0.0873 0.4054
Echinococcus granulosus chromobox protein 1 0.0073 0.1441 0.1439
Brugia malayi Pre-SET motif family protein 0.022 0.4949 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0003 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0136 0.0234
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0566 0.2269
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.002 0.0175 0.0162
Schistosoma mansoni cpg binding protein 0.0032 0.045 0.0437
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.1897 0.334
Loa Loa (eye worm) hypothetical protein 0.0093 0.1907 0.256
Echinococcus granulosus cathepsin L cysteine proteinase 0.0092 0.1897 0.1895
Echinococcus multilocularis transcription factor btf3 0.0037 0.0566 0.0563
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0092 0.1897 0.1895
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0173 0.0325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Leishmania major basic transcription factor 3a, putative 0.0037 0.0566 0.1827
Trypanosoma cruzi cysteine proteinase, putative 0.005 0.0873 0.2527
Onchocerca volvulus 0.0092 0.1897 0.334
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.1084 0.5278
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.1897 0.334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0873 0.1535
Brugia malayi hypothetical protein 0.0172 0.38 0.7673
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0274 0.0478
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0175 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0566 0.0993
Onchocerca volvulus 0.0092 0.1897 0.334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.2092 0.209
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.1248 0.1237
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0364 0.0712
Onchocerca volvulus 0.025 0.5674 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0411 0.067
Loa Loa (eye worm) matrixin family protein 0.0082 0.1657 0.2224
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0969 0.0967
Trypanosoma cruzi cysteine proteinase, putative 0.005 0.0873 0.2527
Leishmania major cathepsin L-like protease 0.0092 0.1897 0.6149
Echinococcus granulosus cpg binding protein 0.0032 0.045 0.0447
Brugia malayi cathepsin F-like cysteine proteinase 0.002 0.0175 0.0328
Onchocerca volvulus Cathepsin L homolog 0.002 0.0175 0.0303
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0092 0.1897 1
Brugia malayi PHD-finger family protein 0.0031 0.0419 0.0823
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Echinococcus granulosus cathepsin L 0.005 0.0873 0.0871
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0092 0.1897 0.1895
Echinococcus granulosus transcription factor btf3 0.0037 0.0566 0.0563
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0592 0.0589
Loa Loa (eye worm) hypothetical protein 0.0157 0.3447 0.4628
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0453 0.044
Echinococcus granulosus snurportin 1 0.0324 0.7448 0.7447
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0873 0.2283
Brugia malayi Cathepsin L-like precursor 0.0063 0.1199 0.2403
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0453 0.044
Brugia malayi Cathepsin L-like precursor 0.0092 0.1897 0.3818
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.002 0.0175 0.0303
Schistosoma mansoni hypothetical protein 0.0054 0.0989 0.0977
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.1897 0.334
Schistosoma mansoni cathepsin F (C01 family) 0.0063 0.1199 0.1188
Mycobacterium ulcerans hydrolase 0.0045 0.0767 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0219 0.0418
Toxoplasma gondii cathepsin CPL 0.0092 0.1897 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.2092 0.209
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.002 0.0175 0.0162
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0566 0.076
Echinococcus granulosus single minded 2 0.0038 0.0592 0.0589
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0049 0.0072
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0045 0.0767 0.5
Echinococcus granulosus cathepsin b 0.0157 0.3447 0.3445
Loa Loa (eye worm) ctsf protein 0.0092 0.1897 0.2548
Toxoplasma gondii hypothetical protein 0.0077 0.1537 0.7906
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.005 0.0873 0.2527
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.1897 0.334
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0175 0.0328
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0969 0.0957
Plasmodium falciparum importin beta, putative 0.003 0.0411 0.1372
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0969 0.1704
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0063 0.1187 0.2088
Schistosoma mansoni cathepsin C 0.002 0.0175 0.0162
Schistosoma mansoni cpg binding protein 0.0032 0.045 0.0437
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0419 0.0407
Onchocerca volvulus 0.0044 0.074 0.13
Brugia malayi beta-NAC-like protein 0.0037 0.0566 0.112
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0175 0.0303
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Plasmodium vivax vivapain-3 0.005 0.0873 0.3769
