Detailed information for compound 1861137

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1318.92 | Formula: C26H33N2Na7O35S7
  • H donors: 8 H acceptors: 23 LogP: -7.21 Rotable bonds: 30
    Rule of 5 violations (Lipinski): 3
  • SMILES: CO[C@H]1O[C@@H](COCC(=O)N(Cc2ccccc2)CC(=O)NCCO[C@H]2O[C@@H](COS(=O)(=O)[O-])[C@H]([C@@H]([C@H]2OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])[C@H]([C@@H]([C@H]1OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
  • InChi: 1S/C26H40N2O35S7.7Na/c1-52-25-23(62-69(46,47)48)21(60-67(40,41)42)19(58-65(34,35)36)15(56-25)11-53-13-18(30)28(9-14-5-3-2-4-6-14)10-17(29)27-7-8-54-26-24(63-70(49,50)51)22(61-68(43,44)45)20(59-66(37,38)39)16(57-26)12-55-64(31,32)33;;;;;;;/h2-6,15-16,19-26H,7-13H2,1H3,(H,27,29)(H,31,32,33)(H,34,35,36)(H,37,38,39)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51);;;;;;;/q;7*+1/p-7/t15-,16-,19+,20+,21-,22-,23+,24+,25-,26-;;;;;;;/m0......./s1
  • InChiKey: ONJAXANHJBYPQB-RFGLKFIBSA-G  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fibroblast growth factor 2 (basic) Starlite/ChEMBL References
Homo sapiens fibroblast growth factor 1 (acidic) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Treponema pallidum integrase/recombinase (codV) fibroblast growth factor 1 (acidic) 155 aa 132 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0493 0.0444
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0072 0.3497 0.3511
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.2412 0.2407
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0013 0.0185 0.0185
Plasmodium falciparum glutathione reductase 0.0052 0.2384 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0493 0.1676
Trypanosoma cruzi metacaspase, putative 0.0049 0.2195 0.6242
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0471 0.1567
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0493 0.2152
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0185 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0274 0.0601
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0493 0.1676
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0471 0.089
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.047 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.2195 1
Echinococcus multilocularis conserved hypothetical protein 0.0013 0.0185 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.2195 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.047 0.0463
Brugia malayi Cathepsin L-like precursor 0.0019 0.0493 0.0493
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0493 0.1676
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.2769 0.2764
Schistosoma mansoni jumonji domain containing protein 0.0018 0.047 0.0326
Loa Loa (eye worm) hypothetical protein 0.0012 0.0151 0.0144
Plasmodium vivax vivapain-2 0.0019 0.0493 0.1404
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0013 0.0185 0.0179
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0013 0.0185 0.0035
Onchocerca volvulus 0.0019 0.0493 0.0746
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0471 0.089
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.3406 1
Onchocerca volvulus 0.0019 0.0493 0.0746
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0185 0.0035
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.1504 0.1897
Echinococcus granulosus caspase 3 0.008 0.3959 0.3976
Trypanosoma cruzi metacaspase 5, putative 0.0049 0.2195 0.6242
Schistosoma mansoni hypothetical protein 0.0188 0.9946 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0672 0.3272
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0274 0.0601
Echinococcus granulosus WW domain containing oxidoreductase 0.0013 0.0185 0.0179
Loa Loa (eye worm) fibroinase 0.0019 0.0493 0.0487
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.3406 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0493 0.0489
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.2384 0.2379
Loa Loa (eye worm) oxidoreductase 0.0013 0.0185 0.0178
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0471 0.0412
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0493 0.0489
Trypanosoma brucei metacaspase 5, putative 0.0049 0.2195 0.6242
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0202 0.0202
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.1743 0.779
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.1743 0.2242
Mycobacterium tuberculosis Probable reductase 0.0119 0.6134 0.8556
Echinococcus multilocularis steroid dehydrogenase 0.0013 0.0185 0.0179
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.1504 0.1971
Schistosoma mansoni caspase-3 (C14 family) 0.0129 0.6697 0.6683
Loa Loa (eye worm) hypothetical protein 0.0013 0.0185 0.0178
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0471 0.0412
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.2412 0.2412
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.2195 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.3406 1
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0672 0.2549
Loa Loa (eye worm) hypothetical protein 0.0013 0.0185 0.0178
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0185 0.0035
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.047 0.0466
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0185 0.0035
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0185 0.0165
