Detailed information for compound 1861911

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1108.78 | Formula: C48H36O31
  • H donors: 15 H acceptors: 21 LogP: -1.82 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 4
  • SMILES: O=C(c1cc(O)c(c(c1)O)O)O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(c(c3c3c(C(=O)O[C@@H]4[C@H]1OC(=O)c1cc(O)c(c5c1C1C6(C(=C)O[C@H]24)CC(=O)C(C1(O5)O)(OC16C(=O)OC2C1(O)OCC2O)O)O)cc(O)c(c3O)O)O)O
  • InChi: 1S/C48H36O31/c1-10-44-7-22(55)46(67,79-45(44)43(66)76-37-20(54)8-71-48(37,45)69)47(68)36(44)25-14(6-19(53)29(59)33(25)78-47)41(65)75-35-34-32(72-10)21(73-42(35)77-38(62)11-2-15(49)26(56)16(50)3-11)9-70-39(63)12-4-17(51)27(57)30(60)23(12)24-13(40(64)74-34)5-18(52)28(58)31(24)61/h2-6,20-21,32,34-37,42,49-54,56-61,67-69H,1,7-9H2/t20?,21-,32-,34+,35-,36?,37?,42+,44?,45?,46?,47?,48?/m1/s1
  • InChiKey: OXVCKBRYFLCOBL-ITJNKTDFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase D1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) CAMK/PKD protein kinase Get druggable targets OG5_130080 All targets in OG5_130080
Loa Loa (eye worm) CAMK/PKD protein kinase Get druggable targets OG5_130080 All targets in OG5_130080
Onchocerca volvulus Get druggable targets OG5_130080 All targets in OG5_130080
Brugia malayi Phorbol esters/diacylglycerol binding domain Get druggable targets OG5_130080 All targets in OG5_130080
Schistosoma japonicum ko:K06070 protein kinase D, putative Get druggable targets OG5_130080 All targets in OG5_130080
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130080 All targets in OG5_130080
Onchocerca volvulus Get druggable targets OG5_130080 All targets in OG5_130080
Schistosoma japonicum hypothetical protein Get druggable targets OG5_130080 All targets in OG5_130080
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130080 All targets in OG5_130080
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130080 All targets in OG5_130080
Onchocerca volvulus Get druggable targets OG5_130080 All targets in OG5_130080
Brugia malayi C1-like domain containing protein Get druggable targets OG5_130080 All targets in OG5_130080
Schistosoma mansoni protein kinase C mu Get druggable targets OG5_130080 All targets in OG5_130080
Schistosoma japonicum ko:K06070 protein kinase D, putative Get druggable targets OG5_130080 All targets in OG5_130080
Schistosoma japonicum expressed protein Get druggable targets OG5_130080 All targets in OG5_130080
Schistosoma japonicum hypothetical protein Get druggable targets OG5_130080 All targets in OG5_130080
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130080 All targets in OG5_130080
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0318 0.0775
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0041 0.0324 0.0025
Echinococcus granulosus cysteine protease 0.0114 0.1289 0.1003
Echinococcus granulosus cathepsin L cysteine proteinase 0.0222 0.2705 0.2465
Plasmodium falciparum serine repeat antigen 1 0.0041 0.0324 0.0798
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.2705 1
Giardia lamblia Cathepsin L-like protease 0.0041 0.0324 0.5
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0041 0.0324 0.0798
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0041 0.0324 0.0798
Onchocerca volvulus 0.0222 0.2705 1
Trypanosoma cruzi cysteine peptidase, putative 0.0222 0.2705 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0041 0.0324 0.0798
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0184 0.0257
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.2705 1
Leishmania major cathepsin L-like protease 0.0222 0.2705 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0887
Plasmodium vivax vivapain-2 0.0222 0.2705 1
Loa Loa (eye worm) cathepsin B 0.0041 0.0324 0.0798
Trypanosoma cruzi cysteine peptidase, putative 0.0222 0.2705 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0184 0.0257
Giardia lamblia Cysteine protease 0.0041 0.0324 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.2705 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0114 0.1289 0.4529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0324 0.0025
Loa Loa (eye worm) hypothetical protein 0.004 0.0318 0.0775
Brugia malayi cathepsin Z-like cysteine proteinase 0.0041 0.0324 0.1199
Onchocerca volvulus 0.0222 0.2705 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0222 0.2705 1
Loa Loa (eye worm) matrix metalloproteinase 0.0043 0.0347 0.0887
