Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0056 | 0.256 | 0.256 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0056 | 0.256 | 0.256 |
Echinococcus multilocularis | acetylcholinesterase | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0056 | 0.256 | 0.256 |
Loa Loa (eye worm) | carboxylesterase | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0056 | 0.256 | 0.256 |
Echinococcus granulosus | carboxylesterase 5A | 0.0092 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0092 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0092 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0092 | 1 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0056 | 0.256 | 0.256 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0056 | 0.256 | 0.256 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0056 | 0.256 | 0.256 |
Brugia malayi | jmjC domain containing protein | 0.0056 | 0.256 | 0.256 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0056 | 0.256 | 0.256 |
Echinococcus granulosus | acetylcholinesterase | 0.0092 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0092 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0056 | 0.256 | 0.256 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.