Detailed information for compound 1862013

Basic information

Technical information
  • TDR Targets ID: 1862013
  • Name: (2S)-2-amino-4-(aminomethyl-hydroxyphosphoryl )butanoic acid dihydrochloride
  • MW: 269.063 | Formula: C5H15Cl2N2O4P
  • H donors: 4 H acceptors: 4 LogP: -5.87 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCP(=O)(CC[C@@H](C(=O)O)N)O.Cl.Cl
  • InChi: 1S/C5H13N2O4P.2ClH/c6-3-12(10,11)2-1-4(7)5(8)9;;/h4H,1-3,6-7H2,(H,8,9)(H,10,11);2*1H/t4-;;/m0../s1
  • InChiKey: MNFMFCIMPIAWKD-FHNDMYTFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-amino-4-(aminomethyl-hydroxy-phosphoryl)butanoic acid dihydrochloride
  • (2S)-2-amino-4-(aminomethyl-hydroxy-phosphoryl)butyric acid dihydrochloride

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli glutamine synthetase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) Get druggable targets OG5_127086 All targets in OG5_127086
Plasmodium berghei glutamine synthetase, putative Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium tuberculosis Glutamine synthetase GlnA1 (glutamine synthase) (GS-I) Get druggable targets OG5_127086 All targets in OG5_127086
Plasmodium falciparum glutamine synthetase, putative Get druggable targets OG5_127086 All targets in OG5_127086
Plasmodium vivax glutamine synthetase, putative Get druggable targets OG5_127086 All targets in OG5_127086
Schistosoma japonicum Glutamine synthetase, putative Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) Get druggable targets OG5_127086 All targets in OG5_127086
Schistosoma mansoni glutamine synthetase bacteria Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium leprae GLUTAMINE SYNTHETASE GLNA1 (GLUTAMINE SYNTHASE) (Glutamate--ammonia ligase 1) (GS-I) Get druggable targets OG5_127086 All targets in OG5_127086
Neospora caninum Glutamine synthetase (EC 6.3.1.2), related Get druggable targets OG5_127086 All targets in OG5_127086
Toxoplasma gondii glutamine synthetase, type I, putative Get druggable targets OG5_127086 All targets in OG5_127086
Schistosoma mansoni glutamine synthetase bacteria Get druggable targets OG5_127086 All targets in OG5_127086
Cryptosporidium parvum glutamate synthetase, possible bacterial origin, beta-grasp+glutamate synthase catalytic domain Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium ulcerans glutamine synthetase Get druggable targets OG5_127086 All targets in OG5_127086
Schistosoma japonicum ko:K01915 glutamine synthetase [EC6.3.1.2], putative Get druggable targets OG5_127086 All targets in OG5_127086
Cryptosporidium hominis glutamine synthetase Get druggable targets OG5_127086 All targets in OG5_127086
Schistosoma japonicum expressed protein Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium ulcerans glutamine synthetase GlnA1 Get druggable targets OG5_127086 All targets in OG5_127086
Mycobacterium tuberculosis Probable glutamine synthetase GlnA4 (glutamine synthase) (GS-II) Get druggable targets OG5_127086 All targets in OG5_127086
Wolbachia endosymbiont of Brugia malayi glutamine synthetase Get druggable targets OG5_127086 All targets in OG5_127086
Plasmodium knowlesi glutamine synthetase, putative Get druggable targets OG5_127086 All targets in OG5_127086
Plasmodium yoelii glutamine synthetase, putative Get druggable targets OG5_127086 All targets in OG5_127086
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0897 0.9983 1
Schistosoma mansoni biogenic amine receptor 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0897 0.9983 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0897 0.9983 1
Onchocerca volvulus 0.0897 0.9983 1
Loa Loa (eye worm) neuropeptide F receptor 0.0897 0.9983 1
Loa Loa (eye worm) TYRA-2 protein 0.0897 0.9983 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0897 0.9983 1
Echinococcus granulosus neuropeptide receptor 0.0897 0.9983 1
Schistosoma mansoni amine GPCR 0.0897 0.9983 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0897 0.9983 1
Echinococcus multilocularis fmrfamide receptor 0.0897 0.9983 1
Brugia malayi putative neuropeptide receptor 0.0897 0.9983 0.5
Brugia malayi AKH receptor 0.0897 0.9983 0.5
Leishmania major glutamine synthetase, putative 0.0089 0 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0897 0.9983 1
Echinococcus multilocularis neuropeptide Y receptor 0.0897 0.9983 1
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.0898 1 1
Onchocerca volvulus 0.0897 0.9983 1
Onchocerca volvulus 0.0897 0.9983 1
Schistosoma mansoni amine GPCR 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus multilocularis somatostatin receptor 0.0897 0.9983 1
Brugia malayi hypothetical protein 0.0897 0.9983 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0897 0.9983 1
Onchocerca volvulus 0.0897 0.9983 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0897 0.9983 1
Brugia malayi hypothetical protein 0.0897 0.9983 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.0897 0.9983 1
Loa Loa (eye worm) G-protein coupled receptor 0.0897 0.9983 1
Wolbachia endosymbiont of Brugia malayi glutamine synthetase 0.0104 0.0189 0.5
Schistosoma mansoni opsin-like receptor 0.0897 0.9983 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0897 0.9983 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0897 0.9983 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0897 0.9983 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0897 0.9983 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0897 0.9983 1
Echinococcus multilocularis neuropeptide receptor 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0897 0.9983 1
Echinococcus multilocularis neuropeptide receptor A26 0.0897 0.9983 1