Trypanosoma cruzi cysteine proteinase, putative 0.0114 0.1289 0.4529
Giardia lamblia Cathepsin L-like protease 0.0041 0.0324 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0222 0.2705 1
Brugia malayi Cathepsin L-like precursor 0.0148 0.174 0.6432
Schistosoma mansoni hypothetical protein 0.006 0.0582 0.0272
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0041 0.0324 0.0798
Loa Loa (eye worm) hypothetical protein 0.0085 0.0907 0.3051
Echinococcus granulosus cathepsin L cysteine protease 0.0114 0.1289 0.1003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0222 0.2705 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0041 0.0324 0.0798
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.0943 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0041 0.0324 0.0798
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0324 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0222 0.2705 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0088 0.0943 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0318 0.0775
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0114 0.1289 0.4069
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0041 0.0324 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0318 0.0775
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0083 0.0878 0.3246
Loa Loa (eye worm) ctsf protein 0.0222 0.2705 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.174 0.6269
Entamoeba histolytica cysteine protease, putative 0.0114 0.1289 0.4054
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0052 0.047 0.1736
Schistosoma mansoni peptidase Clp (S14 family) 0.0088 0.0943 0.0645
Trypanosoma cruzi cysteine peptidase, putative 0.0222 0.2705 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0324 0.0006
Schistosoma mansoni cathepsin C 0.0041 0.0324 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.2705 1
Brugia malayi Cathepsin L-like precursor 0.0222 0.2705 1
Plasmodium vivax vivapain-2 0.0222 0.2705 1
Giardia lamblia Cathepsin B precursor 0.0041 0.0324 0.5
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0052 0.047 0.0526
Entamoeba histolytica cysteine proteinase, putative 0.0222 0.2705 1
Entamoeba histolytica cysteine protease, putative 0.0114 0.1289 0.4054
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.0943 0.3189
Plasmodium falciparum serine repeat antigen 3 0.0041 0.0324 0.0798
Onchocerca volvulus 0.0222 0.2705 1
Giardia lamblia Hypothetical protein 0.0041 0.0324 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0324 0.0025
Loa Loa (eye worm) matrixin family protein 0.0103 0.1144 0.3965
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0222 0.2705 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.047 0.136
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0074 0.0758 0.2474
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0222 0.2705 1
Brugia malayi Cathepsin L-like precursor 0.0222 0.2705 1
Echinococcus granulosus cathepsin L 0.0041 0.0324 0.0006
Brugia malayi Probable ClpP-like protease 0.0088 0.0943 0.3486
Echinococcus multilocularis cysteine protease 0.0222 0.2705 0.2465
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0041 0.0324 0.0798
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0324 0.0006
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0043 0.0347 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.2705 1
Mycobacterium leprae conserved hypothetical protein 0.004 0.0318 0.1768
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0041 0.0324 0.0798
Giardia lamblia Cathepsin L precursor 0.0041 0.0324 0.5
Entamoeba histolytica cysteine protease, putative 0.0114 0.1289 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0222 0.2705 1
Mycobacterium ulcerans hydrolase 0.0052 0.047 0.2421
Onchocerca volvulus 0.0148 0.174 0.5956
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0041 0.0324 0.0798
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0088 0.0943 0.3189
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0324 0.1199
Entamoeba histolytica cysteine protease, putative 0.0114 0.1289 0.4054
Brugia malayi cathepsin L precursor 0.0041 0.0324 0.1199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0222 0.2705 1
Brugia malayi beta-lactamase 0.004 0.0318 0.1177
Leishmania major cathepsin L-like protease 0.0222 0.2705 1
Giardia lamblia Cathepsin B precursor 0.0041 0.0324 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.0324 0.0798
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0324 0.0006