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0453 0.045
Schistosoma mansoni jumonji domain containing protein 0.008 0.1597 0.1586
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0175 0.0303
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0029 0.0382 0.0748
Echinococcus multilocularis cathepsin L cysteine protease 0.0092 0.1897 0.1895
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0235
Echinococcus granulosus cathepsin L cysteine protease 0.005 0.0873 0.0871
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0175 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0409 0.0549
Trypanosoma cruzi cysteine peptidase, putative 0.0142 0.3084 0.8947
Loa Loa (eye worm) hypothetical protein 0.0037 0.0574 0.077
Onchocerca volvulus 0.0053 0.0945 0.1661
Loa Loa (eye worm) hypothetical protein 0.0063 0.1199 0.161
Trypanosoma cruzi cruzipain precursor, putative 0.0142 0.3084 0.8947
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0136 0.0234
Trypanosoma brucei cysteine peptidase C (CPC) 0.0063 0.1187 0.3378
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0744 0.1306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Schistosoma mansoni hypothetical protein 0.0178 0.3958 0.395
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0175 0.0235
Trypanosoma cruzi cysteine peptidase, putative 0.0142 0.3084 0.8947
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0566 0.121
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0136 0.0234
Schistosoma mansoni hypothetical protein 0.043 1 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0219 0.0438
Leishmania major cathepsin L-like protease 0.0092 0.1897 0.6149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.1897 0.334
Loa Loa (eye worm) cysteine protease 0.0092 0.1897 0.2548
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0015 0.0034
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.032 0.092
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0873 0.4054
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0382 0.0667
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.005 0.0873 0.0861
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Loa Loa (eye worm) hypothetical protein 0.0028 0.0364 0.0489
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.002 0.0175 0.0303
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0175 0.0162
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0615 0.0613
Schistosoma mansoni cathepsin B (C01 family) 0.002 0.0175 0.0162
Trypanosoma cruzi major cysteine proteinase, putative 0.002 0.0175 0.05
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Loa Loa (eye worm) hypothetical protein 0.0172 0.38 0.5103
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0969 0.0967
Leishmania major cathepsin L-like protease 0.0142 0.3084 1
Schistosoma mansoni hypothetical protein 0.0031 0.0419 0.0407
Echinococcus granulosus intermediate filament protein 0.0028 0.0364 0.0361
Onchocerca volvulus 0.002 0.0175 0.0303
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0419 0.0417
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0015 0.0034
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0219 0.0295
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0175 0.0162
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0157 0.3447 0.3438
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0969 0.2806
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0453 0.045
Schistosoma mansoni single-minded 0.0051 0.0911 0.0899
Loa Loa (eye worm) hypothetical protein 0.0041 0.0669 0.0899
Schistosoma mansoni cathepsin S (C01 family) 0.002 0.0175 0.0162
Echinococcus granulosus cathepsin l1 0.0063 0.1199 0.1197
Brugia malayi jmjC domain containing protein 0.0039 0.0615 0.122
Brugia malayi Matrixin family protein 0.0037 0.0574 0.1135
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0969 0.2806
Entamoeba histolytica cysteine proteinase, putative 0.0092 0.1897 1
Leishmania major cathepsin L-like protease 0.0092 0.1897 0.6149
Echinococcus multilocularis conserved hypothetical protein 0.0111 0.2343 0.2341
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0873 0.4054
Brugia malayi Cathepsin L-like precursor 0.0092 0.1897 0.3818
Echinococcus granulosus peregrin 0.0031 0.0419 0.0417
Trypanosoma cruzi cysteine protease, putative 0.005 0.0873 0.2527
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Plasmodium vivax hypothetical protein, conserved 0.0077 0.1537 0.735
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0113 0.2386 0.6919
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0364 0.0489
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.032 0.0781
Schistosoma mansoni chromobox protein 0.0073 0.1441 0.143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0175 0.0303
Loa Loa (eye worm) hypothetical protein 0.0037 0.0574 0.077
Leishmania major hypothetical protein, conserved 0.0027 0.032 0.1028
Loa Loa (eye worm) hypothetical protein 0.0032 0.0456 0.0613
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0219 0.0216