Echinococcus multilocularis fmrfamide receptor 0.0897 0.9983 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0897 0.9983 1
Trypanosoma brucei glutamine synthetase, putative 0.0089 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Onchocerca volvulus 0.0897 0.9983 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0897 0.9983 1
Echinococcus granulosus neuropeptide receptor A26 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0897 0.9983 0.5
Onchocerca volvulus 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0897 0.9983 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0897 0.9983 1
Brugia malayi GnHR receptor homolog 0.0897 0.9983 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0897 0.9983 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0897 0.9983 1
Echinococcus multilocularis neuropeptide Y receptor 0.0897 0.9983 1
Brugia malayi hypothetical protein 0.0897 0.9983 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0897 0.9983 1
Schistosoma mansoni hypothetical protein 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0897 0.9983 1
Echinococcus multilocularis neuropeptides capa receptor 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0897 0.9983 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0897 0.9983 0.5
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0897 0.9983 1
Schistosoma mansoni neuropeptide F-like receptor 0.0897 0.9983 1
Onchocerca volvulus 0.0897 0.9983 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus granulosus somatostatin receptor 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus granulosus g-protein coupled receptor 0.0897 0.9983 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0897 0.9983 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0897 0.9983 0.5
Brugia malayi G-protein coupled receptor 0.0897 0.9983 0.5
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Brugia malayi Dopamine receptor protein 1 0.0897 0.9983 0.5
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0897 0.9983 1
Echinococcus granulosus tm gpcr rhodopsin 0.0897 0.9983 1
Brugia malayi ORL1-like opioid receptor 0.0897 0.9983 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0897 0.9983 1
Echinococcus multilocularis g-protein coupled receptor 0.0897 0.9983 1
Echinococcus granulosus g protein coupled receptor 0.0897 0.9983 1
Schistosoma mansoni amine GPCR 0.0897 0.9983 1
Echinococcus granulosus neuropeptides capa receptor 0.0897 0.9983 1
Echinococcus granulosus orexin receptor type 2 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus granulosus g protein coupled receptor 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0897 0.9983 1
Loa Loa (eye worm) neuropeptide F receptor 0.0897 0.9983 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0897 0.9983 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0897 0.9983 1
Echinococcus granulosus sex peptide receptor 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Onchocerca volvulus 0.0897 0.9983 1
Echinococcus multilocularis neuropeptide receptor 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0897 0.9983 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0897 0.9983 1
Onchocerca volvulus 0.0897 0.9983 1
Echinococcus multilocularis g protein coupled receptor 0.0897 0.9983 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0897 0.9983 1
Brugia malayi putative neuropeptide receptor NPR1 0.0897 0.9983 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0897 0.9983 1
Brugia malayi neuropeptide F receptor 0.0897 0.9983 0.5
Brugia malayi hypothetical protein 0.0897 0.9983 0.5
Echinococcus granulosus serotonin receptor 0.0897 0.9983 1
Echinococcus granulosus fmrfamide receptor 0.0897 0.9983 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0897 0.9983 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0897 0.9983 0.5
Onchocerca volvulus 0.0897 0.9983 1
Echinococcus granulosus neuropeptide Y receptor 0.0897 0.9983 1
Echinococcus multilocularis serotonin receptor 0.0897 0.9983 1
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0158 0.0855 0.0678
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Plasmodium falciparum glutamine synthetase, putative 0.0158 0.0855 0.5
Plasmodium vivax glutamine synthetase, putative 0.0158 0.0855 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0897 0.9983 1
Echinococcus multilocularis neuropeptides capa receptor 0.0897 0.9983 1
Brugia malayi G protein-coupled receptor 0.0897 0.9983 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0897 0.9983 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0897 0.9983 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0897 0.9983 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0897 0.9983 1
Brugia malayi neuropeptide F receptor 0.0897 0.9983 0.5
Brugia malayi hypothetical protein 0.0897 0.9983 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0897 0.9983 1
Brugia malayi RE15519p 0.0897 0.9983 0.5
Schistosoma mansoni neuropeptide receptor 0.0897 0.9983 1
Brugia malayi sulfakinin receptor protein 0.0897 0.9983 0.5
Schistosoma mansoni hypothetical protein 0.0897 0.9983 1
Brugia malayi hypothetical protein 0.0897 0.9983 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0897 0.9983 1
Echinococcus granulosus dro:myosuppressin receptor 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0897 0.9983 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0897 0.9983 1
Toxoplasma gondii glutamine synthetase, type I, putative 0.0158 0.0855 0.5
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0897 0.9983 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0897 0.9983 1
