Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | putative regulatory protein | 0.006 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.4368 | 0.6438 |
Brugia malayi | PAS domain containing protein | 0.0081 | 0.0994 | 0.0994 |
Echinococcus granulosus | acetylcholinesterase | 0.0192 | 0.6234 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0192 | 0.6234 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0251 | 0.9006 | 0.7361 |
Onchocerca volvulus | 0.006 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0192 | 0.6234 | 0.6234 |
Echinococcus granulosus | carboxylesterase 5A | 0.0192 | 0.6234 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0192 | 0.6234 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0192 | 0.6234 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0192 | 0.6234 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0192 | 0.6234 | 0.6234 |
Echinococcus multilocularis | acetylcholinesterase | 0.0192 | 0.6234 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0251 | 0.9006 | 0.9006 |
Trypanosoma brucei | RNA helicase, putative | 0.0152 | 0.4368 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.