Brugia malayi oxidoreductase 0.0013 0.0185 0.0185
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0185 0.0035
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0013 0.0185 0.0179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.3406 1
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.0274 0.0267
Brugia malayi cathepsin L-like precursor 0.0012 0.0151 0.0151
Brugia malayi PAS domain containing protein 0.0056 0.26 0.26
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0471 0.0412
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.2195 1
Schistosoma mansoni retinal dehydrogenase 0.0013 0.0185 0.0035
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0493 0.1404
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0471 0.089
Brugia malayi jmjC domain containing protein 0.0018 0.047 0.047
Trypanosoma brucei metacaspase MCA2 0.0049 0.2195 0.6242
Echinococcus granulosus caspase 8 0.0049 0.2195 0.2202
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.047 0.0463
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0137 0.7138 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0185 0.0178
Loa Loa (eye worm) hypothetical protein 0.0065 0.3105 0.31
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0013 0.0185 0.0185
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0471 0.1839
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0013 0.0185 0.0165
Echinococcus multilocularis carbonyl reductase 1 0.0013 0.0185 0.0179
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0471 0.1303
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.1743 0.1747
Plasmodium vivax metacaspase 1, putative 0.0049 0.2195 0.9142
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0471 0.089
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0072 0.3497 0.3497
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0672 0.0665
Brugia malayi TAR-binding protein 0.007 0.3378 0.3378
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.3063 0.8936
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0572 0.0568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0493 0.1676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0493 0.1676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0493 0.1676
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0072 0.3497 0.4763
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.2412 0.242
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0493 0.0489
Echinococcus granulosus cathepsin l1 0.0012 0.0151 0.0145
Onchocerca volvulus 0.0013 0.0185 0.0074
Onchocerca volvulus 0.0013 0.0185 0.0074
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.2195 1
Brugia malayi Dehydrogenases, short chain protein 2 0.0013 0.0185 0.0185
Mycobacterium ulcerans aldehyde dehydrogenase 0.0137 0.7138 1
Echinococcus multilocularis phd:f box containing protein 0.0018 0.047 0.0466
Onchocerca volvulus Cell death protein 3 homolog 0.0095 0.4746 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0185 0.0185
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0493 0.0493
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0274 0.0268
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.047 0.0466
Echinococcus granulosus hypothetical protein 0.0013 0.0185 0.0179
Schistosoma mansoni caspase-7 (C14 family) 0.0129 0.6697 0.6683
Leishmania major cathepsin L-like protease 0.0019 0.0493 0.0444
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0471 0.1303
Echinococcus multilocularis caspase 8 0.0049 0.2195 0.2202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0493 0.1676
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0493 0.1676
Toxoplasma gondii exonuclease III APE 0.0022 0.0672 0.0701
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.2195 1
Brugia malayi CXXC zinc finger family protein 0.0032 0.1235 0.1235
Entamoeba histolytica short chain dehydrogenase family protein 0.0013 0.0185 0.0212
Schistosoma mansoni inositol monophosphatase 0.0041 0.1743 0.1626
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0185 0.0035
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0013 0.0185 0.0179
Loa Loa (eye worm) cysteine protease 0.0019 0.0493 0.0487
Brugia malayi Cathepsin L-like precursor 0.0019 0.0493 0.0493
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0471 0.089
Brugia malayi Retinol dehydrogenase 12 0.0013 0.0185 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.3406 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0672 0.3126
Onchocerca volvulus 0.0013 0.0185 0.0074
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.2195 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.2412 0.242
Onchocerca volvulus 0.0013 0.0185 0.0074
Entamoeba histolytica short chain dehydrogenase family protein 0.0013 0.0185 0.0212
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0471 0.089
Echinococcus granulosus carbonyl reductase 1 0.0013 0.0185 0.0179
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0493 0.1676
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.6879 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.2195 1
Echinococcus granulosus retinol dehydrogenase 11 0.0013 0.0185 0.0179
Echinococcus granulosus oxidoreductase 0.0013 0.0185 0.0179
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0185 0.0035
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.6879 0.9627