Brugia malayi C1-like domain containing protein 0.0083 0.0878 0.3246
Onchocerca volvulus 0.0074 0.0754 0.1826
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0222 0.2705 0.2465
Plasmodium vivax serine-repeat antigen (SERA) 0.0041 0.0324 0.0798
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.1289 0.4529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.2705 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0088 0.0943 0.0645
Schistosoma mansoni cathepsin F (C01 family) 0.0148 0.174 0.1468
Giardia lamblia Cathepsin L precursor 0.0041 0.0324 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.0754 0.246
Plasmodium falciparum serine repeat antigen 6 0.0041 0.0324 0.0798
Trypanosoma cruzi cysteine protease, putative 0.0114 0.1289 0.4529
Brugia malayi Papain family cysteine protease containing protein 0.0114 0.1289 0.4767
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0324 0.1199
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0324 0.0025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0324 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0324 0.0025
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0041 0.0324 0.0006
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0058 0.0544 0.0786
Schistosoma mansoni microtubule-associated protein tau 0.0775 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0114 0.1289 0.1003
Loa Loa (eye worm) beta-lactamase 0.004 0.0318 0.0775
Brugia malayi Cathepsin L-like precursor 0.0222 0.2705 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0324 0.0798
Giardia lamblia Cysteine protease 0.0041 0.0324 0.5
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0114 0.1289 0.1003
Entamoeba histolytica cysteine proteinase, putative 0.0148 0.174 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.2705 1
Entamoeba histolytica cysteine protease, putative 0.0114 0.1289 0.4054
Brugia malayi cathepsin B-like cysteine proteinase 0.0041 0.0324 0.1199
Echinococcus multilocularis cathepsin L cysteine protease 0.0222 0.2705 0.2465
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0073 0.0751 0.2446
Loa Loa (eye worm) hypothetical protein 0.0041 0.0324 0.0798
Brugia malayi Matrixin family protein 0.0043 0.0347 0.1283
Plasmodium falciparum serine repeat antigen 9 0.0041 0.0324 0.0798
Toxoplasma gondii preprocathepsin c precursor, putative 0.0041 0.0324 0.0798
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0155 0.1828 0.1559
Plasmodium falciparum cysteine proteinase falcipain 3 0.0222 0.2705 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.174 0.6269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0324 0.0025
Plasmodium falciparum serine repeat antigen 2 0.0041 0.0324 0.0798
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0088 0.0943 0.3189
Entamoeba histolytica cysteine proteinase 2 0.0114 0.1289 0.4054
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0041 0.0324 0.0798
Echinococcus multilocularis cathepsin L 0.0041 0.0324 0.0006
Onchocerca volvulus Matrix metalloproteinase homolog 0.0095 0.1031 0.2987
Brugia malayi Cathepsin L-like precursor 0.0222 0.2705 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0088 0.0943 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0751 0.2446
Leishmania major cathepsin L-like protease 0.0222 0.2705 1
Brugia malayi Cathepsin L-like precursor 0.0222 0.2705 1
Loa Loa (eye worm) cysteine protease 0.0222 0.2705 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0041 0.0324 0.5
Echinococcus granulosus cathepsin l1 0.0222 0.2705 0.2465
Brugia malayi Cathepsin L-like precursor 0.0073 0.0751 0.2775
Giardia lamblia Cysteine protease 0.0041 0.0324 0.5
Leishmania major cathepsin L-like protease 0.0222 0.2705 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0324 0.0025
Schistosoma mansoni cathepsin F (C01 family) 0.0222 0.2705 0.2465
Entamoeba histolytica cysteine proteinase, putative 0.0114 0.1289 0.4054
Trypanosoma cruzi cruzipain precursor, putative 0.0073 0.0751 0.2446
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.2705 1
Onchocerca volvulus 0.006 0.0582 0.1104
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0073 0.0751 0.2775
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.0943 1
Plasmodium falciparum serine repeat antigen 5 0.0041 0.0324 0.0798
Schistosoma mansoni protein kinase C mu 0.0083 0.0878 0.0578
Onchocerca volvulus 0.0083 0.0875 0.233