Brugia malayi Melatonin receptor type 1A 0.0897 0.9983 0.5
Schistosoma mansoni neuropeptide receptor 0.0897 0.9983 1
Onchocerca volvulus 0.0897 0.9983 1
Schistosoma mansoni biogenic amine receptor 0.0897 0.9983 1
Echinococcus granulosus hypothetical protein 0.0897 0.9983 1
Echinococcus granulosus neuropeptides capa receptor 0.0897 0.9983 1
Schistosoma mansoni opsin-like receptor 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Brugia malayi follicle stimulating hormone receptor 0.0897 0.9983 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0897 0.9983 1
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.0898 1 1
Onchocerca volvulus 0.0897 0.9983 1
Schistosoma mansoni glutamine synthetase bacteria 0.0104 0.0189 0.019
Echinococcus multilocularis sex peptide receptor 0.0897 0.9983 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0897 0.9983 1
Schistosoma mansoni biogenic amine receptor 0.0897 0.9983 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0897 0.9983 1
Schistosoma mansoni hypothetical protein 0.0897 0.9983 1
Echinococcus multilocularis serotonin receptor 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus multilocularis allatostatin A receptor 0.0897 0.9983 1
Brugia malayi Dopamine receptor protein 2 0.0897 0.9983 0.5
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0897 0.9983 1
Schistosoma mansoni amine GPCR 0.0897 0.9983 1
Echinococcus granulosus allatostatin A receptor 0.0897 0.9983 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0897 0.9983 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0897 0.9983 1
Brugia malayi G-protein coupled receptor 0.0897 0.9983 0.5
Echinococcus multilocularis orexin receptor type 2 0.0897 0.9983 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0897 0.9983 1
Trypanosoma cruzi glutamine synthetase, putative 0.0089 0 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0897 0.9983 1
Brugia malayi larval opioid receptor 0.0897 0.9983 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0897 0.9983 1
Brugia malayi hypothetical protein 0.0897 0.9983 0.5
Brugia malayi Dopamine receptor 0.0897 0.9983 0.5
Echinococcus granulosus neuropeptide receptor 0.0897 0.9983 1
Brugia malayi hypothetical protein 0.0897 0.9983 0.5
Schistosoma mansoni adenoreceptor 0.0897 0.9983 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0897 0.9983 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0897 0.9983 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0897 0.9983 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0897 0.9983 1
Loa Loa (eye worm) G-protein coupled receptor 0.0897 0.9983 1
Schistosoma mansoni neuropeptide F-like receptor 0.0897 0.9983 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0897 0.9983 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus granulosus neuropeptide s receptor 0.0897 0.9983 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0897 0.9983 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0897 0.9983 1
Schistosoma mansoni amine GPCR 0.0897 0.9983 1
Echinococcus granulosus neuropeptide Y receptor 0.0897 0.9983 1
Brugia malayi hypothetical protein 0.0897 0.9983 0.5
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Schistosoma mansoni histamine h1 receptor 0.0897 0.9983 1
Schistosoma mansoni glutamine synthetase bacteria 0.0104 0.0189 0.019
Echinococcus granulosus biogenic amine 5HT receptor 0.0897 0.9983 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0897 0.9983 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0897 0.9983 1
Echinococcus granulosus G protein coupled receptor 139 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0897 0.9983 1
Echinococcus multilocularis g protein coupled receptor 0.0897 0.9983 1
Trypanosoma cruzi glutamine synthetase, putative 0.0089 0 0.5
Onchocerca volvulus 0.0897 0.9983 1
Brugia malayi Serotonin receptor 0.0897 0.9983 0.5
Onchocerca volvulus 0.0897 0.9983 1
Onchocerca volvulus 0.0897 0.9983 1
Echinococcus multilocularis neuropeptide s receptor 0.0897 0.9983 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0897 0.9983 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0897 0.9983 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0897 0.9983 1
Schistosoma mansoni hypothetical protein 0.0897 0.9983 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0897 0.9983 1
Brugia malayi Serotonin receptor 0.0897 0.9983 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0897 0.9983 1
Schistosoma mansoni neuropeptide receptor 0.0897 0.9983 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0897 0.9983 1
Schistosoma mansoni neuropeptide receptor 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Loa Loa (eye worm) hypothetical protein 0.0897 0.9983 1
Schistosoma mansoni myosin xvIII 0.0897 0.9983 1
Onchocerca volvulus 0.0897 0.9983 1
Echinococcus multilocularis g protein coupled receptor 0.0897 0.9983 1
Echinococcus granulosus tm gpcr rhodopsin 0.0897 0.9983 1
Onchocerca volvulus 0.0897 0.9983 1
Schistosoma mansoni opsin-like receptor 0.0897 0.9983 1
Brugia malayi hypothetical protein 0.0897 0.9983 0.5
Echinococcus granulosus g protein coupled receptor 0.0897 0.9983 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1 uM Inhibitory concentration against glutamine synthetase incubated at 37 degree C for 20 minutes in pH 7.4 ChEMBL. 16190760
Ki (binding) = -6.229 Binding affinity towards glutamine synthetase ChEMBL. 16190760
Ki (binding) = 0.59 uM Binding affinity towards glutamine synthetase ChEMBL. 16190760

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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