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.1743 0.779
Echinococcus multilocularis retinol dehydrogenase 11 0.0013 0.0185 0.0179
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0185 0.0185
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0274 0.0277
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0185 0.0185
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0672 0.1513
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0493 0.035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0493 0.1676
Onchocerca volvulus 0.0013 0.0185 0.0074
Brugia malayi Cathepsin L-like precursor 0.0019 0.0493 0.0493
Entamoeba histolytica hypothetical protein, conserved 0.0013 0.0185 0.0212
Onchocerca volvulus 0.0046 0.2007 0.404
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0013 0.0185 0.0074
Loa Loa (eye worm) oxidoreductase 0.0013 0.0185 0.0178
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0185 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.3406 1
Toxoplasma gondii cathepsin CPL 0.0019 0.0493 0.0444
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0471 0.1567
Loa Loa (eye worm) dehydrogenase 0.0013 0.0185 0.0178
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.1743 1
Onchocerca volvulus 0.0013 0.0185 0.0074
Schistosoma mansoni inositol monophosphatase 0.0041 0.1743 0.1626
Echinococcus multilocularis transfer RNA-Lys 0.0042 0.1783 0.1787
Plasmodium falciparum metacaspase 1 0.0049 0.2195 0.9142
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0185 0.0035
Onchocerca volvulus 0.0013 0.0185 0.0074
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0049 0.2195 0.2195
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0471 0.0467
Brugia malayi bHLH-PAS transcription factor 0.0042 0.1783 0.1783
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.3406 1
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0493 0.0746
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.2412 0.2308
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.2384 0.2392
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.6134 0.8556
Schistosoma mansoni caspase-7 (C14 family) 0.0095 0.4746 0.4691
Loa Loa (eye worm) hypothetical protein 0.0018 0.047 0.0463
Echinococcus granulosus cathepsin l1 0.0019 0.0493 0.0489
Schistosoma mansoni phd/f-box containing protein 0.0018 0.047 0.0326
Schistosoma mansoni tar DNA-binding protein 0.007 0.3378 0.3295
Plasmodium vivax vivapain-2 0.0019 0.0493 0.1404
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.2384 0.6827
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.2195 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.6134 0.8556
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0493 0.0489
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0471 0.089
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0471 0.1303
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.2412 0.242
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.3228 0.3141
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0493 0.0746
Schistosoma mansoni carbonyl reductase 0.0013 0.0185 0.0035
Onchocerca volvulus 0.0013 0.0185 0.0074
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0493 0.1404
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.2195 1
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0015 0.0274 0.0601
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0185 0.0185
Schistosoma mansoni ap endonuclease 0.0022 0.0672 0.0532
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.6134 0.8556
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.1743 0.779
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0274 0.0268
Brugia malayi jmjC domain containing protein 0.0018 0.047 0.047
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.047 0.0466
Echinococcus granulosus cpg binding protein 0.0034 0.1336 0.1337
Loa Loa (eye worm) hypothetical protein 0.0049 0.2195 0.219
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0672 0.2549
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0471 0.089
Brugia malayi Cell death protein 3 precursor 0.0095 0.4746 0.4746
Plasmodium vivax hypothetical protein, conserved 0.0049 0.2195 0.9142
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0493 0.2152
Echinococcus granulosus caspase 2 0.0095 0.4746 0.4767
Loa Loa (eye worm) hypothetical protein 0.0013 0.0185 0.0178
Schistosoma mansoni single-minded 0.0056 0.26 0.25
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.047 0.0411
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0013 0.0185 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0493 0.1676
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0185 0.0035
Echinococcus granulosus single minded 2 0.0042 0.1783 0.1787
Loa Loa (eye worm) hypothetical protein 0.0013 0.0185 0.0178
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.2195 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0493 0.1676
Loa Loa (eye worm) hypothetical protein 0.0015 0.0274 0.0267
Trypanosoma cruzi metacaspase, putative 0.0049 0.2195 0.6242
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0185 0.0185
Brugia malayi hypothetical protein 0.0046 0.2007 0.2007
Brugia malayi dehydrogenases, short chain protein 2 0.0013 0.0185 0.0185
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0013 0.0185 0.0074