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0222 0.2705 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0222 0.2705 1
Onchocerca volvulus 0.0085 0.0907 0.2467
Brugia malayi beta-lactamase family protein 0.004 0.0318 0.1177
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0088 0.0943 1
Plasmodium falciparum serine repeat antigen 8 0.0041 0.0324 0.0798
Trypanosoma cruzi cysteine peptidase, putative 0.0114 0.1289 0.4529
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.0943 0.5
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.319 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.2705 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.1289 0.4529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.2705 1
Echinococcus granulosus cathepsin l1 0.0148 0.174 0.1468
Onchocerca volvulus Matrilysin homolog 0.0043 0.0347 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0041 0.0324 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0222 0.2705 1
Giardia lamblia Cysteine protease 0.0041 0.0324 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0324 0.0006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0324 0.0006
Toxoplasma gondii cathepsin B 0.0041 0.0324 0.0798
Entamoeba histolytica cysteine protease, putative 0.0114 0.1289 0.4054
Onchocerca volvulus Cathepsin L homolog 0.0222 0.2705 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0041 0.0324 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0222 0.2705 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0222 0.2705 1
Echinococcus granulosus cathepsin b 0.0041 0.0324 0.0006
Echinococcus granulosus cathepsin l cysteine peptidase 0.0222 0.2705 0.2465
Brugia malayi fibroinase precursor 0.0041 0.0324 0.1199
Brugia malayi Papain family cysteine protease containing protein 0.0114 0.1289 0.4767
Entamoeba histolytica cysteine proteinase, putative 0.0114 0.1289 0.4054
Leishmania major cathepsin L-like protease 0.0222 0.2705 1
Giardia lamblia Cathepsin L precursor 0.0041 0.0324 0.5
Loa Loa (eye worm) hypothetical protein 0.0222 0.2705 1
Entamoeba histolytica cysteine proteinase, putative 0.0114 0.1289 0.4054
Brugia malayi Matrixin family protein 0.0103 0.1144 0.4228
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0041 0.0324 0.0798
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0058 0.0544 0.4744
Giardia lamblia Cathepsin L precursor 0.0041 0.0324 0.5
Giardia lamblia Encystation-specific protease 0.0041 0.0324 0.5
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0083 0.0878 0.2939
Trypanosoma cruzi major cysteine proteinase, putative 0.0041 0.0324 0.0798
Trypanosoma cruzi cysteine proteinase, putative 0.0114 0.1289 0.4529
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0041 0.0324 0.0798
Brugia malayi cathepsin F-like cysteine proteinase 0.0073 0.0751 0.2775
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0155 0.1828 0.1559
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0222 0.2705 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.2705 1
Onchocerca volvulus Cathepsin L homolog 0.0222 0.2705 1
Echinococcus multilocularis cathepsin b 0.0041 0.0324 0.0006
Brugia malayi beta-lactamase family protein 0.004 0.0318 0.1177
Toxoplasma gondii ABC1 family protein 0.004 0.0318 0.0775
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0041 0.0324 0.0798
Onchocerca volvulus 0.0041 0.0324 0.0025
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0324 0.0006
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0041 0.0324 0.0006
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0222 0.2705 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.2705 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0114 0.1289 0.4069
Plasmodium falciparum serine repeat antigen 4 0.0041 0.0324 0.0798
Leishmania major cathepsin L-like protease 0.0222 0.2705 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.2705 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0222 0.2705 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.0943 0.5
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0114 0.1289 0.1003
Onchocerca volvulus 0.0043 0.0347 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0148 0.174 0.5956
Entamoeba histolytica cysteine protease, putative 0.0114 0.1289 0.4054
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0324 0.0025
Brugia malayi Matrixin family protein 0.0043 0.0347 0.1283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0148 0.174 0.5956
Echinococcus granulosus cathepsin L 0.0114 0.1289 0.1003
