Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0034 | 0.013 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0117 | 0.1371 | 0.522 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0117 | 0.1371 | 0.522 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0388 | 0.1478 |
Toxoplasma gondii | ABC1 family protein | 0.0117 | 0.1371 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0208 | 0.2626 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0074 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0288 | 0.1099 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0117 | 0.1371 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1371 | 0.522 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0255 | 0.0973 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0726 | 0.2766 |
Schistosoma mansoni | tar DNA-binding protein | 0.0208 | 0.2626 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0208 | 0.2626 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0208 | 0.2626 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0208 | 0.2626 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0208 | 0.2626 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0117 | 0.1371 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0117 | 0.1371 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0388 | 0.1478 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0034 | 0.013 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0117 | 0.1371 | 0.522 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0388 | 0.1478 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0346 | 0.1319 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0117 | 0.1371 | 0.5 |
Onchocerca volvulus | 0.0117 | 0.1371 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0388 | 0.1478 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1371 | 0.522 |
Onchocerca volvulus | 0.0117 | 0.1371 | 0.5 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0117 | 0.1371 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0117 | 0.1371 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0208 | 0.2626 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0255 | 0.0973 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0034 | 0.013 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0074 | 0.0283 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0137 | 0.1646 | 0.6268 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0117 | 0.1371 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0208 | 0.2626 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0137 | 0.1646 | 0.611 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0388 | 0.1478 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0048 | 0.0184 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0388 | 0.1478 |
Brugia malayi | beta-lactamase family protein | 0.0117 | 0.1371 | 0.5018 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1371 | 0.522 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0117 | 0.1371 | 0.5018 |
Onchocerca volvulus | 0.0117 | 0.1371 | 0.5 | |
Loa Loa (eye worm) | RNA binding protein | 0.0208 | 0.2626 | 1 |
Brugia malayi | TAR-binding protein | 0.0208 | 0.2626 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0117 | 0.1371 | 0.5018 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0117 | 0.1371 | 0.522 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0388 | 0.1478 |
Schistosoma mansoni | tar DNA-binding protein | 0.0208 | 0.2626 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0008 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1371 | 0.522 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0117 | 0.1371 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0388 | 0.1119 |
Echinococcus granulosus | tar DNA binding protein | 0.0208 | 0.2626 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0074 | 0.0784 | 0.269 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1371 | 0.522 |
Brugia malayi | RNA binding protein | 0.0208 | 0.2626 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1371 | 0.522 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0117 | 0.1371 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0117 | 0.1371 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0117 | 0.1371 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0074 | 0.0283 |
Mycobacterium leprae | Probable lipase LipE | 0.0117 | 0.1371 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0117 | 0.1371 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.032 | 0.1221 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0117 | 0.1371 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0117 | 0.1371 | 0.522 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0287 | 0.0719 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0117 | 0.1371 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0048 | 0.0184 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.0625 | 0.2382 |
Mycobacterium ulcerans | hypothetical protein | 0.0117 | 0.1371 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0117 | 0.1371 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0117 | 0.1371 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.0577 | 0.2198 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.0577 | 0.2198 |
Loa Loa (eye worm) | beta-lactamase | 0.0117 | 0.1371 | 0.522 |
Brugia malayi | beta-lactamase | 0.0117 | 0.1371 | 0.5018 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0137 | 0.1646 | 0.6268 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0388 | 0.1478 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.3 ug ml-1 | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 by LDH assay | ChEMBL. | 21172735 |
IC50 (functional) | = 2.4 ug ml-1 | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 by LDH assay | ChEMBL. | 21172735 |
IC50 (functional) | = 4 ug ml-1 | Antileishmanial activity against promastigotes of Leishmania donovani by alamar blue assay | ChEMBL. | 21172735 |
IC50 (functional) | = 10 ug ml-1 | Antifungal activity against Candida albicans ATCC 90028 | ChEMBL. | 21172735 |
IC50 (functional) | = 15 ug ml-1 | Antifungal activity against Cryptococcus neoformans ATCC 90113 | ChEMBL. | 21172735 |
IC90 (functional) | = 20 ug ml-1 | Antileishmanial activity against promastigotes of Leishmania donovani by alamar blue assay | ChEMBL. | 21172735 |
MIC (functional) | = 20 ug ml-1 | Antifungal activity against Candida albicans ATCC 90028 | ChEMBL. | 21172735 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Candida albicans | ChEMBL23 | 21172735 | |
Plasmodium falciparum | ChEMBL23 | 21172735 | |
Leishmania donovani | ChEMBL23 | 21172735 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.