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.6134 0.8556
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0274 0.0277
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0072 0.3497 0.4763
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0185 0.0185
Onchocerca volvulus 0.0019 0.0493 0.0746
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0013 0.0185 0.0212
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0013 0.0185 0.0165
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0471 1
Schistosoma mansoni carbonyl reductase 0.0013 0.0185 0.0035
Loa Loa (eye worm) hypothetical protein 0.0188 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0493 0.1676
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0013 0.0185 0.0179
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0015 0.0274 0.0601
Brugia malayi hypothetical protein 0.0013 0.0185 0.0185
Leishmania major cathepsin L-like protease 0.0071 0.3406 0.4633
Schistosoma mansoni aldehyde dehydrogenase 0.0137 0.7138 0.7133
Trypanosoma cruzi metacaspase, putative 0.0049 0.2195 0.6242
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0185 0.0165
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0013 0.0185 0.0212
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0471 0.0412
Entamoeba histolytica cysteine protease, putative 0.0019 0.0493 0.2152
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0471 0.089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.3406 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0471 0.0412
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.047 0.0886
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0493 0.1676
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.2195 0.2892
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.1743 0.2242
Plasmodium falciparum metacaspase-like protein 0.0049 0.2195 0.9142
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0274 0.0277
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0151 0.0151
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0185 0.0165
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0013 0.0185 0.0035
Trichomonas vaginalis steroid dehydrogenase, putative 0.0013 0.0185 0.0165
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0013 0.0185 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.3406 1
Echinococcus granulosus retinol dehydrogenase 11 0.0013 0.0185 0.0179
Leishmania major protein kinase, putative 0.0015 0.0274 0.0128
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0185 0.0035
Onchocerca volvulus Sepiapterin reductase homolog 0.0013 0.0185 0.0074
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.6879 0.9627
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0471 0.0982
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.2384 0.3163
Loa Loa (eye worm) oxidoreductase 0.0013 0.0185 0.0178
Onchocerca volvulus 0.0015 0.0274 0.0267
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0471 0.0412
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0471 0.1839
Echinococcus multilocularis caspase 2 0.0095 0.4746 0.4767
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0471 0.089
Echinococcus granulosus steroid dehydrogenase 0.0013 0.0185 0.0179
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.047 0.0466
Loa Loa (eye worm) hypothetical protein 0.0095 0.4746 0.4742
Loa Loa (eye worm) inositol-1 0.0041 0.1743 0.1738
Schistosoma mansoni ap endonuclease 0.0022 0.0672 0.0532
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0471 0.089
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0013 0.0185 0.0179
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0185 0.0185
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0013 0.0185 0.0165
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.2195 0.2892
Trypanosoma brucei trypanothione reductase 0.0052 0.2384 0.6827
Brugia malayi Inositol-1 0.0041 0.1743 0.1743
Onchocerca volvulus 0.0013 0.0185 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0493 0.1676
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0274 0.0601
Leishmania major cathepsin L-like protease 0.0071 0.3406 0.4633
Schistosoma mansoni carbonyl reductase 0.0013 0.0185 0.0035
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0672 0.1513
Loa Loa (eye worm) hypothetical protein 0.0012 0.0151 0.0144
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0068 0.3256 0.3269
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0013 0.0185 0.0212
Brugia malayi RNA recognition motif domain containing protein 0.007 0.3378 0.3378
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.047 0.0886
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0185 0.0165
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.0185 0.0179
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.047 0.0466
Brugia malayi Cathepsin L-like precursor 0.0019 0.0493 0.0493
Echinococcus multilocularis caspase 3 0.008 0.3959 0.3976
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0274 0.0277
Brugia malayi Cathepsin L-like precursor 0.0012 0.0151 0.0151
Schistosoma mansoni hypothetical protein 0.0046 0.2007 0.1895
Mycobacterium ulcerans aldehyde dehydrogenase 0.0137 0.7138 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0185 0.0185
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.2561 0.7376
Loa Loa (eye worm) oxidoreductase 0.0013 0.0185 0.0178