Loa Loa (eye worm) hypothetical protein 0.0041 0.0324 0.0798
Brugia malayi cathepsin Z-like cysteine proteinase 0.0041 0.0324 0.1199
Onchocerca volvulus Cathepsin F homolog 0.0222 0.2705 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0318 0.0775
Entamoeba histolytica cysteine protease, putative 0.0222 0.2705 1
Onchocerca volvulus 0.0222 0.2705 1
Toxoplasma gondii hypothetical protein 0.003 0.0184 0.0257
Loa Loa (eye worm) hypothetical protein 0.0074 0.0754 0.246
Echinococcus multilocularis cathepsin L 0.0114 0.1289 0.1003
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.0544 0.0233
Loa Loa (eye worm) hypothetical protein 0.0041 0.0324 0.0798
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0318 0.1177
Echinococcus multilocularis cathepsin L cysteine protease 0.0222 0.2705 0.2465
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0041 0.0324 0.0798
Giardia lamblia Hypothetical protein 0.0041 0.0324 0.5
Onchocerca volvulus 0.0222 0.2705 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0318 0.0775
Loa Loa (eye worm) hypothetical protein 0.004 0.0318 0.0775
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0887
Echinococcus multilocularis microtubule associated protein 2 0.0775 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.2705 1
Onchocerca volvulus 0.0222 0.2705 1
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.0544 0.0233
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0222 0.2705 0.2465
Entamoeba histolytica cysteine protease, putative 0.0114 0.1289 0.4054
Trypanosoma cruzi major cysteine proteinase, putative 0.0041 0.0324 0.0798
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0148 0.174 0.6269
Schistosoma mansoni cathepsin F (C01 family) 0.0222 0.2705 0.2465
Brugia malayi Hemopexin family protein 0.006 0.0582 0.2151
Entamoeba histolytica cysteine protease, putative 0.0114 0.1289 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.2705 1
Onchocerca volvulus 0.0222 0.2705 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0324 0.0025
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0041 0.0324 0.1199
Brugia malayi cathepsin F-like cysteine proteinase 0.0041 0.0324 0.1199
Plasmodium vivax unspecified product 0.0041 0.0324 0.0798
Giardia lamblia Cathepsin L precursor 0.0041 0.0324 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0324 0.0025
Brugia malayi Papain family cysteine protease containing protein 0.0222 0.2705 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0041 0.0324 0.0798
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0041 0.0324 0.0006
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0114 0.1289 0.4529
Giardia lamblia Cathepsin L precursor 0.0041 0.0324 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0324 0.0025
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0887
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0324 0.0025
Giardia lamblia Cathepsin B precursor 0.0041 0.0324 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0318 0.0775
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0041 0.0324 0.0798
Schistosoma mansoni cathepsin s 0.0073 0.0751 0.0447
Plasmodium vivax vivapain-3 0.0114 0.1289 0.4529
Entamoeba histolytica cysteine protease, putative 0.0114 0.1289 0.4054
Entamoeba histolytica cysteine protease, putative 0.0114 0.1289 0.4054
Brugia malayi hypothetical protein 0.0025 0.0118 0.0435
Loa Loa (eye worm) hypothetical protein 0.0041 0.0324 0.0798
Entamoeba histolytica cysteine proteinase, putative 0.0114 0.1289 0.4054
Mycobacterium leprae PROBABLE HYDROLASE 0.0052 0.047 0.3761
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0222 0.2705 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0324 0.0006
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0041 0.0324 0.5
Leishmania major cysteine peptidase A (CPA) 0.0222 0.2705 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0222 0.2705 1
Brugia malayi cathepsin L-like precursor 0.0148 0.174 0.6432
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0041 0.0324 0.0798
Plasmodium falciparum serine repeat antigen 7 0.0041 0.0324 0.0798
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0324 0.1199
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0041 0.0324 0.5
Giardia lamblia Cathepsin B precursor 0.0041 0.0324 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.2705 1
Onchocerca volvulus Cathepsin L homolog 0.0041 0.0324 0.0025
