Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0313 | 0.0714 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0313 | 0.0714 | 1 |
Echinococcus granulosus | neuroligin | 0.0313 | 0.0714 | 0.0714 |
Brugia malayi | Carboxylesterase family protein | 0.0313 | 0.0714 | 0.0714 |
Onchocerca volvulus | 0.0313 | 0.0714 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0313 | 0.0714 | 0.0714 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0313 | 0.0714 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1852 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0313 | 0.0714 | 0.0714 |
Loa Loa (eye worm) | carboxylesterase | 0.1852 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0313 | 0.0714 | 0.0714 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.0714 | 0.0714 |
Onchocerca volvulus | 0.0313 | 0.0714 | 1 | |
Echinococcus multilocularis | neuroligin | 0.0313 | 0.0714 | 0.0714 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1852 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0313 | 0.0714 | 0.0714 |
Loa Loa (eye worm) | hypothetical protein | 0.1852 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1852 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0195 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0313 | 0.0714 | 0.0714 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.0714 | 0.0714 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0313 | 0.0714 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0313 | 0.0714 | 0.0714 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0313 | 0.0714 | 1 |
Onchocerca volvulus | 0.0313 | 0.0714 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.0714 | 0.0714 |
Brugia malayi | Carboxylesterase family protein | 0.0313 | 0.0714 | 0.0714 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0313 | 0.0714 | 0.0714 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0195 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1852 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.0714 | 0.0714 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0313 | 0.0714 | 0.0714 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0313 | 0.0714 | 0.0714 |
Loa Loa (eye worm) | hypothetical protein | 0.1852 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0313 | 0.0714 | 0.0714 |
Echinococcus multilocularis | acetylcholinesterase | 0.1852 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1852 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0313 | 0.0714 | 0.0714 |
Schistosoma mansoni | gliotactin | 0.0313 | 0.0714 | 0.0714 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0313 | 0.0714 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0 | 0.5 |
Onchocerca volvulus | 0.0313 | 0.0714 | 1 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0313 | 0.0714 | 0.0714 |
Echinococcus granulosus | carboxylesterase 5A | 0.1852 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0313 | 0.0714 | 0.0714 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0313 | 0.0714 | 0.0714 |
Brugia malayi | Carboxylesterase family protein | 0.1852 | 1 | 1 |
Onchocerca volvulus | 0.0313 | 0.0714 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.0714 | 0.0714 |
Loa Loa (eye worm) | carboxylesterase | 0.0313 | 0.0714 | 0.0714 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.0714 | 0.0714 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1852 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0313 | 0.0714 | 0.0714 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0313 | 0.0714 | 0.0714 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.0714 | 0.0714 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.3 nM | Tested for inhibition against thymidylate synthase(TS) which is partially purified from L1210 mouse leukemia cells | ChEMBL. | 7932557 |
IC50 (binding) | = 4.3 nM | Tested for inhibition against thymidylate synthase(TS) which is partially purified from L1210 mouse leukemia cells | ChEMBL. | 7932557 |
IC50 (functional) | = 0.4 uM | Tested for inhibition against growth of L1210 mouse leukemia cell lines | ChEMBL. | 7932557 |
IC50 (functional) | = 0.4 uM | Tested for inhibition against growth of L1210 mouse leukemia cell lines | ChEMBL. | 7932557 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 7932557 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.