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.3358 0.3274
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0493 0.1676
Trypanosoma brucei metacaspase MCA3 0.0049 0.2195 0.6242
Onchocerca volvulus 0.0032 0.1235 0.2359
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0137 0.7138 0.7175
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0185 0.0035
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.6879 0.9627
Echinococcus multilocularis carbonyl reductase 1 0.0013 0.0185 0.0179
Leishmania major hypothetical protein, conserved 0.0018 0.047 0.0411
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.2195 0.2892
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0185 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0493 0.1676
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0185 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0493 0.1676
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0185 0.0035
Schistosoma mansoni protein phosphatase 2C 0.0018 0.047 0.0326
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0185 0.0035
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.047 0.1298
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0493 0.0487
Onchocerca volvulus 0.0019 0.0493 0.0746
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.047 0.0463
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0493 0.1404
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0274 0.0601
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.3378 0.3374
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0185 0.0035
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0185 0.0165
Brugia malayi Cathepsin L-like precursor 0.0019 0.0493 0.0493
Schistosoma mansoni tar DNA-binding protein 0.007 0.3378 0.3295
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0013 0.0185 0.0212
Brugia malayi glutathione reductase 0.0052 0.2384 0.2384
Loa Loa (eye worm) hypothetical protein 0.0046 0.2007 0.2002
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.3406 1
Brugia malayi Cathepsin L-like precursor 0.0012 0.0151 0.0151
Schistosoma mansoni aryl hydrocarbon receptor 0.0056 0.26 0.25
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0672 0.0669
Plasmodium vivax glutathione reductase, putative 0.0052 0.2384 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0672 0.0701
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.2412 0.242
Brugia malayi jmjC domain containing protein 0.0068 0.3256 0.3256
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0493 0.0746
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0185 0.0035
Onchocerca volvulus 0.0013 0.0185 0.0074
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.1235 0.1229
Echinococcus multilocularis cysteine protease 0.0019 0.0493 0.0489
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0185 0.0035
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.1743 0.4839
Onchocerca volvulus 0.0019 0.0493 0.0746
Loa Loa (eye worm) hypothetical protein 0.0018 0.047 0.0463
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.3406 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0151 0.0144
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0274 0.0601
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0185 0.0185
Toxoplasma gondii aldehyde dehydrogenase 0.0137 0.7138 1
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0185 0.0035
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0185 0.0165
Plasmodium falciparum thioredoxin reductase 0.0052 0.2384 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0129 0.6697 0.6731
Schistosoma mansoni cpg binding protein 0.0034 0.1336 0.121
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.3358 0.3274
Echinococcus multilocularis cysteine protease 0.0019 0.0493 0.0489
Echinococcus multilocularis carbonyl reductase 1 0.0013 0.0185 0.0179
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0185 0.0035
Entamoeba histolytica hypothetical protein 0.0013 0.0185 0.0212
Loa Loa (eye worm) oxidoreductase 0.0013 0.0185 0.0178
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0274 0.0268
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0471 0.0412
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0274 0.0601
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0185 0.0035
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0572 0.0568
Brugia malayi hypothetical protein 0.0013 0.0185 0.0185
Plasmodium falciparum thioredoxin reductase 0.0018 0.0471 0.1303
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0471 0.0412
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.3406 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0072 0.3497 0.4763
Mycobacterium ulcerans aldehyde dehydrogenase 0.0137 0.7138 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.047 0.0463
Loa Loa (eye worm) RNA binding protein 0.007 0.3378 0.3374
Plasmodium vivax JmjC domain containing protein 0.0018 0.047 0.1298
Loa Loa (eye worm) hypothetical protein 0.0013 0.0185 0.0178
Trichomonas vaginalis adenylate cyclase, putative 0.0015 0.0274 0.0601
Loa Loa (eye worm) hypothetical protein 0.0013 0.0185 0.0178
Echinococcus multilocularis carbonyl reductase 1 0.0013 0.0185 0.0179
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.047 0.0326
Echinococcus multilocularis retinol dehydrogenase 13 0.0013 0.0185 0.0179