Leishmania major protein kinase, putative 0.0014 0.0015 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0175 0.0303
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0219 0.0216
Echinococcus granulosus lamin dm0 0.0028 0.0364 0.0361
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0592 0.1173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0063 0.1199 0.2109
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.1441 0.1935
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0566 0.0993
Onchocerca volvulus 0.0032 0.0456 0.0799
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0157 0.3447 0.3438
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0004
Echinococcus multilocularis lamin 0.0028 0.0364 0.0361
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0175 0.0303
Onchocerca volvulus 0.003 0.0409 0.0715
Leishmania major protein kinase, putative 0.0014 0.0015 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0048 0.0079
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0419 0.1319
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0566 0.211
Toxoplasma gondii cathepsin B 0.0063 0.1187 0.5875
Brugia malayi cahepsin L-like non-peptiedase homolog 0.002 0.0175 0.0328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0175 0.0303
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0566 0.1635
Onchocerca volvulus 0.0092 0.1897 0.334
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0274 0.0786
Plasmodium falciparum cysteine proteinase falcipain 3 0.0092 0.1897 1
Trypanosoma cruzi cruzipain precursor, putative 0.0029 0.0382 0.1102
Schistosoma mansoni ran 0.0022 0.0219 0.0207
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0013 0.001
Brugia malayi fibroinase precursor 0.002 0.0175 0.0328
Loa Loa (eye worm) matrix metalloproteinase 0.0037 0.0574 0.077
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.006 0.01
Onchocerca volvulus Matrilysin homolog 0.0082 0.1657 0.2916
Leishmania major cathepsin L-like protease 0.0142 0.3084 1
Schistosoma mansoni eyes absent homolog 0.0093 0.1907 0.1896
Onchocerca volvulus Matrix metalloproteinase homolog 0.0082 0.1657 0.2916
Loa Loa (eye worm) hypothetical protein 0.0027 0.032 0.043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0136 0.0234
Brugia malayi Cathepsin L-like precursor 0.0063 0.1199 0.2403
Brugia malayi hypothetical protein 0.0093 0.1907 0.3836
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0419 0.0563
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0566 0.2269
Echinococcus multilocularis musashi 0.0028 0.0364 0.0361
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0136 0.0234
Onchocerca volvulus Matrilysin homolog 0.0037 0.0574 0.1006
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0175 0.0303
Loa Loa (eye worm) hypothetical protein 0.0063 0.1199 0.161
Trypanosoma brucei protein kinase, putative 0.0054 0.0969 0.2618
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.002 0.0175 0.0303
Brugia malayi Hemopexin family protein 0.0053 0.0945 0.1888
Brugia malayi hypothetical protein 0.0017 0.0095 0.0165
Brugia malayi Cathepsin L-like precursor 0.0029 0.0382 0.0748
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0969 0.1704
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0969 0.2806
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.005 0.0873 0.0861
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0132 0.0119
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0669 0.1175
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0175 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0669 0.1175
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0969 0.0967
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0049 0.0065
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0969 0.2806
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0235
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.032 0.0841
Schistosoma mansoni ran 0.0022 0.0219 0.0207
Schistosoma mansoni intermediate filament proteins 0.0028 0.0364 0.0352
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0274 0.0478
Loa Loa (eye worm) hypothetical protein 0.003 0.0411 0.0552
Trichomonas vaginalis set domain proteins, putative 0.025 0.5674 1
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0566 0.1635
Trichomonas vaginalis chromobox protein, putative 0.0073 0.1441 0.2536
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0017
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0175 0.0328
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Schistosoma mansoni transcription factor btf3 0.0037 0.0566 0.0554
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0092 0.1897 0.334
Brugia malayi hypoxia-induced factor 1 0.0158 0.3481 0.7027
Leishmania major cysteine peptidase A (CPA) 0.0092 0.1897 0.6149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Schistosoma mansoni chromobox protein 0.0073 0.1441 0.143
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0063 0.1187 0.3843
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0969 0.7849