Plasmodium vivax unspecified product 0.0114 0.1289 0.4529
Giardia lamblia Cathepsin B precursor 0.0041 0.0324 0.5
Brugia malayi Cathepsin L-like cysteine proteinase 0.0148 0.174 0.6432
Entamoeba histolytica cysteine protease, putative 0.0114 0.1289 0.4054
Giardia lamblia Cathepsin B precursor 0.0041 0.0324 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.0324 0.0798
Mycobacterium leprae Probable lipase LipE 0.004 0.0318 0.1768
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0041 0.0324 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.2705 1
Echinococcus multilocularis cathepsin b 0.0041 0.0324 0.0006
Giardia lamblia Cathepsin B precursor 0.0041 0.0324 0.5
Loa Loa (eye worm) matrixin family protein 0.0095 0.1031 0.3531
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.2705 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0875 0.2925
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0324 0.0006
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0041 0.0324 0.5
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0041 0.0324 0.0798
Echinococcus granulosus cathepsin b 0.0041 0.0324 0.0006
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.0943 0.3189
Toxoplasma gondii cathepsin CPC2 0.0041 0.0324 0.0798
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0324 0.0006
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0318 0.0775
Loa Loa (eye worm) hypothetical protein 0.0073 0.0751 0.2446
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0751 0.2446
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.2705 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0751 0.2446
Echinococcus multilocularis cysteine protease 0.0222 0.2705 0.2465
Brugia malayi Cathepsin L-like precursor 0.0148 0.174 0.6432
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0041 0.0324 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0324 0.0025
Leishmania major hypothetical protein, conserved 0.004 0.0318 0.0775
Schistosoma mansoni cathepsin B (C01 family) 0.0041 0.0324 0.0006
Entamoeba histolytica cysteine protease, putative 0.0114 0.1289 0.4054
Schistosoma mansoni cathepsin S (C01 family) 0.0041 0.0324 0.0006
Loa Loa (eye worm) hypothetical protein 0.004 0.0318 0.0775
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0324 0.0025
Trypanosoma cruzi cysteine peptidase, putative 0.0222 0.2705 1
Brugia malayi Matrixin family protein 0.0043 0.0347 0.1283
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.2705 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.2705 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0041 0.0324 0.0798
Toxoplasma gondii cathepsin CPL 0.0222 0.2705 1
Toxoplasma gondii cathepsin CPC1 0.0041 0.0324 0.0798
Loa Loa (eye worm) hypothetical protein 0.0088 0.0943 0.3189
Loa Loa (eye worm) hypothetical protein 0.0148 0.174 0.6269
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.2705 1
Plasmodium vivax hypothetical protein, conserved 0.004 0.0318 0.0775
Onchocerca volvulus Matrilysin homolog 0.0095 0.1031 0.2987
Brugia malayi cathepsin L-like cysteine proteinase 0.0041 0.0324 0.1199
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0324 0.0025
Leishmania major cathepsin L-like protease 0.0222 0.2705 1
Brugia malayi Cathepsin L-like precursor 0.0222 0.2705 1
Loa Loa (eye worm) fibroinase 0.0222 0.2705 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.2705 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0088 0.0943 0.0645
Plasmodium vivax unspecified product 0.0073 0.0751 0.2446
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0222 0.2705 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0058 0.0544 0.0786
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0041 0.0324 0.0798
Giardia lamblia Cathepsin B precursor 0.0041 0.0324 0.5
Brugia malayi Matrixin family protein 0.0043 0.0347 0.1283
Leishmania major cathepsin L-like protease 0.0222 0.2705 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0041 0.0324 0.0798
Entamoeba histolytica cysteine proteinase 1, putative 0.0114 0.1289 0.4054
Plasmodium vivax vivapain-1 0.0114 0.1289 0.4529

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 17 uM Inhibitory activity against protein kinase C (PKC) ChEMBL. No reference
Phorbol displacement (binding) <= 50 uM Displacement of phorbol [3H]-PDBu from protein kinase C; A - Did displace phorbol (PDBu) at 50 microM or less ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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