Echinococcus multilocularis retinol dehydrogenase 11 0.0013 0.0185 0.0179
Echinococcus granulosus geminin 0.0188 0.9946 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0185 0.0185
Schistosoma mansoni cpg binding protein 0.0032 0.1235 0.1107
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0068 0.3256 0.3269
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0493 0.0959
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.1743 0.2242
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.047 0.0466
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0493 0.0487
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0493 0.0489
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0049 0.2195 0.2087
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0274 0.0601
Schistosoma mansoni hypothetical protein 0.0188 0.9946 1
Echinococcus multilocularis cpg binding protein 0.0034 0.1336 0.1337
Toxoplasma gondii thioredoxin reductase 0.0052 0.2384 0.3163
Leishmania major cathepsin L-like protease 0.0019 0.0493 0.0444
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0471 0.0471
Loa Loa (eye worm) oxidoreductase 0.0013 0.0185 0.0178
Leishmania major cathepsin L-like protease 0.0019 0.0493 0.0444
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.047 0.0326
Brugia malayi Dehydrogenases, short chain protein 30 0.0013 0.0185 0.0185
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0202 0.0202
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.6134 0.8556
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.2412 0.2308
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.2384 1
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0493 0.035
Leishmania major cathepsin L-like protease 0.0019 0.0493 0.0444
Echinococcus granulosus phd:f box containing protein 0.0018 0.047 0.0466
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.2412 0.2308
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0013 0.0185 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.2195 1
Brugia malayi RNA binding protein 0.007 0.3378 0.3378
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0274 0.0277
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0471 0.089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0493 0.1676
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0672 0.1669
Leishmania major protein kinase, putative 0.0015 0.0274 0.0128
Echinococcus multilocularis caspase 0.0129 0.6697 0.6731
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0493 0.1676
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0013 0.0185 0.0074
Loa Loa (eye worm) hypothetical protein 0.0013 0.0185 0.0178
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.1743 0.4839
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0185 0.0035
Loa Loa (eye worm) glutathione reductase 0.0052 0.2384 0.2379
Onchocerca volvulus 0.0042 0.1783 0.3552
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0119 0.6134 0.8887
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0185 0.0185
Mycobacterium leprae Possible regulatory protein 0.0015 0.0274 0.0133
Loa Loa (eye worm) dehydrogenase 0.0013 0.0185 0.0178
Mycobacterium ulcerans putative regulatory protein 0.0042 0.1783 0.2298
Brugia malayi Cathepsin L-like precursor 0.0019 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0065 0.3105 0.31
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0274 0.0128
Echinococcus granulosus apoptotic protease activating factor 1 0.0046 0.2007 0.2012
Echinococcus multilocularis geminin 0.0188 0.9946 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0471 0.1303
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0013 0.0185 0.0178
Entamoeba histolytica hypothetical protein, conserved 0.0013 0.0185 0.0212
Echinococcus multilocularis apoptotic protease activating factor 1 0.0046 0.2007 0.2012
Echinococcus granulosus hypothetical protein 0.0013 0.0185 0.0179
Brugia malayi dehydrogenases, short chain protein 9 0.0013 0.0185 0.0185
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0672 0.0701
Echinococcus granulosus carbonyl reductase 1 0.0013 0.0185 0.0179
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.3358 0.3353
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.3358 0.3371
Leishmania major cathepsin L-like protease 0.0071 0.3406 0.4633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0493 0.1676
Brugia malayi Thioredoxin reductase 0.0052 0.2384 0.2384
Giardia lamblia Hypothetical protein 0.0065 0.3105 1
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0185 0.0035
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0185 0.0185
Trypanosoma cruzi metacaspase, putative 0.0049 0.2195 0.6242
Onchocerca volvulus 0.0013 0.0185 0.0074
Leishmania major metacaspase, putative 0.0049 0.2195 0.2892
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0129 0.6697 0.6731
Echinococcus granulosus carbonyl reductase 1 0.0013 0.0185 0.0179
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0185 0.0185
Schistosoma mansoni aldehyde dehydrogenase 0.0137 0.7138 0.7133
Schistosoma mansoni tar DNA-binding protein 0.007 0.3378 0.3295
Trypanosoma brucei metacaspase 0.0049 0.2195 0.6242
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.1743 0.4839
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0137 0.7138 0.7175