Loa Loa (eye worm) cathepsin B 0.0063 0.1187 0.1594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0136 0.0234
Echinococcus multilocularis cathepsin L 0.002 0.0175 0.0172
Onchocerca volvulus 0.0028 0.0364 0.0637
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0175 0.0303
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.0382 0.0514
Brugia malayi MAP kinase sur-1 0.0054 0.0969 0.1937
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0098 0.2028 1
Brugia malayi RNA, U transporter 1 0.0086 0.1752 0.3523
Brugia malayi jmjC domain containing protein 0.01 0.2092 0.4213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0873 0.1535
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0136 0.0234
Giardia lamblia Cathepsin B precursor 0.0063 0.1187 1
Plasmodium vivax vivapain-1 0.005 0.0873 0.3769
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.032 0.092
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0566 0.0993
Entamoeba histolytica Ran family GTPase 0.0022 0.0219 0.0257
Onchocerca volvulus 0.0037 0.0574 0.1006
Echinococcus multilocularis cathepsin L 0.005 0.0873 0.0871
Schistosoma mansoni hypothetical protein 0.0178 0.3958 0.395
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0175 0.0303
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0574 0.0571
Echinococcus multilocularis dnaJ subfamily B 0.043 1 1
Brugia malayi cathepsin L-like precursor 0.0063 0.1199 0.2403
Echinococcus multilocularis cathepsin b 0.0157 0.3447 0.3445
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0669 0.1175
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.4949 0.6645
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.1202 0.1614
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0615 0.0826
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0707 0.0705
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0235
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0219 0.0628
Brugia malayi Cathepsin L-like precursor 0.0092 0.1897 0.3818
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0969 0.3136
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0013 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.1897 0.334
Loa Loa (eye worm) matrixin family protein 0.009 0.1834 0.2463
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0175 0.0162
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Loa Loa (eye worm) hypothetical protein 0.0063 0.1199 0.161
Echinococcus multilocularis cysteine protease 0.0092 0.1897 0.1895
Plasmodium vivax transporter, putative 0.0077 0.1537 0.735
Brugia malayi intermediate filament protein 0.0028 0.0364 0.0712
Brugia malayi Cathepsin L-like cysteine proteinase 0.0063 0.1199 0.2403
Echinococcus multilocularis chromobox protein 1 0.0073 0.1441 0.1439
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0092 0.1897 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0175 0.0303
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0015 0.0034
Brugia malayi Matrixin family protein 0.009 0.1834 0.369
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0969 0.1704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0003 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0136 0.0234
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0135 0.2918 0.2915
Schistosoma mansoni importin beta-1 0.003 0.0411 0.0399
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0969 0.0967
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0175 0.0162
Brugia malayi Matrixin family protein 0.0037 0.0574 0.1135
Echinococcus multilocularis peregrin 0.0031 0.0419 0.0417
Brugia malayi cathepsin L-like cysteine proteinase 0.002 0.0175 0.0328
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0175 0.0328
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0092 0.1897 0.2548
Trichomonas vaginalis chromobox protein, putative 0.0073 0.1441 0.2536
Trypanosoma cruzi cysteine peptidase, putative 0.0142 0.3084 0.8947
Trypanosoma cruzi cysteine peptidase, putative 0.0092 0.1897 0.5501
Schistosoma mansoni hypothetical protein 0.0324 0.7448 0.7444
Brugia malayi Cathepsin L-like precursor 0.0092 0.1897 0.3818
Onchocerca volvulus 0.0092 0.1897 0.334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0419 0.0417
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0015 0.0034
Onchocerca volvulus 0.0092 0.1897 0.334
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0707 0.0705
Onchocerca volvulus Cathepsin L homolog 0.0092 0.1897 0.334
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.1897 0.334
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.074 0.0728
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0135 0.2918 0.2915
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0045 0.0767 0.1528
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0175 0.0328
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0219 0.0628
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.002 0.0175 0.0303
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0873 0.4054
Brugia malayi Cathepsin L-like precursor 0.0092 0.1897 0.3818
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0615 0.0603
