Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ferritin | 0.0019 | 0.5 | 0.5 |
Schistosoma mansoni | apoferritin-2 | 0.0019 | 0.5 | 0.5 |
Schistosoma mansoni | ferritin | 0.0019 | 0.5 | 0.5 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0019 | 0.5 | 0.5 |
Schistosoma mansoni | ferritin light chain | 0.0019 | 0.5 | 0.5 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0019 | 0.5 | 0.5 |
Schistosoma mansoni | ferritin | 0.0019 | 0.5 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0019 | 0.5 | 0.5 |
Echinococcus multilocularis | expressed protein | 0.0019 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0019 | 0.5 | 0.5 |
Trichomonas vaginalis | ferritin, putative | 0.0019 | 0.5 | 0.5 |
Echinococcus multilocularis | ferritin | 0.0019 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0019 | 0.5 | 0.5 |
Schistosoma mansoni | apoferritin-2 | 0.0019 | 0.5 | 0.5 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0019 | 0.5 | 0.5 |
Echinococcus granulosus | ferritin | 0.0019 | 0.5 | 0.5 |
Schistosoma mansoni | ferritin | 0.0019 | 0.5 | 0.5 |
Schistosoma mansoni | ferritin light chain | 0.0019 | 0.5 | 0.5 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0019 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 43.3 uM | Inhibition of New Zealand white rabbit lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presence of S-methyl-[14C]adenosylmethionine | ChEMBL. | 423205 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.