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.3406 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.1743 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0174 0.9183 0.9183
Schistosoma mansoni tar DNA-binding protein 0.007 0.3378 0.3295
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0672 0.0701
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0013 0.0185 0.0179
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0185 0.0165
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0493 0.0489
Loa Loa (eye worm) oxidoreductase 0.0013 0.0185 0.0178
Brugia malayi Fibroblast growth factor family protein 0.0065 0.3105 0.3105
Loa Loa (eye worm) TAR-binding protein 0.007 0.3378 0.3374
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.2195 1
Schistosoma mansoni cpg binding protein 0.0034 0.1336 0.121
Brugia malayi jmjC domain containing protein 0.007 0.3358 0.3358
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0274 0.0268
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0013 0.0185 0.0035
Loa Loa (eye worm) ctsf protein 0.0019 0.0493 0.0487
Loa Loa (eye worm) oxidoreductase 0.0013 0.0185 0.0178
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.3406 1
Brugia malayi jmjC domain containing protein 0.0018 0.047 0.047
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.2384 0.2392
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0471 0.0412
Plasmodium falciparum glutathione reductase 0.0018 0.0471 0.1303
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0471 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0274 0.0601
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0493 0.1676
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0185 0.0035
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0013 0.0185 0.0212
Echinococcus granulosus tar DNA binding protein 0.007 0.3378 0.3392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0493 0.1676
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.3406 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0072 0.3497 0.4763
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0471 0.0467
Leishmania major cathepsin L-like protease 0.0019 0.0493 0.0444
Brugia malayi Fibroblast growth factor family protein 0.0065 0.3105 0.3105
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0185 0.0185
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0185 0.0185
Echinococcus multilocularis lysine specific demethylase 5A 0.0068 0.3256 0.3269
Brugia malayi jmjC domain containing protein 0.0018 0.047 0.047
Onchocerca volvulus 0.0019 0.0493 0.0746
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0672 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.047 0.0886
Echinococcus multilocularis tar DNA binding protein 0.007 0.3378 0.3392
Trypanosoma cruzi metacaspase 5, putative 0.0049 0.2195 0.6242
Loa Loa (eye worm) oxidoreductase 0.0013 0.0185 0.0178
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0672 0.2216
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0274 0.0277
Schistosoma mansoni tar DNA-binding protein 0.007 0.3378 0.3295
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0185 0.0035
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.1743 0.1747
Loa Loa (eye worm) hypothetical protein 0.0013 0.0185 0.0178
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0471 0.0327
Echinococcus granulosus caspase 0.0129 0.6697 0.6731
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0672 0.0672
Onchocerca volvulus 0.0013 0.0185 0.0074
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0672 0.2216
Leishmania major trypanothione reductase 0.0052 0.2384 0.3163
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0072 0.3497 0.3511
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0493 0.1676
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0471 0.089
Echinococcus granulosus carbonyl reductase 1 0.0013 0.0185 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.2195 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0137 0.7138 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.2825 0.3797
Onchocerca volvulus 0.0013 0.0185 0.0074
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0672 0.1513
Loa Loa (eye worm) hypothetical protein 0.0019 0.0493 0.0487
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0185 0.0035
Schistosoma mansoni jumonji domain containing protein 0.0068 0.3256 0.317
Echinococcus multilocularis steroid dehydrogenase 0.0013 0.0185 0.0179
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0493 0.1676
Echinococcus multilocularis oxidoreductase 0.0013 0.0185 0.0179
Brugia malayi hypoxia-induced factor 1 0.0174 0.9183 0.9183
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0672 0.0669
Onchocerca volvulus 0.0019 0.0493 0.0746
Trypanosoma brucei Metacaspase-4 0.0049 0.2195 0.6242
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.2195 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0072 0.3497 0.3416

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) = 4.84 uM Binding affinity for human fibroblast growth factor 1 in surface plasmon resonance (SPR) assay ChEMBL. 15081013
Kd (binding) = 16 uM Binding affinity for human fibroblast growth factor 2 in surface plasmon resonance (SPR) assay ChEMBL. 15081013

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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