Trypanosoma cruzi cysteine peptidase, putative 0.0029 0.0382 0.1102
Brugia malayi Pre-SET motif family protein 0.0032 0.0453 0.0891
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0969 0.1302
Brugia malayi cathepsin L precursor 0.002 0.0175 0.0328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Echinococcus multilocularis snurportin 1 0.0324 0.7448 0.7447
Onchocerca volvulus Cathepsin L homolog 0.0092 0.1897 0.334
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.006 0.01
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0411 0.1372
Loa Loa (eye worm) hypothetical protein 0.0028 0.0352 0.0473
Echinococcus granulosus cysteine protease 0.005 0.0873 0.0871
Brugia malayi cathepsin B-like cysteine proteinase 0.0157 0.3447 0.6957
Echinococcus granulosus chromobox protein 1 0.0073 0.1441 0.1439
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0235
Echinococcus multilocularis geminin 0.0178 0.3958 0.3956
Echinococcus multilocularis cathepsin b 0.0157 0.3447 0.3445
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0969 0.3136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.1897 0.334
Brugia malayi Importin beta-1 subunit 0.003 0.0411 0.0807
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Brugia malayi Cathepsin L-like precursor 0.0092 0.1897 0.3818
Leishmania major cathepsin L-like protease 0.0142 0.3084 1
Leishmania major GTP-binding protein, putative 0.0022 0.0219 0.0702
Loa Loa (eye worm) hypothetical protein 0.0093 0.1907 0.256
Brugia malayi Heterochromatin protein 1 0.0073 0.1441 0.2894
Loa Loa (eye worm) hypothetical protein 0.0031 0.0419 0.0563
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0364 0.0489
Brugia malayi Matrixin family protein 0.0037 0.0574 0.1135
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0175 0.0162
Loa Loa (eye worm) fibroinase 0.0092 0.1897 0.2548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0873 0.2283
Onchocerca volvulus 0.0092 0.1897 0.334
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0566 0.2269
Mycobacterium leprae PROBABLE HYDROLASE 0.0045 0.0767 1
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.032 0.0841
Brugia malayi cathepsin F-like cysteine proteinase 0.0029 0.0382 0.0748
Echinococcus granulosus geminin 0.0178 0.3958 0.3956
Echinococcus granulosus cathepsin L 0.002 0.0175 0.0172
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0063 0.1187 0.1175
Entamoeba histolytica hypothetical protein 0.0037 0.0566 0.2269
Schistosoma mansoni cathepsin F (C01 family) 0.0092 0.1897 0.1887
Plasmodium vivax vivapain-2 0.0092 0.1897 0.9297
Echinococcus multilocularis lamin dm0 0.0028 0.0364 0.0361
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0744 0.1306
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0411 0.067
Trypanosoma cruzi major cysteine proteinase, putative 0.007 0.1362 0.3946
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0092 0.1897 0.334
Brugia malayi SET domain containing protein 0.0014 0.0015 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Trichomonas vaginalis ran, putative 0.0022 0.0219 0.0382
Leishmania major cathepsin L-like protease 0.0092 0.1897 0.6149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Entamoeba histolytica cysteine proteinase, putative 0.0063 0.1199 0.5946
Leishmania major cathepsin L-like protease 0.0092 0.1897 0.6149
Loa Loa (eye worm) hypothetical protein 0.0032 0.0453 0.0608
Schistosoma mansoni cathepsin s 0.0029 0.0382 0.037
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.005 0.0873 0.0861
Echinococcus multilocularis cpg binding protein 0.0032 0.045 0.0447
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0175 0.0162
Brugia malayi CXXC zinc finger family protein 0.003 0.0409 0.0801
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0911 0.0899
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0013 0.0018
Onchocerca volvulus Alhambra homolog 0.0031 0.0419 0.0734
Loa Loa (eye worm) hypothetical protein 0.0029 0.0382 0.0514
Entamoeba histolytica cysteine proteinase, putative 0.0092 0.1897 1
Brugia malayi PAS domain containing protein 0.0051 0.0911 0.1819
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0035 0.0529 0.0517
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0157 0.3447 0.3438
Brugia malayi Bromodomain containing protein 0.0031 0.0419 0.0823
Plasmodium vivax importin-beta 2, putative 0.003 0.0411 0.1275
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.002 0.0175 0.0235
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0157 0.3447 0.3438
Plasmodium vivax SET domain protein, putative 0.0032 0.0453 0.1499
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0219 0.0257
Onchocerca volvulus 0.0092 0.1897 0.334

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.0009 M Inhibitory activity of the compound against hog kidney renin (noncompetitive inhibition) ChEMBL. 6352942
Ki (binding) = 0.003 M Inhibitory activity of the compound against human amniotic renin (competitive inhibition) ChEMBL. 6352942

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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