Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0036 | 0.1872 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0064 | 0.4681 | 0.4681 |
Brugia malayi | Cytochrome P450 family protein | 0.0064 | 0.4681 | 0.4681 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0018 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0064 | 0.4681 | 0.4681 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0018 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0018 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0018 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0018 | 0 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0018 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0064 | 0.4681 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0115 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1872 | 0.3 |
Leishmania major | cytochrome p450-like protein | 0.0064 | 0.4681 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0018 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0036 | 0.1872 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.6238 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0018 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0018 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0115 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0064 | 0.4681 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0079 | 0.6238 | 0.6238 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0064 | 0.4681 | 0.4681 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.6238 | 0.6238 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0064 | 0.4681 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0036 | 0.1872 | 0.1872 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0064 | 0.4681 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0036 | 0.1872 | 0.1872 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0036 | 0.1872 | 0.1872 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0018 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0036 | 0.1872 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1872 | 0.1872 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.279 | 0.279 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0018 | 0 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1872 | 0.3 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1872 | 0.3 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0036 | 0.1872 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0036 | 0.1872 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1872 | 0.3 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0018 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0018 | 0 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0036 | 0.1872 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0064 | 0.4681 | 0.4681 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.